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Computational somatic medicine based on predictive coding: A basic study on Irritable Bowel Syndrome

Research Project

Project/Area Number 19KK0062
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 10:Psychology and related fields
Research InstitutionNagoya University

Principal Investigator

Ohira Hideki  名古屋大学, 情報学研究科, 教授 (90221837)

Co-Investigator(Kenkyū-buntansha) 片平 健太郎  国立研究開発法人産業技術総合研究所, 情報・人間工学領域, 主任研究員 (60569218)
木村 健太  国立研究開発法人産業技術総合研究所, 情報・人間工学領域, 研究グループ長 (40589272)
遠山 朝子  一橋大学, 大学院ソーシャル・データサイエンス研究科, 特任助教 (10816549)
齋藤 菜月  名古屋大学, 情報学研究科, 研究員 (60844834)
Project Period (FY) 2019-10-07 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2023: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2022: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords生理 / 計算論的心身医学 / 過敏性腸症候群 / 意思決定 / 予測 / 計算論 / 心身医学
Outline of Research at the Start

脳は身体状態のモデルを構成して身体からの感覚信号を予測し、それにより身体内部の知覚である内受容感覚を創発していると考えられている。本研究は、脳と身体の機能疾患である心身症はこのメカニズムの不全であるとの仮説を設定する。本研究では、代表的な心身症である過敏性腸症候群を対象とし、この疾患について豊富な研究経験と患者のデータ・ベースを持つクロアチアのリエカ大学と共同して、この仮説を実証的に検討する。特に、患者の内受容感覚に関する計算論的モデルを開発し、実験データとの適合性を検討することにより、計算論的心身医学ともいうべき研究と臨床実践の新しい領域を拓くことを目指す。

Outline of Final Research Achievements

In collaboration with the University of Rijeka in Croatia, we empirically examined the hypothesis that irritable bowel syndrome (IBS) leads to alterations in cognition and decision-making due to impaired interoception. We measured psychological indices, cognitive functions, and decision-making in 50 IBS patients and 64 healthy controls. The IBS patient group had higher visceral sensitivity and anxiety, but their cognitive functions were normal, and they were sensitive to rewards and tended to be rational in decision-making. Contrary to the hypothesis, we found no abnormalities in interoception or associated alterations in maladaptive decision-making in IBS patients. Although the cause of this result is unknown, it is suggested that IBS patients may maintain their cognitive functions and ability to make rational decisions in order to compensate for their chronic physical symptoms.

Academic Significance and Societal Importance of the Research Achievements

過敏性腸症候群(IBS)は難治性の機能性消化器疾患であり、この症状に苦しむ患者は増加している。その病理やその背景となる生理学的メカニズムの解明は進んでいるが、IBS患者の性格特性、認知機能や行動の特性などの理解は未知の部分が多い。本研究は、IBSに伴う心理行動的特性を網羅的に調査し、その特性を明らかにした点、さらにその背景メカニズムとして強化学習モデルという計算論モデルを想定して実証的に検討したことで計算論的心身医学とも言うべき新しい研究分野の1事例を提出した点で、高い学術的意義がある。また、患者数が増え社会的関心が高まっているIBSの心理学的理解を深化させたことで社会的意義もあると言える。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (36 results)

All 2024 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (5 results) Journal Article (18 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 16 results,  Open Access: 14 results) Presentation (9 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Book (3 results) Funded Workshop (1 results)

  • [Int'l Joint Research] リエカ大学(クロアチア)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] リエカ大学(クロアチア)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] リエカ大学(クロアチア)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Rijeka University(クロアチア)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] リエカ大学(クロアチア)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Association of brain-autonomic activities and task accuracy under cognitive load: a pilot study using electroencephalogram, autonomic activity measurements, and arousal level estimated by machine learning2024

    • Author(s)
      Sazuka Naoya、Katsumata Koki、Komoriya Yota、Oba Takeyuki、Ohira Hideki
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 18

    • DOI

      10.3389/fnhum.2024.1272121

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集 アロスタシス-ホメオスタシスを超えて 内受容感覚・意思決定・感情の統合-予測的処理としてのアロスタシス2023

    • Author(s)
      大平 英樹
    • Journal Title

      BRAIN and NERVE

      Volume: 75 Issue: 11 Pages: 1197-1203

    • DOI

      10.11477/mf.1416202505

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2023-11-01
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PREDICTIVE PROCESSING AND EMERGENCE OF THE HUMAN MIND2023

    • Author(s)
      Ohira Hideki
    • Journal Title

      PSYCHOLOGIA

      Volume: 65 Issue: 2 Pages: 134-159

    • DOI

      10.2117/psysoc.2023-B032

    • ISSN
      0033-2852, 1347-5916
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of interoceptive accuracy on timing control in the synchronization tapping task2023

    • Author(s)
      Tomyta Kenta、Katahira Kentaro、Ohira Hideki
    • Journal Title

      Frontiers in Neuroscience

      Volume: 16 Pages: 01-09

    • DOI

      10.3389/fnins.2022.907836

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The autonomic nervous system and decision-making2023

    • Author(s)
      大平 英樹
    • Journal Title

      The Autonomic Nervous System

      Volume: 60 Issue: 4 Pages: 144-150

    • DOI

      10.32272/ans.60.4_144

    • ISSN
      0288-9250, 2434-7035
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Examinations of Biases by Model Misspecification and Parameter Reliability of Reinforcement Learning Models2023

    • Author(s)
      Toyama Asako、Katahira Kentaro、Kunisato Yoshihiko
    • Journal Title

      Computational Brain & Behavior

      Volume: 6 Issue: 4 Pages: 651-670

    • DOI

      10.1007/s42113-023-00175-4

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial: Interoception and the autonomic nervous system: Investigating affect, decision-making, and mental health2023

    • Author(s)
      Ueno Daisuke、Ohira Hideki、Narumoto Jin
    • Journal Title

      Frontiers in Neuroscience

      Volume: 16 Pages: 1-2

    • DOI

      10.3389/fnins.2022.1130324

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mothers’ interoceptive sensibility mediates affective interaction between mother and infant2022

    • Author(s)
      Suga Ayami、Naruto Yosuke、Maulina Venie Viktoria Rondang、Uraguchi Maki、Ozaki Yuka、Ohira Hideki
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s41598-022-09988-y

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interoceptive Accuracy Did Not Affect Moral Decision-Making, but Affect Regret Rating for One’s Moral Choices2022

    • Author(s)
      Tamura Kaho、Kobayashi Yoshinari、Ohira Hideki
    • Journal Title

      Frontiers in Psychology

      Volume: 12 Pages: 1-9

    • DOI

      10.3389/fpsyg.2021.746897

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interoceptive accuracy correlates with precision of time perception in the millisecond range2022

    • Author(s)
      Uraguchi Maki、Maulina Venie Viktoria Rondang、Ohira Hideki
    • Journal Title

      Frontiers in Neuroscience

      Volume: 16 Pages: 1-16

    • DOI

      10.3389/fnins.2022.993491

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Somatic Symptoms: Association Among Affective State, Subjective Body Perception, and Spiritual Belief in Japan and Indonesia2022

    • Author(s)
      Maulina Venie Viktoria Rondang、Yogo Masao、Ohira Hideki
    • Journal Title

      Frontiers in Psychology

      Volume: 13 Pages: 851888-851888

    • DOI

      10.3389/fpsyg.2022.851888

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A learning mechanism shaping risk preferences and a preliminary test of its relationship with psychopathic traits2021

    • Author(s)
      Oba Takeyuki, Katahira Kentaro, Ohira Hideki
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 20853-20853

    • DOI

      10.1038/s41598-021-00358-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 感情と意思決定を創発する予測的処理2021

    • Author(s)
      大平英樹
    • Journal Title

      人工知能

      Volume: 36 Pages: 21-27

    • NAID

      130007965563

    • Related Report
      2020 Research-status Report
  • [Journal Article] The neural network basis of altered decision‐making in patients with amyotrophic lateral sclerosis2020

    • Author(s)
      Imai Kazunori、Masuda Michihito、Watanabe Hirohisa、Ogura Aya、Ohdake Reiko、Tanaka Yasuhiro、Kato Toshiyasu、Kawabata Kazuya、Riku Yuichi、Hara Kazuhiro、Nakamura Ryoichi、Atsuta Naoki、Bagarinao Epifanio、Katahira Kentaro、Ohira Hideki、Katsuno Masahisa、Sobue Gen
    • Journal Title

      Annals of Clinical and Translational Neurology

      Volume: 7 Issue: 11 Pages: 2115-2126

    • DOI

      10.1002/acn3.51185

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive processing of interoception, decision-making, and allostasis: A computational framework and implications for emotional intelligence2020

    • Author(s)
      Ohira, H
    • Journal Title

      Psychological Topics,

      Volume: 15 Issue: 1 Pages: 1-16

    • DOI

      10.31820/pt.29.1.1

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biases in estimating the balance between model-free and model-based learning systems due to model misspecification2019

    • Author(s)
      Toyama Asako, Katahira Kentaro, Ohira Hideki
    • Journal Title

      Journal of Mathematical Psychology

      Volume: 91 Pages: 88-102

    • DOI

      10.1016/j.jmp.2019.03.007

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reinforcement learning with parsimonious computation and a forgetting process2019

    • Author(s)
      Toyama Asako, Katahira Kentaro, Ohira Hideki
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 13 Pages: 153-153

    • DOI

      10.3389/fnhum.2019.00153

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脳と身体の予測的符号化とその不全:ー守谷・国里・杉浦論文へのコメントー2019

    • Author(s)
      大平英樹
    • Journal Title

      心理学評論

      Volume: 62 Pages: 132-141

    • NAID

      130007749846

    • Related Report
      2019 Research-status Report
  • [Presentation] Psychological, behavioral, and computatioble bowel syndrome: Decision-Making Processes nal characteristics of irritaand its Relation to Cognitive Functions in IBS2024

    • Author(s)
      Natsuki Saito, Asako Toyama, Kenta Kimura, Kentaro Katahira, Sanda Pletikosic Toncic, Marko Toncic, Mladenka Tkalcic, Hideki Ohira
    • Organizer
      Annual Meeting of American Psychosomatic Society
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Psychological, cognitive, and interoceptive characteristics of IBS: Comparisons between clinical and healthy groups2024

    • Author(s)
      Sanda Pletikosic Toncic, Natsuki Saito, Asako Toyama, Marko Toncic, Kimura Kenta, Kentaro Katahira, Hideki Ohira & Mladenka Tkalcic
    • Organizer
      Annual Meeting of American Psychosomatic Society
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 計算論的精神医学と内受容感覚2020

    • Author(s)
      大平英樹
    • Organizer
      第20回日本認知療法学会・認知行動療法学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 内受容感覚の予測的処理と感情と意思決定の創発2020

    • Author(s)
      大平英樹
    • Organizer
      第34回人工知能学会全国大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Slow EEG fluctuation reflecting behavioral changes by cognitive load.2020

    • Author(s)
      Sazuka, N., Katsumata, K., Komoriya, Y., Ezaki, T., & Ohira, H.
    • Organizer
      42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of increased interoceptive awareness on postpartum depression and emotional states: An experience sampling study using smartphone photoplethysmography.2020

    • Author(s)
      Suga, A., Naruto, Y., Venie Viktoria Rondang Maulina, Uraguchi, M., Sasaki, T., Ozaki, Y., & Ohira, H.
    • Organizer
      2020 Annual conference of the Society for Affective Science
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Human affective-states estimation by a model of meta-level patterns of EEG.2020

    • Author(s)
      Sazuka, N., Komoriya, Y., Ezaki, T., Oba, T., & Ohira, H.
    • Organizer
      2020 Annual conference of the Society for Affective Science
    • Related Report
      2020 Research-status Report
  • [Presentation] 予兆にもとづく意思決定2019

    • Author(s)
      大平英樹
    • Organizer
      名古屋大学予兆学シンポジウム YOCHOU2019
    • Related Report
      2019 Research-status Report
  • [Presentation] 脳と身体の計算メカニズムによる感情と意思決定の創発2019

    • Author(s)
      大平英樹
    • Organizer
      名古屋大学情報学シンポジウム2020
    • Related Report
      2019 Research-status Report
  • [Book] 認知科学講座4 心をとらえるフレームワークの展開2022

    • Author(s)
      横澤一彦(編)
    • Total Pages
      272
    • Publisher
      東京大学出版会
    • ISBN
      9784130152044
    • Related Report
      2022 Research-status Report
  • [Book] 予測と創発2022

    • Author(s)
      中村靖子(編)
    • Total Pages
      450
    • Publisher
      春風社
    • ISBN
      4861108365
    • Related Report
      2022 Research-status Report
  • [Book] Razgovor između mozga i crijeva: što se događa kad crijeva postanu nervozna? Pogled na sindrom iritabilnoga crijeva iz biopsihosocijalne perspektive (Conversation between the brain and the intestine: What happens when the intestines become nervous?: A look at the irritable bowel syndrome from a biopsychosocial perspective)2022

    • Author(s)
      Hideki Ohira, Mladenka Tkalčić i Marko Tončić
    • Total Pages
      515
    • Publisher
      Sveučilište u Rijeci, Filozofski fakultet
    • ISBN
      9789533610566
    • Related Report
      2021 Research-status Report
  • [Funded Workshop] Croatia-Japan International Meeting on Psychology, Philosophy, and Neuroscience2023

    • Related Report
      2023 Annual Research Report

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Published: 2019-10-10   Modified: 2025-01-30  

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