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Development of a novel mass analysis approach on the basis of mechanical deformation induced by gas flow in a micron channel

Research Project

Project/Area Number 19KK0141
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 34:Inorganic/coordination chemistry, analytical chemistry, and related fields
Research InstitutionNational Institute for Materials Science

Principal Investigator

SHIBA Kota  国立研究開発法人物質・材料研究機構, 高分子・バイオ材料研究センター, 主幹研究員 (20638126)

Co-Investigator(Kenkyū-buntansha) 田村 亮  国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, 主幹研究員 (20636998)
Project Period (FY) 2019-10-07 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2022: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2021: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2020: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords粘性係数 / マイクロ流路 / 流体力学 / 構造力学 / 流体―構造相互作用 / 気体 / 液体 / 流体 / 質量分析 / マイクロフルイディクス / 機械学習
Outline of Research at the Start

質量分析は、薬剤探索、食品分析、犯罪捜査など多用途に用いられる分析法である。それ故、2002年ノーベル賞のMALDIを経て今なお開発が進む、研究現場に欠かせない主要分析技術である。本研究では、質量分析を研究用途にとどまらず、より手軽かつ広範に使用可能な技術へと昇華させることを目指す。そのために、申請者が独自開発した簡易分子量測定法を中心技術として利用する。共同研究を推進するHarvard大学Weitz教授の協力の下、上記手法による測定対象を拡張し、現行の質量分析を代替しうる分析法へと発展させる。これにより、いつでもどこでも誰でも利用可能な次世代質量分析法を創出する。

Outline of Final Research Achievements

This study focused on mass spectrometers, which are widely used in research and industrial applications, and worked on the development of technology to realise the creation of new applications through their miniaturisation and mobility. Existing mass spectrometers require ionisation in a vacuum environment due to their operating principle, making it difficult to miniaturise them. In the course of carrying out this research, we succeeded in creating a simple method for measuring the viscosity of the object to be measured in an atmospheric environment. It is also possible to measure molecular weight using a similar method, and combining these methods is expected to lead to the development of an extremely simple and compact instrument that can replace existing mass spectrometers in the future.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、これまでモバイル化のように極端な小型設計が困難であった質量分析装置の小型化・低価格化に資するものである。そのサイズ・価格ゆえに従来の質量分析装置の利用は研究開発現場にとどまっていた。本成果をさらに発展させることで、一般消費者レベルでの手軽な利用までもが視野に入り、これによってヘルスケアや環境モニタリング、安全・安心につながる様々な新規用途が拓けると考えている。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (32 results)

All 2024 2023 2022 2021 2020 Other

All Int'l Joint Research (5 results) Journal Article (21 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 18 results,  Open Access: 11 results) Presentation (2 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] Harvard University/University of Connecticut(米国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Harvard University/University of Connecticut(米国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] Harvard University(米国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Harvard University(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Harvard University(米国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Tailoring stresses in piezoresistive microcantilevers for enhanced surface stress sensing: insights from topology optimization2024

    • Author(s)
      Zhuang Chao、Minami Kosuke、Shiba Kota、Yoshikawa Genki
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 63 Issue: 1 Pages: 015005-015005

    • DOI

      10.35848/1347-4065/ad1939

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Audible sensing of low-ppm concentration gases2024

    • Author(s)
      Yildirim Tanju、Feng Meng-Qun、Shiba Kota、Minami Kosuke、Yoshikawa Genki
    • Journal Title

      Sensors and Actuators A: Physical

      Volume: 370 Pages: 115215-115215

    • DOI

      10.1016/j.sna.2024.115215

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sorption Kinetic Parameters from Nanomechanical Sensing for Discrimination of 2-Nonenal from Saturated Aldehydes2024

    • Author(s)
      Minami Kosuke、Zhou Yingcheng、Imamura Gaku、Shiba Kota、Yoshikawa Genki
    • Journal Title

      ACS Sensors

      Volume: 9 Issue: 2 Pages: 689-698

    • DOI

      10.1021/acssensors.3c01888

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Precipitative Coating of Calcium Phosphate on Microporous Silica?Titania Hybrid Particles in Simulated Body Fluid2023

    • Author(s)
      Kimura Reo、Shiba Kota、Fujiwara Kanata、Zhou Yanni、Yamada Iori、Tagaya Motohiro
    • Journal Title

      Inorganics

      Volume: 11 Issue: 6 Pages: 235-235

    • DOI

      10.3390/inorganics11060235

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A portable audible-range acoustical approach for determining headspace vapour-phase properties2023

    • Author(s)
      Yildirim Tanju、Feng Meng-Qun、Shiba Kota、Minami Kosuke、Yoshikawa Genki
    • Journal Title

      Sensors and Actuators A: Physical

      Volume: 358 Pages: 114438-114438

    • DOI

      10.1016/j.sna.2023.114438

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pattern Recognition Using Chemical Sensor for Identification of Solid Materials by Responses to Multiple Probe Gases2023

    • Author(s)
      Minami Kosuke、Shiba Kota、Yoshikawa Genki
    • Journal Title

      IEEE Sensors Letters

      Volume: 7 Issue: 9 Pages: 1-4

    • DOI

      10.1109/lsens.2023.3300802

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topology optimization for piezoresistive nanomechanical surface stress sensors in anisotropic 〈111〉 orientations2023

    • Author(s)
      Zhuang Chao、Minami Kosuke、Shiba Kota、Yoshikawa Genki
    • Journal Title

      Nano Express

      Volume: 4 Issue: 3 Pages: 035007-035007

    • DOI

      10.1088/2632-959x/acef44

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Strain Sensor-Inserted Microchannel for Gas Viscosity Measurement2023

    • Author(s)
      Shiba Kota、Liu Linbo、Li Guangming
    • Journal Title

      Biosensors

      Volume: 13 Issue: 1 Pages: 76-76

    • DOI

      10.3390/bios13010076

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Linear Stiffness Tuning in MEMS Devices via Prestress Introduced by TiN Thin Films2023

    • Author(s)
      Zhuang Chao、Minami Kosuke、Shiba Kota、Yoshikawa Genki
    • Journal Title

      ACS Applied Engineering Materials

      Volume: - Issue: 4 Pages: 1213-1219

    • DOI

      10.1021/acsaenm.3c00034

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dual domain acoustic olfactory discriminator2023

    • Author(s)
      Yildirim Tanju、Feng Meng-Qun、Ngo Thuc Anh、Shiba Kota、Minami Kosuke、Yoshikawa Genki
    • Journal Title

      Sensors and Actuators A: Physical

      Volume: 350 Pages: 114102-114102

    • DOI

      10.1016/j.sna.2022.114102

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 嗅覚センサと機械学習によりニオイのデジタル化に挑む2023

    • Author(s)
      田村亮、柴弘太
    • Journal Title

      Think & Act

      Volume: - Pages: 23-31

    • Related Report
      2022 Research-status Report
  • [Journal Article] Visualization of Flow‐Induced Strain Using Structural Color in Channel‐Free Polydimethylsiloxane Devices2022

    • Author(s)
      Shiba Kota、Zhuang Chao、Minami Kosuke、Imamura Gaku、Tamura Ryo、Samitsu Sadaki、Idei Takumi、Yoshikawa Genki、Sun Luyi、Weitz David A.
    • Journal Title

      Advanced Science

      Volume: 10 Issue: 1 Pages: 2204310-2204310

    • DOI

      10.1002/advs.202204310

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 構造色で気体を「見る」2022

    • Author(s)
      柴弘太
    • Journal Title

      「低次元系光機能材料研究会」ニュースレター

      Volume: 27 Pages: 10-13

    • Related Report
      2022 Research-status Report
    • Open Access
  • [Journal Article] Drug Molecular Immobilization and Photofunctionalization of Calcium Phosphates for Exploring Theranostic Functions2022

    • Author(s)
      Yamada Iori、Shiba Kota、Galindo Tania Guadalupe Pe?aflor、Tagaya Motohiro
    • Journal Title

      Molecules

      Volume: 27 Issue: 18 Pages: 5916-5916

    • DOI

      10.3390/molecules27185916

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent Advances in Nanomechanical Membrane-Type Surface Stress Sensors towards Artificial Olfaction2022

    • Author(s)
      Minami Kosuke、Imamura Gaku、Tamura Ryo、Shiba Kota、Yoshikawa Genki
    • Journal Title

      Biosensors

      Volume: 12 Issue: 9 Pages: 762-762

    • DOI

      10.3390/bios12090762

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 気体および液体粘度の単一マイクロ流路測定2022

    • Author(s)
      柴弘太
    • Journal Title

      油空圧技術

      Volume: 61 Pages: 45-54

    • NAID

      40022804878

    • Related Report
      2021 Research-status Report
  • [Journal Article] Determination of quasi-primary odors by endpoint detection2021

    • Author(s)
      Xu Hanxiao、Kitai Koki、Minami Kosuke、Nakatsu Makito、Yoshikawa Genki、Tsuda Koji、Shiba Kota、Tamura Ryo
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 12070-12070

    • DOI

      10.1038/s41598-021-91210-6

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microchannel measurements of viscosity for both gases and liquids2021

    • Author(s)
      Shiba Kota、Li Guangming、Virot Emmanuel、Yoshikawa Genki、Weitz David A.
    • Journal Title

      Lab on a Chip

      Volume: 21 Issue: 14 Pages: 2805-2811

    • DOI

      10.1039/d1lc00202c

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Odor-Based Nanomechanical Discrimination of Fuel Oils Using a Single Type of Designed Nanoparticles with Nonlinear Viscoelasticity2021

    • Author(s)
      Shiba Kota、Imamura Gaku、Yoshikawa Genki
    • Journal Title

      ACS Omega

      Volume: 6 Issue: 36 Pages: 23389-23398

    • DOI

      10.1021/acsomega.1c03270

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microfluidic Production of Autofluorescent BSA Hydrogel Microspheres and Their Sequential Trapping for Fluorescence-Based On-Chip Permanganate Sensing2020

    • Author(s)
      Liu Linbo、Li Guangming、Xiang Nan、Huang Xing、Shiba Kota
    • Journal Title

      Sensors

      Volume: 20 Issue: 20 Pages: 5886-5886

    • DOI

      10.3390/s20205886

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Strain-based chemical sensing using metal?organic framework nanoparticles2020

    • Author(s)
      Yeung H. H.-M.、Yoshikawa G.、Minami K.、Shiba K.
    • Journal Title

      Journal of Materials Chemistry A

      Volume: 8 Issue: 35 Pages: 18007-18014

    • DOI

      10.1039/d0ta07248f

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 流れ誘起ひずみの構造色による可視化を利用した気体識別デバイス2023

    • Author(s)
      柴弘太, Chao Zhuang, 南皓輔, 今村岳, 田村亮, 佐光貞樹, 出井拓己, 吉川元起, Luyi Sun, David A. Weitz
    • Organizer
      第70回応用物理学会春季学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] マイクロ流路を用いた気体および液体粘度の測定2021

    • Author(s)
      柴弘太, Guangming Li, Emmanuel Virot, 吉川元起, David A. Weitz
    • Organizer
      第82回応用物理学会秋季学術講演会
    • Related Report
      2021 Research-status Report
  • [Remarks] Experimental soft condensed matter group

    • URL

      https://weitzlab.seas.harvard.edu/kota-shiba

    • Related Report
      2023 Annual Research Report 2022 Research-status Report 2021 Research-status Report 2020 Research-status Report
  • [Patent(Industrial Property Rights)] 流体センサ、流路及びその製造方法並びに流体センサ製造方法2022

    • Inventor(s)
      柴弘太, 吉川元起, 佐光貞樹
    • Industrial Property Rights Holder
      物質・材料研究機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-167263
    • Filing Date
      2022
    • Related Report
      2022 Research-status Report
  • [Patent(Industrial Property Rights)] 粘度測定法及び装置2022

    • Inventor(s)
      柴弘太, 吉川元起
    • Industrial Property Rights Holder
      物質・材料研究機構
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-077844
    • Filing Date
      2022
    • Related Report
      2022 Research-status Report
  • [Patent(Industrial Property Rights)] 粘度測定法及び装置2021

    • Inventor(s)
      柴弘太, 吉川元起
    • Industrial Property Rights Holder
      物質・材料研究機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Research-status Report
    • Overseas

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Published: 2019-10-10   Modified: 2025-01-30  

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