Aberrant skeletal muscle-brain communication in sepsis-associated encephalopathy: Elucidating the pathogenic roles of skeletal muscle-derived exosomes

• Project/Area Number: 19KK0224
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
• Research Institution: Mie University
• Principal Investigator: 川本 英嗣 三重大学, 医学部附属病院, 准教授 (20577415)
• Co-Investigator(Kenkyū-buntansha): 亀井 政孝 三重大学, 医学部附属病院, 教授 (60443503) ; 赤間 悠一 三重大学, 医学部附属病院, 助教 (40763313) ; 中森 裕毅 三重大学, 医学系研究科, リサーチアソシエイト (80815994) ; 池尻 薫 三重大学, 医学部附属病院, 助教 (90813014)
• Project Period (FY): 2019-10-07 – 2025-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2023: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2022: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ミオカイン / イリシン / インテグリン / エキソソーム / PICS / 細胞接着アッセイ / 細胞外小胞 / エクソソーム / インテグリンαLβ2 / 細胞接着 / インテグリンα4β7 / インテグリンα4β1 / インテグリンα5β1 / 骨格筋エキソソーム / マイオカイン / マイオソーム / 敗血症 / ICU-AW / fMRI / miRNA / 敗血症関連脳症

Outline of Research at the Start

感染症に対する免疫系反応の制御不能による多臓器不全である敗血症（Sepsis）は世界で年間数百万人が罹患し、そのうち4人に1人以上が死亡する．敗血症による中枢神経機能障害である敗血症関連脳症（Sepsis-Associated Encephalopathy）は重要な生命予後不良因子であるが、その病態機序は不明である。
本研究では運動器官である骨格筋の“隠れた機能である内分泌能”を介した中枢神経系制御メカニズム「骨格筋-脳コミュニケーション」に着目し、敗血症関連脳症の病態を解明かつ新規治療標的を同定する。

Outline of Annual Research Achievements

骨格筋は運動・骨格筋としての機能だけでなく、内分泌機能を有する臓器として機能している。骨格筋から放出されるミオカインであるイリシンは、近年、間葉系細胞に発現するインテグリンαVβ5、αVβ1、α5β1のリガンドとして働き、骨、骨格筋、脂肪組織の代謝リモデリングに重要な役割を果たすことが分かってきた。現在まで慢性炎症におけるイリシンの免疫調節作用は報告されているが、リンパ球系インテグリンとの相互作用はまだ解明されていない。
我々は、イリシンがヒトおよびマウスのリンパ球の細胞接着をサポートすることを明らかにしてきた。また、インテグリンに対する阻害抗体のパネルを用いた細胞接着アッセイにより、イリシンを介したリンパ球の接着には、α4β1、α5β1だけでなく、白血球特異的なαLβ2やα4β7を含む複数のインテグリンが関与することを示した。β1インテグリンを発現しないマウスリンパ球系TK-1細胞は、αLβ2およびα4β7を介したイリシンへの細胞接着を示した。
さらに、イリシンは精製したリコンビナントインテグリンαLβ2およびα4β7タンパク質と結合することを証明した。
以上よりイリシンはインテグリンαLβ2およびα4β7に対する新規なリガンドであり、β1インテグリンとは独立してリンパ球の細胞接着をサポートすることが可能であると考えられた。これらの結果は、イリシンが炎症を起こした血管系において、リンパ球の接着と移動を制御する重要な役割を担っている可能性を示唆している。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

イリシンがインテグリンαLβ2およびα4β7に対する新規なリガンドであり、β1インテグリンとは独立してリンパ球の細胞接着をサポートすることが可能であることを示した。

Strategy for Future Research Activity

昨年度に引き続きエキソソーム上のイリシンと血管内皮細胞とのインターラクションを解析予定。

Research Products

• [Int'l Joint Research] スぺダリ・シヴィリ大学病院/ブレシア大学(イタリア)
• [Journal Article] Correlation Between the Social Network Structure and Well-Being of Health Care Workers in Intensive Care Units: Prospective Observational Study (2023)
  • Author(s): Esumi Ryo、Ito-Masui Asami、Kawamoto Eiji、Ito Mami、Hayashi Tomoyo、Shinkai Toru、Hane Atsuya、Okuno Fumito、Park Eun Jeong、Kaku Ryuji、Shimaoka Motomu
  • Journal Title: Interactive Journal of Medical Research Volume: 12 Pages: e50148-e50148
  • DOI: 10.2196/50148
  • Peer Reviewed / Open Access
• [Journal Article] Effect of an Internet Delivered Cognitive Behavioral Therapy Based Sleep Improvement App for Shift Workers at High Risk of Sleep Disorder: Single-Arm, Nonrandomized Trial (2023)
  • Author(s): Ito-Masui Asami、Sakamoto Ryota、Matsuo Eri、Kawamoto Eiji、Motomura Eishi、Tanii Hisashi、Yu Han、Sano Akane、Imai Hiroshi、Shimaoka Motomu
  • Journal Title: Journal of Medical Internet Research Volume: 25 Pages: 1-16
  • DOI: 10.2196/45834
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Novel Approach to Reducing Lung Metastasis in Osteosarcoma: Increasing Cell Stiffness with Carbenoxolone (2023)
  • Author(s): Kita Kouji、Asanuma Kunihiro、Okamoto Takayuki、Kawamoto Eiji、Nakamura Koichi、Hagi Tomohito、Nakamura Tomoki、Shimaoka Motomu、Sudo Akihiro
  • Journal Title: Current Issues in Molecular Biology Volume: 45 Issue: 5 Pages: 4375-4388
  • DOI: 10.3390/cimb45050278
  • Peer Reviewed / Open Access
• [Journal Article] Continuous High Positive-End Expiratory Pressure May Worsen Renal Function in Patients With Acute Respiratory Distress Syndrome: Retrospective Analyses of a Nationwide, Multicenter Observational Study in Japan (2023)
  • Author(s): Yokoyama Kazuto、Kaneko Tadashi、Ieki Yohei、Ito Asami、Kawamoto Eiji、Suzuki Kei、Ishikura Ken、Imai Hiroshi
  • Journal Title: Cureus Volume: 15
  • DOI: 10.7759/cureus.35233
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA Profiles in Intestinal Epithelial Cells in a Mouse Model of Sepsis (2023)
  • Author(s): Caidengbate Siqingaowa、Akama Yuichi、Banerjee Anik、Mokmued Khwanchanok、Kawamoto Eiji、Gaowa Arong、McCullough Louise D.、Shimaoka Motomu、Lee Juneyoung、Park Eun Jeong
  • Journal Title: Cells Volume: 12 Issue: 5 Pages: 726-726
  • DOI: 10.3390/cells12050726
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tetraploidy-linked sensitization to CENP-E inhibition in human cells. (2023)
  • Author(s): Yoshizawa Koya、Matsura Akira、Shimada Masaya、Ishida‐Ishihara Sumire、Sato Fuyu、Yamamoto Takahiro、Yaguchi Kan、Kawamoto Eiji、Kuroda Taruho、Matsuo Kazuya、Tamaoki Nobuyuki、Sakai Ryuichi、Shimada Yasuhito、Mishra Mithilesh、Uehara Ryota
  • Journal Title: Molecular Oncology Volume: 10 Issue: 6 Pages: 13379-13379
  • DOI: 10.1002/1878-0261.13379
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Conservative medical management combined with follow-up multidetector computed tomography of tracheobronchial injury caused by penetrating injuries: A case report (2022)
  • Author(s): Takahashi Tsuyoshi、Kaneko Tadashi、Hane Atsuya、Ito Asami、Kawamoto Eiji、Suzumura Misato、Ueda Koki、Shinoda Mari、Ito Atsushi、Imai Hiroshi
  • Journal Title: Trauma Case Reports Volume: 42 Pages: 100710-100710
  • DOI: 10.1016/j.tcr.2022.100710
  • Peer Reviewed / Open Access
• [Journal Article] Sequential organ failure assessment score as a predictor of the outcomes of patients hospitalized for classical or exertional heatstroke (2022)
  • Author(s): Yokoyama Kazuto、Kaneko Tadashi、Ito Asami、Ieki Yohei、Kawamoto Eiji、Suzuki Kei、Ishikura Ken、Imai Hiroshi、Kanda Jun、Yokobori Shoji
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 16373-16373
  • DOI: 10.1038/s41598-022-20878-1
  • Peer Reviewed / Open Access
• [Journal Article] Possible Metastatic Stage-Dependent ILC2 Activation Induces Differential Functions of MDSCs through IL-13/IL-13Rα1 Signaling during the Progression of Breast Cancer Lung Metastasis (2022)
  • Author(s): Ito Atsushi、Akama Yuichi、Satoh-Takayama Naoko、Saito Kanako、Kato Takuma、Kawamoto Eiji、Gaowa Arong、Park Eun Jeong、Takao Motoshi、Shimaoka Motomu
  • Journal Title: Cancers Volume: 14 Issue: 13 Pages: 3267-3267
  • DOI: 10.3390/cancers14133267
  • Peer Reviewed / Open Access
• [Journal Article] miRNA-200c-3p targets talin-1 to regulate integrin-mediated cell adhesion. (2021)
  • Author(s): Obeng G, Park EJ, Appiah MG, Kawamoto E, Gaowa A, Shimaoka M.
  • Journal Title: Sci Rep. Volume: 11 Issue: 1 Pages: 21597-21597
  • DOI: 10.1038/s41598-021-01143-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cytoskeletal Actin Structure in Osteosarcoma Cells Determines Metastatic Phenotype via Regulating Cell Stiffness, Migration, and Transmigration (2021)
  • Author(s): Kita Kouji、Asanuma Kunihiro、Okamoto Takayuki、Kawamoto Eiji、Nakamura Koichi、Hagi Tomohito、Nakamura Tomoki、Shimaoka Motomu、Sudo Akihiro
  • Journal Title: Current Issues in Molecular Biology Volume: 43 Issue: 3 Pages: 1255-1266
  • DOI: 10.3390/cimb43030089
  • Peer Reviewed / Open Access
• [Journal Article] Elevated Plasma Soluble PD-L1 Levels in Out-of-Hospital Cardiac Arrest Patients (2021)
  • Author(s): Sumiyoshi Miho、Kawamoto Eiji、Nakamori Yuki、Esumi Ryo、Ikejiri Kaoru、Shinkai Toru、Akama Yuichi、Ito-Masui Asami、Imai Hiroshi、Gaowa Arong、Park Eun Jeong、Shimaoka Motomu
  • Journal Title: Journal of Clinical Medicine Volume: 10 Issue: 18 Pages: 4188-4188
  • DOI: 10.3390/jcm10184188
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Substrate stiffness modulates endothelial cell function via the YAP-Dll4-Notch1 pathway (2021)
  • Author(s): Matsuo Eri、Okamoto Takayuki、Ito Atsushi、Kawamoto Eiji、Asanuma Kunihiro、Wada Koichiro、Shimaoka Motomu、Takao Motoshi、Shimamoto Akira
  • Journal Title: Experimental Cell Research Volume: 408 Issue: 1 Pages: 112835-112835
  • DOI: 10.1016/j.yexcr.2021.112835
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence and predictors of direct discharge home following hospitalization of patients with serious adverse events managed by the rapid response system in Japan: a multicenter, retrospective, observational study (2021)
  • Author(s): Takashi Hongo, Hiromichi Naito, Toshifumi Fujiwara, Takaki Naito, Yosuke Homma, Yoshihisa Fujimoto, Morooka Takaya, Yuji Yamamori, Taka-Aki Nakada, Tsuyoshi Nojima, Atsunori Nakao, Shigeki Fujitani
  • Journal Title: Acute Medicine & Surgery Volume: 8 Issue: 1 Pages: 1-8
  • DOI: 10.1002/ams2.690
  • Peer Reviewed / Open Access
• [Journal Article] Recombinant soluble thrombomodulin accelerates epithelial stem cell proliferation in mouse intestinal organoids and promotes the mucosal healing in colitis (2021)
  • Author(s): Gaowa A, Park EJ, Kawamoto E, Qin Y, Shimaoka M.
  • Journal Title: J Gastroenterol Hepatol. Volume: 36 Issue: 11 Pages: 3149-3157
  • DOI: 10.1111/jgh.15656
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cellular and exosomal regulations of sepsis-induced metabolic alterations (2021)
  • Author(s): Appiah G. Michael, Park Eun Jeong, Akama Y, Nakamori Y, Kawamoto E, Gaowa A, Shimaoka M
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 15 Pages: 8295-8295
  • DOI: 10.3390/ijms22158295
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sociometric wearable devices for studying human behavior in corporate and healthcare workplaces (2021)
  • Author(s): Ito-Masui Asami、Kawamoto Eiji、Esumi Ryo、Imai Hiroshi、Shimaoka Motomu
  • Journal Title: BioTechniques Volume: 71 Issue: 1 Pages: 392-399
  • DOI: 10.2144/btn-2020-0160
  • Peer Reviewed / Open Access
• [Journal Article] Endothelial connexin-integrin crosstalk in vascular inflammation (2021)
  • Author(s): Okamoto Takayuki、Park Eun Jeong、Kawamoto Eiji、Usuda Haruki、Wada Koichiro、Taguchi Akihiko、Shimaoka Motomu
  • Journal Title: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Volume: 1867 Issue: 9 Pages: 166168-166168
  • DOI: 10.1016/j.bbadis.2021.166168
  • Peer Reviewed / Open Access
• [Journal Article] The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells. (2021)
  • Author(s): Park EJ, Myint PK, Appiah MG, Darkwah S, Caidengbate S, Ito A, Matsuo E, Gaowa a, Shimaoka M. Kawamoto E,
  • Journal Title: Viruses Volume: 13 Issue: 4 Pages: 645-645
  • DOI: 10.3390/v13040645
  • Peer Reviewed / Open Access
• [Journal Article] Randomized trial of granulocyte colony-stimulating factor for spinal cord injury (2021)
  • Author(s): Koda Masao、Hanaoka Hideki、Fujii Yasuhisa、Hanawa Michiko、et al.
  • Journal Title: Brain Volume: 144 Issue: 3 Pages: 789-799
  • DOI: 10.1093/brain/awaa466
  • Peer Reviewed / Open Access
• [Journal Article] Irisin supports integrin-mediated cell adhesion of lymphocytes. (2021)
  • Author(s): Myint PK, Ito A, Appiah MG, Obeng G, Darkwah S, Kawamoto E, Gaowa A, Park EJ, Shimaoka M
  • Journal Title: Biochem Biophys Rep. Volume: 26 Pages: 100977-100977
  • DOI: 10.1016/j.bbrep.2021.100977
  • Peer Reviewed / Open Access
• [Journal Article] Remodeling of Bone Marrow Niches and Roles of Exosomes in Leukemia. (2021)
  • Author(s): Yamaguchi T, Kawamoto E, Gaowa A, Park EJ, Shimaoka M.
  • Journal Title: Int J Mol Sci. Volume: 22 Issue: 4 Pages: 1881-1881
  • DOI: 10.3390/ijms22041881
  • Peer Reviewed / Open Access
• [Journal Article] Veno-arterial extracorporeal membrane oxygenation and targeted temperature management in tricyclic antidepressant-induced cardiac arrest (2021)
  • Author(s): Ikejiri Kaoru、Akama Yuichi、Ieki Yohei、Kawamoto Eiji、Suzuki Kei、Yokoyama Kazuto、Ishikura Ken、Imai Hiroshi
  • Journal Title: Medicine Volume: 100 Issue: 9 Pages: e24980-e24980
  • DOI: 10.1097/md.0000000000024980
  • Peer Reviewed / Open Access
• [Journal Article] Internet-based Individualized Cognitive Behavioral Therapy for Shift Work Sleep Disorder (Empowered by Wellbeing Prediction): A Pilot Study Protocol. (2021)
  • Author(s): Ito-Masui A, Sakamoto R, Yu H,, Sano A, Motomura E, Tanii H, Sakano S, Esumi R, Imai H, Shimaoka M
  • Journal Title: J JMIR Res Protoc. Volume: 10(3) Issue: 3 Pages: e24799-e24799
  • DOI: 10.2196/24799
  • Peer Reviewed / Open Access
• [Journal Article] Potential Roles of Muscle-Derived Extracellular Vesicles in Remodeling Cellular Microenvironment: Proposed Implications of the Exercise-Induced Myokine, Irisin (2021)
  • Author(s): Darkwah Samuel、Park Eun Jeong、Myint Phyoe Kyawe、Ito Atsushi、Appiah Michael G.、Obeng Gideon、Kawamoto Eiji、Shimaoka Motomu
  • Journal Title: Frontiers in Cell and Developmental Biology Volume: 9 Pages: 1-1
  • DOI: 10.3389/fcell.2021.634853
  • Peer Reviewed / Open Access
• [Journal Article] The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin. (2021)
  • Author(s): Kawamoto E, Nago N, Okamoto T, Gaowa A, Masui-Ito A, Akama Y, Darkwah S, Appiah MG, Myint PK, Obeng G, Ito A, Caidengbate S, Esumi R, Yamaguchi T, Park EJ, Imai H, Shimaoka M.
  • Journal Title: Biomedicines Volume: 9 Issue: 2 Pages: 162-162
  • DOI: 10.3390/biomedicines9020162
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ligand-competent fractalkine receptor is expressed on exosomes. (2021)
  • Author(s): Park EJ, Myint PK, Appiah MG, Worawattananutai P, Inprasit J, Prajuabjinda O, Soe ZY, Gaowa A, Kawamoto E, Shimaoka M.
  • Journal Title: Biochem Biophys Rep. Volume: 26 Pages: 100932-100932
  • DOI: 10.1016/j.bbrep.2021.100932
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sepsis Induces Deregulation of IL-13 Production and PD-1 Expression in Lung Group 2 Innate Lymphoid Cells. (2021)
  • Author(s): Akama Y, Park EJ, Satoh-Takayama N, Gaowa A, Ito A, Kawamoto E, Darkwah S, Appiah MG, Myint PK, Ohno H, Imai H, Shimaoka M.
  • Journal Title: Shock Volume: 55 Issue: 3 Pages: 357-370
  • DOI: 10.1097/shk.0000000000001647
  • Peer Reviewed / Open Access
• [Journal Article] Methods to Study Integrin Functions on Exosomes (2020)
  • Author(s): Kawamoto Eiji、Park Eun Jeong、Shimaoka Motomu
  • Journal Title: Methods in Molecular Biology Volume: 2217 Pages: 265-281
  • DOI: 10.1007/978-1-0716-0962-0_15
  • ISBN: 9781071609613, 9781071609620
  • Peer Reviewed / Open Access
• [Journal Article] Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin (2020)
  • Author(s): Park Eun Jeong、Myint Phyoe Kyawe、Ito Atsushi、Appiah Michael G.、Darkwah Samuel、Kawamoto Eiji、Shimaoka Motomu
  • Journal Title: Frontiers in Cell and Developmental Biology Volume: 8 Pages: 588066-588066
  • DOI: 10.3389/fcell.2020.588066
  • Peer Reviewed / Open Access
• [Journal Article] Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins. (2020)
  • Author(s): Myint PK, Park EJ, Gaowa A, Kawamoto E, Shimaoka M.
  • Journal Title: Diagn Pathol. Volume: 15 Issue: 1 Pages: 38-38
  • DOI: 10.1186/s13000-020-00959-3
  • Peer Reviewed / Open Access
• [Journal Article] Feasibility of Measuring Face-to-Face Interactions among ICU Healthcare Professionals Using Wearable Sociometric Badges (2020)
  • Author(s): Ito-Masui Asami、Kawamoto Eiji、Nagai Yuki、Takagi Yuto、Ito Mami、Mizutani Noriko、Yano Ken’ichi、Yano Kazuo、Imai Hiroshi、Shimaoka Motomu
  • Journal Title: American Journal of Respiratory and Critical Care Medicine Volume: 201 Issue: 2 Pages: 245-247
  • DOI: 10.1164/rccm.201904-0779le
  • Peer Reviewed / Open Access
• [Journal Article] Exosomes in Sepsis and Inflammatory Tissue Injury (2019)
  • Author(s): Park EJ, Appiah MG, Myint PK, Gaowa A, 他2名
  • Journal Title: Curr Pharm Des Volume: 25 Issue: 42 Pages: 4486-4495
  • DOI: 10.2174/1381612825666191116125525
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis (2019)
  • Author(s): Darkwah Samuel、Nago Nodoka、Appiah Michael G.、Myint Phyoe Kyawe、Kawamoto Eiji、Shimaoka Motomu、Park Eun Jeong
  • Journal Title: Biomedicines Volume: 7 Issue: 3 Pages: 52-52
  • DOI: 10.3390/biomedicines7030052
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Talin-2 regulates integrin functions in exosomes (2019)
  • Author(s): Soe Zay Yar、Prajuabjinda Onmanee、Myint Phyoe Kyawe、Gaowa Arong、Kawamoto Eiji、Park Eun Jeong、Shimaoka Motomu
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 512 Issue: 3 Pages: 429-434
  • DOI: 10.1016/j.bbrc.2019.03.027
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anti-adhesive effects of human soluble thrombomodulin and its domains (2019)
  • Author(s): Kawamoto Eiji、Nago Nodoka、Okamoto Takayuki、Gaowa Arong、Masui-Ito Asami、Sakakura Yosuke、Akama Yuichi、Soe Zay Yar、Prajuabjinda Onmanee、Darkwah Samuel、Appiah Michael G.、Myint Phyoe Kyawe、Obeng Gideon、Park Eun Jeong、Imai Hiroshi、Shimaoka Motomu
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 511 Issue: 2 Pages: 312-317
  • DOI: 10.1016/j.bbrc.2019.02.041
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Connexins and Integrins in Exosomes (2019)
  • Author(s): Shimaoka M, Kawamoto E, Gaowa A, Okamoto T, Park EJ
  • Journal Title: Cancers (Basel) Volume: － Issue: 1 Pages: 106-106
  • DOI: 10.3390/cancers11010106
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Integrin and PD-1 Ligand Expression on Circulating Extracellular Vesicles in Systemic Inflammatory Response Syndrome and Sepsis (2018)
  • Author(s): Kawamoto Eiji、Masui-Ito Asami、Eguchi Akiko、Soe Zay Yar、Prajuabjinda Onmanee、Darkwah Samuel、Park Eun Jeong、Imai Hiroshi、Shimaoka Motomu
  • Journal Title: SHOCK Volume: - Issue: 1 Pages: 1-1
  • DOI: 10.1097/shk.0000000000001228
  • Peer Reviewed / Open Access / Int'l Joint Research