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Biological effects of radioactive MnO2 particles

Research Project

Project/Area Number 19KK0266
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 63:Environmental analyses and evaluation and related fields
Research InstitutionHiroshima University

Principal Investigator

Fujimoto Nariaki  広島大学, 原爆放射線医科学研究所, 准教授 (40243612)

Co-Investigator(Kenkyū-buntansha) ムサジャノワ ジャンナ  長崎大学, 原爆後障害医療研究所, 助教 (30770432)
佐藤 斉  茨城県立医療大学, 保健医療学部, 教授 (90285057)
星 正治  広島大学, 平和センター, 名誉教授 (50099090)
Project Period (FY) 2019-10-07 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2022: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2021: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2020: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords放射性微粒子被曝 / 内部被曝 / 原爆残留放射能 / 放射性マンガン / 放射性微粒子被曝影響 / マウス系統差 / 放射線微粒子被曝影響 / 放射線マンガン / 放射性マンガン微粒子内部被ばく / 放射性微粒子曝露影響 / マウス / 放射性微粒子 / 内部被曝影響 / 二酸化マンガン
Outline of Research at the Start

放射線の影響を理解するためには、外部被曝ばかりでなく内部被曝の影響評価が重要であるが、現在のところ、防護上で両者の影響は同等とされている。最近、我々は放射性微粒子による内部被曝が強い生物学的影響を示す場合があることを報告した。本研究では、この内部被曝実験を展開し、分子生物学的解析によりその障害作用とメカニズムの詳細を解明することを目的とする。本研究は放射線被曝の防護と安全に関わる極めて重要な国際共同研究である。

Outline of Final Research Achievements

The biological effects of internal exposure to 56MnO2 particles were investigated in Wistar rats, C57BL mice, and BALB/C mice in the international collaborative research with Semey Medical University, Kazakhstan. Inhalation exposure to 56MnO2 resulted in absorbed doses of 25-380 mGy in the lungs. It changed the lung expressions of Aqp5 in rats and Aqp1 in mice. These effects were comparable to or higher than those of external γ-irradiation of 2 Gy, suggesting that exposure to 56MnO2 particles has significantly greater biological effects than external irradiation on the lungs. The other pathophysiological marker gene expressions were also affected by internal irradiation by 56MnO2 particles in the testes and the liver. All these data indicate the possible roles of residual radiation on the health effects of atomic bomb exposure.

Academic Significance and Societal Importance of the Research Achievements

原爆被爆者の健康障害の評価は、これまで爆発時に放出された初期放射線による外部被曝を想定した線量評価システムに基づいて行われてきた。今回の研究成果は、被爆評価において残留放射能の影響(特に放射性微粒子の内部被曝影響)も考慮される必要性があることを示唆した。内部被曝影響については、β/γ核種による差、放射性微粒子の物理化学的性状の違いによる影響の差(特に臓器による差)など解明されるべき点も多く残されている。地震国では将来的に不可避であろう原発事故等による放射性微粒子被曝に備えるため、今後の継続した影響研究が必要不可欠である。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (75 results)

All 2024 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (6 results) Journal Article (36 results) (of which Int'l Joint Research: 26 results,  Peer Reviewed: 36 results,  Open Access: 32 results) Presentation (33 results) (of which Int'l Joint Research: 23 results,  Invited: 7 results)

  • [Int'l Joint Research] Semey Medical University/Eurasian University/Kazakhstan National Nuclear Center(カザフスタン)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] Semey Medical University/Eurasian University/Kazkhstan National Nuclear Center(カザフスタン)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Semey Medical University/Eurasian University/Kazakhstan National Nuclear Center(カザフスタン)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] National Med Res Center of Radiology(ロシア連邦)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Semey Medical University/Eurasian University/Kazakhstan National Nuclear Center(カザフスタン)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Medical Radiological Research Center(ロシア連邦)

    • Related Report
      2019 Research-status Report
  • [Journal Article] The need for measures to prevent radiation exposure in Ukraine, taking both internal and external exposure into account2023

    • Author(s)
      Inoue Ken、Kawano Noriyuki、Fujimoto Nariaki、Takeichi Nobuo、Hoshi Masaharu
    • Journal Title

      Journal of Environmental Radioactivity

      Volume: 266-267 Pages: 107238-107238

    • DOI

      10.1016/j.jenvrad.2023.107238

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Internal Exposure of Radioactive 56MnO2 Particles on the Lung in C57BL Mice2023

    • Author(s)
      Abishev Zhaslan、Ruslanova Bakhyt、Apbassova Saulesh、Chaizhunussova Nailya、Shabdarbayeva Dariya、Azimkhanov Almas、Zhumadilov Kassym、Stepanenko Valeriy、Ivanov Sergey、Shegay Peter、Hoshi Masaharu、Fujimoto Nariaki
    • Journal Title

      Current Issues in Molecular Biology

      Volume: 45 Issue: 4 Pages: 3208-3218

    • DOI

      10.3390/cimb45040209

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Radioactive 56MnO2 Particle Inhalation on Mouse Lungs: A Comparison between C57BL and BALB/c2023

    • Author(s)
      Abishev Zhaslan、Ruslanova Bakhyt、Apbassova Saulesh、Shabdarbayeva Dariya、Chaizhunussova Nailya、Dyusupov Altai、Azhimkhanov Almas、Zhumadilov Kassym、Stepanenko Valeriy、Ivanov Sergey、Shegay Peter、Kaprin Andrey、Hoshi Masaharu、Fujimoto Nariaki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 24 Pages: 17605-17605

    • DOI

      10.3390/ijms242417605

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of external dose estimates using different retrospective dosimetry methods in the settlements located near Semipalatinsk Nuclear Test Site, Republic of Kazakhstan2023

    • Author(s)
      Stepanenko V、Shinkarev S、Kaprin A、Apsalikov K、Ivanov S、Shegay P、Ostroumova E、Kesminiene A、Lipikhina A、Bogacheva V、Zhumadilov K、Yamamoto M、Sakaguchi A、Endo S、Fujimoto N、Grosche B、Iatsenko V、Androsova A、Apsalikova Z、Kawano N、Hoshi M
    • Journal Title

      Journal of Radiation Research

      Volume: 65 Issue: 1 Pages: 36-46

    • DOI

      10.1093/jrr/rrad082

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Changes in the characteristics of suicide in Japan in the third year of the COVID-19 pandemic and the importance of continued suicide prevention measures.2023

    • Author(s)
      Inoue K, et al.
    • Journal Title

      Med Sci Law

      Volume: in press Issue: 1 Pages: 1-2

    • DOI

      10.1177/00258024231165432

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] External dose estimates of laboratory rats and mice during exposure to dispersed neutron-activated 56Mn powder.2022

    • Author(s)
      Stepanenko V, Sato H, Fujimoto N, Shichijo K, Toyoda S, Kawano N, Endo S, Kaprin A, Ivanov S, Shegay P, Petukhov A
    • Journal Title

      Journal of Radiation Research

      Volume: 63(S1) Issue: Supplement_1 Pages: i16-i20

    • DOI

      10.1093/jrr/rrac032

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microdistribution of internal radiation dose in biological tissues exposed to 56Mn dioxide microparticles.2022

    • Author(s)
      Stepanenko V, Kaprin A, Ivanov S, Shegay P, Viktoria B, Sato H, Shichijo K, Toyoda S, Kawano N, Ohtaki M, Fujimoto N, Endo S, Chaizhunusova N, Shabdarbaeva D, Zhumadilov K, Hoshi M
    • Journal Title

      Journal of Radiation Research

      Volume: 63(S1) Issue: Supplement_1 Pages: i21-i25

    • DOI

      10.1093/jrr/rrac023

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of internal exposure to neutron-activated 56MnO2 powder on locomotor activity in rats2022

    • Author(s)
      Otani Keiko、Ohtaki Megu、Fujimoto Nariaki、Uzbekov Darkhan、Kairkhanova Ynkar、Saimova Aisulu、Chaizhunusova Nailya、Habdarbaeva Dariya、Azhimkhanov Almas、Zhumadilov Kassym、Stepanenko Valeriy、Hoshi Masaharu
    • Journal Title

      Journal of Radiation Research

      Volume: 63 Issue: Supplement_1 Pages: i38-i44

    • DOI

      10.1093/jrr/rrac003

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Estimation of ‘dose-depth’ profile in the surface layers of a quartz-containing tile from the former Hiroshima University building indicates the possible presence of beta-irradiation from residual radioactivity after A-bombing2022

    • Author(s)
      Stepanenko Valeriy、Kaprin Andrey、Ivanov Sergey、Shegay Peter、Sato Hitoshi、Toyoda Shin、Kawano Noriyuki、Fujimoto Nariaki、Endo Satoru、Bogacheva Viktoria、Kolyzhenkov Timofey、Khailov Artem、Zhumadilov Kassym、Zhumalina Aidana、Yerimbetova Dana、Hoshi Masaharu
    • Journal Title

      Journal of Radiation Research

      Volume: 63 Issue: Supplement_1 Pages: i54-i60

    • DOI

      10.1093/jrr/rrac029

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular Pathological Characteristics of Thyroid Follicular-Patterned Tumors Showing Nodule-in-Nodule Appearance with Poorly Differentiated Component2022

    • Author(s)
      Ueda Mayu、Matsuda Katsuya、Kurohama Hirokazu、Mussazhanova Zhanna、Sailaubekova Yerkezhan、Kondo Hisayoshi、Shimizu Tomoki、Takada Nami、Matsuoka Yuki、Otsubo Chieko、Sato Shinya、Yamashita Hiroyuki、Kawakami Atsushi、Nakashima Masahiro
    • Journal Title

      Cancers

      Volume: 14 Issue: 15 Pages: 3577-3577

    • DOI

      10.3390/cancers14153577

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Overview and analysis of internal radiation dose estimates in experimental animals in a framework of international studies of the sprayed neutron-induced 56Mn radioactive microparticles effects2022

    • Author(s)
      Stepanenko Valeriy、Kaprin Andrey、Ivanov Sergey、Shegay Peter、Bogacheva Viktoria、Hoshi Masaharu
    • Journal Title

      Journal of Radiation Research

      Volume: 63 Issue: Supplement_1 Pages: i8-i15

    • DOI

      10.1093/jrr/rrac043

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The overview of neutron-induced 56Mn radioactive microparticle effects in experimental animals and related studies2022

    • Author(s)
      Hoshi Masaharu
    • Journal Title

      Journal of Radiation Research

      Volume: 63 Issue: Supplement_1 Pages: i1-i7

    • DOI

      10.1093/jrr/rrac020

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tooth enamel ESR dosimetry for Hiroshima ‘black rain’ zone residents2022

    • Author(s)
      Zhumadilov Kassym、Ivannikov Alexander、Stepanenko Valeriy、Toyoda Shin、Kazymbet Polat、Kaprin Andrey、Ivanov Sergey、Shegay Peter、Endo Satoru、Hoshi Masaharu
    • Journal Title

      Journal of Radiation Research

      Volume: 63 Issue: Supplement_1 Pages: i61-i65

    • DOI

      10.1093/jrr/rrac024

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Studies on Gamma Dose Rates in Outdoor Environment and Assessment of External Exposure to Public in Stepnogorsk Area, Northern Kazakhstan2022

    • Author(s)
      Ibrayeva Danara、Ilbekova Kuralay、Aumalikova Moldir、Kazymbet Polat、Zhumadilov Kassym、Bakhtin Meirat、Hoshi Masaharu
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 198 Pages: 1387-1398

    • DOI

      10.1093/rpd/ncac180

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationships Between Types of Protective Eyewear and Eye Lens Dose Within Endoscopic Retrograde Cholangiopancreatography2022

    • Author(s)
      Nakajima Erika、Sato Hitoshi
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 198 Pages: 1399-1408

    • DOI

      10.1093/rpd/ncac181

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suicides following an earthquake: Japanese proposals arising from post-earthquake analyses.2021

    • Author(s)
      Inoue K, et al.
    • Journal Title

      Med Sci Law.

      Volume: in press Issue: 2 Pages: 158-159

    • DOI

      10.1177/00258024211049598

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biological impacts on the lungs in rats internally exposed to radioactive 56MnO2 particle2021

    • Author(s)
      Fujimoto Nariaki、Ruslanova Bakhyt、Abishev Zhaslan、Chaizhunussova Nailya、Shabdarbayeva Dariya、Amantayeva Gaukhar、Farida Rakhimzhanova、Sandybayev Marat、Nagano Kasuke、Zhumadilov Kassym、Kaprin Andrey、Ivanov Sergey、Stepanenko Valeriy、Hoshi Masaharu
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 11055-11055

    • DOI

      10.1038/s41598-021-90443-9

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hepatic Gene Expression Changes in Rats Internally Exposed to Radioactive 56MnO2 Particles at Low Doses2021

    • Author(s)
      Ruslanova Bakhyt、Abishev Zhaslan、Chaizhunussova Nailya、Shabdarbayeva Dariya、Tokesheva Sholpan、Amantayeva Gaukhar、Kairkhanova Ynkar、Stepanenko Valeriy、Hoshi Masaharu、Fujimoto Nariaki
    • Journal Title

      Current Issues in Molecular Biology

      Volume: 43 Issue: 2 Pages: 758-766

    • DOI

      10.3390/cimb43020055

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid2021

    • Author(s)
      Matsuyama M, Shichijo K, Matsuda K, Fujimoto N, Kondo H, Miura S, Kurashige T, Nagayama Y, Nakashima M.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 19096-19096

    • DOI

      10.1038/s41598-021-98481-z

    • NAID

      120007175565

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single neonatal irradiation induces long-term gene expression changes in the thyroid gland, which may be involved in the tumorigenesis2021

    • Author(s)
      Fujimoto Nariaki、Matsuu-Matsuyama Mutsumi、Nakashima Masahiro
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 23620-23620

    • DOI

      10.1038/s41598-021-03012-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 53BP1 expression as a biomarker to differentiate thyroid follicular tumors2021

    • Author(s)
      Sato Ayako、Matsuda Katsuya、Motoyama Takahiro、Mussazhanova Zhanna、Otsubo Ryota、Kondo Hisayoshi、Akazawa Yuko、Higuchi Miyoko、Suzuki Ayana、Hirokawa Mitsuyoshi、Miyauchi Akira、Nagayasu Takeshi、Nakashima Masahiro
    • Journal Title

      Endocrine Connections

      Volume: 10 Issue: 3 Pages: 309-315

    • DOI

      10.1530/ec-20-0630

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Contribution of Genetic Variants to the Risk of Papillary Thyroid Carcinoma in the Kazakh Population: Study of Common Single Nucleotide Polymorphisms and Their Clinicopathological Correlations2021

    • Author(s)
      Mussazhanova Z, Rogounovitch TI, Saenko VA, Krykpayeva A, Espenbetova M, Azizov B, Kondo H, Matsuda K, Kalmatayeva Z, Issayeva R, Yeleubayeva Z, Madiyeva M, Mukanova A, Sandybayev M, Bolsynbekova S, Kozykenova Z, Yamashita S, Nakashima M.
    • Journal Title

      Front Endocrinol (Lausanne)

      Volume: 11 Pages: 1-10

    • DOI

      10.3389/fendo.2020.543500

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An Exploration of the Labor, Financial, and Economic Factors Related to Suicide in the Republic of Kazakhstan.2021

    • Author(s)
      Inoue K, et al.
    • Journal Title

      Int J Environ Res Public Health.

      Volume: 18 Issue: 13 Pages: 6992-6992

    • DOI

      10.3390/ijerph18136992

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Early detection of excessive stress in people due to the ongoing COVID-19 pandemic: studies including those using biological markers.2021

    • Author(s)
      Fujita Y, Inoue K, et al.
    • Journal Title

      Int Marit Health.

      Volume: 72 Issue: 2 Pages: 143-144

    • DOI

      10.5603/imh.2021.0025

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A combined scientific and public health approach is needed to evaluate the health impacts of internal exposure to radiation2021

    • Author(s)
      Ken Inoue, Noriyuki Kawano, Nobuo Takeichi, Yoshihiro Noso, Masaharu Hoshi
    • Journal Title

      The Lancet Regional Health - Western Pacific

      Volume: 15 Pages: 1-2

    • DOI

      10.1016/j.lanwpc.2021.100296

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristic evaluation of a simple hand-made semiconductor dosimeter for mammography2021

    • Author(s)
      Nakajima Erika、Yamashita Hiromi、Sato Hitoshi
    • Journal Title

      Journal of Radiological Protection

      Volume: 41 Issue: 4 Pages: 1018-1033

    • DOI

      10.1088/1361-6498/ac20b2

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Occupational eye lens dose in endoscopic retrograde cholangiopancreatography using a dedicated eye lens dosimeter2021

    • Author(s)
      Imai Shinya、Akahane Manabu、Ogata Yuji、Tanki Nobuyoshi、Sato Hitoshi、Tameike Kazuma
    • Journal Title

      Journal of Radiological Protection

      Volume: 41 Issue: 3 Pages: 579-589

    • DOI

      10.1088/1361-6498/ac091f

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] ESR tooth enamel doses of rats and mice exposed to radioactive 56MnO2 dust2021

    • Author(s)
      Azumi Todaka, Shin Toyoda, Nariaki Fujimoto, Hitoshi Saito, Valeriy tepanenko, Noriyuki Kawano, Nailya Chaizhunusova, Darkhan Uzbekov, Ynkar Kairkhanova, Bakhyt Ruslanova,Zhaslan Abishev, Gaukhar Amantayeva, Dariya Shabdarbaeva, Kassym Zhumadilov,Almas Azhimkhanov, Masaharu Hoshi
    • Journal Title

      Advances in ESR Applications

      Volume: 37 Pages: 13-18

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Low-Dose Radiation Exposure with 56MnO2 Powder Changes Gene Expressions in the Testes and the Prostate in Rats2020

    • Author(s)
      Fujimoto Nariaki、Amantayeva Gaukhar、Chaizhunussova Nailya、Shabdarbayeva Dariya、Abishev Zhaslan、Ruslanova Bakhyt、Zhunussov Yersin、Azhimkhanov Almas、Zhumadilov Kassym、Petukhov Aleksey、Stepanenko Valeriy、Hoshi Masaharu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 14 Pages: 4989-4989

    • DOI

      10.3390/ijms21144989

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Internal doses in experimental mice and rats following various exposures to neutron-activated 56Mn02 powder: results of international multicenter study2020

    • Author(s)
      Stepanenko V, Zhumadilov K, Hoshi M, Zhunussov YT, Endo S, Ohtaki M, Otani M, Fujimoto N, Shichijo K, Kawano N, Sakaguchi A, Chaizhunusova N, Shabdarbaeva D, Gnyrya V, Аzimkhanov A, Kaprin A, Ivanov S, Yaskova E, Belukha I, Kolyzhenkov T, Petukhov A , Bogacheva V.
    • Journal Title

      Radiation and Environmental Biophysics

      Volume: 59 Issue: 4 Pages: 683-692

    • DOI

      10.1007/s00411-020-00870-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantitative Analysis of Effects of a Single 60Co Gamma Ray Point Exposure on Time-Dependent Change in Locomotor Activity in Rats2020

    • Author(s)
      Otani Keiko、Ohtaki Megu、Fujimoto Nariaki、Saimova Aisulu、Chaizhunusova Nailya、Rakhypbekov Tolebay、Sato Hitoshi、Kawano Noriyuki、Hoshi Masaharu
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 17 Issue: 16 Pages: 5638-5638

    • DOI

      10.3390/ijerph17165638

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Causative role for defective expression of mitochondria-eating protein in accumulation of mitochondria in thyroid oncocytic cell tumors.2020

    • Author(s)
      Mussazhanova Z, Shimamura M, Kurashige T, Ito M, Nakashima M, Nagayama Y
    • Journal Title

      Cancer Sci.

      Volume: 111 Issue: 8 Pages: 2814-2823

    • DOI

      10.1111/cas.14501

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cutaneous pilomatrical carcinosarcoma: a case report with molecular analysis and literature review2020

    • Author(s)
      Luong Thi My Hanh、Akazawa Yuko、Mussazhanova Zhanna、Matsuda Katsuya、Ueki Nozomi、Miura Shiro、Hara Toshihide、Yokoyama Hiroko、Nakashima Masahiro
    • Journal Title

      Diagnostic Pathology

      Volume: 15 Issue: 1 Pages: 7-7

    • DOI

      10.1186/s13000-020-0925-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of local high doses of radiation by neutron activated Mn dioxide powder in rat lungs: Protracted pathologic damage initiated by internal exposure.2020

    • Author(s)
      Shichijo K, Takatsuji T, Abishev Z, Uzbekov D, Chaizhunusova N, Shabdarbaeva D, Niino D, Kurisu M, Takahashi Y, Stepanenko V, Azhimkhanov A, Hoshi M.
    • Journal Title

      Biomedicines

      Volume: 8 Issue: 6 Pages: 171-171

    • DOI

      10.3390/biomedicines8060171

    • NAID

      120006988116

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Internal Exposure to 56MnO2 Powder on Blood Parameters in Rats2020

    • Author(s)
      Fujimoto N, Baurzhan A, Chaizhunusova N, Amantayeva G, Kairkhanova Y, Shabdarbaeva D, Zhunussov Y, Zhumadilov K, Stepanenko V, Gnyrya V, Azhimkhanov A, Kolbayenkov A, Hoshi M.
    • Journal Title

      The Eurasian Journal of Medicine

      Volume: 52 Issue: 1 Pages: 52-56

    • DOI

      10.5152/eurasianjmed.2020.19228

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preliminary assessment of dose distribution on the spatial micro level for internal exposure of alveolar epithelium of rats by 56M2019

    • Author(s)
      Stepanenko V, Zhumadilov K, Hoshi M, Zhunussov YT, Endo S, Ohtaki M, Otani M, Fujimoto N, Shichijo K, Kawano N, Sakaguchi A, Chaizhunusova N, Shabdarbaeva D, Gnyrya V, Аzimkhanov A, Kaprin A, Ivanov S, Yaskova E, Belukha I, Kolyzhenkov T, Petukhov A , Bogacheva V.
    • Journal Title

      Bulletin of the Karaganda University. "Physics" Series

      Volume: 95 Issue: 3 Pages: 59-63

    • DOI

      10.31489/2019ph3/59-63

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Gene expression changes in the spleen, the lung, and the liver of rats exposed to 31SiO2 particles2024

    • Author(s)
      Fujimoto, N
    • Organizer
      The 25th Hiroshima International Symposium "Research on radiation and its effects in Kazakhstan and other countries" 2/9-10/2024 (Web)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ラット甲状腺新生仔期被曝による遺伝子発現変化とその腫瘍化への関与2023

    • Author(s)
      藤本成明, 松山睦美, 中島正洋
    • Organizer
      第96回日本内分泌学会学術総会 6/1-3/2023 (名古屋)
    • Related Report
      2023 Annual Research Report
  • [Presentation] 甲状腺若年期被曝による遺伝子発現変化と腫瘍化への関与2023

    • Author(s)
      藤本成明, 松山睦美, 中島正洋
    • Organizer
      第47回中国地区放射線影響研究会 8/18/2023 (広島)
    • Related Report
      2023 Annual Research Report
  • [Presentation] Radiation health effects of radioactive particles produced by atomic bombing: Studies in laboratory rats and mice at SMU2023

    • Author(s)
      Fujimoto N, Chaizhunussova C
    • Organizer
      XVI International Scientific and Practical Conference "Ecology. Radiation. Health" 8/28-29/2023 (Semey, Kazakhstan)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The pulmonary and hepatic gene expression changes in mice exposed to radioactive particles of 56MnO22023

    • Author(s)
      Fujimoto N, Chaizhunussova C, Hoshi M
    • Organizer
      The 8th International Conference on Advances in Biochemistry and Molecular Biology, 12/8-10/2023 (Sanya, China)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ラット新生仔期被曝による甲状腺腫瘍化に関与する遺伝子発現変化II低ヨード腫瘍化モデルの解析2022

    • Author(s)
      藤本成明, 松山睦美, 中島正洋
    • Organizer
      第95回日本内分泌学会学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] ラット新生仔期被曝による甲状腺の遺伝子発現変化と腫瘍化2022

    • Author(s)
      藤本成明, 松山睦美, 中島正洋
    • Organizer
      第6回放射線災害・医科学研究拠点カンファランス
    • Related Report
      2022 Research-status Report
  • [Presentation] Single neonatal irradiation induces long-term morphological and gene expression changes in the thyroid of rats - a possible mechanism of thyroid carcinogenesis by childhood radiation2022

    • Author(s)
      Fujimoto N
    • Organizer
      International Conference - Modern Perspectives for Biomedical Sciences
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 充実性成分を呈する結節内結節型甲状腺結節の分子病理学的特徴解析2022

    • Author(s)
      松田勝也, 上田真由, Mussazhanova Zhanna, Saiaubekova Yerkezhan, 黒濵大和, 松岡優毅,大坪智恵子, 佐藤伸也, 山下弘幸, 中島正洋
    • Organizer
      第111回日本病理学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 低分化成分を有する非浸潤性甲状腺結節の分子病理学的特徴解析2022

    • Author(s)
      上田真由, 松田勝也, 黒濵大和, Mussazhanova Zhanna, Yerkezhan Sailaubekova, 近藤久義, 松岡優毅, 大坪智恵子, 佐藤信也, 山下弘幸, 川上 純, 中島正洋
    • Organizer
      第9回日本甲状腺病理学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] Molecular Pathological Characteristics of Benign Thyroid Nodules with Poorly Differentiated Component2022

    • Author(s)
      Ueda M, Matsuda K, Kurohama H, Mussazhanova Z, Sailaubekova Y, Kondo H, Matsuoka Y, Otsubo C, Sato S, Yamashita H, Kawakami A, Nakashima M
    • Organizer
      34th European Congress of Pathology
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 低分化成分を有する結節内結節型甲状腺良性結節の分子病理学的特徴解析2022

    • Author(s)
      上田真由, 松田勝也, 黒濵大和, Mussazhanova Zhanna, Yerkezhan Sailaubekova, 近藤久義, 松岡優毅, 大坪智恵子, 佐藤信也, 山下弘幸, 川上 純, 中島正洋
    • Organizer
      第65回日本甲状腺学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] A new indicator to differentiate thyroid follicular inclusions in the cervical lymph nodes from patients with thyroid cancer2022

    • Author(s)
      Mussazhanova Z, Otsubo C, Kurohama H, Shalgimbayeva G, Ueki N, Matsuoka Y, Madiyeva M, Sato S, Yamashita H, Nakashima M
    • Organizer
      Scientific and practical aspects of the treatment and diagnosis of oncological diseases
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] The new effects of radioactive microparticles for rats and mice and our future plan2022

    • Author(s)
      Hoshi M
    • Organizer
      International Conference - Modern Perspectives for Biomedical Sciences
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Animal studies of 56MnO2 exposure in 2018-192022

    • Author(s)
      Fujimoto N
    • Organizer
      The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Overview of our studies of radiation effects in Kazakhstan2022

    • Author(s)
      Hoshi M
    • Organizer
      The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Study of 7Be and 210Pb in atmosphere of Akmola region of Kazakhstan2022

    • Author(s)
      Kassym Zhumadilov, Aidana Zhumalina, Yernaz Sambayev, Yeldos Bekzhanov, Asel Bagramova, Tulegen Kusainov, Aya Sakaguchi, Satoru Endo, Shin Toyoda, Hitoshi Sato, Masaharu Hoshi,
    • Organizer
      The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Trial of remote thyroid examination 10 years after the Fukushima nuclear power accident in COVID-19 pandemic2022

    • Author(s)
      Yoshihiro Noso, Atsuko Imagawa, Akio Haruta, Motomi Ushiyama, Takashi Sawada, Laura Pak, Nailya Chaizhunussova, Ken Inoue, Nobuo Takeichi, Masaharu Hoshi
    • Organizer
      The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Anxiety and fear about mental and physical health for radiation exposure in the people -importance of dissemination about correct knowledge based on the cooperation in various fields2022

    • Author(s)
      Ken Inoue, Noriyuki Kawano, Nailya Chaizhunussova, Nursultan Seksenbayev, Madina Apbassova, Nobuo Takeichi, Yoshihiro Noso, Masaharu Hoshi
    • Organizer
      The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of internal exposure to neutron-activated 56MnO2 powder on locomotor activity in rats2022

    • Author(s)
      Keiko Otani, Megu Ohtaki, Nariaki Fujimoto, Darkhan Uzbekov, Ynkar Kairkhanova, Aisulu Saimova, Nailya Chaizhunussova, Dariya Habdarbaeva, Almas Azhimkhanov, Kassym Zhumadilov, Valeriy Stepanenko, Masaharu Hoshi
    • Organizer
      The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of various doses of ionizing radiation on liver tissue in experiment2022

    • Author(s)
      Bakhyt Ruslanova, Nailya Chaizhunussova, Dariya Shabdarbayeva, Nariaki Fujimoto, Masaharu Hoshi
    • Organizer
      The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effects of internal and external exposure on morphological indicators and gene expression in lungs in experiment (rats and mice)2022

    • Author(s)
      Zhaslan Abishev, Nailya Chaizhunussova, Dariya Shabdarbayeva, Nariaki Fujimoto, Masaharu Hoshi
    • Organizer
      The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Influence of internal and external ionizing radiation on gene expression of the reproductive system in male laboratory animals.2022

    • Author(s)
      Nailya Chaizhunussova, Gauhar Amantayeva, Dariya Shabdarbayeva, Nariaki Fujimoto, Masaharu Hoshi
    • Organizer
      The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Interlaboratory comparison of EPR tooth enamel dosimetry with investigations of the dose responses of the standard samples2022

    • Author(s)
      Toyoda, S., Inoue, K., Yamaguchi, I., Hoshi, M., Hirota, S., Oka, T., Shimazaki, T., Mizuno, H., Tani, A., Yasuda, H., Gonzales, C. A. B., Okutsu, K., Takahashi, A., Tanaka, N., Todaka, A
    • Organizer
      EPR BioDose 2022
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラット新生仔期被曝による甲状腺腫瘍化に関与する遺伝子発現変化(O2-7-1)2021

    • Author(s)
      藤本成明, 松山睦美, 中島正洋
    • Organizer
      第94回日本内分泌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 放射性56MnO2 微粒子曝露による低線量被曝でのラット雄性生殖線機能低下2021

    • Author(s)
      藤本成明, 星正治, Chaizhunussova N
    • Organizer
      第5回放射線災害 医科学研究拠点カンファランス
    • Related Report
      2021 Research-status Report
  • [Presentation] Biological effects of radioactive particles produced by atomic bombing; animal studies2021

    • Author(s)
      Fujimoto N
    • Organizer
      15th international scientific-practical conference ecology. radiation. health, Semey, Kazakhstan
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Biological effects of internal exposure to radioactive particles of 56MnO2 in rats2021

    • Author(s)
      Fujimoto N, Chaizhunussova N, Shabdarbayeva D, Gnyrya V, Azhimkhanov A, Kolbayenkov A, Zhumadilov K, Stepanenko V, Hoshi M
    • Organizer
      9th international conference semipalatinsk test site, Kurchatov, Kazakhstani
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] International collaboration of radiation risk evaluation in Semipalatinsk, 4th dosimetry and health risk assessment in the Semipalatinsk cohort of subjects2021

    • Author(s)
      Hoshi M
    • Organizer
      4th Dosimetry Meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Animal exposure experiments using Mn-56 dioxide radioactive microparticles,2021

    • Author(s)
      Hoshi M, Chaizhunusova N, Zhumadilov K, Uzbekov D, Shabdarbaeva D, Kairkhanova Y, Amantaeva G, Ruslanova B, Apbassova M et al
    • Organizer
      9th international conference semipalatinsk test site, Kurchatov, Kazakhstani
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] International collaboration between Kazakhstan and Japan; Studies with Shakarim University2021

    • Author(s)
      M. Hoshi, S. Duyssembayev, Z. Serikov, A. Klivenko, K. Zhumadilov, A. Zhumalina, P. Kazymbet, M. Bakhtin, A. Sakaguchi, M. Yamamoto, S. Endo, H. Satoh, S. Toyoda, N. Kawano
    • Organizer
      Shakarim University Symposium
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Changes in morphology and gene expressions of neonatally X-irradiated thyroid gland in rats2020

    • Author(s)
      Fujimoto N, Matsuu-Matsuyama M, Nakashima M
    • Organizer
      22nd European Congress of Endocrinology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 結節内結節を伴う甲状腺良性結節の53BP1による分子病理学的特徴解析2020

    • Author(s)
      清水智貴、松田勝也、高田奈美、黒濵大和、Mussazhanova Zhanna、Sailaubekova Yerkezhan、大坪智恵子、佐藤伸也、山下弘幸、中島正洋
    • Organizer
      第24回日本臨床内分泌病理学会
    • Related Report
      2020 Research-status Report

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Published: 2019-10-10   Modified: 2025-01-30  

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