| Outline of Final Research Achievements |
In Japan, we embarked on an experiment, inhaling IL-33 and soluble ST2 in mice. To our surprise, soluble ST2 acted as a carrier protein for IL-33, significantly enhancing neutrophilic airway inflammation. We promptly reported this unexpected finding to the international journal.
In Canada, our focus was on analyzing neutrophil functions in live mice. In the Alternaria-induced neutrophilic asthma model, we observed an increase in the number and activity of neutrophils in the pulmonary microvasculature. Neutrophils were found to interact with platelets at a steady state, and this interaction was heightened in the neutrophil asthma model. However, the most surprising finding was the frequent migration of neutrophils between intra-microvascular spaces and alveoli, where they interacted with alveolar macrophages. This phenomenon was observed in both steady-state and neutrophilic asthma models, but the duration of the interaction was shorter in the neutrophilic asthma model.
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