| Budget Amount *help |
¥395,460,000 (Direct Cost: ¥304,200,000、Indirect Cost: ¥91,260,000)
Fiscal Year 2012: ¥80,340,000 (Direct Cost: ¥61,800,000、Indirect Cost: ¥18,540,000)
Fiscal Year 2011: ¥80,340,000 (Direct Cost: ¥61,800,000、Indirect Cost: ¥18,540,000)
Fiscal Year 2010: ¥80,340,000 (Direct Cost: ¥61,800,000、Indirect Cost: ¥18,540,000)
Fiscal Year 2009: ¥73,190,000 (Direct Cost: ¥56,300,000、Indirect Cost: ¥16,890,000)
Fiscal Year 2008: ¥81,250,000 (Direct Cost: ¥62,500,000、Indirect Cost: ¥18,750,000)
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| Research Abstract |
We investigated the mechanisms of the cooperation between cadherin superfamily members and cytoskeletal proteins. The findings include 1) EPLIN is involved in the epithelial to mesenchymal transition of junctional architecture, 2) Fat4 and Dachsous1 are required for apical domain formation in neuroepithelial cells, 3) Willin regulates junctional constriction, 4) Celr1 is required for PCP formation of the neural plate, 5) protocadherin17 regulates collective axon extension. Furthermore, we identified Nezha/CAMSAP3 as a microtubule minus-end anchoring protein, and thereby advanced the research fields of non-centrosomal microtubules.
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