| Project/Area Number |
20011002
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AKIYOSHI Kazunari Tokyo Medical and Dental University, 生体材料工学研究所, 教授 (90201285)
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| Co-Investigator(Kenkyū-buntansha) |
松田 修 京都府立医科大学, 医学研究科, 准教授 (00271164)
森本 展行 東北大学, 工学研究科, 准教授 (00313263)
渡辺 昭彦 東京医科歯科大学, 生体材料工学研究所, 助教 (30126263)
澤田 晋一 東京医科歯科大学, 生体材料工学研究所, 助教 (50444104)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥22,000,000 (Direct Cost: ¥22,000,000)
Fiscal Year 2009: ¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 2008: ¥11,000,000 (Direct Cost: ¥11,000,000)
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| Keywords | 癌免疫 / サイトカイン / ナノゲル / 遺伝子デリバリー / 分子シャペロン / カチオン性多糖 / タンパク質ワクチン / トランスフェクション / サイトカン / 潰伝子デリバリー |
|---|
| Research Abstract |
Raspberry-like assembly of polysaccharide nanogels with a high potential as a carrier for protein delivery was prepared. The present study proposes a novel therapeutic intervention technology, taking advantage of slow and sustained release of bioactive cytokines such as IL12. New siRNA or CpG DNA delivery systems were also developed by functional cycloamylose nanogels.
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