| Project/Area Number |
20012029
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
CHIBA Tsutomu Kyoto University, 医学研究科, 教授 (30188487)
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|---|
| Co-Investigator(Renkei-kenkyūsha) |
MARUSAWA Hiroyuki 京都大学, 医学研究科, 講師 (80324630)
|
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2009: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 2008: ¥9,000,000 (Direct Cost: ¥9,000,000)
|
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| Keywords | AID / H.pylori / 胃癌 / CagA / 4型分泌装置 / 遺伝子不安定性 / NFκB / p53 |
|---|
| Research Abstract |
H.pylori enhances gastric cancer development through gastritis. In this study, we found that H.pylori infection induces AID expression, a member of APOBEC family protein, in the gastric mucosal cells, resulting in accumulation of various gene mutations. In addition, AID expression by H.pylori infection also causes not only loss but also gain of various genes, thus contributing to genome instability.
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