Roles of actin cytoskeletal regulation system in tumor cell migrationand invasion
| Project/Area Number |
20013004
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tohoku University |
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Principal Investigator |
MIZUNO Kensaku Tohoku University, 大学院・生命科学研究科, 教授 (70128396)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2009: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 2008: ¥8,000,000 (Direct Cost: ¥8,000,000)
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| Keywords | 癌 / シグナル伝達 / コフィリン / 細胞運動 / 浸潤・転移 / アクチン骨格 / 浸潤突起 / LIMキナーゼ / 癌浸潤 / 浸潤仮足 / Slinshot / 阻害剤 / Slingshot |
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| Research Abstract |
We investigated the roles of actin cytoskeletal regulation in tumor cell migration and invasion and obtained the results, as follows : Cofilin and its regulatory enzymes, LIM-kinase and Slingshot, play critical roles in the invadopodium formation. LIM-kinase is critical for the mesenchymal-to-amoeboid cell morphological transition of tunor cells in 3D matrices. Protein kinase D1 regulates actin reorganization through Slingshot inactivation. We also developed inhibitors for LIM-kinase and found that these inhibitors suppressed tumor cell invasion.
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Report
(3 results)
Research Products
(64 results)
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[Journal Article] LIM-kinase is critical for the mesenchymal-to-amoeboid cell morphological transition in 3D matrices.2010
Author(s)
Mishima, T., Naotsuka, M., Horita, Y., Sato, M., Ohashi, K., Mizuno, K
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Journal Title
Biochem. Biophys. Res. Commum. 392
Pages: 577-581
Related Report
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[Journal Article] Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through Slingshot.2009
Author(s)
Eiseler, T., Doppler, H., Yan, I.K., Kitatani, K., Mizuno, K., Storz, P.
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Journal Title
Nat. Cell Biol. 11(5)
Pages: 545-556
Related Report
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[Journal Article] Ca2+/calmodulin-dependent protein kinase IV-mediated LIM-kinase activation is critical for calcium signal-induced neurite outgrowth.2009
Author(s)
Takemura, M., Mishima, T., Wang, Y., Kasahara, J., Fukunaga, K., Ohashi, K., Mizuno, K.
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Journal Title
J. Biol. Chem. 284
Pages: 28554-28562
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[Journal Article] Critical roles of actin-interacting protein 1 in cytokinesis and chemotactic migration of mammalian cells.2008
Author(s)
Kato, A., Kurita, S., Hayashi, A., Kaji, N., Ohashi, K., Mizuno, K.
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Journal Title
Biochem. J. 414
Pages: 261-270
Related Report
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[Journal Article] Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase/c-Src complex.2008
Author(s)
Kim, Y.B., Choi, S., Choi, M.C., Oh, M.A., Lee, S.A., Cho, M., Mizuno, K., Kim, S.H., Lee, J.W.
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Journal Title
J. Biol. Chem. 283
Pages: 10089-10096
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