The functions of autotaxin in the regulation of blood vessel formation

• Project/Area Number: 20013005
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University
• Principal Investigator: AOKI Junken Tohoku University, 大学院・薬学研究科, 教授 (20250219)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,000,000 (Direct Cost: ¥18,000,000); Fiscal Year 2009: ¥9,000,000 (Direct Cost: ¥9,000,000); Fiscal Year 2008: ¥9,000,000 (Direct Cost: ¥9,000,000)
• Keywords: オートタキシン / 血管新生 / リゾホスファチジン酸 / ゼブラフィッシュ / リゾリン脂質 / GPCR / 生理活性脂質 / がん

Research Abstract

Recent studies of autotaxin deficient-mice revealed critical roles of autotaxin in blood vessel formation in mice, although the precise effect of autotaxin has been still elsive. In this study we utilized zebrafish to study the physiological roles of autotaxin in vasculogenesis. Significant lysoPLD activity was observed in the zebrafish homologue of autotaxin. We further suppressed the functions of autotaxin in zebrafish embryos by injecting antisense morpholino against autotaxin, and clarified that autotaxin has important roles in the blood vessel formation in zebrafish.

Research Products

• [Journal Article] Biological roles of lysophosphatidic acid signaling through its production by autotaxin. (2010)
  • Author(s): Okudaira S, Yukiura H, Aoki J
  • Journal Title: Biochimie (in press)
  • Peer Reviewed
• [Journal Article] Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts. (2010)
  • Author(s): David M, Wannecq E, Descotes F, Jansen S, Deux B, Ribeiro J, Serre CM, Gres S, Bendriss-Vermare N, Bollen M, Saez S, Aoki J, Saulnier-Blache JS, Clezardin P, Peyruchaud O
  • Journal Title: PLoS One 5 Pages: 9741-9741
  • Peer Reviewed
• [Journal Article] PA3, a unique G protein-coupled receptor for lysophosphatidic acid. (2010)
  • Author(s): Hama K, Aoki J
  • Journal Title: Prog Lipid Res (in press)
  • Peer Reviewed
• [Journal Article] Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis. (2010)
  • Author(s): Shinkuma S, Akiyama M, Inoue A, Aoki J, Natsuga K, Nomura T, Arita K, Abe R, Ito K, Nakamura H, Ujiie H, Shibaki A, Suga H, Tsunemi Y, Nishie W, Shimizu H.
  • Journal Title: Hum Mutat (in press)
  • Peer Reviewed
• [Journal Article] Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain. (2010)
  • Author(s): Ma L, Uchida H, Nagai J, Inoue M, Aoki J, Ueda H
  • Journal Title: J Pharmacol Exp Ther. 333 Pages: 540-546
  • Peer Reviewed
• [Journal Article] Adiponectin suppresses tumorigenesis in Apc(Min)(/+) mice. (2010)
  • Author(s): Otani K, Kitayama J, Yasuda K, Nio Y, Iwabu M, Okudaira S, Aoki J, Yamauchi T, Kadowaki T, Nagawa H
  • Journal Title: Cancer Lett 288 Pages: 177-182
  • Peer Reviewed
• [Journal Article] Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts (2010)
  • Author(s): David M, et al.14人中13番目
  • Journal Title: PLoS One 5(3)
  • Peer Reviewed
• [Journal Article] LPA(3), a unique G protein-coupled receptor for lysophosphatidic acid (2010)
  • Author(s): Hama K, Aoki J
  • Journal Title: Prog Lipid Res (未定, In press)
  • Peer Reviewed
• [Journal Article] Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain (2010)
  • Author(s): Ma L, Uchida H, Nagai J, Inoue M, Aoki J, Ueda H
  • Journal Title: J Pharmacol Exp Ther 333(2) Pages: 540-546
  • Peer Reviewed
• [Journal Article] Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. (2009)
  • Author(s): Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N,Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M,Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Brauer AU, Chun J,Ninnemann O, Schmitz D, Nitsch R.
  • Journal Title: Cell 138 Pages: 1222-1235
  • Peer Reviewed
• [Journal Article] Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain. (2009)
  • Author(s): Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H.
  • Journal Title: Mol Pain Pages: 5-64
  • NAID: 120006984666
  • Peer Reviewed
• [Journal Article] Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta. (2009)
  • Author(s): Iwasawa Y, Fujii T, Nagamatsu T, Kawana K, Okudaira S, Miura S, Matsumoto J, Tomio A, Hyodo H, Yamashita T, Oda K, Kozuma S, Aoki J, Yatomi Y, Taketani Y
  • Journal Title: Am J Reprod Immunol. 62 Pages: 90-95
  • Peer Reviewed
• [Journal Article] Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression. (2009)
  • Author(s): Nouh MA, Wu XX, Okazoe H, Tsunemori H, Haba R, Abou-Zeid AM, Saleem MD, Inui M, Sugimoto M, Aoki J, Kakehi Y
  • Journal Title: Cancer Sci. 100 Pages: 1631-1638
  • NAID: 10027194307
  • Peer Reviewed
• [Journal Article] Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood. (2009)
  • Author(s): Endo T, Kano K, Motoki R, Hama K, Okudaira S, Ishida M, Ogiso H, Tanaka M, Matsuki N, Taguchi R, Kanai M, Shibasaki M, Arai H, Aoki J
  • Journal Title: J Biochem. 146 Pages: 283-93
  • NAID: 10026303013
  • Peer Reviewed
• [Journal Article] Autotaxin enzyme immunoassay in human cerebrospinal fluid samples. (2009)
  • Author(s): Nakamura K, Ohkawa R, Okubo S, Yokota H, Ikeda H, Yatomi Y, Igarashi K, Ide K, Kishimoto T, Masuda A, Yamamoto T, Tsuji S, Saito N, Kurokawa M, Okudaira S, Aoki J
  • Journal Title: Clin Chim Act 405 Pages: 160-162
  • Peer Reviewed
• [Journal Article] merging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamineandlysophosphatidylglycerol. (2009)
  • Author(s): Makide K, Kitamura H, Sato Y, Okutani M, Aoki J
  • Journal Title: Prostaglandins Other Lipid Mediat. 89 Pages: 135-139
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative (2009)
  • Author(s): Iwashita M, et al.11人中9番目
  • Journal Title: J Med Chem 52(19)
  • Peer Reviewed
• [Journal Article] Adiponectin suppresses tumorigenesis in Apc(Min)(/+)mice (2009)
  • Author(s): Otani K, et al.10人中7番目
  • Journal Title: Cancer Lett 288(2) Pages: 177-182
  • Peer Reviewed
• [Journal Article] Expression of autotaxin, an ectoenzyme that produces lysophosphatidicacid, in human placenta (2009)
  • Author(s): Iwasawa Y, et al.15人中13番目
  • Journal Title: Am J Reprod Immunol 62(2) Pages: 90-95
  • Peer Reviewed
• [Journal Article] Expression of autotaxin and acylglycerol kinase in prostate cancer : association with cancer development and progression (2009)
  • Author(s): Nouh MA, et al.11人中10番目
  • Journal Title: Cancer Sci 100(9) Pages: 1631-1638
  • Peer Reviewed
• [Journal Article] Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood (2009)
  • Author(s): Endo T, et al.14人中14番目
  • Journal Title: J Biochem 146(2) Pages: 283-293
  • Peer Reviewed
• [Journal Article] Autotaxin enzyme immunoassay in human cerebrospinal fluid samples (2009)
  • Author(s): Nakamura K, et al.16人中16番目
  • Journal Title: Clin Chim Acta 405(1-2) Pages: 160-162
  • Peer Reviewed
• [Journal Article] Protection against oxidative stress-induced hepatic injury by intracellular type II PAF-acetylhydrolase by metabolism of oxidized phospholipids in vivo (2009)
  • Author(s): Nakamura, K., Igarashi, K., Ohkawa, R., Okubo, S., Yokota, H., Kishimoto, T., Ide, K., Masuda, A., Yamamoto, T., Saito, N., Kurokawa, M., Tsuji, S., Okudaira, S., Ikeda, H., Aoki, J., and Yatomi, Y
  • Journal Title: J. Biol. Chem (In press)
  • Peer Reviewed
• [Journal Article] Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome (2009)
  • Author(s): Makide, K., Kitamura, H., Sato, Y, Okutani, M., and Aoki, J
  • Journal Title: POLM (In press)
  • Peer Reviewed
• [Journal Article] Embryo Spacing and Implantation Timing Are Differentially Regulated by LPA3-Mediated Lysophosphatidic Acid Signaling in Mice (2009)
  • Author(s): Endo, T., Kano, K., Motoki, R., Hama, K., Okudaira, S., Ishida, M., Ogiso, H., Tanaka, M., Matsuki, N., Taguchi, R., Kanai, M., Shibasaki, M., Arai, H., and Aoki. J.
  • Journal Title: J. Biochem. In press
  • Peer Reviewed
• [Journal Article] Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hvnoalbuminemia differentiation (2008)
  • Author(s): Makide, K., Kano, K., Kitamura, H., Arima, N., and Aoki, I
  • Journal Title: Tanpakushitsu Kakusan Koso 54 Pages: 29-39
• [Journal Article] Phospholipase A(1) assays using a radiolabeled substrate and mass spectrometry (2008)
  • Author(s): Ohuchi, H., Hamada, A., Matsuda, H., Takagi, A., Tanaka, M., Aoki, J., Arai, H., and Noii, S
  • Journal Title: Dev. Dyn 237 Pages: 3280-3294
  • Peer Reviewed
• [Journal Article] Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker : study on prostate cancer patients (2008)
  • Author(s): Nakasaki, T., Tanaka, T., Okudaira, S., Hirosawa, M., Umemoto, E., Otani, K., Jin, S., Bai, Z., Hayasaka, H., Fukui, Y., Aozasa, K., Fujita, N., Tsuruo, T., Ozono, K., Aoki, J., and Miyasaka, M.
  • Journal Title: Am J Pathol. 173 Pages: 1566-1576
  • Peer Reviewed
• [Presentation] 肺線維症におけるオートタキシンの機能解析 (2011)
  • Author(s): 奥平真一, 青木淳賢
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2011-03-30
• [Presentation] 血中におけるリゾホスファチジルコリン産生機構の解明 (2010)
  • Author(s): 小野めぐみ, 青木淳賢
  • Organizer: 次世代を担う若手ファーマ・バイオフォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-23
• [Presentation] ATX-LPAシグナルのS1Pシグナル抑制機構 (2010)
  • Author(s): 中永景太, 青木淳賢
  • Organizer: 次世代を担う若手ファーマ・バイオフォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-23
• [Presentation] 肺線維症におけるリゾホスファチジン酸産生酵素オートタキシンの機能解析 (2010)
  • Author(s): 青木淳賢
  • Organizer: 第6回東京呼吸器リサーチフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2010-11-07
• [Presentation] Roles of Autotaxin in Pulmonary Fibrosis, Bioactive Lipids in Cancer, Infalammation and Related Disease (2010)
  • Author(s): 奥平真一, 青木淳賢
  • Organizer: 11th International Conference
  • Place of Presentation: メキシコカンクン
  • Year and Date: 2010-10-25
• [Presentation] Baculovirusを用いたオートタキシンの大量発現系の確立 (2010)
  • Author(s): 菅野究, 青木淳賢
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-23
• [Presentation] オートタキシントランスジェニックマウスの解析 (2010)
  • Author(s): 雪浦弘志, 青木淳賢
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-23
• [Presentation] トリプシンによって切断されるAutotaxinの性状解析 (2010)
  • Author(s): 小川貴子, 青木淳賢
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-23
• [Presentation] 血中におけるリゾホスファチジルコリン産生機構の解明 (2010)
  • Author(s): 小野めぐみ, 青木淳賢
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-23
• [Presentation] ゼブラフィッシュを用いたオートタキシンの血管形成メカニズムの解析 (2010)
  • Author(s): 中永景太, 青木淳賢
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-23
• [Presentation] コンディショナルノックアウトマウスを用いたオートタキシンの機能解析 (2010)
  • Author(s): 有馬直明, 青木淳賢
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-23
• [Presentation] 肺線維症におけるリゾホスファチジン酸産生酵素オートタキシンの機能解析 (2010)
  • Author(s): 奥平真一, 青木淳賢
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-23
• [Presentation] トリプシンによって切断されるAutotaxinの性状解析 (2010)
  • Author(s): 小川貴子, 青木淳賢
  • Organizer: 第48回日本薬学会東北支部大会
  • Place of Presentation: 仙台
  • Year and Date: 2010-10-18
• [Presentation] リゾホスファチジン酸産生酵素オートタキシンの血管形成過程における役割 (2010)
  • Author(s): 中永景太, 青木淳賢
  • Organizer: 第15回小型魚類研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-09-12
• [Presentation] 肺線維症におけるリゾホスファチジン酸産生酵素オートタキシンの機能解析 (2010)
  • Author(s): 奥平真一, 青木淳賢
  • Organizer: 第51回日本脂質生化学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-31
• [Presentation] Pathways for LPA production and their path-physiological roles (2010)
  • Author(s): 青木淳賢
  • Organizer: FASEB SummerResearchConference"Lysophospholipid Mediators in Health and Disease"
  • Place of Presentation: アメリカアリゾナ
  • Year and Date: 2010-06-28
• [Presentation] Roles of Autotaxin in Pulmonary Fibrosis FASEB Summer Research Conference (2010)
  • Author(s): 奥平真一, 青木淳賢
  • Organizer: Lysophospholipid Mediators in Health and Disease
  • Place of Presentation: アメリカアリゾナ
  • Year and Date: 2010-06-28
• [Presentation] 血中におけるリゾホスファチジルコリン産生機構の解明 (2010)
  • Author(s): 小野めぐみ, 青木淳賢
  • Organizer: 第6回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2010-06-16
• [Presentation] Physiological roles of Autotaxin during late pregnancy (2010)
  • Author(s): 小野めぐみ, 青木淳賢
  • Organizer: 4th International Conference on Phospholipase A2 and Lipid Mediators (PLM2009)
  • Place of Presentation: 東京
  • Year and Date: 2010-05-28
• [Presentation] Roles of Autotaxin in Pulmonary Fibrosis (2010)
  • Author(s): 奥平真一, 青木淳賢
  • Organizer: 4th International Conference on Phospholipase A2 and Lipid Mediators (PLM2009)
  • Place of Presentation: 東京
  • Year and Date: 2010-05-28
• [Presentation] Physiological roles of Autotaxin during late pregnancy (2010)
  • Author(s): 小野めぐみ, 青木淳賢
  • Organizer: The 5th Takeda Science Foundation Symposium on PharmaSciences
  • Place of Presentation: 東京
  • Year and Date: 2010-05-26
• [Presentation] Two pathways for LPA production and their path-physiological roles (2010)
  • Author(s): 青木淳賢
  • Organizer: The 5th Takeda Science Foundation Symposium on PharmaSciences
  • Place of Presentation: 東京
  • Year and Date: 2010-05-26
• [Presentation] Roles of Autotaxin in Pulmonary Fibrosis (2010)
  • Author(s): 奥平真一, 青木淳賢
  • Organizer: The 5th Takeda Science Foundation Symposium on PharmaSciences
  • Place of Presentation: 東京
  • Year and Date: 2010-05-26
• [Presentation] 血中におけるリゾホスファチジルコリン産生機構の解明 (2010)
  • Author(s): 小野めぐみ, 青木淳賢
  • Organizer: 日本生化学会東北支部第75回例会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-09
• [Presentation] 肺線維症におけるオートタキシンの機能解析 (2010)
  • Author(s): 奥平真一
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-30
• [Presentation] 血中におけるリゾホスファチジルコリン産生機構の解明 (2010)
  • Author(s): 小野めぐみ, 青木淳賢
  • Organizer: 第129年会日本薬学会
  • Place of Presentation: 京都
• [Presentation] 細がん細胞の運動・増殖性促進因子オートタキシンは血管新生を促進する (2009)
  • Author(s): 青木淳賢
  • Organizer: 日本癌学会シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-12-30
• [Presentation] 生理活性リゾリン脂質の生体内機能-リゾリン脂質メディエーターの生理・病態機能- (2009)
  • Author(s): 青木淳賢
  • Organizer: 第30回東北薬学セミナー
  • Place of Presentation: 仙台
  • Year and Date: 2009-12-05
• [Presentation] ATX-LPAシグナルのS1Pシグナル抑制機構 (2009)
  • Author(s): 中永景太
  • Organizer: 次世代を担う若手ファーマ・バイオフォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-23
• [Presentation] 血中におけるリゾホスファチジルコリン産生機構の解明 (2009)
  • Author(s): 小野めぐみ
  • Organizer: 次世代を担う若手ファーマ・バイオフォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-23
• [Presentation] Roles of Autotaxin in Pulmonary Fibrosis (2009)
  • Author(s): 奥平真一
  • Organizer: Bioactive Lipids in Cancer, Infalammation and Related Disease, 11th International Conference
  • Place of Presentation: メキシコ カンクン
  • Year and Date: 2009-10-25
• [Presentation] 肺線維症におけるリゾホスファチジン酸産生酵素オートタキシンの機能解析 (2009)
  • Author(s): 奥平真一
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] コンディショナルノックアウトマウスを用いたオートタキシンの機能解析 (2009)
  • Author(s): 有馬直明
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] ゼブラフィッシュを用いたオートタキシンの血管形成メカニズムの解析 (2009)
  • Author(s): 中永景太
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] 血中におけるリゾホスファチジルコリン産生機構の解明 (2009)
  • Author(s): 小野めぐみ
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] トリプシンによって切断される Autotaxin の性状解析 (2009)
  • Author(s): 小川貴子
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] オートタキシントランスジェニックマウスの解析 (2009)
  • Author(s): 雪浦弘志
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] Baculovirus を用いたオートタキシンの大量発現系の確立 (2009)
  • Author(s): 菅野究
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] トリプシンによって切断される Autotaxin の性状解析 (2009)
  • Author(s): 小川貴子
  • Organizer: 第48回日本薬学会東北支部大会
  • Place of Presentation: 仙台
  • Year and Date: 2009-10-18
• [Presentation] リゾホスファチジン酸産生酵素オートタキシンの血管形成過程における役割 (2009)
  • Author(s): 中永景太
  • Organizer: 第15回小型魚類研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-12
• [Presentation] メディエーターとしての生体膜脂質の機能-リゾリン脂質メディエーターの生理・病態機能- (2009)
  • Author(s): 青木淳賢
  • Organizer: 生体パーオキシド研究会
  • Place of Presentation: 仙台
  • Year and Date: 2009-08-30
• [Presentation] 肺線維症におけるリゾホスファチジン酸産生酵素オートタキシンの機能解析 (2009)
  • Author(s): 奥平真一
  • Organizer: 第51回日本脂質生化学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-31
• [Presentation] Pathways for LPA production and their path-physiological roles (2009)
  • Author(s): 青木淳賢
  • Organizer: FASEB Summer Research Conference "Lysophospholipid Mediators in Health and Disease"
  • Place of Presentation: アメリカ アリゾナ
  • Year and Date: 2009-06-28
• [Presentation] Roles of Autotaxin in Pulmonary Fibrosis (2009)
  • Author(s): 奥平真一
  • Organizer: FASEB Summer Research Conference "Lysophospholipid Mediators in Health and Disease"
  • Place of Presentation: アメリカ アリゾナ
  • Year and Date: 2009-06-28
• [Presentation] 血中におけるリゾホスファチジルコリン産生機構の解明 (2009)
  • Author(s): 小野めぐみ
  • Organizer: 第6回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-16
• [Presentation] 生理活性リゾリン脂質-新しいドラッグターゲット- (2009)
  • Author(s): 青木淳賢
  • Organizer: 東北大学バイオシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-06-06
• [Presentation] Roles of Autotaxin in Pulmonary Fibrosis (2009)
  • Author(s): 奥平真一
  • Organizer: 4th International Conference on Phospholipase A2 and Lipid Mediators(PLM2009)
  • Place of Presentation: 東京
  • Year and Date: 2009-05-28
• [Presentation] Physiological roles of Autotaxin during late pregnancy (2009)
  • Author(s): 小野めぐみ
  • Organizer: 4th International Conference on Phospholipase A2 and Lipid Mediators(PLM2009)
  • Place of Presentation: 東京
  • Year and Date: 2009-05-28
• [Presentation] Roles of Autotaxin in Pulmonary Fibrosis (2009)
  • Author(s): 奥平真一
  • Organizer: The 5th Takeda Science Foundation Symposium on PharmaSciences
  • Place of Presentation: 東京
  • Year and Date: 2009-05-26
• [Presentation] Physiological roles of Autotaxin during late pregnancy (2009)
  • Author(s): 小野めぐみ
  • Organizer: The 5th Takeda Science Foundation Symposium on PharmaSciences
  • Place of Presentation: 東京
  • Year and Date: 2009-05-26
• [Presentation] 血中におけるリゾホスファチジルコリン産生機構の解明 (2009)
  • Author(s): 小野めぐみ
  • Organizer: 日本生化学会東北支部第75回例会
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-09
• [Presentation] VE-カドヘリンの接着抑制に関わる内皮細胞上のLPA受容体の解析 (2009)
  • Author(s): 中永景太, 青木淳賢
  • Organizer: BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Role of autotaxin in lysophosphatidic acid-induced hypertension in murine plasma (2009)
  • Author(s): 可野邦行, 青木淳賢
  • Organizer: BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 肝障害時における血中autotaxin発現変動の解析 (2009)
  • Author(s): 小川貴子, 青木淳賢
  • Organizer: BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 創傷治癒におけるリゾホスファチジン酸産生酵素autotaxinの機能解析 (2009)
  • Author(s): 奥平真一, 青木淳賢
  • Organizer: BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] コンディショナルノックアウトマウスを用いたリゾホスファチジン酸産生酵素オートタキシンの機能解析 (2009)
  • Author(s): 大上満, 青木淳賢
  • Organizer: ファーマ・バイオフォーラム2008
  • Place of Presentation: 東京
• [Presentation] リゾホスファチジン酸産生酵素オートタキシンの初期炎症過程における機能 (2009)
  • Author(s): 青木淳賢
  • Place of Presentation: 徳島
• [Presentation] コンディショナルノックアウトマウスを用いたリゾホスファチジン酸産生酵素オートタキシンの機能解析 (2008)
  • Author(s): 大上満、奥平真一、Wouter Moolenaar、新井洋由、青木淳賢
  • Organizer: ファーマ・バイオフォーラム2008
  • Place of Presentation: 東京都、渋谷、日本薬学会長井記念ホール
  • Year and Date: 2008-11-29
• [Presentation] 初期炎症反応に生理活性脂質リゾホスファチジン酸の役割 (2008)
  • Author(s): 青木淳賢
  • Organizer: 日本脂質生化学会
  • Place of Presentation: 徳島県徳島市徳島県郷土文化会館
  • Year and Date: 2008-06-05
• [Presentation] ホスファチジン酸特異的ホスホリパーゼA1の体毛形成への関与 (2008)
  • Author(s): 井上飛鳥、有馬直明、新井洋由、青木淳賢
  • Organizer: 日本脂質生化学会
  • Place of Presentation: 徳島県徳島市徳島県郷土文化会館
  • Year and Date: 2008-06-05
• [Book] 実験医学, 「情報伝達をつかさどる生理活性物質脂質メディエーターの機能」 (2009)
  • Author(s): 井上飛鳥/青木淳賢
  • Publisher: 羊土社
• [Remarks]
  • URL: http://www.pharm.tohoku.ac.jp/~seika/H21/index.html
• [Remarks]
  • URL: http://www.pharm.tohoku.ac.jp/%7Eseika/H21/index.html