Regulation of transformation and cell growth by molecules controlling cell death
Project/Area Number |
20013020
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Kyoto University |
Principal Investigator |
YONEHARA Shin Kyoto University, 大学院・生命科学研究科, 教授 (00124503)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2009: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 2008: ¥8,000,000 (Direct Cost: ¥8,000,000)
|
Keywords | 細胞死 / 遺伝子 / 癌 / 細胞・組織 / シグナル伝達 |
Research Abstract |
We show that tetraploid cells induced by impaired mitotic chromosomal condensation are eliminated by a novel type of cell death different from caspase-dependent apoptosis. The cell death was executed by the downregulation of eukaryotic translation elongation factor 1 alpha 1 (eEF1A1), a typical housekeeping gene products. The downregulation of eEF1A1 expression was shown to be induced by both destabilization of its mRNA and its translational inhibition.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Mechanism of NKT cell activation by intranasal coadministration of α-galactosylceramide, which can induce cross-protection against influenza viruses2008
Author(s)
Kamijuku H, Nagata Y, Jiang X, Ichinohe T, Tashiro T, Mori K, Taniguchi M, Hase K, Ohno H, Shimaoka T, Yonehara S, Odagiri T, Tashiro M, Sata T, Hasegawa H, Seino K
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Journal Title
Mucosal Immunology 1
Pages: 208-218
Related Report
Peer Reviewed
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