Genomic damage and cancer cell death caused by reactive oxygen species

• Project/Area Number: 20013034
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyushu University
• Principal Investigator: NAKABEPPU Yusaku Kyushu University, 生体防御医学研究所, 教授 (30180350)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,000,000 (Direct Cost: ¥18,000,000); Fiscal Year 2009: ¥9,000,000 (Direct Cost: ¥9,000,000); Fiscal Year 2008: ¥9,000,000 (Direct Cost: ¥9,000,000)
• Keywords: 酸化ストレス / 8-オキソグアニン / プログラム細胞死 / p53 / MUTYH / 8-oxoguanine / MLH1 / MSH2 / 核DNA / ミトコンドリアDNA / (2)-ヒドロキシアデン / 細胞死 / P53

Research Abstract

8-Oxoguanine (8-oxoG) is one of the major oxidative base lesions in DNA or nucleotides, and is highly mutagenic because it can pair with adenine as well as cytosine. To minimize accumulation of 8-oxoG in mammalian genomes, MTH1 hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, and OGG1 excises 8-oxoG paired with cytosine in DNA, while MUTYH excises adenine inserted opposite 8-oxoG in template DNA during DNA replication and whose deficiency is known to cause MUTYH-associated familial adenomatous polyposis. We found that the buildup of 8-oxoG in nuclear or mitochondrial DNA initiates MUTYH-dependent cell death, and unveiled its regulatory mechanisms, thus demonstrating that the cell death is crucial for tumor suppression.

Research Products

• [Journal Article] Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase. (2010)
  • Author(s): Nakabeppu Y, Oka S, Sheng Z, Tsuchimoto D, Sakumi K
  • Journal Title: Mutation Res. inpress
  • Peer Reviewed
• [Journal Article] DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1. (2010)
  • Author(s): Martin SA, McCabe N, Mullarkey M, Cummins R, Burgess DJ, Nakabeppu Y, Oka S, Kay E, Lord CJ, Ashworth A
  • Journal Title: Cancer Cell 17 Pages: 235-248
  • Peer Reviewed
• [Journal Article] NUDT16 is a (deoxy) inosine diphosphatase, and its deficiency induces accumulation of single strand breaks in nuclear DNA and growth arrest (2010)
  • Author(s): Iyama T, Abolhassani N, Tsuchimoto D, Nonaka M, Nakabeppu Y.
  • Journal Title: Nucleic Acids Research (In press)
  • Peer Reviewed
• [Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dIDP/IDP from nucleotide pools in mammals. (2010)
  • Author(s): Abolhassani N, Iyama T, Tsuchimoto D, Sakumi K, Ohno M, Behmanesh M, Nakabeppu Y.
  • Journal Title: Nucleic Acids Research (In press)
  • Peer Reviewed
• [Journal Article] DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1. (2010)
  • Author(s): Martin SA, McCabe N, Mullarkey M, Cummins R, Burgess DJ, Nakabeppu Y, Oka S, Kay E, Lord Cj, Ashworth A.
  • Journal Title: Cancer Cell 17 Pages: 235-248
  • Peer Reviewed
• [Journal Article] Altered expression of MUTYH and an increase in 8-hydroxydeoxyguanosine are early events in ulcerative colitis-associated carcinogenesis. (2009)
  • Author(s): Gushima M, Hirahashi M, Matsumoto T, Fujita K, Fujisawa R, Mizumoto K, Nakabeppu Y, Iida M, Yao T, Tsuneyoshi M
  • Journal Title: J Pathol 219 Pages: 77-86
  • Peer Reviewed
• [Journal Article] ミトコンドリアのデオキシリボヌクレオチドプールの酸化と細胞死 (2009)
  • Author(s): 中別府雄作
  • Journal Title: 医学のあゆみ 232巻 Pages: 681-689
• [Journal Article] AIF (2009)
  • Author(s): 中別府雄作
  • Journal Title: Medical Tribune 42巻 Pages: 46-46
• [Journal Article] 塩基除去修復酵素MUTYHに依存したプログラム細胞死と発癌抑制機構 (2009)
  • Author(s): 中別府雄作
  • Journal Title: 実験医学 27巻 Pages: 135-139
• [Journal Article] Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methy1-4-pheny1-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. (2009)
  • Author(s): Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda M.
  • Journal Title: PLoS One 30
  • Peer Reviewed
• [Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. (2009)
  • Author(s): Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, Honjo T.
  • Journal Title: International Immunology 21 Pages: 947-955
  • Peer Reviewed
• [Journal Article] Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage (2009)
  • Author(s): Oka S, Ohno M, Nakabeppu Y.
  • Journal Title: Methods in Molecular Biology 554 Pages: 251-264
• [Journal Article] Quantitative analysis of oxidized guanine, 8-oxoguanine, in mitochondrial DNA by immunofluorescence method. (2009)
  • Author(s): Ohno M, Oka S, Nakabeppu Y.
  • Journal Title: Methods in Molecular Biology 554 Pages: 199-212
• [Journal Article] ITPase-deficient mice show growth retardation and die before weaning. (2009)
  • Author(s): Behmanesh M, Sakumi K, Abolhassani N, Toyokuni S, Oka S, Ohnishi YN, Tsuchimoto D, Nakabeppu Y.
  • Journal Title: Cell Death and Differentiation 16 Pages: 1315-1322
  • Peer Reviewed
• [Journal Article] Altered expression of MUTYH and an increase in 8-hydroxy-deoxyguanosine are early events in ulcerative colitis-associated carcinogenesis. (2009)
  • Author(s): Gushima M, Hirahashi M, Matsumoto T, Fujita K, Fujisawa R, Mizumoto K, Nakabeppu Y, Iida M, Yao T, Tsuneyoshi M
  • Journal Title: Journal of Pathology 219 Pages: 77-86
  • Peer Reviewed
• [Journal Article] Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine. (2009)
  • Author(s): Nonaka, M., et.al.
  • Journal Title: FEBS J. 276 Pages: 1654-1666
  • Peer Reviewed
• [Journal Article] Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice. (2008)
  • Author(s): Nakane H, Hirota S, Brooks PJ, Nakabeppu Y, Nakatsu, Y, Nishimune Y, Iino A, Tanaka K
  • Journal Title: DNA Repair 7 Pages: 1938-1950
  • Peer Reviewed
• [Journal Article] A Role for Oxidized DNA Precursors in Huntington's Disease-Like Striatal Neurodegeneration. (2008)
  • Author(s): De Luca G, Russo MT, Degan P, Tiveron C, Zijno A, Meccia E, Ventura I, Mattei E, Nakabeppu Y, Crescenzi M, Pepponi R, Pezzola A, Popoli P, Bignami M
  • Journal Title: PLoS Genet 4
  • Peer Reviewed
• [Journal Article] Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus. (2008)
  • Author(s): Dan Y, Ohta Y, Tsuchimoto D, Ohno M, Ide Y, Sami M, Kanda T, Sakumi K, Nakabeppu Y
  • Journal Title: DNA Repair 7 Pages: 1437-1454
  • Peer Reviewed
• [Journal Article] Genomic and functional analyses of MUTYH in Japanese patients with adenomatous polyposis. (2008)
  • Author(s): Yanaru-Fujisawa R, Matsumoto T, Ushijima, Y, Esaki M, Hirahashi M, Gushima M, Yao T, Nakabeppu Y, Iida M
  • Journal Title: Clin Genet 73 Pages: 545-553
  • Peer Reviewed
• [Journal Article] Suberoylanilide hydroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines. (2008)
  • Author(s): Yamamoto S, Tanaka K, Sakimura R, Okada T, Nakamura T, Li Y, Takasaki M, Nakabeppu Y, Iwamoto Y
  • Journal Title: Anticancer Res 28 Pages: 1585-1591
  • Peer Reviewed
• [Journal Article] Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death. (2008)
  • Author(s): Ichikawa J, Tsuchimoto D, Oka S, Ohno M, Furuichi M, Sakumi K, Nakabeppu Y
  • Journal Title: DNA Repair 7 Pages: 418-430
  • Peer Reviewed
• [Journal Article] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. (2008)
  • Author(s): Oka S, Ohno M, Tsuchimoto D, Sakumi K, Furuichi M, Nakabeppu Y
  • Journal Title: EMBO J 27 Pages: 421-432
  • Peer Reviewed
• [Journal Article] 核およびミトコンドリアDNAの酸化損傷によって引き起こされる2つの独立した細胞死の経路 (2008)
  • Author(s): 岡素雅子, 中別府雄作
  • Journal Title: 実験医学 26巻 Pages: 1376-1379
• [Journal Article] Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus. (2008)
  • Author(s): Dan Y., et.al.
  • Journal Title: DNA Repair 7 Pages: 1437-1454
  • Peer Reviewed
• [Journal Article] Genomic and, functional analyses of MUTYH in Japanese patients with adenomatous nolyposis. (2008)
  • Author(s): Yanaru-Fujisawa R, et.al.
  • Journal Title: Clin Genet 73 Pages: 545-553
  • Peer Reviewed
• [Presentation] MUTYH, a molecular switch for programmed cell death and tumor suppression. (2010)
  • Author(s): S Oka, Y Nakabeppu
  • Organizer: AACR/JCA 8th Joint Conference
  • Place of Presentation: Waikoloa, Hawai, USA
  • Year and Date: 2010-02-07
• [Presentation] 核酸の酸化がもたらす生体障害とその防御機構 (2010)
  • Author(s): 中別府雄作
  • Organizer: 第26回臨床フリーラジカル会議
  • Place of Presentation: 大津
  • Year and Date: 2010-01-30
• [Presentation] MUTYH, a molecular switch for programmed cell death and tumor suppression (2010)
  • Author(s): S Oka, Y Nakabeppu
  • Organizer: AACR/JCA 8th Joint Conference
  • Place of Presentation: Waikoloa, Hawai, USA
• [Presentation] MUTYH is a potential mediator of p53 tumor suppression. (2009)
  • Author(s): S Oka, J J Leon-Incio, Y Nakabeppu
  • Organizer: 第33回日本分子生物学会年会/第83回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] Base excision repair-mediated programmed cell death responsible for tumor suppression and neurodegeneration (2009)
  • Author(s): Y Nakabeppu, S Oka, Z Sheng, D Tsuchimoto, K Sakumi
  • Organizer: 4th International Workshop on Cell Regulations in Division and Arrest
  • Place of Presentation: Okinawa
  • Year and Date: 2009-12-02
• [Presentation] 核酸の酸化と細胞死のシグナル伝達 (2009)
  • Author(s): 中別府雄作
  • Organizer: 大阪大学蛋白質研究所セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-28
• [Presentation] 酸化的DNA損傷と生殖細胞ゲノム変異 (2009)
  • Author(s): 大野みずき, 作見邦彦, 古市正人, 續輝久, 中別府雄作
  • Organizer: 日本環境変異原学会
  • Place of Presentation: 静岡
  • Year and Date: 2009-11-26
• [Presentation] 酸化的DNA損傷と生殖細胞ゲノム変異 (2009)
  • Author(s): 大野みずき, 作見邦彦, 古市正人, 續輝久, 中別府雄作
  • Organizer: 日本放射線影響学会第52回大会
  • Place of Presentation: 広島
  • Year and Date: 2009-11-11
• [Presentation] MUTYH, A MOLECULAR SWITCH FOR PROGRAMMED CELL DEATH AND TUMOR SUPPRESSION (2009)
  • Author(s): S Oka, M Ohno, D Tsuchimoto, K Sakumi, Y Nakabeppu
  • Organizer: The Fortieth International Symposium of The Princess Takamatsu Cancer Research Fund
  • Place of Presentation: Tokyo
  • Year and Date: 2009-11-10
• [Presentation] Production and analysis of the Ogg1, Mth1, Mutyh triple knockout mouse strain (2009)
  • Author(s): K Sakumi, M Ohno, K Taguchi, M Hokama, Y Nakatsu, T Tsuzuki, Y Nakabeppu
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] MUTYH is a potential mediator of p53 tumor suppression (2009)
  • Author(s): S Oka, Y Nakabeppu
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Mitochondrial toxin, 3-nitropropionic acid induces MUTYH-dependent striatal degeneration. (2009)
  • Author(s): Z Sheng, H Yamada, Y Nakabeppu.
  • Organizer: 第32回日本神経科学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] 酸化損傷塩基の修復能を欠損するマウスにおける継世代的影響の解析 (2009)
  • Author(s): 大野みずき, 作見邦彦, 古市正人, 續輝久, 中別府雄作
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] Oxidative damage in nucleic acids and mitochondrial dysfunction. (2009)
  • Author(s): Y Nakabeppu
  • Organizer: SFRR International Summer School 2009 in Japan
  • Place of Presentation: Minamiuonuma
  • Year and Date: 2009-09-05
• [Presentation] Programmed cell death triggered by nucleotide pool damage. (2009)
  • Author(s): Y Nakabeppu, E Ohta, J Ichikawa, D Tsuchimoto
  • Organizer: The 10th International Conference on Environmental Mutagenesis (ICEM)
  • Place of Presentation: Italy
  • Year and Date: 2009-08-21
• [Presentation] MUTYH-dependent cell death and neurodegeneration (2009)
  • Author(s): Z Sheng, S Oka, Y Nakabeppu
  • Organizer: The 2nd Erling Seeberg symposium on DNA repair
  • Place of Presentation: Norway
  • Year and Date: 2009-06-22
• [Presentation] 酸化ヌクレオチドによるシグナル伝達 (2009)
  • Author(s): 太田詠子, 土本大介, 中別府雄作
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-06-11
• [Presentation] Oxidative Stress-Induced Tumorigenesis in the Small Intestine of Various DNA Repair-Deficient Mice (2009)
  • Author(s): T Tsuzuki, J Piao, T Isoda, K Sakumi, Y Nakabeppu, Y Nakatsu
  • Organizer: The 3rd ASM Conference on DNA Repair and Mutagenesis
  • Place of Presentation: Whistler, Canada
  • Year and Date: 2009-05-31
• [Presentation] 8-Oxoguanine promotes base substitution and homologous recombination in mammalian germ cells. (2009)
  • Author(s): M Ohno, M Furuichi, K Sakumi, Y Nakabeppu
  • Organizer: The 3rd ASM Conference on DNA Repair and Mutagenesis: From Molecular Structure to Human Disease
  • Place of Presentation: Whistler, Canada
  • Year and Date: 2009-05-31
• [Presentation] Oxidative damage in brain genome and neuroprotection. (2009)
  • Author(s): Yusaku Nakabeppu
  • Organizer: The 11th Meeting of Hirosaki International Forum of Medical Science Emerging Frontiers in Brain Research -Crossroads of metabolic regulation, stress response and disease
  • Place of Presentation: Hirosaki
  • Year and Date: 2009-03-28
• [Presentation] 核酸の酸化とプログラム細胞死 (2009)
  • Author(s): 中別府雄作
  • Organizer: レドックス170委員会第20回研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-23
• [Presentation] MUTYH, a molecular switch for programmed cell death under oxidative stress-friend or foe? (2009)
  • Author(s): Yusaku Nakabeppu
  • Organizer: The 3rd Global COE International Symposium on Stem Cells and Regenerative Medicine
  • Place of Presentation: Singapore
  • Year and Date: 2009-02-15
• [Presentation] Oxidative genomic damage in brain and neuroprotection. (2009)
  • Author(s): Yusaku Nakabeppu
  • Organizer: The Joint Symposium of the 4th International Symposium of Institutes Network and Osaka University Global COE (Frontier Biomedical Science Underlying Organelle Network Biology) Symposium
  • Place of Presentation: Osaka
  • Year and Date: 2009-02-01
• [Presentation] MUTYH is a potential mediator of p53 tumor suppression (2009)
  • Author(s): S Oka, J J Leon-Incio, Y Nakabeppu
  • Organizer: 第33回日本分子生物学会年会/第83回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] Base excision repair-mediated programmed cell death responsible for tumor suppression and neurodegeneration (2009)
  • Author(s): Y Nakabeppu, S Oka, Z Sheng, D Tsuchimoto, K Sakumi
  • Organizer: 4th International Workshop on Cell Regulations in Division and Arrest
  • Place of Presentation: 沖縄
• [Presentation] MUTYH, A MOLECULAR SWITCH FOR PROGRAMMED CELL DEATH AND TUMOR SUPPRESSION (2009)
  • Author(s): S Oka, M Ohno, D Tsuchimoto, K Sakumi, Y Nakabeppu
  • Organizer: The Fortieth International Symposium of The Princess Takamatsu Cancer Research Fund
  • Place of Presentation: 東京
• [Presentation] Oxidative damage in nucleic acids and mitochondrial dysfunction (2009)
  • Author(s): Y Nakabeppu
  • Organizer: SFRR International Summer School 2009 in Japan
  • Place of Presentation: Minamiuonuma
• [Presentation] Programmed cell death triggered by nucleotide pool damage (2009)
  • Author(s): Y Nakabeppu, E Ohta, J Ichikawa, D Tsuchimoto
  • Organizer: The 10th International Conference on Environmental Mutagenesis
  • Place of Presentation: Firenze, Italy
• [Presentation] MUTYH-dependent cell death and neurodegeneration (2009)
  • Author(s): Z Sheng, S Oka, Y Nakabeppu
  • Organizer: The 2nd Erling Seeberg symposium on DNA repair
  • Place of Presentation: Alesund-Geiranger, Norway
• [Presentation] 8-Oxoguanine promotes base substitution and homologous recombination in mammalian germ cells (2009)
  • Author(s): M Ohno, M Furuichi, K Sakumi, Y Nakabeppu
  • Organizer: The 3rd ASM Conference on DNA Repair and Mutagenesis
  • Place of Presentation: Whistler, Canada
• [Presentation] ミトコンドリア毒3-ニトロプロピオン酸は8-オキソグアニンの蓄積を伴うMUTYH依存性の線条体変性を誘発するが, MTH1とOGG1により抑制される (2008)
  • Author(s): 中別府雄作, 盛子敬, 岡素雅子
  • Organizer: 第8回日本ミトコンドリア学会年会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-20
• [Presentation] Overview of programmed cell death and oxidative stress. (2008)
  • Author(s): 中別府雄作
  • Organizer: 第8回日本ミトコンドリア学会年会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-18
• [Presentation] Overview of programmed cell death and oxidative stress (2008)
  • Author(s): 中別府雄作
  • Organizer: 第8回日本ミトコンドリア学会年会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-18
• [Presentation] 活性酸素によるゲノム障害とその防御機構 (2008)
  • Author(s): 中別府雄作
  • Organizer: 第3回放射線防護研究センターシンポジウム(独立行政法人放射線医学総合研究所)「生き物はどのようにして放射線に立ち向かうか-DNA損傷応答と適応応答-」
  • Place of Presentation: 千葉
  • Year and Date: 2008-12-16
• [Presentation] OGG1/MTH1/MUTYH三重欠損マウスは遺伝性の異常形質を頻発するミューテータ・フェノタイプを示す (2008)
  • Author(s): 大野みずき, 作見邦彦, 古市正人, 中別府雄作
  • Organizer: BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] Ogg1, Mth1, Mutyhの3重遺伝子欠損マウス系統のミュテーター・フェノタイプに起因した遺伝性水頭症 (2008)
  • Author(s): 外間政朗, 大野みずき, 作見邦彦, 佐々木富男, 中別府雄作
  • Organizer: BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] OGG1/MTH1/UTYH三重欠損マウスは遺伝性の異常形質を頻発するミューテータ・フェノタイプを示す (2008)
  • Author(s): 大野みずき, 作見邦彦, 古市正人, 中別府雄作
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] 核とミトコンドリアDNAへの8-oxoguanineの同時蓄積によって起動されるプログラム細胞死 (2008)
  • Author(s): 岡素雅子, 大野みずき, 土本大介, 作見邦彦, 中別府雄作
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] 核とミトコンドリアDNAへの8-oxoguanineの同時蓄積によって起動されるプログラム細胞死 (2008)
  • Author(s): 岡素雅子, 大野みずき, 土本大介, 作見邦彦, 中別府雄作
  • Organizer: BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] 8-Oxoguanine is a major cause for the genome instability and diversity through enhancing the somatic and meiotic recombination. (2008)
  • Author(s): Mizuki Ohno, Yusaku Nakabeppu
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾
  • Year and Date: 2008-12-04
• [Presentation] The mitochondrial toxin, 3-nitropropionic acid induces MUTYH-dependent striatal neurodegeneration with accumulation of 8-oxoguanine which is effectively suppressed by OGG1 and MTH1. (2008)
  • Author(s): Zijing Sheng, Sugako Oka, Yusaku Nakabeppu
  • Organizer: The 5th ASMRM and Chinese Mit'2008
  • Place of Presentation: Tianjin, China
  • Year and Date: 2008-11-09
• [Presentation] MUTYHは核とミトコンドリアDNA中の8-オキソグアニンの制御により2つの異なる細胞死経路を引き起こす (2008)
  • Author(s): 岡素雅子, 大野みずき, 土本大介, 作見邦彦, 古市正人, 中別府雄作
  • Organizer: 第67回日本癌学会学術総会(シンポジウム)
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 8-Oxoguanine, a major form of spontaneously oxidized guanine base, promotes genome diversity through enhancing chromosome recombination. (2008)
  • Author(s): Mizuki Ohno, Yusaku Nakabeppu
  • Organizer: The 6th 3R (Replication, recombination, repair) Symposim
  • Place of Presentation: Kakegawa
  • Year and Date: 2008-10-29
• [Presentation] MUTYHは核とミトコンドリアDNA中の8-オキソグアニンの制御により2つの異なる細胞死経路を引き起こす (2008)
  • Author(s): 岡素雅子, 大野みずき, 土本大介, 作見邦彦, 古市正人, 中別府雄作
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] 8-オキソグアニンは染色体組換えを促進し, ゲノム多様性の原因となる (2008)
  • Author(s): 大野みずき, 作見邦彦, 中別府雄作
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-04
• [Presentation] Ogg1/Mth1/Mutyh三重遺伝子欠損マウスは遺伝性の異常形質を頻発するミューテータ・フェノタイプを示す (2008)
  • Author(s): 野みずき, 作見邦彦, 古市正人, 中別府雄作
  • Organizer: 日本遺伝学会第80回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-03
• [Presentation] 8-Oxoguanine promotes genetic diversity through enhancing meiotic recombination (2008)
  • Author(s): Mizuki Ohno, Masato Furuichi, Kunihiko Sakumi, Yusaku Nakabeppu
  • Organizer: XX International Congress of Genetics
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2008-07-12
• [Presentation] OGG1 and MTH1 effectively suppress accumulation of 8-oxoguanine in striatal medium spiny neurons and their degeneration induced by mitochondrial toxin, 3-nitropropionic acid. (2008)
  • Author(s): Sheng Zijing, Hidetaka Yamada, Yusaku Nakabeppu
  • Organizer: 第31回日本神経科学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] ミトコンドリアヌクレオチドプールの酸化に起因する細胞死とその防御機構 (2008)
  • Author(s): 中別府雄作, 市川淳二, 岡素雅子, 大野みずき, 太田詠子, 土本大介, 作見邦彦
  • Organizer: 第61回日本酸化ストレス学会
  • Place of Presentation: 京都
  • Year and Date: 2008-06-20
• [Presentation] Oxidation of mitochondrial deoxynucleotide pools induces mitochondrial degeneration and cell death. (2008)
  • Author(s): Junji Ichikawa, Daisuke Tsuchimoto, Sugako Oka, Mizuki Ohno, Kunihiko Sakumi, Yusaku Nakabeppu
  • Organizer: The 7th European Meeting on Mitochondrial Pathology, Stockholm
  • Place of Presentation: Sweden.
  • Year and Date: 2008-06-12
• [Presentation] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. (2008)
  • Author(s): Sugako Oka, Mizuki Ohno, Daisuke Tsuchimoto, Kunihiko Sakumi, Masato Furuichi, Yusaku Nakabeppu
  • Organizer: The 7th European Meeting on Mitochondrial Pathology, Stockholm
  • Place of Presentation: Sweden
  • Year and Date: 2008-06-12
• [Presentation] 8-オキソグアニンは染色体組換えを誘発する (2008)
  • Author(s): 大野みずき, 作見邦彦, 中別府雄作
  • Organizer: がん予防大会2008福岡(第9回日本がん分子疫学研究会, 第15回日本がん予防学会, 第31回日本がん疫学研究会合同大会)
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-22
• [Presentation] Msh2遺伝子欠損マウスにおける酸化ストレス誘発小腸腫瘍の解析 (2008)
  • Author(s): 朴晶淑, 中津可道, 磯田拓郎, 續輝久, 作見邦彦, 中別府雄作
  • Organizer: がん予防大会2008福岡(第9回日本がん分子疫学研究会, 第15回日本がん予防学会, 第31回日本がん疫学研究会合同大会)
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-22
• [Presentation] DNA修復関連遺伝子欠損マウスにおける酸化ストレス誘発消化管発がん (2008)
  • Author(s): 中津可道, 朴晶淑, 磯田拓郎, 續輝久, 作見邦彦, 中別府雄作
  • Organizer: がん予防大会2008福岡(第9回日本がん分子疫学研究会, 第15回日本がん予防学会, 第31回日本がん疫学研究会合同大会)
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-22
• [Presentation] 活性酸素によるゲノム障害とその防御機構-発がんと神経変性の分子病態- (2008)
  • Author(s): 中別府雄作
  • Organizer: 第27回分子病理学研究会
  • Place of Presentation: 神奈川県三浦郡葉山町
• [Book] Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage (2009)
  • Author(s): Oka, S., Ohno, M., Nakabeppu, Y.
• [Book] in mitochondrial DNA by immunofluorescence method. Methods Mol Biol (2009)
  • Author(s): Ohno, M., Oka, S., Nakabeppu, Y.
• [Remarks]
  • URL: http://www.bioreg.kyushu-u.ac.jp/nfg/index.html
• [Remarks]
  • URL: http://www.bioreg.kyushu-u.ac.jp/nfg/index.htm1