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Risk assessment of cancer using telomere G-tail length measurement

Research Project

Project/Area Number 20014015
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionHiroshima University

Principal Investigator

TAHARA Hidetoshi  Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (00271065)

Co-Investigator(Renkei-kenkyūsha) ANNO Kumiko  広島大学, 大学院・医歯薬学総合研究科, 助教 (30452585)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2009: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 2008: ¥8,000,000 (Direct Cost: ¥8,000,000)
KeywordsGテール / テロメア / がん / リスク診断 / 診断
Research Abstract

We have previously developed the assay to measure the G-tail length, so-called G-tail telomere hybridization protection assay (HPA). We also developed the kit and the high-throughput automated machine for G-tail measurement. We applied these technologies for not only basic research but also for the clinical research, and found that peripheral blood from gastrointestinal cancer patients exhibited significant shorter average G-tail lengths than non-cancerous control group. Whereas total telomere length also reduced in cancer patients, G-tail lengths are markedly reduced in gastrointestinal cancer patients. These findings suggest that G-tail length can be a useful marker for the cancer risk assessment.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (35 results)

All 2010 2009 2008 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (22 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A chiral wedge molecule inhibits telomerase activity2010

    • Author(s)
      Shinohara K, Sannohe Y, Kaieda S, Tanaka K, Osuga H, Tahara H, Xu Y, Kawase T, Bando T, Sugiyama H
    • Journal Title

      Journal of the American Chemical Society VOL.132

      Pages: 3778-3782

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anti-cancer drug development2010

    • Author(s)
      Waki K, Anno K, Ono T, Ide T, Chayama K, Tahara H
    • Journal Title

      Cancer Science (Epub ahead of print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A chiral wedge molecule inhibits telomerase activity.2010

    • Author(s)
      Shinohara K, Sannohe Y, Kaieda S, Tanaka K, Osuga H, Tahara H, Xu Y, Kawase T, Bando T, Sugiyama H.
    • Journal Title

      Journal of the American Chemical Society VOL.132

      Pages: 3778-3782

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anti-cancer drug development.2010

    • Author(s)
      Waki K, Anno K, Ono T, Ide T, Chayama K, Tahara H.
    • Journal Title

      Cancer Science (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation2008

    • Author(s)
      Muramatsu Yukiko, Tahara H., et al
    • Journal Title

      Experimental Cell Research 314(5)

      Pages: 1115-1124

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of menin in the regulation of telomerase activity in normal and cancer cells2008

    • Author(s)
      Hashimoto Manabu, Tahara H., et al
    • Journal Title

      International Journal of Oncology 33(2)

      Pages: 333-340

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Telomere elongation by a mutant tankyrase1 without TRF1 poly (ADP-ribosyl) ation2008

    • Author(s)
      Muramatsu Yukiko
    • Journal Title

      Experimental Cell Research 314・5

      Pages: 1115-1124

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of menin in the regulation of telomerase activity in normal and cancer cells2008

    • Author(s)
      Hashimoto Manabu
    • Journal Title

      International Journal of Oncology 33・2

      Pages: 333-340

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 鎖交換反応を用いたテロメア結合タンパク質の結合を評価する新規測定法の確立2010

    • Author(s)
      喜々津彩、宮城徹、田原栄俊
    • Organizer
      日本薬学会
    • Place of Presentation
      就実大学(岡山市)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] G-tail telomere HPA測定法のハイスループット化2010

    • Author(s)
      平田直之、平塩秀磨、青木絵里子、鳩岡未沙子、頼岡徳在、田原栄俊
    • Organizer
      日本薬学会
    • Place of Presentation
      就実大学(岡山市)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Down-regulation of PRPF-19 involves cellular senescence in human fibroblasts2009

    • Author(s)
      松永純子、徐丹、須藤優樹、嶋本顕、田原栄俊
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-12-10
    • Related Report
      2009 Final Research Report
  • [Presentation] テロメラーゼ遺伝子TERTは人工多能性幹(iPS)細胞の誘導を抑制する2009

    • Author(s)
      嶋本顕、世良行寛、禅正和真、日野由美子、田原栄俊
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Down-regulation of PRPF-19 involves cellular senescence in human fibroblasts.2009

    • Author(s)
      松永純子、徐丹、須藤優樹、嶋本顕、田原栄俊
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of transcriptional regulators binding to minimum suppressive region in HDAC2 promoter in human senescent fibroblasts2009

    • Author(s)
      Nakamura A, Yamanaka Y, Hoshikawa Y, Shimamoto A, Noda T, Tahara H
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-12-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification of transcriptional regulators binding to minimum suppressive region in HDAC2 promoter in human senescent fibroblasts.2009

    • Author(s)
      Nakamura A, Yamanaka Y, Hoshikawa Y, Shimamoto A, Noda T, Tahara H.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞老化におけるp21発現上昇におけるHDAC2の関与2009

    • Author(s)
      中村亜由美、田原栄俊
    • Organizer
      日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      アスティとくしま(徳島市)
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] ヒトがん細胞におけるスプライシングファクターSF3B3のsiRNA創薬の可能性2009

    • Author(s)
      須藤優樹、田原栄俊
    • Organizer
      日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      アスティとくしま(徳島市)
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] MicroRNA10a regulates cellular senescence through CDK6 down-regulation2009

    • Author(s)
      松永純子、徐丹、嶋本顕、田原栄俊
    • Organizer
      広島がんセミナー
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2009-11-01
    • Related Report
      2009 Final Research Report
  • [Presentation] MicroRNA1Oa regulates cellular senescence through CDK6 down-regulation.2009

    • Author(s)
      松永純子、徐丹、鴻本顕、田原栄俊
    • Organizer
      広島がんセミナー
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] High-throughput screening of telomere G-tail length in normal and cancer patients2009

    • Author(s)
      Aoki Eriko, Shimamoto Akira, Tahara Hidetoshi
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] テロメアG-tailを短縮させる薬剤の抗がん剤としての可能性2009

    • Author(s)
      小島安由里、喜々津彩、嶋本顕、田原栄俊.
    • Organizer
      第13回日本がん分子治療学会学術集会
    • Place of Presentation
      アスティとくしま(徳島市)
    • Year and Date
      2009-06-25
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] The importance of telomere G-tail length in normal and cancer cells2009

    • Author(s)
      Hidetoshi Tahara
    • Organizer
      2009年日独がんワークショップ
    • Place of Presentation
      Elsa- Brandstrom (ハンブルグ市、ドイツ)
    • Related Report
      2009 Final Research Report
  • [Presentation] Down regulation of HDAC2 in senescent fibroblasts involves cellular senescence through induction of p53 independent p21cip1/sdi1 trans-activation2009

    • Author(s)
      Yusuke Yamanaka, Hidetoshi Tahara
    • Organizer
      The American Association for Cancer Research, AACR 100th Annual Meeting 2009
    • Place of Presentation
      Colorado Convention Center(Denver, CO, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] The importance of telomere G-tail length in normal and cancer cells2009

    • Author(s)
      Hidetoshi Tahara
    • Organizer
      2009年日独がんワークショツプ
    • Place of Presentation
      Elsa-Brandstrom(ハンブルグ市、ドイッ)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Down regulation of HDAC2 in senescent fibroblasts involves cellular senescence through induction of p53 independent p21cip1/sdi1 trans-activation.2009

    • Author(s)
      Yusuke Yamanaka, Hidetoshi Tahara
    • Organizer
      The American Association for Cancer Research, AACR 100th Annual Meeting 2009
    • Place of Presentation
      Colorado Convention Center (Denver, CO, USA)
    • Related Report
      2009 Annual Research Report
  • [Presentation] G-tail telomere HPA法を用いたMRN complexのテロメア維持における機能解析2008

    • Author(s)
      Angie Sera, Tahara H., et al
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-12-11
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Construction of the Telomere Fingerprint Database, a novel platform for telomere dynamics and drug sensitivity studies2008

    • Author(s)
      Seimiya Hiroyuki, Tahara H., et al
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-28
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] TRF1 mediates mitotic abnormalities induced by Aurora A overexpression2008

    • Author(s)
      Ohishi Tomokazu, Tahara H., et al
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-28
    • Related Report
      2009 Final Research Report
  • [Presentation] TRF 1 mediates mitotic abnormalities induced by Aurora A overexpression2008

    • Author(s)
      Ohishi Tomokazu
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] V-ATPase阻害剤によるテロメラーゼhTERTの転写抑制による抗がん効果2008

    • Author(s)
      小島安由里、田原栄俊, 他
    • Organizer
      第12回がん分子標的治療研究会総会
    • Place of Presentation
      東京都
    • Year and Date
      2008-06-27
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Book] Telomeres and Telomerase in Cancer2009

    • Author(s)
      Keiko Hiyama, Tahara H., et al
    • Total Pages
      380
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] Telomeres and Telomerase in Cancer2009

    • Author(s)
      Keiko Hiyama
    • Total Pages
      380
    • Publisher
      Springer
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://cell.pharm.hiroshima-u.ac.jp/TaharaLAB/Welcome.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://cell.pharm.hiroshima-u.ac.jp/TaharaLAB/Welcome.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 老化の診断方法、老化の診断キット、老化抑制物質のスクリーニング方法、および、癌抑制剤2010

    • Inventor(s)
      田原栄俊
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      2010-049928
    • Filing Date
      2010-03-05
    • Related Report
      2009 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2018-03-28  

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