| Project/Area Number |
20014030
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
OKAMOTO Akimitsu The Institute of Physical and Chemical Research, 岡本独立主幹研究ユニット, ユニットリーダー(独立主幹研究員) (60314233)
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|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2009: ¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 2008: ¥6,700,000 (Direct Cost: ¥6,700,000)
|
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| Keywords | オスミウム / 一塩基多型 / メチルシトシン / 蛍光 / 人工核酸 / シトシンメチル化 / 同時多項目解析 / エピゲノム解析 |
|---|
| Research Abstract |
For cancer research, we developed base-discriminating fluorescence nucleic acid systems and methylation detection systems. Particularly, we developed a conceptually new nucleic acid probe for methylcytosine-specific detection, 'ICON probe', and applied it for detection of methlcytosines. In addition, we studied on effective color imaging of methylcytosine toward methylated DNA visualization.
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