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炎症性サイトカインとC型レクチンによる発がん制御機構の解析

Research Project

Project/Area Number 20015015
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

角田 茂  The University of Tokyo, 医科学研究所, 助教 (80345032)

Co-Investigator(Kenkyū-buntansha) 岩倉 洋一郎  東京大学, 医科学研究所, 教授 (10089120)
西城 忍  東京大学, 医科学研究所, 助教 (60396877)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥8,300,000 (Direct Cost: ¥8,300,000)
Fiscal Year 2009: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2008: ¥3,500,000 (Direct Cost: ¥3,500,000)
Keywordsサイトカイン / C型レクチン / 腫瘍免疫 / T細胞 / 樹状細胞
Research Abstract

がん細胞に対する宿主側の免疫応答を利用した癌治療は、長年その実現が求められてきたにも拘わらず、多くの課題が残されている分野の1つである。申請者らはこれまでIL-1/IL-17などの炎症性サイトカインやDectin-1、DCIRなどのC型レクチンの遺伝子欠損(KO)マウスを作製するなどして、免疫系に於けるこれらの遺伝子の役割を解析してきた。この中で、Th17が新しいT細胞サブセットとして炎症や自己免疫の発症に重要な役割を果たすことを明らかにしてきた。また、Dectin-1シグナルは選択的にTh17分化を促進させることが報告され、Dectin-1のシグナルとIL.17産生の関連が示唆されている。さらにDCIRを欠損させると樹状細胞(DC)が過剰増殖し、自己免疫を発症することを示した。そこで本研究では、これまでのサイトカインおよびC型レクチン研究を発展させることを目指した。腫瘍形成における炎症性サイトカインの役割を明らかにするためにKOマウスを大腸がんモデルマウスと交配させたところ、IL-17欠損により腸管ポリープの形成抑制が認められた。一方、IL-1欠損、IFN-γ欠損マウスではポリープ形成に有意な変化は認められなかった。このことから、大腸がん発症においてはIL-17ががん促進に対して極めて重要な役割を担っていることがわかった。一方、DCIR KOマウスでは一部腫瘍細胞株において移植時の成長遅延が認められ、DCIRのシグナルの欠損により腫瘍免疫能が亢進した。これらのことから、IL-17およびDCIRは、がん治療における新たな分子標的となる可能性が示された。

Report

(2 results)
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (24 results)

All 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (8 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Dectin-2 recognition of α-mannans and induction of Th17 differentiation is essential for host defense against Candida albicans2010

    • Author(s)
      Saijo, S.
    • Journal Title

      Immunity (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis2010

    • Author(s)
      Teng, M.W.
    • Journal Title

      Proc.Natl.Acad.Sci.USA (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor-infiltrating IL-17-producing γδ T cells support the progression of tumor via promoting angiogenesis2010

    • Author(s)
      Wakita, D.
    • Journal Title

      Eur.J.Immunol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pivotal role of cerebral interleukin-17-producing γδT cells in the delayed phase of ischemic brain injury2009

    • Author(s)
      Shichita, T.
    • Journal Title

      Nat.Med. 15

      Pages: 946-550

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A protective function for interleukin 17A in T cell-mediated intestinal inflammation2009

    • Author(s)
      O'Connor, W.Jr
    • Journal Title

      Nat.Immunol. 10

      Pages: 603-309

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal differentiation and tissue-specific pathogenesisof Th1, Th2, and Th17 cells in graft versus host disease2009

    • Author(s)
      Yi, T.
    • Journal Title

      Blood 114

      Pages: 3101-3112

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma2009

    • Author(s)
      Yoneda, M.
    • Journal Title

      Cancer Sci 100

      Pages: 225-232

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential roles of IL-17A and-17F in host defense against mucoepithelial bacterial infection and allergic responses2009

    • Author(s)
      Ishigame, H.
    • Journal Title

      Immunity 29

      Pages: 628-636

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host-derived interleukin-la is important in determining the immunogenicity of 3-methylcholantrene tumor cells2009

    • Author(s)
      Elkabets, M
    • Journal Title

      J. Immunol 182

      Pages: 4874-4881

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding2008

    • Author(s)
      Kubota, N.
    • Journal Title

      Cell Metab 8

      Pages: 49-64

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The roles of IL-17A in inflammatory immune responses and host defense against pathogens2008

    • Author(s)
      Iwakura, Y.
    • Journal Title

      Immunol. Rev 226

      Pages: 57-79

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] The roles of IL-17A and IL-17F in inflammation and host defense against infection2010

    • Author(s)
      岩倉洋一郎
    • Organizer
      Host and Microbe : New windows on homeostasis, new roads to intervention, 2^<nd> Symposium of the IMSUT & RCAST Global COE
    • Place of Presentation
      Tokyo(JPN)
    • Year and Date
      2010-03-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adoptive and innate immunity related gene-deficient mice generated by IMSUT2009

    • Author(s)
      角田茂
    • Organizer
      Manitoba Centre for Disease Modeling Symposium
    • Place of Presentation
      Winnipeg(CAN)
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 発生工学的アプローチによるサイトカインの機能解明への取り組み2009

    • Author(s)
      角田茂
    • Organizer
      第18回AGH Seminar Consortium
    • Place of Presentation
      帯広
    • Year and Date
      2009-07-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Roles of IL-17A and IL-17F in Inflammation and Host Defense against Bacteria2009

    • Author(s)
      岩倉洋一郎
    • Organizer
      The 9^<th> World Congress on Inflammation
    • Place of Presentation
      Tokyo(JPN)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 発生工学的アプローチによる創薬ターゲットの探索:関節リウマチをモデルとして2009

    • Author(s)
      岩倉洋一郎
    • Organizer
      第56回日本実験動物学会総会
    • Place of Presentation
      大宮
    • Related Report
      2009 Annual Research Report
  • [Presentation] C型レクチン遺伝子ノックアウトマウスライブラリーの作製2009

    • Author(s)
      西城忍
    • Organizer
      第56回日本実験動物学会総会
    • Place of Presentation
      大宮
    • Related Report
      2009 Annual Research Report
  • [Presentation] Differential roles of IL-17A and IL-17F in allergic responses and host defense against mucoepithelial bacterial infection2008

    • Author(s)
      Harumichi Ishigame
    • Organizer
      The 8th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Hyogo
    • Related Report
      2008 Annual Research Report
  • [Presentation] A C-type lectin that involved in the host defense against fungi plays an important role in the development of autoimmune arthritis2008

    • Author(s)
      Shinobu Saijo
    • Organizer
      13th Congress of the Asia Pacific League of Associations for Rheumatology
    • Place of Presentation
      Yokohama
    • Related Report
      2008 Annual Research Report
  • [Book] The roles of IL-17A and IL-17F in mucosal infection and allergy. In "Th17 cells in health and disease"(ed.S.Jiang)2010

    • Author(s)
      石亀晴道
    • Publisher
      Springer Science+Buisiness Media(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Book] IL-17、IL-21、IL-22、IL-23「炎症・再生医学事典」(松島綱治、西脇徹編)2009

    • Author(s)
      石亀晴道
    • Publisher
      朝倉書店
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/cem_dcb/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/cem_dcb/index.html

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] IL-17A/IL-17Fを介した大腸がん発症制御2010

    • Inventor(s)
      岩倉洋一郎、角田茂、鈴木俊佐
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2010-02-03
    • Related Report
      2009 Annual Research Report
    • Overseas

URL: 

Published: 2008-04-01   Modified: 2018-03-28  

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