| Project/Area Number |
20017015
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Nagoya University |
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Principal Investigator |
OBOKATA Junichi Nagoya University, 遺伝子実験施設, 招へい教員 (50185667)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yoshiharu 岐阜大学, 応用生物科学部, 准教授 (50301784)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2009: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 2008: ¥8,000,000 (Direct Cost: ¥8,000,000)
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| Keywords | シンビオジェネシス / プロモーター獲得 / クロマチンリモデリング / エピゲノム / H2A.Z / H3K4me3 / 植物ゲノム / ChIP-on-chip解析 / ChIP-on-chip / 遺伝子移動 / プロモーター / コアプロモーター / 転写開始点 / クリプティックプロモーター / 転写開始複合体 / クロマチン免疫沈降 |
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| Research Abstract |
In endosymbiotic evolution, genes of the endosymbionts are gradually transferred to the host nucleus whereby they obtained new promoters to become functional host genes. We analyzed the molecular process of this promoter acquisition, using promoter trap lines of Arabidopsis as a model system. As a result, we found that the promoter acquisition occurs in three types ; namely de novo origination type, trapping preexisting promoter type, and the combination type of the former two. Further analyses of these subtypes revealed that the de novo origination of new promoters is closely related with chromatin remodeling that occurs at the insertion sites of the coding sequences.
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