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行動機制の脳内機構に関する行動神経学的研究

Research Project

Project/Area Number 20020004
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

森 悦朗  Tohoku University, 大学院・医学系研究科, 教授 (30368477)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 2009: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2008: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordsプラダ・ウィリー症候群 / MRI / voxel-based morhometry / 脱抑制 / 前頭葉 / 臨床神経心理学 / 神経機能画像学 / 行動神経科学 / パーキンソン病 / 解離性健忘 / fMRI / PET
Research Abstract

この研究では,認知・行動に障害をもたらす非局所性損傷の患者疾患を対象にして,FDG-PET,fMRI,voxel-based morhphometry(VBM)を用いた病巣研究のパラダイムで機能障害,特に錯視や脱抑制,解離現象,性格変化などのいわゆる陽性症状の神経基盤を求める研究を続けてきた.今年度の研究では.これまでのパーキンソン病や解離性健忘の研究を進めるととともに,特にプラダ・ウィリー症候群(PWS)対象として,これらにおける行動異常の神経基盤をFDG-PETあるいはVBMを用いて検討した.PWSでは,常同行動,強迫性行動,過食を始め様々な脱抑制行動が極めて特徴的・定型的にみられる.PWSの行動に関する全国調査を行い,本能的行動パターンの抑制障害と考えられる異常食行動(過食),常同行動,収集行動を高頻度に認め,前頭葉眼窩皮質損傷時の行動障害に類似することを確認した.本年度は,PWS成人と,年・齢・性別を一致させた健常成人を対象に,3D-MRIとVBMを用いて脳の局所灰白質量を比較し,PWSでは前頭葉眼窩皮質,尾状核,海馬傍回,一次運動野,運動連合野,小脳の灰白質体積が小さく,全脳体積で補正すると右前頭葉眼窩皮質と右小脳で有意に灰白質量が小さいことが示された.このことからPWSでは前頭葉眼窩皮質の灰白質が特異的に小さく,前頭葉眼窩皮質の形成・発育の違いがPWSの行動障害の背景となっている可能性が示唆された.

Report

(2 results)
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (1 results) Book (1 results)

  • [Journal Article] Memory repression : Brain mechanisms underlying dissociative amnesia2010

    • Author(s)
      Kikuchi H, Fujii T, Abe N, Suzuki M, Takagi M, Mugikura S, Takahashi S, Mori E
    • Journal Title

      J Cogn Neurosci 22

      Pages: 602-613

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Do parkinsonian patients have trouble telling lies? The neurobiological basis of deceptive behavior2009

    • Author(s)
      Abe N, Fujii T, Hirayama K, Takeda A, Hosokai Y, Ishioka T, Nishio Y, Suzuki K, Itoyama Y, Takahashi S, Fukuda H, Mori E
    • Journal Title

      Brain 132

      Pages: 1386-1395

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment2009

    • Author(s)
      Hosokai Y, Nishio Y, Hirayama K, Takeda A, Ishioka T, Sawada Y, Suzuki K, Itoyama Y, Takahashi S, Fukuda H, Mori E
    • Journal Title

      Mov Disord 24

      Pages: 854-862

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Memory Repression : Brain Mechanisms Underlying Dissocia tive Amnesia2009

    • Author(s)
      Kikuchi H, Fujii T, Abe N, Suzuki M, Takagi M, M ugikura S, Takahashi S, Mori E
    • Journal Title

      J Cogn Neurosci (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Do parkinsonian patients have trouble telling lies? The neurobiological basis of deceptive behaviour2009

    • Author(s)
      Abe N, Fujii T, Hirayama K, Takeda A, Hosokai Y, Ishioka T, Nishio Y, Suzuki K, Itoyama Y, Takah ashi S. Fukuda H. Mori E
    • Journal Title

      Do parkinsonian patients have trouble telling lies? The neurobiological basis of deceptive behaviour 132

      Pages: 1386-1395

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frontal behavioral syndromes in Prader-Willi syndrome2008

    • Author(s)
      Ogura K, Shinohara M, Ohno K. Mori E.
    • Journal Title

      Brain Dey 30

      Pages: 469-476

    • NAID

      10025577455

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 認知症性疾患の画像診断2008

    • Author(s)
      森悦朗
    • Organizer
      第49回日本神経学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Book] International Handbook of Behavior, Diet and Nutrition(Victor R Preedy, Colin Martin and Ronald Ross Watson, eds., Frontal behavioural symptoms in Prader-Willi syndrome.)2010

    • Author(s)
      Kaeko Ogura, Toshikatsu Fujii, Etsuro Mori
    • Publisher
      Springer(印刷中)
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2018-03-28  

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