高磁場fMRIによるMT分野のコラム構造に関する研究

• Project/Area Number: 20020033
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: 程 康 The Institute of Physical and Chemical Research, 認知機能表現研究チーム, 副チームリーダー (70425635)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥5,100,000 (Direct Cost: ¥5,100,000); Fiscal Year 2009: ¥2,400,000 (Direct Cost: ¥2,400,000); Fiscal Year 2008: ¥2,700,000 (Direct Cost: ¥2,700,000)
• Keywords: ヒト / MT野 / 方向選択性コラム / 高解像度fMRI / 事象関連fMRI実験課題 / ランダムドット / 順応 / 連続刺激

Research Abstract

私たちは、4テスラMRIを用いることでヒトのMT野のコラム構造を調べています。MT野には方向選択コラム構造が存在しており、2つの特徴があります。一つは、方向選択性は一方向に緩やかに変化することです。二つ目は、方向選択性はこの方向と異なる方向に180度急激に変化することです。MTコラムも高解像度fMRIにとってよいモデルとなります。しかしながら、ブロックデザイン実験で2つの刺激条件のみが必要とされた眼優位性コラムとは異なり、できるだけ多くの方向へ動く刺激条件をつくりだすことが望まれます。そこで私たちは事象関連fMRI実験課題を工夫して、さらに新しい解析手法を開発しました。被験者は撮像中ずっとランダムな方向に動くドットに対して順応状態にありました。時折、全てのドットが4つの方向のうち1つの方向に動きます。この4つの方向はランドムな順番で提示し、何度も繰り返されます。開発した手法を用いることで、一時的な動き方向の変化に対する応答を定量化して調べることができました。ヒトのMT野のほとんどのボクセルが、ある一方向への動きに対して良い応答を示すことがわかりました。この方向選択性はベクトル和で定量化することができました。ベクトルの方向はボクセルが好む方向を示しており、長さは方向選択性の強さを示しています。そこで、MT野に方向選択性の空間分布をみることができます。被験者のMTで各ボクセルから得られたベクトルの平均長さは0より著しく大きく、平均してある方向への動きに対してよい応答をしたことを示唆します。次に、隣り合うボクセルの方向選択性の違いにっいて調べました。実際、ほとんどの隣り合うボクセルは非常に似通った選択性を持つか、或は180度異なる選択性を持ちます。これはモデルとよく一致しています。これらの結果はヒトのMT方向選択性コラムを示した最初の報告になります。最近の研究で、360度の運動方向を連続的に変化する刺激を用いても、MT野に方向選択性を見出すことができます。

Research Products

• [Journal Article] Grey and white matter changes associated with tool-use learning in macaque monkey (2009)
  • Author(s): Quallo, M., Price, C.J., Ueno, K., Asamizuya, T., Cheng, K., Lemon, R.N., Iriki, A.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America 106 Pages: 18379-18384
  • Peer Reviewed
• [Journal Article] Effects of shifting perspective of the self an fMRI study (2008)
  • Author(s): Corrado Corradi-Dell' Acqua, kenichi Ueno, Akitoshi Ogawa, Kang Cheng, Raffaella I. Rumiati, Atsushi Iriki
  • Journal Title: Neuroimage 40 Pages: 1902-1911
  • Peer Reviewed
• [Journal Article] ヒト視覚野の視野表現地図と機能構造のfMRI研究 (2008)
  • Author(s): 程 康、上野健一
  • Journal Title: 実験医学 26 Pages: 165-172
• [Journal Article] New hirizons for the next era of human brain imaging, cognitive, and behavioral resarch : Pacific Rim interactivity (2008)
  • Author(s): John Darrell Van Horn, Peter Bandettini, Kang Cheng, Gary, F.Egan, V. Andrew Stenger, Stephen Strother, Arthur W. Toga
  • Journal Title: Brain Imaging and Behavior 2 Pages: 227-231
• [Journal Article] Neural correlates of species-typical illogical cognitive bias in human inference
  • Author(s): Ogawa, A., Yamazaki, Y., Ueno, K., Cheng, K., Iriki, A.
  • Journal Title: Journal of Cognitive Neuroscience (In press)
  • Peer Reviewed
• [Journal Article] Opposing effects of contextual surround in human early visual cortex revealed by fMRI with continuously modulated visual stimuli
  • Author(s): Tajima, S., Watanabe, M., Imai, C., Ueno, K., Asamizuya, T., Sun, P., Tanaka, K., Cheng, K.
  • Journal Title: Journal of Neuroscience (In press)
  • Peer Reviewed
• [Journal Article] 後頭葉および下側頭皮質における最近のヒト視覚領域fMRI研究
  • Author(s): Tanskanen T.、上野賢一、程康
  • Journal Title: Medical View (In press)
• [Journal Article] Correction of 3D rigid body motion in fMRI time series by independent estimation of rotational and traslational effects in k-space
  • Author(s): Costagli, M., Waggoner, R.A., Ueno, K., Tanaka, K., and Cheng, K.
  • Journal Title: Neuroimage (in press)
  • Peer Reviewed
• [Presentation] Optimized fMRI of human temporo-occipital cortex by accelerated multi-shot spin-echo EPI (2009)
  • Author(s): Tanskanen, T., Waggoner, R.A., Ueno, K., Tanaka, K., Cheng, K.
  • Organizer: The 39^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2009-10-18
• [Presentation] Neural correlates of the experience-based intuition in human dorsal striatum (2009)
  • Author(s): Wan, X., Nakatani, H., Asamizuya, T., Ueno, K., Cheng, K., Tanaka, K.
  • Organizer: The 39^<th> Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, Illinois, USA
  • Year and Date: 2009-10-17
• [Presentation] Cerebeller activation during check-mate task execution (2009)
  • Author(s): 藤井盛光、上野賢一、浅水屋剛、中谷裕教、万小紅、程康、伊藤正男
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] Neural correlates of intuitive judgment in professional shogi players (2009)
  • Author(s): Wan, X., Nakatani, H., Asamizuya, T., Ueno, K., Cheng, K., Tanaka, K.
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] FMRI study on the hue selectivity of neurons in human visual cortex (2009)
  • Author(s): Kuriki, I., Sun P, Ueno, K., Tanaka, K., Cheng, K.
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] Neural correlated of exclusion for rapid formation of novel-to-novel relation (2009)
  • Author(s): Ogawa, A., Yamazaki, Y., Ueno, K., Cheng, K., Iriki A.
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-08-01
• [Presentation] Visualizing columnar architectures using high-field functional magnetic resonance imaging (2009)
  • Author(s): 程康
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-07-29
• [Presentation] Exploring the origins of the DfMRI signal at 4 Tesla (2009)
  • Author(s): Waggoner, R.A., Tanaka, K., Cheng, K.
  • Organizer: The 15^<th> Annual Meeting of the Organization of Human Brain Mapping
  • Place of Presentation: San Francisco, California, USA
  • Year and Date: 2009-06-23
• [Presentation] DTI based muscle fiber tractography in humans at 4 Tesla using stimulated-echoes (2009)
  • Author(s): Waggoner, R.A., Oda, T., Kinugasa, R., Ueno, K., Cheng, K., Yokota, H., Himeno, R.
  • Organizer: The 17^<th> Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2009-04-23
• [Presentation] High-resolution BOLD fMRI, neural decoding and blood vessels (2009)
  • Author(s): 程康
  • Organizer: The International Symposium on New Horizons in Human Brain Imaging : A Focus on the Pacific Rim
  • Place of Presentation: Hawaii Island, Hawaii, USA
  • Year and Date: 2009-04-13
• [Presentation] Positive and negative change in motion coherence from adapted state always elicit positive BOLD responses in hV4 (2008)
  • Author(s): Costagli, M., Ueno, K., Wan, X., Ricciardi, E., Pietrini, P., Tanaka, K., and Cheng, K.
  • Organizer: The14^<th> Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Melbourne, Australia
• [Presentation] The Neural substrate of Shogi pattern recognition shaped by long-term training in professional players (2008)
  • Author(s): Wan, X., Nakatani, H., Ueno, K., Asamizuya, T., Cheng, K., and Tanaka, K.
  • Organizer: The 14^<th> Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Melbourne, Australia
• [Presentation] Human V4 responds positively to both positive and negative changes in motion coherence from adapted state : an event-related BOLD-fMRI study (2008)
  • Author(s): Costagli, M., Ueno, K., Sun, P., Wan, X., Ricciardi, E., Pietrini, P., Tanaka, K., and Cheng, K.
  • Organizer: 第31回日本神経科学学会大会
  • Place of Presentation: 東京
• [Presentation] Specific medial parietal activation evoked by seeing Shogi patterns in professional players (2008)
  • Author(s): Wan, X., Nakatani, H., Ueno K., Asamizuya, T., Cheng, K., and Tanaka, K.
  • Organizer: 第31回日本神経科学学会大会
  • Place of Presentation: 東京
• [Presentation] Neural correlates of the exclusion to facilitate stimulus relation formation (2008)
  • Author(s): Ogawa, A., amazaki, Y., Ueno, K., Cheng, K., Iriki, A.
  • Organizer: 第31回日本神経科学学会大会
  • Place of Presentation: 東京
• [Presentation] 連続的に変調する視覚刺激を用いたfMRI計測によるヒト低次視覚野における相反する周辺文脈効果の検出 (2008)
  • Author(s): 田嶋達裕、渡辺正峰、今井千尋、上野賢一、浅水屋剛、田中啓治、程康
  • Organizer: 日本神経回路学会
  • Place of Presentation: つくば
• [Presentation] Opposing effects of contextual surround in human early visual cortex revealed by fMRI with continuously modulated visual stimuli (2008)
  • Author(s): Tajima, S., Watanabe, M., Imai, C., Ueno, K., Asamizuya, T., Tanaka, K., and Cheng, K.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, D.C., USA
• [Presentation] Structural changes in cortex associated with tool-use in non-human primates (2008)
  • Author(s): Quall, M., Price, C.J., Devlin, J.T., Ueno, K., Asamizuya, T., Waggoner, R.A., Cheng, K., Tanaka, K., Kherif, F., Lemon, R.N., and Iriki, A
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, D.C., USA
• [Presentation] Shogi pattern recognition in professional players (2008)
  • Author(s): Wan X., Nakatani, H., Ueno, K., Asamizuya, T., Cheng, K., and Tnaka K
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, D.C., USA
• [Presentation] Neural correlates of exclusive selection bias of human to form novel-to-novel stimulus relation (2008)
  • Author(s): Ogawa, A., Yamazaki, Y., Ueno, K., Cheng, K., and Iriki, A.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, D.C., USA
• [Presentation] An fMRI study of visual smear induced by saccadic eye movements (2008)
  • Author(s): Watanabe, J., Watanabe, M., Ueno, K., Asamizuya, T., Tanaka, K., and Cheng, K.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington D.C., USA
• [Presentation] Differences in fMRI-BOLD responses to transient motion coherency changes across human extrastriate visual areas (2008)
  • Author(s): Costagli, M., Ueno, K., Sun, P., Wan, X., Ricciardi, E., Pietrini, P., Tanaka, K., and Cheng, K.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, D.C., USA
• [Presentation] The activelet method : a feasibility study in event-related fMRI (2008)
  • Author(s): Khalidov, I.., Costagli, M., Vonesch, C., Van de Ville, D., Unser, M., and Cheng, K.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington, D.C., USA
• [Remarks]
  • URL: http://www.brain.riken.go.jp/labs/cbms/tanaka.html
• [Remarks]
  • URL: http://www.brain.riken.go.jp/en/rrc_fmri.html
• [Remarks]
  • URL: http://www.brain.riken.go.jp/labs/cbms/tanaka.html
• [Remarks]
  • URL: http://www.brain.riken.go.jp/en/rrc_fmri.html