• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

広汎性発達障害の視線解析と機能画像による病態の研究

Research Project

Project/Area Number 20023004
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionHokkaido University

Principal Investigator

福島 順子  Hokkaido University, 大学院・保健科学研究院, 教授 (40208939)

Co-Investigator(Kenkyū-buntansha) 宮本 環  北海道大学, 大学院・保健科学研究院, 特任准教授 (20271679)
KURKIN Sergei  北海道大学, 大学院・医学研究科, 助教 (00344466)
傳田 健三  北海道大学, 大学院・保健科学研究院, 教授 (10227548)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2009: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2008: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords自閉症 / アスペルガー障害 / 表情認知 / fMRI / 広汎性発達障害 / PDD / 紡錘状回 / ミラーニューロン領域 / 機能的脳画像 / アスペルガー症候群 / 視線解析 / 顔認知
Research Abstract

自閉性障害、アスペルガー障害などの広汎性発達障害の主要な症状に対人的相互性の障害があるが、その基礎となるのは他者の感情を推定する表情認知の障害であると報告されている。そこで、自閉性障害、アスペルガー障害などの成人広汎性発達障害者について、健常者群と同様の表情の顔をみたときに賦活される脳部位についてfMRIを用いて解析を行って検討した。被験者は12名の成人広汎性発達障害者(平均29.8才)と12名の健常者(平均27.4才)とし、1.5TのMRI装置に仰臥位となり、ヘッドコイルに装着したミラーを通してスクリーンに投影されるHappy(H),Sad(S),Angry(A),Neutral(N)の4種の表情の顔の視覚刺激(ATR製)を見せた。得られた機能画像はSPM5を用いて解析し、H,S,A,Nの4種の表情間の脳の賦活の違いを3つの方法を用いて比較した。すなわち(1)健常群とPDD群においてHvs.N,Svs.N,A vs.Nのように、Happy,Sad,AngryからNeutralを引いた各条件で個人データの解析を行い、引き続き各条件で健常群とPDD群の群間比較を行った。(2)PDD群各個人で(H)vs(N),(S)vs(N),(A)vs(N)の条件間比較による統計画像(contrast map)を求め、次いで、条件間比較で得られたcontrast mapの各ボクセルの値と各個人のAQ-Jスコアの値との相関を求めた。さらに、(3)健常者群の賦活部位から関心領域(Region of Interest:ROI)を設定し、PDD群と比較した。(1),(2)(3)ともに、PDD群では紡錘状回(Ba逹9)、ミラーニューロン領域(Ba44)、補足運動野(Ba6)、帯状回(Ba24)において、(H),(S)の条件下でPDD群が有意な低下を示していた。「悲しみ」や「喜び」の表情でControl群とPDD群に賦活の差があることは、PDD群は相手の情動の状態を読み取る機能に障害があることを示唆し、これらの部位の機能障害あるいは、発達の遅延があることが推定された。

Report

(2 results)
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (46 results)

All 2010 2009 2008 2007 Other

All Journal Article (25 results) (of which Peer Reviewed: 22 results) Presentation (12 results) Book (6 results) Remarks (3 results)

  • [Journal Article] 眼球運動障害から見た前頭葉の役割2010

    • Author(s)
      福島順子
    • Journal Title

      実験医学増刊号「脳神経系の情報伝達と疾患」 28

      Pages: 667-673

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Eye-pursuit and reafferent head movement signals carried by pursuit neurons in the caudal part of the frontal eye fields during head-free pursuit2009

    • Author(s)
      Fukushima K
    • Journal Title

      Cerebral cortex 19

      Pages: 263-275

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discharge of pursuit-related neurons in the caudal part of the frontal eye fields in juvenile monkeys with up-down pursuit asymmetry2009

    • Author(s)
      Kurkin S
    • Journal Title

      Experimental brain research 193

      Pages: 181-188

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Otolith inputs to pursuit neurons in the frontal eye fields of alert monkeys2009

    • Author(s)
      Akao T
    • Journal Title

      Experimental brain research 193

      Pages: 455-466

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Memory and decision making in the frontal cortex during visual motion processing for smooth pursuit eye movements2009

    • Author(s)
      Shichinohe N
    • Journal Title

      Neuron 62

      Pages: 717-732

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reafferent head-movement signals carried by pursuit neurons of the simian frontal eye fields during head movements2009

    • Author(s)
      Fukushima K
    • Journal Title

      Annals of the New York Academy of Sciences 1164

      Pages: 194-200

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Representation of Neck Velocity and Neck-Vestibular Interactions in Pursuit Neurons in the Simian Frontal Eye Fields2009

    • Author(s)
      Fukushima K
    • Journal Title

      Cerebral cortex

    • NAID

      120005946612

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 広汎性発達障害における眼球運動と表情認知の視線解析2009

    • Author(s)
      福島順子
    • Journal Title

      脳と精神の医学 20

      Pages: 101-110

    • NAID

      10028261838

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 姿勢反射の中枢2009

    • Author(s)
      福島順子
    • Journal Title

      Clinical Neuroscience 27

      Pages: 1386-1387

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Otolith inputs to pursuit neurons in the frontal eye fields of alert monkeys2009

    • Author(s)
      Akao T
    • Journal Title

      Exp Brain Res 193

      Pages: 455-466

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discharge of pursuit-related neurons in the caudal part of the frontal eye fields in juvenile monkeys with up-down pursuit asymmetry2009

    • Author(s)
      Kurkin S
    • Journal Title

      Exp Brain Res 193

      Pages: 181-188

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eye-pursuit and reafferent head movement signals carried by pursuit neurons in the caudal part of the frontal eye fields during head-free pursuit2009

    • Author(s)
      Fukushima K
    • Journal Title

      Cereb Cortex 19

      Pages: 263-75

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutually Adaptable EMG Devices for Prosthtic Hand2009

    • Author(s)
      Yokoi H
    • Journal Title

      International Journal of Factory Automation, Robotics and Soft Computing 1

      Pages: 74-83

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictive signals in the pursuit area of the monkey frontal eye fields2008

    • Author(s)
      Fukushima K
    • Journal Title

      Proq Brain Res 171

      Pages: 433-440

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postural changes during eye-head movements2008

    • Author(s)
      Fukushima J
    • Journal Title

      Prog Brain Res 171

      Pages: 335-338

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal pursuit eye movement and cerebral physiopathology of pervasive developmental disorders2008

    • Author(s)
      Fukushima J
    • Journal Title

      Psychiat Neurol Jap 110

      Pages: 900-907

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Learning effects on muscle modes and multi-mode postural synergies2008

    • Author(s)
      Asaka T
    • Journal Title

      Exp Brain Res 184

      Pages: 323-338

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vergence eye movement signals in the cerebellar dorsal vermis2008

    • Author(s)
      Nitta T
    • Journal Title

      Prog Brain Res 171

      Pages: 173-176

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical study of early-onset eating disorders2008

    • Author(s)
      Denda K
    • Journal Title

      Jon J Child Adolesc. Psychiatr 48suppl

      Pages: 11-21

    • NAID

      40016188950

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 児童・青年期の気分障害の臨床的特徴と最新の動向2008

    • Author(s)
      傳田健三
    • Journal Title

      児童青年精神医学とその近接領域 49

      Pages: 89-100

    • NAID

      10024427529

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子どものうつ病-発達障害とbipolarityの視点から-2008

    • Author(s)
      傳田健三
    • Journal Title

      精神科治療学 23

      Pages: 813-822

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] うつ病, 不安障害と広汎性発達障害の関係2008

    • Author(s)
      傳田健三
    • Journal Title

      臨床精神医学 37

      Pages: 1535-1541

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 児童・青年期の気分障害の診断学-MINI-KIDを用いた疫学調査から-2008

    • Author(s)
      傳田健三
    • Journal Title

      児童青年精神医学とその近接領域 49

      Pages: 286-292

    • NAID

      10024427954

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the cerebellar dorsal vermis in vergence eye movements in monkeys2007

    • Author(s)
      Nitta T
    • Journal Title

      Cereb Cortex 18

      Pages: 1042-1057

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Re-afferent head movement signals carried by pursuit neurons of the simian frontal eye fields during ehadkmovements

    • Author(s)
      Fukushima K
    • Journal Title

      Annals NYAS (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Neuronal activity in the caudal frontal eye fields(FEF): comparison with the supplementary eye fields(SEF)and cerebellar dorsal vermis during memory-based smooth pursuit eye movements2009

    • Author(s)
      福島順子
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] MST activity during memory-based smooth pursuit eye movements : comparison with SEF2009

    • Author(s)
      Kurkin S
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大脳皮質と眼球運動障害2009

    • Author(s)
      福島順子
    • Organizer
      めまい平衡学会夏期セミナー
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Disturbance in eye movements in Autism Spectrum Disorders2009

    • Author(s)
      福島順子
    • Organizer
      19^<th> Annual meeting of Neural control of Movements
    • Place of Presentation
      Big island of Hawaii, USA
    • Year and Date
      2009-04-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neural Correlates of Memory and Decision-making in the Supplementary Eye Fields during Visual motion Perception in monkeys2009

    • Author(s)
      Fukushima K
    • Organizer
      19^<th> Annual meeting of Neural control of Movements
    • Place of Presentation
      Big island of Hawaii, USA
    • Year and Date
      2009-04-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of repetition of whole body reaching on anticipatory postural adjustments2009

    • Author(s)
      Saito H
    • Organizer
      19^<th> Annual meeting of Neural control of Movements
    • Place of Presentation
      Big island of Hawaii, USA
    • Year and Date
      2009-04-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 子どもの双極性障害をめぐる最近の動向2008

    • Author(s)
      傳田健三
    • Organizer
      子どもの双極性障害をめぐって
    • Place of Presentation
      広島国際会議場(広島)
    • Year and Date
      2008-11-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Disorders in eye movements and recognition of facial expression in PDDs2008

    • Author(s)
      Fukushima J
    • Organizer
      2^<nd> WFSBP Asia-Pacific Congress and 30^<th> Annual Meeting of JSBP
    • Place of Presentation
      Toyama International Conference Center (Toyama)
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 追跡眼球運動の異常と広汎性発達障害の脳機能病態2008

    • Author(s)
      福島順子
    • Organizer
      第104回目本精神神経学会シンポジウム発達障害の病態と治療
    • Place of Presentation
      ホテルグランパシフィックメリデイアン(東京)
    • Year and Date
      2008-05-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of pursuit eye movement in children2008

    • Author(s)
      Fukushima, J.
    • Organizer
      XXV Barany Society Meeting
    • Place of Presentation
      Kyoto International Convention Center (Kyoto)
    • Year and Date
      2008-04-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Activity of pursuit-related neurons in medial superior temporal area (MST) during static roll-tilt.2008

    • Author(s)
      Fujiwara, K
    • Organizer
      XXV Barany Society Meeting
    • Place of Presentation
      Kyoto International Convention Center (Kyoto)
    • Year and Date
      2008-04-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Saccular Stimulation Activated Human Cortex : A fMRI Study2008

    • Author(s)
      Miyamoto T.
    • Organizer
      XXV Barany Society Meeting
    • Place of Presentation
      Kyoto International Convention Center (Kyoto)
    • Year and Date
      2008-04-01
    • Related Report
      2008 Annual Research Report
  • [Book] トートラ人体の構造と機能第3版2010

    • Author(s)
      福島順子
    • Publisher
      丸善出版(in press)
    • Related Report
      2009 Annual Research Report
  • [Book] Devices for Prosthetic Hand, Resent advances in Control Systems, Robotics and Automation. Third edition2009

    • Author(s)
      Yokoi H
    • Total Pages
      11
    • Publisher
      Mutually Adaptable EMG
    • Related Report
      2008 Annual Research Report
  • [Book] 子どもの摂食障害-拒食と過食の心理と治療-2009

    • Author(s)
      傳田健三
    • Total Pages
      181
    • Publisher
      新興医学出版社
    • Related Report
      2008 Annual Research Report
  • [Book] エッセンシャル神経科学(訳書)2008

    • Author(s)
      福島順子
    • Total Pages
      30
    • Publisher
      丸善株式会社
    • Related Report
      2008 Annual Research Report
  • [Book] 児童期の精神療法2008

    • Author(s)
      傳田健三
    • Publisher
      医学書院
    • Related Report
      2008 Annual Research Report
  • [Book] 専門医のための精神科臨床リュミエール6 : 双極性障害2008

    • Author(s)
      傳田健三
    • Publisher
      中山書店
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://niseiri2.med.hokudai.ac.jp/~nokagaku/DataBase/JunkoFukushima/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://ibr.neuroinf.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://niseiri2.med.hokudai.ac.jp/-nokaaku/DataBa6e/JunkoFukushima/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2018-03-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi