| Project/Area Number |
20023035
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KATO Tadafumi The Institute of Physical and Chemical Research, 精神疾患動態研究チーム, チームリーダー (30214381)
|
|---|
| Research Collaborator |
垣内 千尋
林 朗子
笠原 和起
窪田 美恵
福家 聡
岩本 和也
高田 篤
石渡 みずほ
宮内 妙子
亀谷 瑞枝
磯野 蕗子
小森 敦子
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥27,200,000 (Direct Cost: ¥27,200,000)
Fiscal Year 2009: ¥13,600,000 (Direct Cost: ¥13,600,000)
Fiscal Year 2008: ¥13,600,000 (Direct Cost: ¥13,600,000)
|
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| Keywords | 双極性障害 / 小胞体ストレス / GABA / ミトコンドリアDNA |
|---|
| Research Abstract |
Neurons lacking XBP1 showed diminished upregulation of GABAergic marker genes (somatostatin, neuropeptide Y, calbindin) in response to BDNF. Knockout (KO) mice of Wfs1, the gene regulated by XBP1, showed slight but significant behavioral phenotypes in emotion-related behavior. Double mutant mice, Wfs1 KO and Polg transgenic, showed exaggerated behavioral phenotypes. The brain regions accumulating mtDNA deletions in Polg1 Tg mice were identified.
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