多角的計測に基づく歩行の環境適応メカニズムの計算論的理解

• Project/Area Number: 20033030
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: 花川 隆 National Center of Neurology and Psychiatry, 神経研究所疾病研究第七部, 室長 (30359830)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥10,700,000 (Direct Cost: ¥10,700,000); Fiscal Year 2009: ¥5,300,000 (Direct Cost: ¥5,300,000); Fiscal Year 2008: ¥5,400,000 (Direct Cost: ¥5,400,000)
• Keywords: 歩行制御 / イメージング / 計算論神経科学 / 医工連携 / 環境適応

Research Abstract

(1) 運動中の脳活動は、運動の結果としての固有感覚処理に伴う脳活動を含むため、解釈には注意が必要である。そこで磁気刺激-fMRIの同時計測システムを応用し、表面筋電図の同時計測と末梢神経刺激により中枢神経系の活動を伴わない筋活動誘発条件を併用することで、運動に伴い発生する固有知覚入力量を補正することのできる脳機能イメージング手法を開発した。結果、運動閾値上の磁気刺激により誘発される脳活動の大部分は感覚処理ではなく誘発性脳活動であることが示された(投稿準備中)。
(2) 歩行の環境適応メカニズムを計算論レベルで理解するための基礎知識を得ることを目的として、歩行・姿勢制御課題中にバイオメカニクス的情報と脳活動を同時に測定することのできるシステムを開発した。歩行・姿勢制御に伴う動作解析のためピエゾ素子を使用した床反力計、歩行や姿勢課題時に懸念される動作ノイズに強いアクティブ電極による8チャンネル筋電図と高速カメラを統合した計測システムを構築した。脳活動の計測系としてトレッドミル歩行時の計測にも応用可能な近赤外線スペクトロスコピー装置を導入し、動作解析と脳活動の同時計測システムを完成させた。
(3) 経頭蓋直流電気刺激(tDCS)を下肢の一次運動野に適応することにより、健常被験者において下肢の筋力を一時的に促進しうることを初めて示した。神経リハビリテーションへの応用を目指し、tDCSが脳卒中後患者の下肢運動機能に与える影響を検討した。

Research Products

• [Journal Article] Differential effect of double-pulse TMS applied to dorsal premotor cortex andprecuneus during internal operation of visuospatial information. (2010)
  • Author(s): Oshio R, Tanaka S, Sadato N, Sokabe M, Hanakawa T, Honda M
  • Journal Title: Neurolmage 49 Pages: 1108-15
  • Peer Reviewed
• [Journal Article] Gait disturbance associated with white matter changes : a gait analysis and blood flow study. (2010)
  • Author(s): Iseki K, Hanakawa T, et al.
  • Journal Title: Neurolmage 49 Pages: 1659-66
  • Peer Reviewed
• [Journal Article] 運動計画における前頭前野と運動前野の役割 (2009)
  • Author(s): 花川隆
  • Journal Title: Climcal Neuroscience 27 Pages: 799-802
• [Journal Article] 脳機能イメージングによるヒト二足歩行の中枢神経制御機構の解明 (2009)
  • Author(s): 花川隆
  • Journal Title: Equilibrium Research 68 Pages: 176-182
  • NAID: 10026088310
  • Peer Reviewed
• [Journal Article] Involvement of insula and cingulate cortices in control and suppression of naturalurges. (2009)
  • Author(s): Lerner A, Bagic A, Hanakawa T, et al.
  • Journal Title: Cerebral Cortex 19 Pages: 218-23
  • Peer Reviewed
• [Journal Article] Functional coupling underlying motor and cognitive functions of the dorsal premotorcortex. (2009)
  • Author(s): Abe M, Hanakawa T
  • Journal Title: Behavioural Brain Research 198 Pages: 13-23
  • Peer Reviewed
• [Journal Article] Connectivity and signal intensity in the parieto-occipital cortex predicts top-downattentional effect in visual masking : an fMRI study based on individual differences. (2009)
  • Author(s): Tsubomi H, Ikeda T, Hanakawa T, Hirose N, Fukuyama H, Osaka N
  • Journal Title: Neurolmage 45 Pages: 587-97
  • Peer Reviewed
• [Journal Article] Stimulus-response profile during single-pulse transcranial magnetic stimulation to the primary motor cortex. (2009)
  • Author(s): Hanakawa T, Mima T, Matsumoto R, et al.
  • Journal Title: Cerebral Cortex 19 Pages: 2605-15
  • Peer Reviewed
• [Journal Article] A novel composite targeting method using high-field magnetic resonance imaging for subthalamic nucleus deep brain stimulation. (2009)
  • Author(s): Toda H, Sawamoto N, Hanakawa T, et al.
  • Journal Title: Journal of Neurosurgery 111 Pages: 737-45
  • Peer Reviewed
• [Journal Article] Impairment of the cortical GABAergic inhibitory system in catatonic stupor : a case report with neuroimaging. (2009)
  • Author(s): Iseki K, et al(8人省略5番日)
  • Journal Title: Epileptic Disorders 11 Pages: 126-31
  • Peer Reviewed
• [Journal Article] Enhancement of pinch force in the lower leg by anodal transcranial direct current stimulation. (2009)
  • Author(s): Tanaka S, Hanakawa T, Honda M, Watanabe K
  • Journal Title: Experimental Brain Research 196 Pages: 459-65
  • Peer Reviewed
• [Journal Article] Is the insula responsible for suppression of natural urges? (2009)
  • Author(s): Lerner A, Bagic A, Hanakawa T, Boudreau EA, Pagan F, Mari Z, Bara-Jimenez W, Aksu M, Sato S, Murphy DL, Hallett M
  • Journal Title: Cerebral Cortex 19 Pages: 218-223
  • Peer Reviewed
• [Journal Article] Functional coupling underlying motor and cognitive functions of the dorsal premotor cortex (2009)
  • Author(s): Abe M, Hanakawa T
  • Journal Title: Behavioural Brain Research 198 Pages: 13-23
  • Peer Reviewed
• [Journal Article] The representation of blinking movement in cingulate motor areas : a functional mgnetic resonance imaging study (2008)
  • Author(s): Hanakawa T, Dimyan MA, Halleftt M
  • Journal Title: Cerebral Cortex 18 Pages: 930-937
  • Peer Reviewed
• [Journal Article] Motor planning, imagery and execution : a time-course study with fun ctional MRI (2008)
  • Author(s): Hanakawa T, Dimyan MA, Halleftt M
  • Journal Title: Cerebral Cortex 18 Pages: 2775-2788
  • Peer Reviewed
• [Journal Article] Neural mechmisms involved in observation and imagery of gait movement (2008)
  • Author(s): Iseki K, Hanakawa T, Shinozaki J, Nankaku M, Fukuyama H.
  • Journal Title: Neuroimage 41 Pages: 1021-1031
  • Peer Reviewed
• [Journal Article] The stereokinetic effect reveals different roles of the lateral occipito-temporal and parietal cortex for 3-D perception from motion : An fMRI study (2008)
  • Author(s): Yamamoto T, Takahashi S, Hanakawa T, Urayama S, Fukuyama H, Ejima Y.
  • Journal Title: Journal of Vision 8 Pages: 1-17
  • Peer Reviewed
• [Journal Article] High resolution MRI revealed small orbitofrontal traumatic lesions responsible for behavioral changes (2008)
  • Author(s): Namiki C, Yamada M, Yoshida H, Hanakawa T, Fukuyama H, Murai T
  • Journal Title: Neurocase 14 Pages: 474-479
  • Peer Reviewed
• [Journal Article] Hemispheric asymmetry of the arcuate fasciculus in patients with unilateral language dominancy defined by Wada test (2008)
  • Author(s): Matsumoto R, Okada T, Mikuni N, Mitsueda T, Taki J, Sawamoto N, Hanakawa T, Miki Y, Ikeda A, Hashimoto N, Fukuyama H, Takahashi RiZ, Bara-Jimenez W, Aksu M, Sato S, Murphy DL, Hallett M
  • Journal Title: Journal of Neurology 255 Pages: 1703-1711
  • Peer Reviewed
• [Journal Article] 基底核と認知 (2008)
  • Author(s): 花川隆
  • Journal Title: 分子精神医学 8 Pages: 41-47
• [Journal Article] Differential Contribution of the Supplementary Motor Area to Stabilization of aProcedural Motor Skill Acquired through Different Practice Schedules.
  • Author(s): Tanaka S, Honda M, Hanakawa T, Cohen LG
  • Journal Title: Cerebral Cortex (In press)
  • Peer Reviewed
• [Journal Article] Cerebro-cerebellar Interactions Underlying Temporal Information Processing.
  • Author(s): Aso K, Hanakawa T, Aso T, Fukuyama H
  • Journal Title: Journal of Cognitive Neuroscience (In press)
  • Peer Reviewed
• [Presentation] Pathophysiology of gait disturbance in age-related white matter changes : a combinedgait analysis and blood flow study (2010)
  • Author(s): Iseki K, Hanakawa T, Hallett M, Fukuyama H
  • Organizer: The 3rd International Congress on Gait and Mental Function
  • Place of Presentation: Omni Shoreham Hotel, Washington DC, USA
  • Year and Date: 2010-02-26
• [Presentation] The neural corcelates of the sensorimotor rhythms as revealed by simultaneous EEG-tMRI : implications for brain-computer interfaces (2009)
  • Author(s): Hanakawa T, Kaneko E, Omata K
  • Organizer: The 3rd International Symposium on Mobiligence 2009
  • Place of Presentation: 淡路夢舞台、淡路島
  • Year and Date: 2009-11-20
• [Presentation] 多次元イメージングによる神経ネットワークの評価 (2009)
  • Author(s): 花川隆
  • Organizer: 第39回日本臨床神経生理学会:シンポジウム
  • Place of Presentation: 北九州国際会議場、北九州
  • Year and Date: 2009-11-19
• [Presentation] EEG-fMRI同時計測における呼吸変動の影響 (2009)
  • Author(s): 小俣圭、花川隆、本田学
  • Organizer: 第39回日本臨床神経生理学会
  • Place of Presentation: 北九州国際会議場、北九州
  • Year and Date: 2009-11-19
• [Presentation] 閉眼安静状態における中心部 律動および 律動に相関する脳活動 (2009)
  • Author(s): 金子瑛士、花川隆、小俣圭、本田学
  • Organizer: 第39回日本臨床神経生理学会
  • Place of Presentation: 北九州国際会議場、北九州
  • Year and Date: 2009-11-19
• [Presentation] Towards Understanding of Neural Control of Movement : Simultaneous Mulitidisciplinary Neuroimaging (2009)
  • Author(s): 花川隆
  • Organizer: 磁気刺激の臨床応用と安全性に関する研究会
  • Place of Presentation: 北九州国際会議場、北九州
  • Year and Date: 2009-11-18
• [Presentation] Neuroimaging Approach to Understanding of Gait Disturbances in Parkinson's Disease and Related Disorders (2009)
  • Author(s): 花川隆
  • Organizer: 第18回パーキンソン病治療研究会
  • Place of Presentation: 赤坂プリンスホテル、東京
  • Year and Date: 2009-09-26
• [Presentation] Correlation between cortico-subcortical gray matter volume and proficiency in second language (2009)
  • Author(s): 細田千尋、花川隆、田中悟志、成相直、大野喜久雄、本田学
  • Organizer: 第32回日本神経科学学会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2009-09-18
• [Presentation] 運動・認知迅速操作における基底核の機能 (2009)
  • Author(s): 花川隆, Mark Hallett
  • Organizer: 第32回日本神経科学学会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2009-09-17
• [Presentation] The role of cerebro-cerebellar intelactions in temporal information processing (2009)
  • Author(s): 麻生謙二、花川隆、麻生俊彦、福山秀直
  • Organizer: 第32回日本神経科学学会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2009-09-16
• [Presentation] Analysis of simultaneous recording of spontaneous EEG and fMRI (2009)
  • Author(s): 小俣圭、森本雅子、花川隆、本田学
  • Organizer: 第32回日本神経科学学会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2009-09-16
• [Presentation] 整形外科領域における脳機能イメージング応用の可能性 (2009)
  • Author(s): 花川隆
  • Organizer: 第9回群馬大学整形外科卒後研修会
  • Place of Presentation: 群馬大学、前橋
  • Year and Date: 2009-08-30
• [Presentation] 競技経験が運動予測および予測に関わる脳活動に及ぼす影響について (2009)
  • Author(s): 持永新、古田島浩子、花川隆、柳原大
  • Organizer: 第17回日本運動生理学会大会
  • Place of Presentation: 慈恵医科大学、東京
  • Year and Date: 2009-07-25
• [Presentation] Keynote : Neuroimaging Studies of Motor-related Behavior (2009)
  • Author(s): Hanakawa T
  • Organizer: Japan-Italy International Seminar : Musculoskeletal System and Computational Neuroscience for Rehabilitation
  • Place of Presentation: Istituto Italiano di Tecnologia, Genoa, Italy
  • Year and Date: 2009-06-18
• [Presentation] Mechanisms underlying cognitive and motor slowing in Parkinson's disease (2009)
  • Author(s): Hanakawa T, Hallett M
  • Organizer: 13^<th> International Congress of Movement Disorder Society
  • Place of Presentation: Le Palais Des Congres de Paris, Paris, France
  • Year and Date: 2009-06-09
• [Presentation] パーキンソン病の認知・運動遅延の神経基盤 (2009)
  • Author(s): 花川隆
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台国際センター、仙台
  • Year and Date: 2009-05-22
• [Presentation] 多モダリティイメージングによる脳領域間連関計測へのアプローチ (2008)
  • Author(s): 花川隆
  • Organizer: 第38回日本臨床神経生理学会・学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-18
• [Presentation] Parallel basal ganglia-frontal cortical loops for the control of motor and cognitive agility (2008)
  • Author(s): Hanakawa T, Hallett M
  • Organizer: Neuroscience 2008
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-17
• [Presentation] 歩行-中枢 (2008)
  • Author(s): 花川隆
  • Organizer: 第67回日本めまい平衡学会総会
  • Place of Presentation: 秋田
  • Year and Date: 2008-10-30
• [Presentation] Does mental rotation of hands and feet involve somatotopically organlzed brain regions? (2008)
  • Author(s): Hanakawa T, Hosoda C, Honda M
  • Organizer: 14th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2008-06-16
• [Presentation] 行動制御における大脳基底核・皮質系の役割 : 脳機能イメージングからの知見 (2008)
  • Author(s): 花川隆
  • Organizer: ロボテイクス・メカトロニクス講演会2008
  • Place of Presentation: 長野
  • Year and Date: 2008-06-05
• [Presentation] 運動実行・認知処理速度に関わる基底核皮質活動 (2008)
  • Author(s): 花川隆、Mark Hallett
  • Organizer: 第2回Motor Control研究会
  • Place of Presentation: 岡崎
  • Year and Date: 2008-05-30
• [Presentation] 運動・認知実行速度に関わる脳活動とその加齢性変化 (2008)
  • Author(s): 花川隆、Mark Hallett
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Book] シリーズ移動知 第2巻 身体適応-歩行運動の神経機構とシステムモデル 第三章第二・三節pp.81-97(土屋和男、高草木薫、萩原直道編) (2010)
  • Author(s): 花川隆
  • Total Pages: 320
  • Publisher: オーム社