Dynamics of Nuclear Architecture and Genome Organization during Neuronal Differentiation
| Project/Area Number |
20200009
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neuroscience in general
Nanomaterials/Nanobioscience
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
SUGO Noriyuki Osaka University, 大学院・生命機能研究科, 助教 (20372625)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ARAI Yoshiyuki 大阪大学, 大学院・生命機能研究科, 特任助教 (20444515)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥33,020,000 (Direct Cost: ¥25,400,000、Indirect Cost: ¥7,620,000)
Fiscal Year 2010: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2009: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2008: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
|
|---|
| Keywords | 分子・細胞神経科学 / 1分子生理・生化学 / 転写因子 / 大脳皮質 / クロマチン / DNA修復 |
|---|
| Research Abstract |
Dynamics between multiple nuclear factors and genomic DNA in the nucleus during neuronal differentiation remain undiscovered. Here, we quantitatively observed dynamics of some nuclear proteins and genomic loci by fluorescent imaging in vitro and in vivo. As a result, we can detect an interaction between a transcription factor and its recognition sequence at the single-molecule level.
|
Report
(4 results)
Research Products
(13 results)
