| Budget Amount *help |
¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Research Abstract |
Ascending spinal tracts (AST) relay various external and internal information received in a body to the brain. The origins and destinations of AST have been extensively studied in wide variety of species ; however, relatively little is known on the pathways and processes taken by the axons to reach their destinations during development. We developed the method utilizing newly developed in ovo electroporation conditions for making possible to follow the single axons derived from an intended single spinal segment of chick embryos, and followed the elongation time course and the paths of the ascending axons, including the mammalian counterparts of ventral and dorsal spinocerebellar tracts. Our observations unveiled the pathways and elongation processes taken by AST neurons, and suggested that a spinal cord may provide cues to coordinate their behavior.
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