Neurodegenerative mechanism and treatment with MOCA.

• Project/Area Number: 20200012
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• Allocation Type: Single-year Grants
• Research Field: Neurochemistry/Neuropharmacology; Experimental pathology
• Research Institution: Tokyo Metropolitan Organization for Medical Research
• Principal Investigator: NAMEKATA Kazuhiko Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 研究員 (70392355)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥29,900,000 (Direct Cost: ¥23,000,000、Indirect Cost: ¥6,900,000); Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000); Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000); Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
• Keywords: 再生治療 / 神経変性疾患 / Dock3 / WAVE / BDNF / 軸索再生 / 視神経 / MOCA / 神経化学 / 生体機能利用 / 再生医学 / トランスジェニックマウス / 軸策伸長

Research Abstract

Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.

Research Products

• [Journal Article] Glia-and neuron-specific functions of TrkB signaling during retinal degeneration and regeneration. (2011)
  • Author(s): Harada C, Guo X, Namekata K, Kimura A, Nakamura K, Tanaka K, Parada LF, Harada, T.
  • Journal Title: Nature Communications 2 Pages: 189-189
• [Journal Article] Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis. (2011)
  • Author(s): Guo X, Harada C, Namekata K, Kimura A., Mitamura Y., Yoshida H., Matsumuto Y., Harada T.
  • Journal Title: Invest Ophthalmol Vis Sci. 12
• [Journal Article] Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration. (2011)
  • Author(s): Harada, C., et al.
  • Journal Title: Nature Communications Volume: 2 Pages: 189-189
  • Peer Reviewed
• [Journal Article] Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. (2010)
  • Author(s): Guo X, Harada C, Namekata K, Matsuzawa A, Camps M, Ji H, Swinnen D, Jorand-Lebrun C, Muzerelle M, Vitte PA, Ruckle T, Kimura A, Kohyama K, Matsumoto Y, Ichijo H, Harada T.
  • Journal Title: EMBO Mol Med. 2(12) Pages: 504-515
• [Journal Article] Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice. (2010)
  • Author(s): Guo, X., Harada, C., Namekata, K., Mitamura, Y., Yoshida, H., Matsumoto, Y., Harada, T.
  • Journal Title: PLoS ONE 5(9) Pages: 13083-13083
• [Journal Article] ASK1 deficiency attenuates neural cell death in GLAST deficientmice, a model of normal tension glaucoma. (2010)
  • Author(s): Harada C, Namekata K, Guo X, Yoshida H, Mitamura Y, Matsumoto Y, Tanaka K, Ichijo H, Harada T.
  • Journal Title: Cell Death Differ. 17(11) Pages: 1751-1759
• [Journal Article] Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. (2010)
  • Author(s): Namekata K, Harada C, Taya C, Guo X, Kimura H, Parada LF, Harada T.
  • Journal Title: Proc Natl Acad Sci U S A. 107(16) Pages: 7586-7591
• [Journal Article] Expression of Epiplakin1 in the developing and adult mouse retina. (2010)
  • Author(s): Yoshida T, Guo X, Namekta K, Mitamura Y, Kume S, HARADA T.
  • Journal Title: Jpn J Ophthalmol. 54(1) Pages: 85-88
• [Journal Article] Transcription factor, SP1, in epiretinal membranes of patients with proliferative diabetic retinopathy. (2010)
  • Author(s): Yoshida-Hata N, Mitamura Y, Oshitari T, Namekata K, Harada C, Harada T, Yamamoto S.
  • Journal Title: Diabetes Res Clin Pract. 87(3) Pages: 26-28
• [Journal Article] Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. (2010)
  • Author(s): Guo, X., et al.
  • Journal Title: EMBO Molecular Medicine Volume: 2 Pages: 504-515
  • Peer Reviewed
• [Journal Article] ASK1 deficiency attenuates neural cell death in GLAST deficient mice, a model of normal tension glaucoma. (2010)
  • Author(s): Harada, C., et al.
  • Journal Title: Cell Death and Differentiation Volume: 17 Pages: 1751-1759
  • Peer Reviewed
• [Journal Article] Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice. (2010)
  • Author(s): Guo, X., et al.
  • Journal Title: PLoS ONE Volume: 5
  • Peer Reviewed
• [Journal Article] Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. (2010)
  • Author(s): Namekata, K., et al.
  • Journal Title: Proceedings of the National Academy of Sciences of the U.S.A. Volume: 107 Pages: 7586-7591
  • Peer Reviewed
• [Journal Article] Expression of Epiplakinl in the developing and adult mouse retina. (2010)
  • Author(s): Yoshida, T.
  • Journal Title: Japanese Journal of Ophthalmology 54 Pages: 85-88
  • Peer Reviewed
• [Journal Article] Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient mice. (2009)
  • Author(s): Namekata K, Harada C, Guo X, Kikushima K, Kimura A, Fuse N, Mitamura Y, Kohyama K, Matsumoto Y, Tanaka K, Harada T.
  • Journal Title: Neurosci Lett. 465(2) Pages: 160-164
• [Journal Article] Effect of geranylgeranylacetone on optic neuritis in experimental autoimmune encephalomyelitis. (2009)
  • Author(s): Guo X, Harada C, Namekata K, Kikushima K, Mitamura Y, Yoshida H, Matsumoto Y, Harada T.
  • Journal Title: Neurosci Lett. 462(3) Pages: 281-285
• [Journal Article] Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1 deficident mice. (2009)
  • Author(s): Namekata, K.
  • Journal Title: Neuroscience Letters 465 Pages: 160-164
  • Peer Reviewed
• [Journal Article] Effect of geranylgeranylacetone on optic neuritis in experimental autoimmune encephalomyelitis. (2009)
  • Author(s): Guo, X.
  • Journal Title: Neuroscience Letters 462 Pages: 281-285
  • Peer Reviewed
• [Journal Article] Interleukin-1 stimulates glutamate uptake in glial cells by accelerating membrane trafficking of Na+/K+-ATPase via actin depolymerization. (2008)
  • Author(s): Namekata K, Harada C, Kohyama K, Matsumoto Y, Harada T.
  • Journal Title: Mol Cell Biol. 28(10) Pages: 3273-3280
• [Journal Article] Interleukin-1 stimulates glutamate uptake in glial cells by accelerating membrane trafficking of Na^+/K^+-ATPase via actin depolymerization. (2008)
  • Author(s): Kazuhiko Namekata
  • Journal Title: Molecular and Celular Biology 28 Pages: 3273-3280
  • Peer Reviewed
• [Journal Article] Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis.
  • Author(s): Guo, X., et al.
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: (in press)
  • Peer Reviewed
• [Journal Article] Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.
  • Author(s): Namekata, K.
  • Journal Title: Proceedings of the National Academy of Sciences of the U.S.A. (in press)
  • Peer Reviewed
• [Presentation] ASK1 inhibition ameliorates optic neuritis by modulating glial innate immunity. (2011)
  • Author(s): Guo X., Harada C., Namekata K., Kimura A., Ichijo H., Harada T.
  • Organizer: 26^<th> Asia Pacific Academy of Ophthalmology (APAO) Congress
  • Place of Presentation: Sydney.
  • Year and Date: 2011-03-22
• [Presentation] ASK1 deficiency attenuates neural cell death in a mouse model of normal tension glaucoma. (2011)
  • Author(s): Harada T., Namekata K., Guo X., Tanaka K., Ichijo H., Harada C.
  • Organizer: 26^<th> Asia Pacific Academy of Ophthalmology (APAO) Congress
  • Place of Presentation: Sydney.
  • Year and Date: 2011-03-22
• [Presentation] Optic Nerve Regeneration is Enhanced in Dock3 Overexpressing Transgenic Mice. (2011)
  • Author(s): Namekata K., Harada C., Guo X., Harada T.
  • Organizer: 26^<th> Asia Pacific Academy of Ophthalmology (APAO) Congress
  • Place of Presentation: Sydney.
  • Year and Date: 2011-03-22
• [Presentation] 軸索伸長におけるDock3とWAVEの機能解析 (2010)
  • Author(s): 行方和彦、原田知加子、郭暁麗、原田高幸
  • Organizer: BMB2010 (第33回日本分子生物学会大会・第83回日本生化学会大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] グルタミン酸毒性と酸化ストレスに対してのDock3による網膜神経細胞保護 (2010)
  • Author(s): 木村敦子、行方和彦、田中光一、原田高幸
  • Organizer: Neuro2010 (第33回日本神経科学大会・第53回日本神経科学会大会・第20回日本神経回路学会大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-09-03
• [Presentation] 軸索伸長におけるDock3とWAVEの機能解析 (2010)
  • Author(s): 行方和彦、原田知加子、郭暁麗、原田高幸
  • Organizer: Neuro2010 (第33回日本神経科学大会・第53回日本神経科学会大会・第20回日本神経回路学会大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-09-02
• [Presentation] 軸索伸長におけるDock3とWAVEの機能解析 (2010)
  • Author(s): 行方和彦、原田知加子、郭暁麗、原田高幸
  • Organizer: BMB2010(第33回日本分子生物学会大会・第83回日本生化学会大会)
• [Presentation] 軸索伸長におけるDock3とWAVEの機能解析 (2010)
  • Author(s): 行方和彦、原田知加子、郭暁麗、原田高幸
  • Organizer: Neuro2010(第33回日本神経科学大会・第53回日本神経科学会大会・第20回日本神経回路学会大会)
• [Presentation] グルタミン酸毒性と酸化ストレスに対してのDock3による網膜神経細 (2010)
  • Author(s): 木村敦子、行方和彦、田中光一、原田高幸
  • Organizer: Neuro2010(第33回日本神経科学大会・第53回日本神経科学会大会・第20回日本神経回路学会大会)
• [Remarks] ホームページ等
• [Remarks] ホームページ
  • URL: http://tmin.ac.jp/topics/harada.html
• [Remarks]
  • URL: http://tmin.ac.jp/topics/harada2.html
• [Remarks]
  • URL: http://tmin.ac.jp/topics/harada3.html
• [Remarks]
  • URL: http://tmin.ac.jp/topics/harada4.html
• [Remarks] 平成22年5月2日の毎日新聞(朝刊)に掲載
• [Remarks]
  • URL: http://tmin.ac.jp/topics/harada2.html
• [Remarks]
  • URL: http://tmin.ac.jp/topics/harada3.html
• [Remarks]
  • URL: http://tmin.ac.jp/topics/harada4.html
• [Remarks]
  • URL: http://tmin.ac.jp/research/dept/10/10.html