Neurodegenerative mechanism and treatment with MOCA.
Project/Area Number |
20200012
|
Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
|
Allocation Type | Single-year Grants |
Research Field |
Neurochemistry/Neuropharmacology
Experimental pathology
|
Research Institution | Tokyo Metropolitan Organization for Medical Research |
Principal Investigator |
NAMEKATA Kazuhiko Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 研究員 (70392355)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥29,900,000 (Direct Cost: ¥23,000,000、Indirect Cost: ¥6,900,000)
Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
|
Keywords | 再生治療 / 神経変性疾患 / Dock3 / WAVE / BDNF / 軸索再生 / 視神経 / MOCA / 神経化学 / 生体機能利用 / 再生医学 / トランスジェニックマウス / 軸策伸長 |
Research Abstract |
Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.
|
Report
(4 results)
Research Products
(41 results)
-
-
-
-
[Journal Article] Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway.2010
Author(s)
Guo X, Harada C, Namekata K, Matsuzawa A, Camps M, Ji H, Swinnen D, Jorand-Lebrun C, Muzerelle M, Vitte PA, Ruckle T, Kimura A, Kohyama K, Matsumoto Y, Ichijo H, Harada T.
-
Journal Title
EMBO Mol Med. 2(12)
Pages: 504-515
Related Report
-
[Journal Article] Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice.2010
Author(s)
Guo, X., Harada, C., Namekata, K., Mitamura, Y., Yoshida, H., Matsumoto, Y., Harada, T.
-
Journal Title
PLoS ONE 5(9)
Pages: 13083-13083
Related Report
-
-
-
-
-
-
-
-
-
-
[Journal Article] Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient mice.2009
Author(s)
Namekata K, Harada C, Guo X, Kikushima K, Kimura A, Fuse N, Mitamura Y, Kohyama K, Matsumoto Y, Tanaka K, Harada T.
-
Journal Title
Neurosci Lett. 465(2)
Pages: 160-164
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-