| Project/Area Number |
20200017
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
Medical pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
MUKAI Yohei Osaka University, 大学院・薬学研究科, 助教 (60444501)
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| Co-Investigator(Kenkyū-buntansha) |
SEINO Satoshi 大阪大学, 大学院・工学研究科, 講師 (90432517)
OKADA Yoshiaki 大阪大学, 大学院・薬学研究科, 助教 (50444500)
MORITA Masahito 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (30381594)
HATAZAWA Jun 大阪大学, 大学院・医学研究科, 教授 (70198745)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAGAWA Shinsaku 大阪大学, 大学院・薬学研究科, 教授 (70207728)
YAMAMOTO Takao 大阪大学, 大学院・工学研究科, 教授 (00174798)
DOI Takefumi 大阪大学, 大学院・薬学研究科, 教授 (00211409)
INUBUSHI Toshiro 滋賀医科大学, MR医学総合研究センター, 教授 (20213142)
KANAI Yasukazu 大阪大学, 大学院・医学研究科, 助教 (80467555)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥30,680,000 (Direct Cost: ¥23,600,000、Indirect Cost: ¥7,080,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2008: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | 医用・生体画像 / 腫瘍血管 / 抗体 / SPECT / MRI / 医療薬剤学 |
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| Research Abstract |
We aim to develop a method to analyze a progress of tumor blood vessels by antibody-based imaging using anti-tumor endothelial marker antibodies. In the assessment of these antibodies, we show that cell-internalizing antibody can accumulate into the endothelial cells efficiently. This property may be useful for specific labeling of tumor endothelial cells. In the development of a novel MR imaging agent, we show that PEG-modified gold-iron oxide nanoparticles can accumulate in the tumor, and they can visualize a tumor tissue using MRI. In addition, we also developed a method to modify antibodies on a tip of PEG. It may be novel tumor endothelial specific MR imaging agent. We also developed a method of antibody labeling using 123I. We are challenging an antibody based SPECT imaging with help of Dr. Hatazawa, Osaka University. In the future, these antibody-based technologies will be useful for the analysis of the progress of tumor blood vessels.
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