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Construction of antibody-based molecular imaging techniques to analyze a development of tumor angiogenesis.

Research Project

Project/Area Number 20200017
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Medical pharmacy
Research InstitutionOsaka University

Principal Investigator

MUKAI Yohei  Osaka University, 大学院・薬学研究科, 助教 (60444501)

Co-Investigator(Kenkyū-buntansha) SEINO Satoshi  大阪大学, 大学院・工学研究科, 講師 (90432517)
OKADA Yoshiaki  大阪大学, 大学院・薬学研究科, 助教 (50444500)
MORITA Masahito  大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (30381594)
HATAZAWA Jun  大阪大学, 大学院・医学研究科, 教授 (70198745)
Co-Investigator(Renkei-kenkyūsha) NAKAGAWA Shinsaku  大阪大学, 大学院・薬学研究科, 教授 (70207728)
YAMAMOTO Takao  大阪大学, 大学院・工学研究科, 教授 (00174798)
DOI Takefumi  大阪大学, 大学院・薬学研究科, 教授 (00211409)
INUBUSHI Toshiro  滋賀医科大学, MR医学総合研究センター, 教授 (20213142)
KANAI Yasukazu  大阪大学, 大学院・医学研究科, 助教 (80467555)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥30,680,000 (Direct Cost: ¥23,600,000、Indirect Cost: ¥7,080,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2009: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2008: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords医用・生体画像 / 腫瘍血管 / 抗体 / SPECT / MRI / 医療薬剤学
Research Abstract

We aim to develop a method to analyze a progress of tumor blood vessels by antibody-based imaging using anti-tumor endothelial marker antibodies. In the assessment of these antibodies, we show that cell-internalizing antibody can accumulate into the endothelial cells efficiently. This property may be useful for specific labeling of tumor endothelial cells. In the development of a novel MR imaging agent, we show that PEG-modified gold-iron oxide nanoparticles can accumulate in the tumor, and they can visualize a tumor tissue using MRI. In addition, we also developed a method to modify antibodies on a tip of PEG. It may be novel tumor endothelial specific MR imaging agent. We also developed a method of antibody labeling using 123I. We are challenging an antibody based SPECT imaging with help of Dr. Hatazawa, Osaka University. In the future, these antibody-based technologies will be useful for the analysis of the progress of tumor blood vessels.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (128 results)

All 2010 2009 2008 Other

All Journal Article (54 results) (of which Peer Reviewed: 52 results) Presentation (69 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletalmuscle2010

    • Author(s)
      Liu J, Yuan L, Molema I, Regan E, Janes L, Beeler D, Spokes K, Okada Y, Minami T, Oettgen P, Aird WC
    • Journal Title

      Blood (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cellular and molecular MR and fluorescence imaging.2010

    • Author(s)
      森田将史
    • Journal Title

      日本放射線技術学会雑誌 (in press )

    • NAID

      10026453378

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Solution of the Structure of the TNF-TNFR2 Complex.2010

    • Author(s)
      Mukai Y, Nakamura T, Yoshikawa M, Yoshioka Y, Tsunoda S, Nakagawa S,, Yamagata Y, Tsutsumi Y
    • Journal Title

      Sci Signal. 3(148)

      Pages: 83-83

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simple PEG Conjugation of SPIO via an Au-S Bond Improves Its Tumor Targeting Potency as a Novel MR Tumor Imaging Agent.2010

    • Author(s)
      Kojima H, Mukai Y, Yoshikawa M, Kamei K, Yoshikawa T, Morita M, Inubushi T, Yamamoto TA, Yoshioka Y, Okada N, Seino S, Nakagawa S,
    • Journal Title

      Bioconjug Chem. 21(6)

      Pages: 1026-1031

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腫瘍MRイメージングにおける造影剤開発2010

    • Author(s)
      向洋平、中川晋作
    • Journal Title

      JSMI Report. 3(1)

      Pages: 14-17

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure of the TNF-TNFR2 complex : crystal structure and supra-complex on the living cell surface.2010

    • Author(s)
      Mukai Y, Nakamura T, Yoshikawa M, Yoshioka Y, Tsunoda S, Nakagawa S, Yamagata Y, Tsutsumi Y.
    • Journal Title

      Science Signaling

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletalmuscle.2010

    • Author(s)
      Liu J, Yuan L, Molema I, Regan E, Janes L, Beeler D, Spokes K, Okada Y, Minami T, Oettgen P, Aird WC
    • Journal Title

      Blood

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腫瘍標的MRI造影剤の研究開発動向2010

    • Author(s)
      向洋平、中川晋作
    • Journal Title

      PETジャーナル

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular and molecular MR and fluorescence imaging2010

    • Author(s)
      森田将史
    • Journal Title

      日本放射線技術学会雑誌

      Volume: (in press)

    • NAID

      10026453378

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple PEG conjugation of SPIO via an Au-S bond improves its tumor targeting potency as a novel MR tumor imaging agent.2010

    • Author(s)
      Kojima H, Mukai Y, Yoshikawa M, Kamei K, Yoshikawa T, Morita M, Inubushi T, Yamamoto TA, Yoshioka Y, Okada N, Seino S, Nakagawa S.
    • Journal Title

      Bioconjug Chem.

      Volume: 21(6) Pages: 1026-31

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor.2010

    • Author(s)
      Morishige T, Yoshioka Y, Inakura H, Tanabe A, Yao X, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 393(4) Pages: 888-93

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor-targeting CTL expressing a single-chain Fv specific for VEGFR2.2010

    • Author(s)
      Kanagawa N, Yanagawa T, Mukai Y, Yoshioka Y, Okada N, Nakagawa S.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 393(4) Pages: 888-93

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy.2010

    • Author(s)
      Morishige T, Yoshioka Y, Inakura H, Tanabe A, Yao X, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S.
    • Journal Title

      Biomaterials

      Volume: 31(12) Pages: 3357-63

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation for highly sensitive MRI contrast agents using core/shell type nanoparticles consisting of multiple SPIO cores with thin silica coating.2010

    • Author(s)
      Tanaka K, Narita A, Kitamura N, Uchiyama W, Morita M, Inubushi T, Chujo Y.
    • Journal Title

      Langmuir

      Volume: 26(14) Pages: 11759-62

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice.2010

    • Author(s)
      Nomura T, Abe Y, Kamada H, Shibata H, Kayamuro H, Inoue M, Kawara T, Arita S, Furuya T, Yamashita T, Nagano K, Yoshikawa T, Yoshioka Y, Mukai Y, Nakagawa S, Taniai M, Ohta T, Serada S, Naka T, Tsunoda SI, Tsutsumi Y.
    • Journal Title

      J Control Release. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor.2010

    • Author(s)
      Morishige T, Yoshioka Y, Inakura H, Tanabe A, Yao X, Tsunoda SI, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S
    • Journal Title

      Biochem Biophys Res Commun. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy.2010

    • Author(s)
      Morishige T, Yoshioka Y, Inakura H, Tanabe A, Yao X, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S.
    • Journal Title

      Biomaterials. 31(12)

      Pages: 3357-3363

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Creation of lysine-deficient mutant lymphotoxin-alpha with recepor selectivity by using a phage display system.2010

    • Author(s)
      Yoshioka Y, Watanabe H, Morishige T, Yao X, Ikemizu S, Nagao C, Ahmad S, Mizuguchi K, Tsunoda SI, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S.
    • Journal Title

      Biomaterials. 31(7)

      Pages: 1935-1943

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腫瘍MRイメージングにおける造影剤開発2010

    • Author(s)
      向洋平、中川晋作
    • Journal Title

      JSMI Report 3(1)

      Pages: 14-17

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] in vitroとin vivoで異なるレポータージーンアッセイの結果2010

    • Author(s)
      岡田欣晃、土井健史
    • Journal Title

      生産と技術 62

      Pages: 51-56

    • NAID

      40017231022

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Direct cell-entry of gold/iron-oxide magnetic nanoparticles in adenovirus mediated gene delivery.2009

    • Author(s)
      Kamei K, Mukai Y, Kojima H, Yoshikawa T, Yoshikawa M, Kiyohara G, Yamamoto TA, Yoshioka Y, Okada N, Seino S, Nakagawa S,
    • Journal Title

      Biomaterials. 30(9)

      Pages: 1809-1814

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.2009

    • Author(s)
      Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S
    • Journal Title

      Nature. 459(7250)

      Pages: 1126-1130

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dispersibility improvement of gold/iron-oxide composite nanoparticles by polyethylenimine modification.2009

    • Author(s)
      Seino S, Matsuoka Y, Kinoshita T, Nakagawa S,, Yamamoto TA
    • Journal Title

      J Magn Magn Mater. 321(10)

      Pages: 1404-1407

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF.2009

    • Author(s)
      Shibata H, Yoshioka Y, Abe Y, Ohkawa A, Nomura T, Minowa K, Mukai Y, Nakagawa S, Taniai M, Ohta T, Kamada H, Tsunoda S, Tsutsumi Y.
    • Journal Title

      Biomaterials. 30(34)

      Pages: 6638-6647

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LIGHT protein suppresses tumor growth by augmentation of immune response.2009

    • Author(s)
      Morishige T, Yoshioka Y, Inakura H, Tanabe A, Watanabe H, Yao X, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S.
    • Journal Title

      Immunol Lett. 127(1)

      Pages: 33-38

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel protein engineering strategy for creating highly receptor-selective mutant TNFs.2009

    • Author(s)
      Nomura T, Abe Y, Kamada H, Inoue M, Kawara T, Arita S, Furuya T, Yoshioka Y, Shibata H, Kayamuro H, Yamashita T, Nagano K, Yoshikawa T, Mukai Y, Nakagawa S, Taniai M, Ohta T, Tsunoda SI, Tsutsumi Y.
    • Journal Title

      Biochem Biophys Res Commun. 388(4)

      Pages: 667-671

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF : useful information for designing artificial proteo-antagonists.2009

    • Author(s)
      Mukai Y, Nakamura T, Yoshioka Y, Shibata H, Abe Y, Nomura T, Taniai M, Ohta T, Nakagawa S, Tsunoda S, Kamada H, Yamagata Y, Tsutsumi Y.
    • Journal Title

      J Biochem.(表紙掲載) 146(2)

      Pages: 167-172

    • NAID

      10026302534

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The augmentation of intracellular delivery of peptide therapeutics by artificial protein transduction domains.2009

    • Author(s)
      Yoshikawa T, Sugita T, Mukai Y, Yamanada N, Nagano K, Nabeshi H, Shibata H, Yoshioka Y, Nakagawa S, Kamada H, Tsunoda S, Tsutsumi Y.
    • Journal Title

      Biomaterials. 30(19)

      Pages: 3318-3323

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid isolation of intrabody candidates by using an optimized non-immune phage antibody library.2009

    • Author(s)
      Nagano K, Imai S, Mukai Y, Nakagawa S, Abe Y, Kamada H, Tsunoda S, Tsutsumi Y
    • Journal Title

      Pharmazie. 64(4)

      Pages: 238-241

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization and preliminary X-ray analysis of the tumour necrosis factor α-tumour necrosis factor receptor tvpe 2 complex.2009

    • Author(s)
      Mukai Y.Nakamura T, Yoshioka Y, Tsunoda S, Kamada H, Nakagawa S, Yamagata Y, Tsutsumi Y.
    • Journal Title

      Acta Cryst. F65(Pt3)

      Pages: 295-298

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血管内皮細胞の遺伝子発現制御研究からみたin vivoプロモーター解析の重要性2009

    • Author(s)
      岡田欣晃、土井健史
    • Journal Title

      生化学 81

      Pages: 117-121

    • NAID

      10024915912

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR12009

    • Author(s)
      Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Foikman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S.
    • Journal Title

      Nature 459

      Pages: 1126-1130

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A+220 GATA motif mediates basal but not endotoxin-repressible expression of the von Willebrand factor promoter in Hprt-targeted transgenic mice2009

    • Author(s)
      Liu J, Kanki Y, Okada Y. Jin E, Yano K, Shih SC, Minami T, Aird WC.
    • Journal Title

      Journal of thrombosis and haemostasis 284

      Pages: 22195-22205

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential. roles for ETS, CREB and EGR binding sites in mediating VEGF receptor 1 expression in vivo2009

    • Author(s)
      Jin E, Liu J, Suehiro J, Yuan L, Okada Y, Nikolova-Krstevski V, Yano K, Janes L, Beeler D, Spokes KC, Li D, Regan E, Shih SC, Oettgen P, Minami T, Aird WC.
    • Journal Title

      Blood 114

      Pages: 5557-5566

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct cell entry of gold/iron-oxide magnetic nanoparticles in adenovirus mediated gene delivery2009

    • Author(s)
      Kamei K, Mukai Y, Kojima H, Yoshikawa T, Yoshikawa M, Kiyohara G, Yamamoto TA, Yoshioka Y, Okada N, Seino S, Nakagawa S.
    • Journal Title

      Biomaterials 30

      Pages: 1809-14

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural a nalysis of a fully active TNFR1-selective TNF mutant2009

    • Author(s)
      Mukai Y, Shibata H, Nakamura T, Yoshioka Y, Abe Y, Nomura T, Tariiai M, Ohta T, Ikemizu S, Nakagawa S, Tsunoda S, Kamada H, Yarnagata Y, Tsutsumi Y.
    • Journal Title

      J Mol Biol 385

      Pages: 1221-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (18) F-FDG PET for the evaluation of thymic epithelial tumors : Correlation with the World Health Organization classification in addition to dual-time-point imaging2009

    • Author(s)
      Inoue A, Tomiyama N, Tatsumi M, Ikeda N, Okumura M, Shiono H, Inoue M, Higuchi I, Aozasa K, Johkoh T, Nakamura H, Hatazawa J.
    • Journal Title

      Eur J Nucl Med Mol Imaging (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of chemotherapy response in osteosarcoma with FDG-PET2009

    • Author(s)
      Hamada K, Tomita Y, Inoue A, Fujimoto T, Hashimoto N, Myoui A, Yoshikawa H, Hatazawa J.
    • Journal Title

      Ann Nucl Med 23

      Pages: 89-95

    • NAID

      10025135442

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo.2008

    • Author(s)
      Okada Y, Jin E, Nikolova-Krstevski V, Yano K, Liu J, Beeler D, Spokes K, Kitayama M, Funahashi N, Doi T, Janes L, Minami T, Oettgen P, Aird WC.
    • Journal Title

      Blood. 112(6)

      Pages: 2336-2339

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] MRI-based correction for partial-volume effect improves detectability of intractable epileptogenic foci on 123I-iomazenil brain SPECT images.2008

    • Author(s)
      Kato H, Shimosegawa E, Oku N, Kitagawa K, Kishima H, Saitoh Y, Kato A, Yoshimine T, Hatazawa J
    • Journal Title

      J Nucl Med. 49

      Pages: 383-389

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ligand-independent assembly of purified soluble magic roundabout (Robo4), a tumor-specific endothelial marker2008

    • Author(s)
      Yoshikawa M, Mukai Y, Okada Y, Yoshioka Y, Tsunoda S, Tsutsumi Y, Okada N, Aird WC, Doi T, NakaEawa S.
    • Journal Title

      Protein Expr Purif. 61

      Pages: 78-82

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A GABP-binding element in the Robo 4 promoter is necessary for endothelial expression in vivo2008

    • Author(s)
      Okada Y, Jin E, Nikolova-Krstevski V, Yano K, Liu J, Beeler D, Spokes K, Kitayama M, Funahashi N, Doi T, Janes L, Minami T, Oettgen P, Aird WC.
    • Journal Title

      Blood 112

      Pages: 2336-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated levels of placental growth factor represent anadaptive host response in sepsis2008

    • Author(s)
      Yano K, Okada Y, Beldi G, Shih SC, Bodyak N, Okada H, Kang PM, Luscirtskas W, Robson SC, Carmeliet P, Karumanchi SA, Aird WC.
    • Journal Title

      J Exp Med 205

      Pages: 2623-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Brain and Whole-body Pharmacokinetics of ^<11>C-labeled Diphenyl-hydantoin in Rats by Means of Planar Positron Imaging System2008

    • Author(s)
      Hasegawa Y, Kanai Y, Hasegawa S, Okamoto T, Mats ui T, Shimosegawa E,Kurachi Y, Hatazawa J.
    • Journal Title

      Ann Nucl Med 22

      Pages: 301-307

    • NAID

      10021281082

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ^<18>F-FDG PET in patients with malignant lymphoma having long-term follow up : staging and restaging, and evaluation of treatment resnonse and recurrence2008

    • Author(s)
      Isohashi K, Tatsumi M, Higuchi I, Inoue A, Nakajo K, Ishikawa J, Shimosegawa E, Kanakura Y, Nakamura H, Hatazawa J.
    • Journal Title

      Ann Nucl Med 22

      Pages: 795-802

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 18F-FDG-PET of musculoskeletal tumors : a correlation with the expression of elucose transporter 1 and hexokinase II.2008

    • Author(s)
      Hamada K, Tomita Y, Qiu Y, Zhang B, Ueda T, Myoui A. Hieuchi I, Yoshikawa H, Aozasa K, Hatazawa J.
    • Journal Title

      Ann Nucl Med 22

      Pages: 699-705

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mucosa-associated lymphoid tissue lymphoma studiedwith FDGPET : a comparison with CT and endoscopic findings2008

    • Author(s)
      Enomoto K, Hamada K, Inohara H, Higuchi I, Tomita Y, Kubo T, Hatazawa J.
    • Journal Title

      Ann Nucl Med 22

      Pages: 261-267

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral hemodynamics and oxygen metabolism in patients with moyamoya syndrome associated with atherosclerotic steno-occlusive arterial lesions2008

    • Author(s)
      Kato H, Shimosegawa E, Oku N, Kimura Y, Kajimoto K, Tanaka M, Hori M, Kitagawa K, Hatazawa J
    • Journal Title

      Cerebrovasc Dis 26

      Pages: 9-15

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MRI-based correction for partial-volume effect improves detectability of intractable epileptogenic foci on 123I-iomazenil brain SPECT images2008

    • Author(s)
      Kato H, Shimosegawa E, Oku N, Kitagawa K, Kishima H, Saitoh Y, Kato A, Yoshimine T, Hatazawa J.
    • Journal Title

      J Nucl Med 49

      Pages: 383-389

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monden M. Lack of fludeoxyglucose F 18 uptake in posttreatment positron emission tomography as a significant predictor of survival after subsequent surgery in multimodality treatment for patients with locally advanced esophageal squamous cell carcinoma2008

    • Author(s)
      Higuchi I, Yasuda T, Yano M, Doki Y, Miyata H, Tatsumi M, Fukunaga H, Takiguchi S, Fujiwara Y, Hatazawa J
    • Journal Title

      J Thorac Cardiovasc Surg 136

      Pages: 205-212

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (18) F-FDG accumulation in the oral cavity is associated with periodontal disease and apical periodontitis : an initial demonstration on PET/CT2008

    • Author(s)
      Shimamoto H, Tatsumi M, Kakimoto N, Hamada S, Shimosegawa E, Murakami S, Furukawa S, Hatazawa J.
    • Journal Title

      Ann Nucl Med 22

      Pages: 587-593

    • NAID

      10024456275

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of cardiac energy efficiency in diastolic heart failure : assessment with positron emission tomography with 11 C-acetate2008

    • Author(s)
      Hasegawa S, Yamamoto K, Sakata Y, Takeda Y, Kajimoto K, Kanai Y, Hori M, Hatazawa J.
    • Journal Title

      Hypertens Res 31

      Pages: 1157-1162

    • NAID

      10021936525

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic middle cerebral artery occlusion : a hemodynamic and metabolic study with positron-emission tomography2008

    • Author(s)
      Tanaka M, Shimosegawa E, Kajimoto K, Kimura Y, Kato H. Oku N. Hori M. Kitaaawa K. Hatazawa J
    • Journal Title

      AJNR Am J Neuroradiol 29

      Pages: 1841-1846

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dispersibility improvement of gold/iron-oxide compositenanoparticles by polyethylenimine modification

    • Author(s)
      Satoshi Seino, Yu Matsuoka, Takuya Kinoshita, Takashi Nakagawa, Takao A. Yamamoto
    • Journal Title

      J Magn Magn Mater (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Immuno-conjugate製剤における抗体の細胞内侵入活性と抗腫瘍効果の連関解析2010

    • Author(s)
      吉川舞、向洋平、堤康央、角田慎一、吉岡靖雄、岡田直貴、中川晋作
    • Organizer
      第26回日本DDS学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規腫瘍MRI造影剤としてのPEG化金SPIOの有用性評価2010

    • Author(s)
      松尾奈緒美、向洋平、小島拓記、吉川舞、清野智史、山本孝夫、吉岡靖雄、岡田直貴、高島庄太夫、中川晋作
    • Organizer
      第26回日本DDS学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immune-conjugate製剤の開発に適う細胞内侵入抗体の効率的創製法の確立2010

    • Author(s)
      吉川舞、向洋平、吉岡靖雄、岡田直貴、堤康央、角田慎一、中川晋作
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      徳島
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗体-薬物複合体;Antibody-drug conjugateの開発に適う細胞内侵入抗体の効率的探索法2010

    • Author(s)
      吉川舞、向洋平、中川晋作
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管内皮細胞特異的に発現するレセプターROBO4とSLITの相互作用解析2010

    • Author(s)
      蒋志侠、鈴木綾乃、舟橋伸昭、加納義浩、成瀬啓樹、岡田欣晃、土井健史
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] ROBO4の血管内皮細胞特異的発現制御とDNAメチル化の関連性の解析2010

    • Author(s)
      加納義浩、舟橋伸昭、成瀬啓樹、蒋志侠、鈴木綾乃、岡田欣晃、土井健史
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Antibody Drug Conjugate製剤の開発を目指した細胞内侵入抗体の効率的探索法2010

    • Author(s)
      向洋平
    • Organizer
      技術情報協会セミナー「次世代抗体医薬品開発に向けた最新研究動向」
    • Place of Presentation
      東京
    • Year and Date
      2010-01-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Antibody-drug conjugateの開発に適う細胞内侵入抗体の効率的探索法2009

    • Author(s)
      吉川舞、向洋平、吉岡靖雄、岡田直貴、堤康央、角田慎一、中川晋作
    • Organizer
      第8回ファーマ・バイオフォーラム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Robo4遺伝子の血管内皮細胞特異的な発現とDNAメチル化との関連2009

    • Author(s)
      舟橋伸昭、成瀬啓樹、加納義浩、Ziang Zhixia、鈴木綾乃、岡田欣晃、土井健史
    • Organizer
      第8回次世代を担う若手ファーマバイオフォーラム2009
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管内皮細胞に特異的に発現するRobo4遺伝子の新規転写調節配列の同定と解析2009

    • Author(s)
      成瀬啓樹、蒋志侠、舟橋伸昭、加納義浩、鈴木綾乃、Aird WC、岡田欣晃、土井健史
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] High-throughput screening method of "Cell-internalizing monoclonal antibodies", potent anti-tumor drug delivery carriers2009

    • Author(s)
      吉川舞、向洋平、吉岡靖雄、岡田直貴、堤康央、角田慎一、中川晋作
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 金磁性複合ナノ粒子のバイオ・DDS分野への展開2009

    • Author(s)
      向洋平
    • Organizer
      第3回「ナノメディスン・アプリケーション研究会」
    • Place of Presentation
      大阪
    • Year and Date
      2009-09-16
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 金磁性複合ナノ粒子のバイオ分野への応用2009

    • Author(s)
      向洋平
    • Organizer
      第31回ナノバイオ磁気工学専門研究会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 金磁性複合ナノ粒子のバイオ分野への応用2009

    • Author(s)
      向洋平
    • Organizer
      第31回 ナノバイオ磁気工学専門研究会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Robo4プロモーターに存在するGABP結合配列のin vivoにおける重要性2009

    • Author(s)
      岡田欣晃、金恩京、北山美絵、舟橋伸昭、矢野喜一郎、Aird WC、土井健史
    • Organizer
      第10回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-06-20
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] immuno-conjugate製剤の開発に適う細胞内侵入抗体の効率的創製法の確立2009

    • Author(s)
      吉川舞、向洋平、久保貴、吉岡靖雄、岡田直貴、堤康央、角田慎一、中川晋作
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 微細超常磁性酸化鉄粒子(USPIO)をコアとしたPEG化金磁性ナノ粒子の創製とそのMRI腫瘍造影剤としての有用性評価2009

    • Author(s)
      小島拓記、向洋平、森田将史、犬伏俊郎、山本孝夫、吉岡靖雄、岡田直貴、清野智史、中川晋作
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] TNFR1選択的阻害剤の開発を目指したTNFR1選択的変異体の創製とそのレセプター結合における構造-活性相関研究2009

    • Author(s)
      向洋平、柴田寛子、中村照也、吉岡靖雄、阿部康弘、野村鉄也、谷合まどか、太田恒考、池水信二、鎌田春彦、角田慎一、中川晋作、山縣ゆり子、堤康央
    • Organizer
      第9回蛋白質科学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ligand independent assembly of purified soluble Magic Roundabout (Robo4), a tumor-specific endothelial marker2009

    • Author(s)
      Yoshikawa M, Mukai Y, Okada Y, Yoshioka Y, Tsunoda S, Tsutsumi Y, Okada N, Aird WC, Doi T, Nakagawa S
    • Organizer
      ECCO 15 and 34th ESMO Multidisciplinary Congress
    • Place of Presentation
      Berlin (Germany)
    • Related Report
      2010 Final Research Report
  • [Presentation] Design of tumor targeting magnetic resonance imaging (MRI) agent based on gold/iron-oxide composite nanoparticle.2009

    • Author(s)
      Kojima H, Mukai Y, Kamei K, Seino S, Morita M, Inubushi T, Yoshioka Y, Okada N, Nakagawa S
    • Organizer
      ECCO 15 and 34th ESMO Multidisciplinary Congress
    • Place of Presentation
      Berlin (Germany)
    • Related Report
      2010 Final Research Report
  • [Presentation] Direct cell entry of gold/iron-oxide magnetic nanoparticles in adenovirus mediated gene delivery2009

    • Author(s)
      Mukai Y, Kojima H, Yoshikawa T, Kamei K, Yoshikawa M, Yamamoto TA, Yoshioka Y, Okada N, Seino S, Nakagawa S
    • Organizer
      ECCO 15 and 34th ESMO Multidisciplinary Congress
    • Place of Presentation
      Berlin (Germany)
    • Related Report
      2010 Final Research Report
  • [Presentation] 生体内応用を目指したPEG化金/酸化鉄磁性複合ナノ粒子の合成2009

    • Author(s)
      清野智史、山中誠之、中川貴、小島拓記、向洋平、中川晋作、山本孝夫
    • Organizer
      第33回日本磁気学会学術講演会
    • Place of Presentation
      長崎
    • Related Report
      2010 Final Research Report
  • [Presentation] Receptor interaction of Tumor Necrosis Factor (TNF) based on 3D structural analysis of a fully active TNFR1-selective TNF mutant2009

    • Author(s)
      Mukai Y, Nakamura T, Yoshioka Y, Abe Y, Nakamura T, Taniai M, Ohta T, Ikemizu S, Nakagawa S, Tsunoda S, Kamada H, Yamagata Y, Tsutsumi Y
    • Organizer
      12th International TNF Conference
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2009 Annual Research Report
  • [Presentation] The development of fully active receptor selective Tumor Necrosis Factor (TNF) mutants2009

    • Author(s)
      Yoshikawa M, Mukai Y, Shibata H, Yoshioka Y, Abe Y, Nomura T, Taniai M, Ohta T, Tsunoda S, Kamada H, Nakagawa S, Tsutsumi Y
    • Organizer
      12th International TNF Conference
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2009 Annual Research Report
  • [Presentation] Direct cell entry of gold/iron-oxide magnetic nanoparticles in adenovirus mediated gene delivery2009

    • Author(s)
      Mukai Y, Kojima H, Yoshikawa T, Kamei K, Yoshikawa M, Yamamoto TA, Yoshioka Y, Okada N, Seino S, Nakagawa S
    • Organizer
      ECCO 15 and 34th ESMO Multidisciplinary Congress
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ligand independent assembly of purified soluble Magic Roundabout (Robo4), a tumor-specific endothelial marker2009

    • Author(s)
      Yoshikawa M, Mukai Y, Okada Y, Yoshioka Y, Tsunoda S, Tsutsumi Y, Okada N, Aird WC, Doi T, Nakagawa S
    • Organizer
      ECCO 15 and 34th ESMO Multidisciplinary Congress
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2009 Annual Research Report
  • [Presentation] Design of tumor targeting magnetic resonance imaging (MRI) agent based on gold/iron-oxide composite nanoparticle.2009

    • Author(s)
      Kojima H, Mukai Y, Kamei K, Seino S, Morita M, Inubushi T, Yoshioka Y, Okada N, Nakagawa S.
    • Organizer
      ECCO 15 and 34th ESMO Multidisciplinary Congress
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体内応用を目指したPEG化金/酸化鉄磁性複合ナノ粒子の合成2009

    • Author(s)
      清野智史、山中誠之、中川貴、小島拓記、向洋平、中川晋作、山本孝夫
    • Organizer
      第33回 日本磁気学会学術講演会
    • Place of Presentation
      長崎大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規血管内皮細胞マーカーRobo4のin vivo発現制御機構解析2008

    • Author(s)
      岡田欣晃、金恩京、北山美絵、舟橋伸昭、矢野喜一郎、William Aird、土井健史
    • Organizer
      第81回日本生化学会大会第31回日本分子生物学会年会合同大会(BMB2008)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血管内皮細胞と非血管内皮細胞におけるROBO4プロモーターのDNAメチル化状態の相違2008

    • Author(s)
      舟橋伸昭、成瀬啓樹、加納義浩、Zhixia Jiang、岡田欣晃、土井健史
    • Organizer
      第81回日本生化学会大会第31回日本分子生物学会年会合同大会(BMB2008)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 超高分解能半導体PETを用いた124I-iomazenilによるラット脳中枢性ベンゾジアゼピン受容体分布の画像化およびin vivoにおける基礎的検討2008

    • Author(s)
      金井泰和,船木善仁,山崎浩道,菊池洋平,松山成男,高沢正志、今泉昌男、中村賢治,中沢浩一,下瀬川恵久,石井慶造,畑澤順
    • Organizer
      第86回放射性医薬品・画像診断薬研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 超高分解能半導体PETを用いた^<124>I-iomazenilによるラット脳中枢性ベンゾジアゼピン受容体分布の画像化およびin vivoにおける基礎的検討2008

    • Author(s)
      金井泰和, 船木善仁, 山崎浩道, 菊池洋平, 松山成男, 高沢正志、今泉昌男、中村賢治, 中沢浩一, 下瀬川恵久, 石井慶造, 畑澤順
    • Organizer
      第8回放射性医薬品・画像診断薬研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規MRI腫瘍造影剤を目指したPEG化金磁性ナノ粒子の創製2008

    • Author(s)
      小島拓記、亀井数正、向洋平、森田将史、犬伏俊郎、清野智史、山本孝夫、吉岡靖雄、岡田直貴、中川晋作
    • Organizer
      ファーマ・バイオフォーラム2008
    • Place of Presentation
      東京
    • Year and Date
      2008-11-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 気相式C-11ヨウ化メチル合成装置の使用状況(液相式との比較)2008

    • Author(s)
      金井泰和
    • Organizer
      第14回サイプリス技術交流会
    • Place of Presentation
      千葉
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生体内利用に適した金/酸化鉄磁性複合ナノ粒子の放射線合成2008

    • Author(s)
      清野智史, 柴田雄仁, 山中誠之, 上野浩二, 山本孝夫
    • Organizer
      第32回日本磁気学会学術講演会
    • Place of Presentation
      宮城
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 金磁性ナノ粒子が可能とする新規遺伝子導入法2008

    • Author(s)
      小島拓記、吉川友章、亀井数正、清野智史、山本孝夫、吉岡靖雄、岡田直貴、向洋平、中川晋作
    • Organizer
      遺伝子・デリバリー研究会第8回夏季セミナー
    • Place of Presentation
      神戸
    • Year and Date
      2008-08-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規腫瘍MR造影剤の開発を目指したPEG化金磁性ナノ粒子の創製2008

    • Author(s)
      亀井数正, 向洋平, 小島石記, 森田将史, 犬伏俊郎, 清野智史, 山本孝夫, 吉岡靖雄, 岡田直貴, 中川晋作
    • Organizer
      第24回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 金磁性ナノ粒子が可能とする遺伝子導入技術の確立2008

    • Author(s)
      小島拓記, 向洋平, 亀井数正, 吉川友章, 吉岡靖雄, 清野智史, 山本孝夫, 岡田直貴, 中川晋作
    • Organizer
      第24回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Synthesis of^124I-iomazenil and imaging of central benzodiazepine receptor distribution in rat brain by means of semiconductor high resolution animal PET scanner.2008

    • Author(s)
      Kanai Y, Yamazaki H, Funaki Y, Matsuyama S, Kikuchi Y, Sakamaki M, Shimosegawa E, Ishii K, Hatazawa J
    • Organizer
      第55回米国核医学会議
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2008-06-14
    • Related Report
      2010 Final Research Report
  • [Presentation] FDG-PET Is More Accurate Than CT/MRI for Evaluating Therapy Response in Patients with Malignant Lymphoma2008

    • Author(s)
      Isohashi K, Tatsumi M, Higuchi I, Inoue A, Nakajyo K, Shimosegawa E, Nakamura H. Hatazawa J.
    • Organizer
      第55回米国核医学会議
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Synthesis of ^<124>I-iomazenil and imaging of central benzodiazepine receptor distribution in rat brain by means of semiconductor high resolution animal PET scanner2008

    • Author(s)
      Kanai Y, Yamazaki H, Funaki Y, Matsuyama S, Kikuchi. Y, Sakamaki M, Shimosegawa E, Ishii K, Hatazawa J.
    • Organizer
      第55回米国核医学会議
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Simultaneous Measurements Using Multi-slice Dual Layer DOIPET/MRI System : First Small Animal Studies2008

    • Author(s)
      Imaizumi M, Yamamoto S, Kanai Y. Hasegawa Y,Higuchi I, Takasawa M, Aoki M, Sugiyama E, Shimosegawa E. Hatazawa J.
    • Organizer
      第55回米国核医学会議
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Metallic artifacts of CT caused by dental metal prostheses on the oral cavity : A PET/CT phantom study2008

    • Author(s)
      Shimamoto H, Kakimoto N, Fujino K, Hamada S, Shimosegawa E, Murakami S, Furukawa S, Hatazawa J.
    • Organizer
      第94回北米放射線学会議
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新しいPET用薬剤を立ち上げるために=大阪大学医学部付属病院の場合=2008

    • Author(s)
      金井泰和
    • Organizer
      PET chemical work shop 2008
    • Place of Presentation
      神戸
    • Year and Date
      2008-02-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Difference of the methylation pattern of the Robo 4 promoter between endothelial cell and non-endothelial cell2008

    • Author(s)
      Yoshiaki Okada, Nobuaki Funahashi, Yoshihiro Kano, Hiroki Naruse, Zhixia Jiang, Enjing Jin, Kiichiro Yano, William Aird, Takefumi Doi
    • Organizer
      The 6^<th> Korea Japan Joint Symposium on Vascular Biology and The 16th Annual Meeting of the Japan Vascular Biology and Medicine Organization JOINT MEETING
    • Place of Presentation
      金沢
    • Related Report
      2008 Annual Research Report
  • [Presentation] 放射線を利用した複合ナノ粒子合成における高分子の影響2008

    • Author(s)
      宮川雅洋, 清野智史, 上野浩二, 小嶋崇夫, 中川貴, 山本孝夫
    • Organizer
      日本原子力学会2008年秋の大会
    • Place of Presentation
      高知
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生体内応用をめざした金/酸化鉄複合ナノ粒子の放射線合成2008

    • Author(s)
      山中誠之, 清野智史, 柴田雄仁, 上野浩二, 山本孝夫
    • Organizer
      ナノ学会第6回大会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] 超高分解型半導体PETと18F-FDGを用いたラット脳微細構造の画像化2008

    • Author(s)
      高沢正志, 桃崎壮太郎, 山嵜洋一, 金井泰和, 今泉昌男, 細井理恵, 谷崎直昭, 村瀬研也, 井上修, 石井慶造, 下瀬川恵久, 畑澤順
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] 動物PET定量測定のための2層薄膜GSO小型高感度ポジトロン検出器の開発と評価2008

    • Author(s)
      高沢正志、山本誠一、坂本祐輔、湊小太郎、金井泰和、今泉昌男、下瀬川恵久、畑澤順
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] C-11 methionine PETを用いた膠芽腫に対するWT1免疫療法の評価2008

    • Author(s)
      小川洋二、樋口一郎、礒橋佳也子、中城和也、巽光朗、下瀬川恵久、畑澤順
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小動物用DOI型マルチスライスPET-MRI装置による同時計測 : ラット頭部イメージング2008

    • Author(s)
      今泉昌男、山本誠一、金井泰和、長谷川雪憲、樋口一郎、高沢正志、青木雅昭、杉山英二、川上誠、下瀬川恵久、畑澤順
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] 広視野高分解能3D-PETによる無動脈採血脳循環測定 : 1. 内頸動脈放射能値による時間放射能曲線作成2008

    • Author(s)
      下瀬川恵久、水田哲郎、藤埜浩一、北村圭司、畑澤順
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] 広視野高分解能3D-PETによる無動脈採血脳循環測定 : 3.従来法との比較および正常値2008

    • Author(s)
      下瀬川恵久、水田哲郎、藤埜浩一、北村圭司、今泉昌男、高沢正志、加藤弘樹、畑澤順
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] I-123 iomazenil SPECT画像のSPM解析における部分容積効果補正の必要性について2008

    • Author(s)
      加藤弘樹、下瀬川恵久、木村泰之、梶本勝文、田中真希子、今泉昌男、高沢正志、畑澤順
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] FDG-PETを用いた食道癌手術適応症例の選択〜PETによるN診断と予後の比較から2008

    • Author(s)
      樋口一郎、井上敦夫、巽光朗、下瀬川恵久、畑澤順
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨盤内悪性腫瘍に対するPET/MRI Fusionの有用性2008

    • Author(s)
      中城和也、巽光朗、井上敦夫、金東石、大西裕満、礒橋佳也子、樋口一郎、小川洋二、下瀬川恵久、畑澤順
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] 動物用PET/MRI一体型装置の開発 : 基礎的検討と初期データ2008

    • Author(s)
      畑澤順、山本誠一、青木雅昭、川上誠、杉山英二、下瀬川恵久、勝山義昭
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] [^<124>I]iomazenilのPET用薬剤としての基礎的検討2008

    • Author(s)
      金井泰和, 船木善仁, 山崎浩道, 菊池洋平, 松山成男, 中村賢治, 中沢浩一, 下瀬川恵久, 石井慶造, 畑澤順
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] 超高分解能半導体PETと18F-FDGを用いたラット脳微細構造のin vivo糖代謝イメージング2008

    • Author(s)
      高沢正志, 桃崎壮太郎, 山嵜洋一, 金井泰和, 今泉昌男, 細井理恵, 谷崎直昭, 村瀬研也, 井上修, 石井慶造, 下瀬川恵久, 畑澤順
    • Organizer
      第20回日本脳循環代謝学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] ^<11>C-酢酸PETによる脳グリア細胞のエネルギー代謝イメージング-in vitro, in-vivoでの評価2008

    • Author(s)
      梶本勝文、佐々木勉、畑澤順
    • Organizer
      第20回日本脳循環代謝学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小動物用PET-MRI装置によるラット脳イメージング2008

    • Author(s)
      今泉昌男、山本誠一、金井泰和、樋口一郎、高沢正志、加藤弘樹、青木雅昭、杉山英二、川上誠、勝山義昭、巽光朗、下瀬川恵久、畑澤順
    • Organizer
      第20回日本脳循環代謝学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳酸素摂取率の上昇にはなぜ上限があるのか? 一脳血流と有効酸素拡散能からの検討2008

    • Author(s)
      下瀬川恵久、藤井歩、今泉昌男、高沢正志、加藤弘樹、畑澤順
    • Organizer
      第20回日本脳循環代謝学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] I-123 iomazenil SPECT画像の統計画像解析における部分容積効果の影響とその補整の必要性について2008

    • Author(s)
      加藤弘樹、下瀬川恵久、今泉昌男、高沢正志、木村泰之、梶本勝文、田中真希子、北川一夫、畑澤順
    • Organizer
      第20回日本脳循環代謝学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 超高分解能半導体PETと^<124>I-iomazenilによるラット脳中枢性ベンゾジアゼピン受容体分布の画像化2008

    • Author(s)
      金井泰和, 船木善仁, 山崎浩道, 菊池洋平, 松山成男, 中村賢治, 中沢浩一, 下瀬川恵久, 石井慶造, 畑澤順
    • Organizer
      第20回日本脳循環代謝学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳血管拡張剤アセタゾラミドによる脳血流変化の局所差について2008

    • Author(s)
      鉾之原健太郎、下瀬川恵久、藤井歩、井上裕之、今泉昌男、加藤弘樹、高沢正志、畑澤順
    • Organizer
      第20回日本脳循環代謝学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラットにおけるプラナーポジトロンイメージング装置による^<11>C-Phenytoinの薬物動態評価2008

    • Author(s)
      長谷川雪憲、金井泰和、三宅義徳、倉智嘉久、今泉昌男、高沢正志、下瀬川恵久、畑澤順
    • Organizer
      第67回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] 悪性黒色腫の再発/転移診断における^<18>F-FDG PET-CTの役割2008

    • Author(s)
      礒橋佳也子、巽光朗、種村篤、樋口一郎、井上敦夫、中城和也、下瀬川恵久、片山一朗、中村仁信、畑澤順
    • Organizer
      第67回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] PET用核種としての超高分解能半導体PET(Fine-PET)を用いた^<124>Iの評価および基礎的な検討2008

    • Author(s)
      金井泰和, 船木善仁, 山崎浩道, 菊池洋平, 中村賢治, 中沢浩一, 下瀬川恵久, 石井慶造, 畑澤順
    • Organizer
      第29回サイクロトロン共同利用実験研究報告会
    • Place of Presentation
      仙台
    • Related Report
      2008 Annual Research Report
  • [Presentation]

    • Author(s)
      岡田欣晃、金恩京、北山美絵、舟橋伸昭
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks] 大阪大学研究者総覧(向洋平)

    • URL

      http://www.dma.jim.osaka-u.ac.jp/kg-portal/aspI/RX0011D.asp?UNO=15207&page=1

    • Related Report
      2010 Final Research Report
  • [Remarks] 大阪大学研究者総覧向洋平

    • URL

      http://www.dma.jim.osaka-u.ac.jp/kg-portal/aspI/RX0011D.asp?UNO=15207&page=1

    • Related Report
      2010 Annual Research Report
  • [Remarks] 大阪大学研究者総覧 向洋平

    • URL

      http://www.dma.jim.osaka-u.ac.jp/kg-portal/aspI/RX0011D.asp?UNO=15207&page=1

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] MRI造影剤2010

    • Inventor(s)
      向洋平、清野智史、森田将史、中川貴、中川晋作
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      2010-041460
    • Filing Date
      2010
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2018-03-28  

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