| Project/Area Number |
20200021
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General human life sciences
Hygiene
|
|---|
| Research Institution | Chubu University |
|---|
Principal Investigator |
ICHIHARA Masatoshi Chubu University, 生命健康科学部, 教授 (00314013)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Tamaki 中部大学, 生命健康科学部, 助手 (90392018)
MURAKUMO Yoshiki 名古屋大学, 大学院・医学系研究科, 准教授 (40324438)
MASUDA Akio 名古屋大学, 大学院・医学系研究科, 助教 (10343203)
YONEDA Makoto 福井大学, 医学部, 准教授 (70270551)
|
|---|
| Research Collaborator |
OHNO Kinji 名古屋大学, 大学院・医学系研究科, 教授 (80397455)
ITO Masafumi 岐阜県国際バイオ研究所, 部長 (80393114)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2009: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2008: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
|
|---|
| Keywords | 住環境 / 分子状水素 / 活性酸素 / 酸化ストレス / ヒドロキシラジカル / パーキンソン病 |
|---|
| Research Abstract |
Recent studies demonstrated that molecular hydrogen functions as a novel antioxidant. We examined whether molecular hydrogen attenuates disease progression using model animals such as Parkinson disease, allergic reaction, liver damage by bacterial toxin and others and found that molecular hydrogen is effective for a wide variety of diseases including inflammatory diseases in which oxidative stress is not a major cause of the pathogenesis. We also found that hydrogen slightly extended the lifespan in C. elegans under 60% oxygen condition. DNA microarray analysis revealed that short-lasting hydrogen exposure by hydrogen-rich water induced more significant change in gene expression in the liver tissue. These results suggest that intermittent administration of hydrogen in living environment may serve as a new approach for health maintenance.
|
