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Measurement and Numerical Modeling of the Characteristics of Red Blood Cell Suspended in Fluid Under Uniform Magnetic Field

Research Project

Project/Area Number 20200026
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)

Allocation TypeSingle-year Grants
Research Field Thermal engineering
Microdevices/Nanodevices
Research InstitutionKyoto University

Principal Investigator

TATSUMI Kazuya  Kyoto University, 大学院・工学研究科, 准教授 (90372854)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥34,970,000 (Direct Cost: ¥26,900,000、Indirect Cost: ¥8,070,000)
Fiscal Year 2010: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2009: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2008: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Keywords赤血球 / マイクロ流路 / 強磁場 / 数値解析 / 計算モデル / マイクロ電気センサ / 数値解析モデル / 配向運動 / 回転トルク / 3次元連成解析 / 異方的磁化率 / 変形能
Research Abstract

Experimental technology that can measure the magnetic and electric characteristics of a single red blood cell (RBC) suspended in a fluid exposed under strong magnetic field using high-speed camera, microchannels, micro-electric sensors was developed in this study. Further, a novel fluid temperature measurement in microchannels using fluorescent polarization method was also developed. By using these measurement technologies, the RBC motions in fluids under magnetic field of 0-10 Tesla could be analyzed. The measurement data was further used to develop a numerical model that can directly simulate the physics of the magnetic effect on the RBC membrane. This model possesses a high general versatility to simulate three-dimensional RBC motion in fluids and can be applied to a biologic numerical simulator.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (43 results)

All 2011 2010 2009 2008

All Journal Article (20 results) (of which Peer Reviewed: 19 results) Presentation (23 results)

  • [Journal Article] Numerical Investigation on Fluid Flow and Heat Transfer Characteristics in a Peristaltic Micro Pump2011

    • Author(s)
      K.Tatsumi, R.Kuroki, M.Nakamura, K.Nakabe
    • Journal Title

      Progress in Computational Fluid Dynamics (in printing)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Numerical Investigation on Fluid Flow and Heat Transfer Characteristics in a Peristaltic Micro Pump2011

    • Author(s)
      K.Tatsumi, R.Kuroki, M.Nakamura, K.Nakabe
    • Journal Title

      Progress in Computational Fluid Dynamics

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Numerical Modeling of Red Blood Cell Suspended in a Channel with Uniform Magnetic Field2011

    • Author(s)
      K.Tatsumi, R.Kuroki, K.Nishitani, T.Arakawa, K.Nakabe
    • Journal Title

      Proc.ASME-JSME-KSME Joint Fluids Engineering Conference

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Motion of Red Blood Cell in Stationary Fluid under Uniform Magnetic Field2011

    • Author(s)
      K.Tatsumi, Y.Nishitani, K, Fukuda, K.Katsumoto, K.Nakabe
    • Journal Title

      Proc.3^<rd> Int.Symposium on Computational Heat Transfer and Fluid Flow (ASCHT-2011)

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microscopic Fluid Temperature Measurements using Fluorescence Polarization Method2011

    • Author(s)
      K.Tatsumi, A.Tozaki, K.Nakabe
    • Journal Title

      Proc.ASME/JSME 8th Thermal Engineering Joint Conference (AJTEC2011)

      Volume: Vol.1

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurements of Electroosmotic Flow Velocity and Electric Field in Micro-channels using PIV2010

    • Author(s)
      K.Tatsumi, Y.Nishitani, K.Fukuda, K.Katsumoto, K.Nakabe
    • Journal Title

      Measurements Science and Technology Vol.21, No.10

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrical Classification of Single Red Blood Cell Deformability in High Shear Rate Micro-Channel Flows2010

    • Author(s)
      Y.Katsumoto, K.Tatsumi, T.Doi, K.Nakabe
    • Journal Title

      International Journal of Heat and Fluid Flow Vol.31, No.6

      Pages: 985-995

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrical Classification of Single Red Blood Cell Deformability in High Shear Rate Micro-Channel Flows2010

    • Author(s)
      Y.Katsumoto, K.Tatsumi, T.Doi, K.Nakabe
    • Journal Title

      International Journal of Heat and Fluid Flow

      Volume: Vol.31, No.6 Pages: 985-995

    • Related Report
      2010 Annual Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurements of Electroosmotic Flow Velocity and Electric Field in Micro-channels using PIV2010

    • Author(s)
      K.Tatsumi, Y.Nishitani, K.Fukuda, K.Katsumoto, K.Nakabe
    • Journal Title

      Measurements Science and Technology

      Volume: Vol.21, No.10

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Swirl and Buoyancy Effects on Mixing Performance of a Baffle-Plate-Type Miniature Confined Multi-Jet2010

    • Author(s)
      K.Tatsumi, M.Tanaka, P.L.Woodfield, K.Nakabe
    • Journal Title

      International Journal of Heat and Fluid Flow 31-1

      Pages: 45-56

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flow and Heat Transfer Characteristics of a Channel with Cut-fins2010

    • Author(s)
      K.Tatsumi, M.Yamaguchi, Y.Nishio, K.Nakabe
    • Journal Title

      Journal of Enhanced Heat Transfer 17-2

    • NAID

      110006367694

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高剪断マイクロ流れと電気的測定を用いた赤血球変形能の評価2009

    • Author(s)
      勝本洋一, 巽和也, 土井立樹, 中部主敬
    • Journal Title

      日本機械学会論文集(B編) Vol.75, No.759

      Pages: 2215-2224

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] PIVを用いたマイクロ流路内の電気浸透流速度と電場強度計測2009

    • Author(s)
      巽和也, 福田啓介, 勝本洋一, 中部主敬
    • Journal Title

      日本機械学会論文集(B編) Vol.75, No.750

      Pages: 251-258

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Numerical Study on Fluid Flow Characteristics of Peristaltic Pump, International Journal of Heat and Fluid Flow2009

    • Author(s)
      K.Tatsumi, Y.Matsunaga, Y.Miwa, K.Nakabe
    • Journal Title

      Progress of Computational Fluid Dynamics Vol.9

      Pages: 176-182

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高剪断マイクロ流れと電気的測定を用いた赤血球変形能の評価2009

    • Author(s)
      勝本洋一, 巽和也, 土井立樹, 中部主敬
    • Journal Title

      日本機械学会論文集,B編 75-759

      Pages: 2215-2224

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurements of Human Red Blood Cell Deformability in Micro-channel Using Electric Sensors2009

    • Author(s)
      Y.Katsumoto, K.Tatsumi, T.Doi, K.Nakabe
    • Journal Title

      Proc.of International Conference on Miniaturized Systems for Chemistry and Life Sciences MicroTAS 1

      Pages: 424-426

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Red Blood Cell Deformability Sensing System using Electric Sensors and Micro-channels2009

    • Author(s)
      K.Tatsumi, Y.Katsumoto, T.Doi, K.Nishitani, K.Nakabe
    • Journal Title

      Proc.9th Kyoto-Seoul National-Tsinghua University Thermal Engineering Conference 1

      Pages: 173-176

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Electrical. Classification of Single Red Blood Cell Deformability in High Shear Micro-Channel Flows2009

    • Author(s)
      Y.Katsumoto, K.Tatsumi, T.Doi, K.Nakabe
    • Journal Title

      Proc.of 7th World Conference on Experimental Heat Transfer, Fluid Mechanics and Thermodynamics 1

      Pages: 201-208

    • NAID

      120002661527

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Numerical Study on Fluid Flow Characteristics of Peristaltic Pump2009

    • Author(s)
      K.Tatsumi, Y.Matsunaga, Y.Miwa, K.Nakabe
    • Journal Title

      Progress of Computational Fluid Dynamics 9

      Pages: 176-182

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PIVを用いたマイクロ流路内の電気浸透流速度と電場強度計測2009

    • Author(s)
      巽和也, 福田啓介, 勝本洋一, 中部主敬
    • Journal Title

      日本機械学会論文集,B編 75

      Pages: 251-258

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Microscopic Fluid Temperature Measurements using Fluorescence Polarization Method2011

    • Author(s)
      K.Tatsumi, A.Tozaki, K.Nakabe
    • Organizer
      ASME/JSME 8^<th> Thermal Engineering Joint Conference (AJTEC2011)
    • Place of Presentation
      Honolulu USA
    • Year and Date
      2011-03-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Numerical and Experimental Study on Measurement of a Single Red Blood Cell Deformability using a Microchannel and Electric Sensors2011

    • Author(s)
      R.Fujiwara, K.Tatsumi, Y.Katsumoto, K.Nakabe
    • Organizer
      3rd Int.Symposium on Computational Heat Transfer and Fluid Flow (ASCHT-2011)
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Final Research Report
  • [Presentation] Motion of Red Blood Cell in Stationary Fluid under Uniform Magnetic Field2011

    • Author(s)
      Y.Komori, T.Arakawa, K.Nishitani, K.Tatsumi, K.Nakabe
    • Organizer
      3rd Int.Symposium on Computational Heat Transfer and Fluid Flow (ASCHT-2011)
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Final Research Report
  • [Presentation] Numerical Modeling of Red Blood Cell Suspended in a Channel with Uniform Magnetic Field2011

    • Author(s)
      K.Tatsumi, R.Kuroki, K.Nishitani, T.Arakawa, K.Nakabe
    • Organizer
      ASME-JSME-KSME Joint Fluids Engineering Conference (AJK2011)
    • Place of Presentation
      Hamamatsu
    • Related Report
      2010 Final Research Report
  • [Presentation] Microscopic Fluid Temperature Measurements using Fluorescence Polarization Method2011

    • Author(s)
      K.Tatsumi, A.Tozaki, K.Nakabe
    • Organizer
      ASME/JSME 8th Thermal Engineering Joint Conference (AJTEC2011) pp.AJTEC2011 44461
    • Place of Presentation
      Honolulu
    • Related Report
      2010 Final Research Report
  • [Presentation] Microscopic Fluid Temperature Measurements in Channels using Fluorescence Polarization Method2010

    • Author(s)
      K.Tatsumi, A.Tozaki, K.Nakabe
    • Organizer
      10th Kyoto-Seoul National-Tsinghua University Thermal Engineering Conference
    • Place of Presentation
      Beijin Chaina
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 一様磁場下の流路内赤血球運動に関する数値解析2010

    • Author(s)
      巽和也, 黒木遼, 荒川智樹, 中部主敬
    • Organizer
      日本機械学会2009年度年次大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-09-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロ蛍光偏光法を用いた流路内の流体温度計測(第2報)2010

    • Author(s)
      遠崎晃久, 巽和也, 中部主敬
    • Organizer
      第47回日本伝熱シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Microscopic Fluid Temperature Measurements in Channels using Fluorescence Polarization Method2010

    • Author(s)
      K.Tatsumi, A.Tozaki, K.Nakabe
    • Organizer
      10th Kyoto-Seoul National-Tsinghua University Thermal Engineering Conference pp.173-176
    • Place of Presentation
      Beijin
    • Related Report
      2010 Final Research Report
  • [Presentation] 一様磁場下の流路内赤血球運動に関する数値解析2010

    • Author(s)
      巽和也, 黒木遼, 荒川智樹, 中部主敬
    • Organizer
      日本機械学会2010年度年次大会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] Measurements of Human Red Blood Cell Deformability in Micro-channel Using Electric Sensors2009

    • Author(s)
      Y.Katsumoto, K.Tatsumi, T.Doi, K.Nakabe
    • Organizer
      International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2009)
    • Place of Presentation
      Jeju(大韓民国)
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Red Blood Cell Deformability Sensing System using Electric Sensors and Micro-channels2009

    • Author(s)
      K.Tatsumi, Y.Katsumoto, T.Doi, K.Nishitani, K.Nakabe
    • Organizer
      9th Kyoto - Seoul National - Tsinghua University Thermal Engineering Conference
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-10-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Numerical Study on Flow and Heat Transfer Characteristics of Peristaltic Pump2009

    • Author(s)
      R.Kuroki, K.Tatsumi, M.Nakamura, K.Nakabe
    • Organizer
      2nd Asian Symposium on Computational Heat Transfer and Fluid Flow
    • Place of Presentation
      Jeju(大韓民国)
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] テスラバルブ内流れの指向性向上に及ぼす流路形状の検討2009

    • Author(s)
      今荘和也, 巽和也, Sonny H.Winoto, 中部主敬
    • Organizer
      日本機械学会2009年度年次大会
    • Place of Presentation
      盛岡
    • Year and Date
      2009-09-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Electrical Classification of Single Red Blood Cell Deformability in High Shear Micro-Channel Flows2009

    • Author(s)
      Y.Katsumoto, K.Tatsumi, T.Doi, K.Nakabe
    • Organizer
      7th World Conference on Experimental Heat Transfer, Fluid Mechanics and Thermodynamics (ExHFT-7)
    • Place of Presentation
      Krakow (ポーランド)
    • Year and Date
      2009-06-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蠕動運動型ポンプの熱流動特性に関する数値解析(第3報)2009

    • Author(s)
      黒木遼, 巽和也, 中部主敬
    • Organizer
      第46回日本伝熱シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2009-06-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] マイクロ蛍光偏光法を用いた流路内の流体温度計測2009

    • Author(s)
      遠崎晃久, 巽和也, 中部主敬
    • Organizer
      熱工学コンファレンス2009
    • Place of Presentation
      山口
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Numerical Study on Flow and Heat Transfer Characteristics of Peristaltic Pump2009

    • Author(s)
      R.Kuroki, K.Tatsumi, M.Nakamura, K.Nakabe
    • Organizer
      2nd Asian Symposium on Computational Heat Transfer and Fluid Flow
    • Place of Presentation
      Jeju
    • Related Report
      2010 Final Research Report
  • [Presentation] Measurements of Human Red Blood Cell Deformability in Micro-channel Using Electric Sensors2009

    • Author(s)
      Y.Katsumoto, K.Tatsumi, T.Doi, K.Nakabe
    • Organizer
      International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2009) pp.424-426
    • Place of Presentation
      Jeju
    • Related Report
      2010 Final Research Report
  • [Presentation] 高せん断マイクロ流路内流れにおける赤血球変形能の電気的計測(第2報)2009

    • Author(s)
      西谷幸祐, 土井立樹, 勝本洋一, 巽和也, 中部主敬
    • Organizer
      日本機械学会2009年度年次大会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Red Blood Cell Deformability Sensing System using Electric Sensors and Micro-channels2009

    • Author(s)
      K.Tatsumi, Y.Katsumoto, T.Doi, K.Nishitani, K.Nakabe
    • Organizer
      9th Kyoto-Seoul National-Tsinghua University Thermal Engineering Conference pp.173-176
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Final Research Report
  • [Presentation] Electrical Classification of Single Red Blood Cell Deformability in High Shear Micro-Channel Flows2009

    • Author(s)
      Y.Katsumoto, K.Tatsumi, T.Doi, K.Nakabe
    • Organizer
      7th World Conference on Experimental Heat Transfer, Fluid Mechanics and Thermodynamics (ExHFT-7) pp.201-208
    • Place of Presentation
      Krakow
    • Related Report
      2010 Final Research Report
  • [Presentation] 蠕動運動型マイクロポンプ内流れにおける赤血球挙動に関する数値解析2008

    • Author(s)
      中村真彦, 黒木遼, 巽和也, 中部主敬
    • Organizer
      第21回日本機械学学会算力学講演会
    • Place of Presentation
      那覇
    • Year and Date
      2008-11-01
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2018-03-28  

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