Development of Selective Modulators for Autophagic Cell Death and Novel Chemotherapeutic Strategy for Leukemia
Project/Area Number |
20200038
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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Allocation Type | Single-year Grants |
Research Field |
Drug development chemistry
Living organism molecular science
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Research Institution | Kumamoto University |
Principal Investigator |
KUNIYASU Akihiko Kumamoto University, 大学院・生命科学研究部, 准教授 (90241348)
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Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Makoto 北海道大学, 大学院・農学研究院, 准教授 (90292094)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥33,540,000 (Direct Cost: ¥25,800,000、Indirect Cost: ¥7,740,000)
Fiscal Year 2010: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2008: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
|
Keywords | 医薬分子機能学 / 分子認識 / 生体機能利用 / 生体分子 / 薬学 |
Research Abstract |
We developed a hybrid peptide, which induces leukemia cell death associated with autophagy. The mode of cell death induced with this peptide is different from previously recognized apoptosis. Further, the length of peptide sequence was shortened by analyzing active motif of the peptide. The hybrid peptide will be a useful tool for development of novel concept-based anti-leukemia agents.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Targeting neuropilin-1 in human leukemia and lymphoma.2011
Author(s)
Karjalainen K., Jaalouk D.E., Bueso- Ramos C.E., Zurita A.J., Kuniyasu A., Lichtiger B., O'Brien S., Kantarjian H.M., Cortes J.E., Koivunen E., Arap W., Pasqualini R.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Targeting neuropilin-1 in human leukemia and lymphoma.2011
Author(s)
Karjalainen K., Jaalouk DE., Bueso-Ramos CE., Zurita AJ., Kuniyasu A., Lichtiger B., O'Brien S., Kantarjian HM., Cortes JE., Koivunen E., Arap W., Pasqualini R.
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Journal Title
Blood
Volume: 117
Pages: 920-927
Related Report
Peer Reviewed
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[Journal Article] Interconversion between pure chemotactic ligands and chemoattractant/secretagogue ligands of neutrophil C5a receptor by a single amino acid substitution.2010
Author(s)
Jia, N., Semba, U., Nishiura, H., Kuniyasu, A., Nsiama, T.K., Nishino, N., Yamamoto, T.
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Journal Title
J.Leukoc.Biol. 87
Pages: 965-975
Related Report
Peer Reviewed
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[Journal Article] Interconversion between pure chemotactic ligands and chemoattractant/secretagogue ligands of neutrophil C5a receptor by a single amino acid substitution.2010
Author(s)
Jia, N., Semba, U., Nishiura, H., Kuniyasu, A., Nsiama, T.K., Nishino, N., Yamamoto, T.
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Journal Title
J.Leukoc.Biol.
Volume: 87
Pages: 965-975
Related Report
Peer Reviewed
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[Journal Article] Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain β -amyloid Pharm.2009
Author(s)
Kawahara K., Nishi K., Suenobu M., Ohtsuka H., Maeda A., Nagatomo K., Kuniyasu A., Staufenbiel M., Nakagomi M., Shudo K., Nakayama H.
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Journal Title
Bull. 32
Pages: 1307-1309
Related Report
Peer Reviewed
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[Journal Article] A synthetic approach to develop peptide inhibitors selective for brain-type sodium channels on the basis of pompilidotoxin structure2009
Author(s)
Yokote S., Setoguchi R., Shimizu E., Mishima N., Kawahara K., Kuniyasu A., Shirasaki S., Takahama K., Konno K., Kawai N., Yamaoka K., Kinoshita E., Nakayama H.
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Journal Title
Heterocycles 79
Pages: 925-933
NAID
Related Report
Peer Reviewed
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[Journal Article] Oral administration of syntetic retinoid Am80 (Tamibarotene) decreases brainbeta-amyloid peptides in APP23 mice.2009
Author(s)
Kawahara K, Nishi K, Suenobu M, Ohtsuka H, Maeda A, Nagatomo K, Kuniyasu A, Staufenbiel M, Nakagomi M, Shudo K, Nakayama H
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Journal Title
Biol.Pharm.Bull. 32
Pages: 1307-1309
Related Report
Peer Reviewed
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[Journal Article] Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells2008
Author(s)
Hirayama C., Watanabe H., Nakashima R., Nanbu T., Hamada A., Kuniyasu A., Nakayama H., Kawaguchi T., Saito H.
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Journal Title
Pharm.Res. 25
Pages: 827-835
Related Report
Peer Reviewed
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[Journal Article] Combinatorial targeting of the macropinocytotic pathway in leukemia and lymphoma cells2008
Author(s)
Nishimura S., Takahashi S., Kamikatahira H., Kuroki Y., Jaalouk DE., O'Brien S., Koivunen E., Arap W., Pasqualini R., Nakayama H., Kuniyasu A.
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Journal Title
J.Biol.Chem. 283
Pages: 11752-11762
Related Report
Peer Reviewed
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