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Research for changes of genetic diversity after the 1492 Columbus Day in Mesoamericans

Research Project

Project/Area Number 20200041
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)

Allocation TypeSingle-year Grants
Research Field Physical anthropology
Archaeology
Research InstitutionToho University

Principal Investigator

KUROSAKI Kunihiko  東邦大学, 医学部, 教授 (60240701)

Co-Investigator(Kenkyū-buntansha) KUROSAKI Naoko  千葉工業大学, 工学部, 教授 (60337706)
Co-Investigator(Renkei-kenkyūsha) UEDA Shintaro  東京大学, 理学研究科, 教授 (20143357)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000)
Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2009: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2008: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords分子・遺伝 / 考古学一般 / 新大陸 / 集団遺伝学 / 分子ウイルス学 / ハプログループ / ミトコンドリアDNA / 中米先住民 / 古人骨 / B型肝炎ウイルス / メキシコ
Research Abstract

Teotihuacan was a mega-state in ancient Mesoamerica, but there are many uncertainties about its community and history owing to undeciphered writing system. To investigate its society through the genetic origins of individuals offered as sacrifices, we analyzed mitochondrial DNA of sacrifices of the Moon Pyramid at Teotihuacan. The Moon Pyramid sacrifices comprise some individuals with rare haplogroups: haplogroup A with a 9-bp deletion and haplogroup X. Based on the distribution of these rare haplogroups within the vicinity of Teotihuacan, we discuss this mega-state sphere of influence, possibly indicating it expanded from southwestern North America to the entire area of Mesoamerica.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (9 results)

All 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (2 results)

  • [Journal Article] Existence of a threshold for hydroxyl radical generation independent of hypoxia in rat striatum during carbon monoxide poisoning2011

    • Author(s)
      S. Hara, H. Mizukami, K. Kurosaki, F. Kuriiwa, T. Mukai
    • Journal Title

      Arch Toxicol

      Volume: 85 Pages: 1091-1099

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determination of dextromethorphan in human plasma using pipette tip solid-phase extraction and gas chromatography-mass spectrometry2011

    • Author(s)
      C. Hasegawa, T. Kumazawa, S. Uchigasaki, X-P. Lee, K. Sato, M. Terada, K. Kurosaki
    • Journal Title

      Anal Bioanal Chem

      Volume: 401 Pages: 2215-2223

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 2-Aminophenoxazine-3-one prevents pulmonary metastasis of mouse B16 melanoma cells in mice2010

    • Author(s)
      T. Hongo, N. Miyano-Kurosaki, K. Kurosaki, A. Hata, S. Harigae, A. Tomoda
    • Journal Title

      J Pharmacol Sci

      Volume: 114 Pages: 63-68

    • NAID

      10029889793

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 2-Aminophenoxazine-3-one prevents pulmonary metastasis of mouse B16 melanoma cells in mice.2010

    • Author(s)
      T.Hongo, N.Miyano-Kurosaki, K.Kurosaki, et al.
    • Journal Title

      J.Pharmacol Sci.

      Volume: 114 Pages: 63-68

    • NAID

      10029889793

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anticancer effects of phenoxazine derivatives revealed by inhibition of cell growth and viability, disregulation of cell cycle, and apoptosisinduction in HTLV-1-positive leukemia cells2009

    • Author(s)
      N. Miyano-Kurosaki, K. Ikegami, K. Kurosaki, T. Endo, H. Aoyagi, M. Hanami, J. Yasumoto, A. Tomoda
    • Journal Title

      J Pharmacol Sci

      Volume: 110 Pages: 87-97

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of extracellular ascorbate and iron in hydroxyl radical generation in rat striatum in carbon monoxide poisoning2009

    • Author(s)
      S. Hara, H. Mizukami, T. Mukai, K. Kurosaki, F. Kuriiwa, T. Endo
    • Journal Title

      Toxicology

      Volume: 264 Pages: 69-73

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anticancer effects of phenoxazine derivatives revealed by inhibition of cell growth and viability, disregulation of cell cycle, and apoptosis induction in HTLV-1-positive leukemia cells.2009

    • Author(s)
      N.Miyano-Kurosaki, K.Ikegami K.Kurosaki, et al.
    • Journal Title

      J.Pharmacol Sci. 110

      Pages: 87-97

    • NAID

      10025736745

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] メキシコ先住民族におけるHBV感染および遺伝子型の分析2011

    • Author(s)
      照沼脩、後藤才郎、黒崎久仁彦、植田信太郎、王瀝、Acuna Victor、杉山三郎、山下篤哉、黒崎直子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Related Report
      2010 Final Research Report
  • [Presentation] メキシコ先住民族におけるHBV感染および遺伝子型の分析2011

    • Author(s)
      照沼脩, 後藤才郎, 黒崎久仁彦, 植田信太郎, 王瀝, Acuna Victor, 杉山三郎, 山下篤哉, 黒崎直子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-14
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2018-03-28  

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