Advanced Control of Stereoselectivity and Chemoselectivity Through Supramolecular Chemistry

• Project/Area Number: 20200053
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• Allocation Type: Single-year Grants
• Research Field: Synthetic chemistry; Chemical pharmacy
• Research Institution: 公益財団法人微生物化学研究会・微生物化学研究所 (2010); The University of Tokyo (2008-2009)
• Principal Investigator: KUMAGAI Naoya 公益財団法人微生物化学研究会・微生物化学研究所, 有機合成研究部, 主任研究員 (40431887)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥30,680,000 (Direct Cost: ¥23,600,000、Indirect Cost: ¥7,080,000); Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000); Fiscal Year 2009: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000); Fiscal Year 2008: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
• Keywords: 触媒設計・反応 / 不斉合成 / 動的構造多様性触媒 / 希土類金属 / アミド配位子 / 協奏触媒 / 適時構造変化 / ヘテロキラル集積 / 触媒的不斉Conia-ene反応 / 水素結合 / 適時機能制御型触媒 / 不斉触媒 / 動的構造多様性 / 機能多様性 / 4級炭素構築 / 不斉Mannich型反応 / CDスペクトル / 斉Mannich型反応

Research Abstract

Advanced asymmetric catalysts exhibiting trigger-responsive property and self-assembly capability were developed based on structurally flexible amide-based ligands. These smart catalysts allowed us to link the structural dynamics and functional diversity in asymmetric catalysis.

Research Products

• [Journal Article] Asymmetric Synthesis of Isothiazole Entities Through Cu Catalysis : Direct Catalytic Asymmetric Conjugate Addition of Allyl Cyanide to α,β-Unsaturated Thioamides (2011)
  • Author(s): Yuka Yanagida, Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: Angew.Chem., Int.Ed. in press
  • Peer Reviewed
• [Journal Article] La/Ag Heterobimetallic Catalysis : Catalytic Asymmetric Conia-ene Reaction (2011)
  • Author(s): Akinobu Matsuzawa, Tomoyuki Mashiko, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: Angew. Chem., Int.Ed. in press
  • Peer Reviewed
• [Journal Article] A Simplified Catalytic System for Direct Catalytic Asymmetric Aldol Reaction of Thioamides; Application to an Enantioselective Synthesis of Atorvastatin (2011)
  • Author(s): Yuji Kawato, Mitsutaka Iwata, Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: Tetrahedron in press
  • Peer Reviewed
• [Journal Article] Direct Catalytic Enantio-and Diastereoselective Aldol Reaction of Thioamides (2011)
  • Author(s): Mitsutaka Iwata, Ryo Yazaki, I-Hon Chen, Devarajulu Sureshkumar, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: J.Am.Chem.Soc. 133(14) Pages: 5554-5560
  • NAID: 130006996047
  • Peer Reviewed
• [Journal Article] Cooperative Activation of Alkyne and Thioamide Functionalities; Direct Catalytic Asymmetric Conjugate Addition of Terminal Alkynes to α,β-Unsaturated Thioamides (2011)
  • Author(s): Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: Chem.Asian J. in press
  • Peer Reviewed
• [Journal Article] Enantioselective Synthesis of a GPR40 Agonist AMG 837 via inal Alkyne to α,β-Unsaturated Thioamide (2011)
  • Author(s): Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: Org.Lett. 13(5) Pages: 952-955
  • Peer Reviewed
• [Journal Article] Catalytic Asymmetric Hydroxylation of α-Alkoxycarbonyl Amides with a Pr(OiPr)3 /Amide-Based Ligand Catalyst (2011)
  • Author(s): Sho Takechi, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: Tetrahedron Lett. 52(17) Pages: 2140-2143
  • Peer Reviewed
• [Journal Article] Catalytic Asymmetric Amination of N-Nonsubstituted α-Alkoxycarbonyl Amides : Concise Enantioselective Total Synthesis of Mycestericin F and G (2011)
  • Author(s): Farouk Berhal, Sho Takechi, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: Chem.Eur.J. 17(6) Pages: 1915-1921
  • Peer Reviewed
• [Journal Article] Direct Catalytic Enantio- and Diastereoselective Aldol Reaction of Thioamides (2011)
  • Author(s): Mitsutaka Iwata, Ryo, 他
  • Journal Title: J.Am.Chem.Soc Volume: 133 Pages: 5554-5560
  • Peer Reviewed
• [Journal Article] Recent Advances in Direct Catalytic Asymmetric Transformations Under Proton Transfer Conditions (2011)
  • Author(s): Naoya Kumagai, 他
  • Journal Title: Angew.Chem., Int.Ed Volume: 50 Pages: 4760-4772
  • Peer Reviewed
• [Journal Article] Development of Atom-Economical Catalytic Asymmetric Reactions Under Proton Transfer Conditions : Construction of Tetrasubstituted Stereogenic Centers and Their Application to Therapeutics (2011)
  • Author(s): Naoya Kumagai
  • Journal Title: Chem.Pharm.Bull Volume: 59 Pages: 1-22
  • NAID: 130000405482
  • Peer Reviewed
• [Journal Article] Enantioselective Synthesis of a GPR40 Agonist AMG 837 via Catalytic Asymmetric Conjugate Addition of Terminal Alkyne to α,β-Unsaturated Thioamide (2011)
  • Author(s): Ryo Yazaki, 他
  • Journal Title: Org.Lett Volume: 13 Pages: 952-955
  • Peer Reviewed
• [Journal Article] Catalytic Asymmetric Hydroxylation of □-Alkoxycarbonyl Amides with a Pr(O^iPr)_3/Amide-Based Ligand Catalyst (2011)
  • Author(s): Sho Takechi, 他
  • Journal Title: Tetrahedron Lett Volume: 52 Pages: 2140-2143
  • Peer Reviewed
• [Journal Article] Catalytic Asymmetric Amination of N-Nonsubstituted α-Alkoxycarbonyl Amides : Concise Enantioselective Total Synthesis of Mycestericin F and G (2011)
  • Author(s): Farouk Berhal, 他
  • Journal Title: Chem.Eur.J Volume: 17 Pages: 1915-1921
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Conjugate Addition of Terminal Alkynes to α,β-Unsaturated Thioamides (2010)
  • Author(s): Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: J.Am.Chem.Soc. 132(30) Pages: 10275-10277
  • NAID: 130006997370
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Aldol Reaction of Thioamides : A Concise Asymmetric Synthesis of (R)-Fluoxetine (2010)
  • Author(s): Mitsutaka Iwata, Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: Tetrahedron : Asymmetry 21(13-14) Pages: 1688-1694
  • Peer Reviewed
• [Journal Article] Solvent-Dependent Self-Discrimination of Bis(2-hydroxyphenyl)diamides (2010)
  • Author(s): Akinobu Matsuzawa, Akihiro Nojiri, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: Chem.Eur.J. 16(17) Pages: 5036-5042
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones via Soft-Lewis Acid/Hard Bronsted Base/Hard Lewis Base Cooperative Catalysis (2010)
  • Author(s): Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: J.Am.Chem.Soc. 132(15) Pages: 5522-5531
  • Peer Reviewed
• [Journal Article] Catalytic Asymmetric Conjugate Addition of α-Cyanoketones For the Construction of a Quaternary Stereogenic Center (2010)
  • Author(s): Yuji Kawato, Noriko Takahashi, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: Org.Lett. 12(7) Pages: 1484-1487
  • Peer Reviewed
• [Journal Article] Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst (2010)
  • Author(s): Tatsuya Nitabaru, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: Molecules 15(3) Pages: 1280-1290
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Conjugate Addition of Terminal Alkynes to α,β-Unsaturated Thioamides (2010)
  • Author(s): Ryo Yazaki, 他
  • Journal Title: J.Am.Chem.Soc Volume: 132 Pages: 10275-10277
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Aldol Reaction of Thioamides : A Concise Asymmetric Synthesis of (R)-Fluoxetine (2010)
  • Author(s): Mitsutaka Iwata, 他
  • Journal Title: Tetrahedron : Asymmetry Volume: 21 Pages: 1688-1694
  • Peer Reviewed
• [Journal Article] Solvent-Dependent Self-Discrimination of Bis(2-hydroxyphenyl)diamides (2010)
  • Author(s): Akinobu Matsuzawa, 他
  • Journal Title: Chem.Eur.J Volume: 16 Pages: 5036-5042
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones via Soft-Lewis Acid/Hard Bronsted Base/Hard Lewis Base Cooperative Catalysis (2010)
  • Author(s): Ryo Yazaki, 他
  • Journal Title: J.Am.Chem.Soc Volume: 132 Pages: 5522-5531
  • Peer Reviewed
• [Journal Article] Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst (2010)
  • Author(s): Tatsuya Nitabaru
  • Journal Title: Molecules 15 Pages: 1280-1290
  • Peer Reviewed
• [Journal Article] Catalytic Asymmetric Conjugate Addition of α-Cyanoketones For the Construction of a Quaternary Stereogenic Center (2010)
  • Author(s): Yuji Kawato
  • Journal Title: Organic Letters 12 Pages: 1484-1487
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Aldol Reactions of Thioamides : Toward a Stereocontrolled Synthesis of 1,3-Polyols (2009)
  • Author(s): Mitsutaka Iwata, Ryo Yazaki, Yuta Suzuki, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: J.Am.Chem.Soc. 131(51) Pages: 18244-18245
  • Peer Reviewed
• [Journal Article] Managing Highly Coordinative Substrates in Asymmetric Catalysis : a Catalytic Asymmetric Amination with a Lanthanum-based Ternary Catalyst (2009)
  • Author(s): Tomoyuki Mashiko, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: J.Am.Chem.Soc. 131(41) Pages: 14990-14999
  • Peer Reviewed
• [Journal Article] anti-Selective Catalytic Asymmetric Nitroaldol Reaction via a Heterobimetallic Heterogeneous Catalyst (2009)
  • Author(s): Tatsuya Nitabaru, Akihiro Nojiri, Makoto Kobayashi, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: J.Am.Chem.Soc. 131(38) Pages: 13860-13869
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Mannich-type Reaction of Thioamides (2009)
  • Author(s): Yuta Suzuki, Ryo Yazaki, Naoya Kumagai, Msakatsu Shibasaki
  • Journal Title: Angew.Chem., Int.Ed. 48(27) Pages: 5026-5029
  • Peer Reviewed
• [Journal Article] Linking Structural Dynamics and Functional Diversity in Asymmetric Catalysis (2009)
  • Author(s): Akihiro Nojiri, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: J.Am.Chem.Soc. 131(10) Pages: 3779-3784
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones (2009)
  • Author(s): Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: J.Am.Chem.Soc. 131(9) Pages: 3195-3197
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones (2009)
  • Author(s): Ryo Yazaki
  • Journal Title: Journal of the American Chemical Society 131 Pages: 3195-3197
  • Peer Reviewed
• [Journal Article] Linking Structural Dynamics and Functional Diversity in Asymmetric Catalysis (2009)
  • Author(s): Akihiro Nojiri
  • Journal Title: Journal of the American Chemical Society 131 Pages: 3779-3784
  • Peer Reviewed
• [Journal Article] Recent Progress in Asymmetric Bifunctional Catalysis Using Multimetallic Systems (2009)
  • Author(s): Masakatsu Shibasaki
  • Journal Title: Accounts of Chemical Research 42 Pages: 1117-1127
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Mannich-type Reaction of Thioamides (2009)
  • Author(s): Yuta Suzuki
  • Journal Title: Angewandte Chemie International Edition 48 Pages: 5026-5029
  • Peer Reviewed
• [Journal Article] anti-Selective Catalytic Asymmetric Nitroaldol Reaction via a Heterobimetallic Heterogeneous Catalyst (2009)
  • Author(s): Tatsuya Nitabaru
  • Journal Title: Journal of the American Chemical Society 131 Pages: 13860-13869
  • Peer Reviewed
• [Journal Article] Managing Highly Coordinative Substrates in Asymmetric Catalysis : a Catalytic Asymmetric Amination with a Lanthanum-based Ternary Catalyst (2009)
  • Author(s): Tomoyuki Mashiko
  • Journal Title: Journal of the American Chemical Society 131 Pages: 14990-14999
  • Peer Reviewed
• [Journal Article] Inventing and Understanding Catalytic, Enantioselective Reactions (2009)
  • Author(s): Masakatsu Shibasaki
  • Journal Title: Current Opinion in Drug Discovery and Development 12 Pages: 862-875
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Aldol Reactions of Thioamides : Toward a Stereocontrolled Synthesis of 1, 3-Polyol (2009)
  • Author(s): Mitsutaka Iwata
  • Journal Title: Journal of the American Chemical Society 131 Pages: 18244-18245
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Addition of Allyl Cyanide to ketones (2009)
  • Author(s): Ryo Yazaki
  • Journal Title: Journal of the American Chemical Society 131 Pages: 3195-3197
  • Peer Reviewed
• [Journal Article] Linking Structural Dynamics and Functional Diversity in Asymmetric catalysis (2009)
  • Author(s): Akihiro Nojiri
  • Journal Title: Journal of the American Chemical Society 131 Pages: 3779-3784
  • Peer Reviewed
• [Journal Article] Recent progress in Asymmetric Bifunctional Catalysis Using Multimetallic Systems (2009)
  • Author(s): Masakatsu Shibasaki
  • Journal Title: Accounts of Chemical Research 42 Pages: 1117-1127
  • Peer Reviewed
• [Journal Article] anti-Selective Catalytic Asymmetric nitroaldol Reaction via a Heterobimetallic Heterogeneous Cotalyst (2009)
  • Author(s): Tatsuya Nitabaru
  • Journal Title: Journal of the American Chemical Society 131 Pages: 13860-13869
  • Peer Reviewed
• [Journal Article] Managing Highly Coordiative Substrates in Asymmetric Catalysis : a Catalytic Asymmetric Amination with a Lanthanum-based Ternary Catalyst (2009)
  • Author(s): Tomoyuki Mashiko
  • Journal Title: Journal of the American Chemical Society 131 Pages: 14990-14999
  • Peer Reviewed
• [Journal Article] Direct Catalytic Asymmetric Addition of Allylic Cyanides to Ketoimines (2008)
  • Author(s): Ryo Yazaki, Tatsuya Nitabaru, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: J.Am.Chem.Soc. 130(44) Pages: 14477-14479
  • Peer Reviewed
• [Journal Article] An Improved Lanthanum Catalytic System for Asymmetric Amination; Toward a Practical Asymmetric Synthesis of AS-3201 (Ranirestat) (2008)
  • Author(s): Tomoyuki Mashiko, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: Org.Lett. 10(13) Pages: 2725-2728
  • Peer Reviewed
• [Journal Article] Asymmetric Catalysis via Dynamic ustrate/Ligand Rare Earth Metal Conglomerate (2008)
  • Author(s): Akihiro Nojiri, Naoya Kumagai, Masakatsu Shibasaki
  • Journal Title: J.Am.Chem.Soc. 130(17) Pages: 5630-5631
  • Peer Reviewed
• [Presentation] La/Ag/アミド配位子触媒による触媒的不斉Conia-ene反応 (2011)
  • Author(s): 益子智之
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 日本薬学会第131年会
  • Year and Date: 2011-03-05
• [Presentation] シャペロン分子による立体制御を利用した不斉触媒反応 (2011)
  • Author(s): 松澤彰信
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 日本薬学会第131年会
  • Year and Date: 2011-03-05
• [Presentation] 光によるジアミド誘導体の可逆的ヘテロキラル凝集制御 (2011)
  • Author(s): 野尻明宏
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 日本薬学会第131年会
  • Year and Date: 2011-03-05
• [Presentation] 末端アルキンのα,β-不飽和チオアミドへの触媒的不斉共役付加反応 (2010)
  • Author(s): 矢崎亮
  • Organizer: 第98回有機合成シンポジウム
  • Place of Presentation: 早稲田大学国際会議場
  • Year and Date: 2010-11-06
• [Presentation] チオアミドの触媒的不斉ダイレクトアルドール反応 (2010)
  • Author(s): 岩田光貴
  • Organizer: 第98回有機合成シンポジウム
  • Place of Presentation: 早稲田大学国際会議場
  • Year and Date: 2010-11-05
• [Presentation] チオアミドの触媒的不斉ダイレクトアルドール反応 (2010)
  • Author(s): 岩田光貴
  • Organizer: 第36回反応と合成の進歩シンポジウム
  • Place of Presentation: ウインク愛知
  • Year and Date: 2010-11-01
• [Presentation] 末端アルキンのα,β-不飽和チオアミドへの触媒的不斉共役付加反応 (2010)
  • Author(s): 矢崎亮
  • Organizer: 第36回反応と合成の進歩シンポジウム
  • Place of Presentation: ウインク愛知
  • Year and Date: 2010-11-01
• [Presentation] 抗HCV薬を志向したSerine Palmitoyl Transferase阻害剤の触媒的不斉合成 (2010)
  • Author(s): 熊谷直哉
  • Organizer: 創造機能化学第116委員会
  • Place of Presentation: 神田学士会館
  • Year and Date: 2010-10-12
• [Presentation] ソフトLewis酸/ハードBronsted塩基/ハードLewis塩基型協奏触媒反応 (2010)
  • Author(s): 矢崎亮
  • Organizer: 第57回有機金属討論会
  • Place of Presentation: 中央大学多摩キャンパス
  • Year and Date: 2010-09-17
• [Presentation] A Flexible Catalyst for Asymmetric Amination (2010)
  • Author(s): 益子智之
  • Organizer: 3rd EuCheMS Chemistry Congress
  • Place of Presentation: Nurnberg, Germany
  • Year and Date: 2010-09-01
• [Presentation] Soft Lewis Acid/Hard Bronsted Base/Hard Lewis Base Catalyzed Highly Atom Economical Construction of Enantioenriched Tertiary Alcohols (2010)
  • Author(s): 矢崎亮
  • Organizer: 3rd EuCheMS Chemistry Congress
  • Place of Presentation: Nurnberg, Germany
  • Year and Date: 2010-08-31
• [Presentation] University of Colorado (2010)
  • Organizer: Soft Lewis Acid/Hard Bronsted Base Cooperative Catalysis for the Construction of Tetrasubstituted Stereogenic Centers
  • Place of Presentation: 依頼講演コロラド大学,アメリカ
  • Year and Date: 2010-08-09
• [Presentation] Direct Catalytic Asymmetric Addition of Terminal Alkynes to α,β-Unsaturated Thioamides (2010)
  • Author(s): 熊谷直哉
  • Organizer: Gordon Research Conference on Stereochemistry
  • Place of Presentation: Salve Regina University, RI, USA
  • Year and Date: 2010-08-04
• [Presentation] Soft-Lewis Acid/Hard-Bronsted Base/Hard Lewis Base CooperativeCatalysis for the Construction of Quaternary Stereogenic Center (2010)
  • Author(s): 熊谷直哉
  • Organizer: University of Colorado講演会
  • Place of Presentation: Department of Chemistry, University of Colorado at Boulder, CO, USA
  • Year and Date: 2010-08-04
• [Presentation] Tampere University of Technology (2010)
  • Organizer: Recent Progress in Asymmetric C.C Bond formation via Proton Transfer
  • Place of Presentation: 依頼講演Tampere University of Technology,フィンランド
  • Year and Date: 2010-07-19
• [Presentation] Soft-Lewis Acid/Hard-Bronsted Base/Hard Lewis Base Cooperative Catalysis for the Construction of Quaternary Stereogenic Center (2010)
  • Author(s): 熊谷直哉
  • Organizer: Tampere Institute of Technology講演会
  • Place of Presentation: Tampere Institute of Technology, Tampere, Finland
  • Year and Date: 2010-07-19
• [Presentation] RSC-CSJ Joint Symposium. (2010)
  • Organizer: Atom-economical Catalytic Asymmetric Reactions and Their Application to Efficient Synthesis of Therapeutics
  • Place of Presentation: Chemistry for a Sustainable World RSC Burlington House,ロンドン,イギリス
  • Year and Date: 2010-07-16
• [Presentation] Atom-economical Catalytic Asymmetric Reactions and Their Application to Efficient Synthesis of Therapeutics (2010)
  • Author(s): 熊谷直哉
  • Organizer: RSC-CSJ Joint Symposium : Catalysis for a Sustainable World
  • Place of Presentation: Burlington House, London, UK
  • Year and Date: 2010-07-16
• [Presentation] anti-Selective Catalytic Asymmetric Nitroaldol Reaction via Heterobimetallic Heterogeneous Catalysis and Application to Asymmetric Synthesis of Therapeutics (2010)
  • Author(s): 二田原達也
  • Organizer: RSC-CSJ Joint Symposium : Catalysis for a Sustainable World
  • Place of Presentation: Burlington House, London, UK
  • Year and Date: 2010-07-15
• [Presentation] A Flexible Catalyst for Asymmetric Amination (2010)
  • Author(s): 益子智之
  • Organizer: Chirality 2010 : 22nd International Symposium on Chirality
  • Place of Presentation: 札幌コンベンションセンター、札幌
  • Year and Date: 2010-07-14
• [Presentation] アミドの求核的活性化を基盤とする触媒的不斉炭素-炭素結合形成反応の開発 (2010)
  • Author(s): 川戸勇士
  • Organizer: 第43回有機金属若手の会
  • Place of Presentation: 休暇村(志賀島)、福岡
  • Year and Date: 2010-07-06
• [Presentation] マロン酸ハーフチオエステルを求核剤とする触媒的不斉1,4-付加反応の開発 (2010)
  • Author(s): 古舘信
  • Organizer: 第43回有機金属若手の会
  • Place of Presentation: 休暇村(志賀島)、福岡
  • Year and Date: 2010-07-06
• [Presentation] ソフトLewis酸・ハードBronsted塩基協奏触媒を用いるプロトン移動型触媒的不斉C-C結合形成反応 (2010)
  • Author(s): 熊谷直哉
  • Organizer: 日本学術振興会 創造機能化学第116委員会合同分科会・講演会
  • Place of Presentation: 学士会館(神保町)
  • Year and Date: 2010-06-07
• [Presentation] ジアミド配位子の溶媒依存的self-discrimination (2010)
  • Author(s): 松澤彰信
  • Organizer: 第59回 有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 東京農工大学小金井キャンパス
  • Year and Date: 2010-05-22
• [Presentation] BIT's 1st Annual World Congress in Catalytic Asymmetric Synthesis北京コンベンションセンター (2010)
  • Organizer: Rare Earth Metal/Amide-Based Ligand Complexes : Structural Dynamics, Functional Diversity, and Asymmetric Catalysis
  • Place of Presentation: 北京,中国
  • Year and Date: 2010-05-21
• [Presentation] Rare Earth Metal/Amide-Based Ligand Complexes : Structural Dynamics, Functional Diversity, and Asymmetric Catalysis (2010)
  • Author(s): 熊谷直哉
  • Organizer: BIT's 1st Annual World Congress in Catalytic Asymmetric Synthesis
  • Place of Presentation: Beijing International Convention Center、Beijing, China
  • Year and Date: 2010-05-21
• [Presentation] 日本薬学会 (2010)
  • Organizer: 高原子効率的な触媒的不斉反応の開発と医薬品の効率的合成への応用
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-03-28
• [Presentation] アリルシアニドのケトンへの触媒的不斉付加反応 (2010)
  • Author(s): 矢崎亮
  • Organizer: 第130回日本薬学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-03-28
• [Presentation] 高原子効率的な触媒的不斉反応の開発と医薬品の効率的合成への応用 (2010)
  • Author(s): 熊谷直哉
  • Organizer: 第130回日本薬学会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-03-28
• [Presentation] 動的平衡化にあるLa/アミド配位子触媒系を用いる触媒的不斉アミノ化反応 (2010)
  • Author(s): 益子智之
  • Organizer: 第130回日本薬学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-03-28
• [Presentation] チオアミドの触媒的不斉ダイレクトアルドール反応 (2010)
  • Author(s): 岩田光貴
  • Organizer: 第130回日本薬学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-03-28
• [Presentation] SPT阻害剤合成を志向した触媒的不斉ヒドロキシル化反応 (2010)
  • Author(s): 武智翔
  • Organizer: 第130回日本薬学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-03-28
• [Presentation] ジアミド誘導体の溶媒依存型ヘテロキラル集積 (2010)
  • Author(s): 野尻明宏
  • Organizer: 第130回日本薬学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-03-28
• [Presentation] 希土類金属/アミドリガンド触媒による4級炭素構築型不斉共役付加反応 (2010)
  • Author(s): 川戸勇士
  • Organizer: 第130回日本薬学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-03-28
• [Presentation] Efficient Catalytic Asymmetric Synthesis of Serine Palmitoyl Transferase Inhibitors (2010)
  • Author(s): 熊谷直哉
  • Organizer: 第130回日本薬学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-03-28
• [Presentation] anti及びsyn選択的触媒的不斉ニトロアルドール反応を駆使するAC98-6446の合成研究 (2010)
  • Author(s): 二田原達也
  • Organizer: 第130回日本薬学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-03-28
• [Presentation] 一度会ったら手を離さない人工低分子 (2010)
  • Author(s): 野尻明宏
  • Organizer: 第130回日本薬学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-03-28
• [Presentation] Catalytic Asymmetric Amination with a Dynamic Lanthanum-Based Ternary Catalyst (2009)
  • Author(s): 益子智之
  • Organizer: IFOC-6
  • Place of Presentation: 東大弥生講堂
  • Year and Date: 2009-11-16
• [Presentation] Development of anti-Selective Nitroaldol Reaction by a Nd/Na Heterobimetallic Heterogeneous Catalyst (2009)
  • Author(s): 二田原達也
  • Organizer: IFOC-6
  • Place of Presentation: 東大弥生講堂
  • Year and Date: 2009-11-16
• [Presentation] Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones (2009)
  • Author(s): 矢崎亮
  • Organizer: IFOC-6
  • Place of Presentation: 東大弥生講堂
  • Year and Date: 2009-11-16
• [Presentation] Catalytic Asymmetric Amination with a Dynamic Lanthanum-Based Ternary Catalyst (2009)
  • Author(s): Tomoyuki Mashiko
  • Organizer: IFOC-6
  • Place of Presentation: 東大 弥生講堂
  • Year and Date: 2009-11-16
• [Presentation] Development of anti-Selective Nitroaldol Reaction by a Nd/Na Heterobimetallic Heterogeneous Catalyst (2009)
  • Author(s): Tatsuya Nitabaru
  • Organizer: IFOC-6
  • Place of Presentation: 東大 弥生講堂
  • Year and Date: 2009-11-16
• [Presentation] Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones (2009)
  • Author(s): Ryo Yazaki
  • Organizer: IFOC-6
  • Place of Presentation: 東大 弥生講堂
  • Year and Date: 2009-11-16
• [Presentation] Development of anti-Selective Nitroaldol Reaction by a Nd/Na Heterobimetallic Heterogeneous Catalyst (2009)
  • Author(s): 熊谷直哉
  • Organizer: 9th Tateshina Conference
  • Place of Presentation: 長野県蓼科フォーラム
  • Year and Date: 2009-11-14
• [Presentation] Nd/Na異種多核不均一錯体によるanti選択的触媒的不斉ニトロアルドール反応の開発 (2009)
  • Author(s): 二田原達也
  • Organizer: 第96回有機合成シンポジウム
  • Place of Presentation: 早稲田大学国際会議場
  • Year and Date: 2009-11-05
• [Presentation] Catalytic Asymmetric Amination with a Dynamic Lanthanum-Based Ternary Catalyst (2009)
  • Author(s): 益子智之
  • Organizer: 第26回有機合成化学セミナー
  • Place of Presentation: 群馬県前橋市中央公民館
  • Year and Date: 2009-09-17
• [Presentation] Catalytic Asymmetric Construction of Stereogenic Tetrasubstituted Carbon Under Proton-transfer Conditions : Allylic Cyanides as Amibident Pronucleophile (2009)
  • Author(s): 熊谷直哉
  • Organizer: Gordon Research Conference in Natural Products
  • Place of Presentation: Tilton School, NH, USA
  • Year and Date: 2009-07-28
• [Presentation] アリリックシアニドのケトンへの触媒的不斉付加反応 (2009)
  • Author(s): 熊谷直哉
  • Organizer: 第129回 日本薬学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-03-26
• [Presentation] ジアステレオスイッチングを示す希土類・アミド錯体:触媒的不斉Mannich型反応による不斉4級炭素構築 (2008)
  • Author(s): 熊谷直哉
  • Organizer: 第94回 有機合成シンポジウム
  • Place of Presentation: 早稲田大学国際会議場
  • Year and Date: 2008-11-07
• [Book] Multimetallic Multifunctional Catalysts For Asymmetric Reactions (2011)
  • Author(s): Masakatsu Shibasaki, 他
  • Total Pages: 30
  • Publisher: Springer
• [Book] Phospholane,1,1_-(1,2-Ethanediyl)-bis[2,5-diphenyl- (2S,2S_,5S,5S_)1 and Phospholane, 1,1-(1,2-Ethanediyl)-bis[2,5-diphenyl-(2R,2R_,5R,5R_)" ,Encyclopedia of Reagents for Organic Synthesis (2010)
  • Author(s): Naoya Kumagai
• [Book] Phospholane, 1,1_-(1,2-Ethanediyl)-bis[2,5-diphenyl-(2S,2S_,5S,5S_)1 and Phospholane, 1,1-(1,2-Ethanediyl)-bis[2,5-diphenyl-(2R,2R_,5R,5R_) (2010)
  • Author(s): Naoya Kumagai
  • Total Pages: 8
  • Publisher: Encyclopedia of Reagents for Organic Synthesis
• [Book] e-EROS (1,2-Bis((2R,5R)-2,5-Diisopropylphospholan-1-yl)benzene1 and 1,2-Bis((2S,5S)-2,5-diisopropylphospholan-1-yl)benzene), Wiley-VCH (2009)
  • Author(s): Naoya Kumagai
  • Total Pages: 11
• [Book] e-EROS(1, 2-Bis((2R, 5R)-2, 5-diisopropylphospholan-1-yl)benzene1 and 1, 2-Bis((2S, 5S)-2, 5-diisopropylphospholan-1-yl)benzene) (2009)
  • Author(s): Naoya Kumagai
  • Total Pages: 11
  • Publisher: Wiley-VCH
• [Remarks] ホームページ等
  • URL: http://www.bikaken.or.jp/research/group/shibasaki/shibasaki-lab/index.html
• [Remarks]
  • URL: http://www.bikaken.or.jp/research/group/shibasaki/shibasaki-lab/index.html
• [Remarks]
  • URL: http://www.f.u-tokyo.ac.jp/~kanai/index.html
• [Patent(Industrial Property Rights)] チオアミド化合物、チオアミド化合物の製造方法、[(4R,6R)-6-アミノエチル-1,3-ジオキサン-4-イル]アセテート誘導体の製造方法、及びアトルバスタチンの製造方法 (2011)
  • Inventor(s): 熊谷直哉, 柴崎正勝
  • Industrial Property Rights Holder: 微生物化学研究会
  • Filing Date: 2011-02-21
• [Patent(Industrial Property Rights)] チオアミド化合物、チオアミド化合物の製造方法、[(4R,6R)-6-アミノエチル-1,3-ジオキサン-4-イル]アセテート誘導体の製造方法、及びアトルバスタチンの製造方法 (2011)
  • Inventor(s): 熊谷直哉, 柴崎正勝
  • Industrial Property Rights Holder: (財)微生物化学研究会
  • Industrial Property Number: 2011-035006
  • Filing Date: 2011-02-21
• [Patent(Industrial Property Rights)] 立体選択的不斉ニトロアルドール反応用触媒 (2010)
  • Inventor(s): 二田原達也, 熊谷直哉, 柴崎正勝
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2010-01-25
  • Overseas
• [Patent(Industrial Property Rights)] 立体選択的不斉ニトロアルドール反応用触媒 (2010)
  • Inventor(s): 柴崎正勝, 熊谷直哉, 二田原達也
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2010-01-25
  • Overseas
• [Patent(Industrial Property Rights)] 立体選択的不斉ニトロアルドール反応用触媒 (2009)
  • Inventor(s): 二田原達也, 熊谷直哉, 柴崎正勝
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2009-01-26
• [Patent(Industrial Property Rights)] 立体選択的不斉ニトロアルドール反応用触媒 (2009)
  • Inventor(s): 二田原達也、熊谷直哉、柴崎正勝
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2009-01-26