Membrane morphology -An attempt to reconstitute the cristae structure in liposome-
| Project/Area Number |
20200058
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphology/Structure
Cell biology
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| Research Institution | Kyushu University |
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Principal Investigator |
OKA Toshihiko Kyushu University, 医学研究院, 准教授 (40263321)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥29,900,000 (Direct Cost: ¥23,000,000、Indirect Cost: ¥6,900,000)
Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Keywords | メンブレンモルフォロジー / クリステ構造 / ひだ状人工膜 / ミトコンドリア |
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| Research Abstract |
Biomembranes are various in form, and the diversity of the shapes of biomembranes are critical for cell viability. To understand the function of the shapes in intra-and inter-cellular activities, we attempted to reconstitute in vitro the cristae structure, an invaginated inner membrane of mitochondria, onto liposomes. Using a recombinant protein of LETM1, a mitochondrial protein required for maintenance of the cristae structure, multiple membrane invagination was successfully formed on liposomes.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with an AAA-ATPase BCS1L.2008
Author(s)
Tamai, S., Iida, H., Yokota, S., Sayano, T., Kiguchiya' S., Ishihara, N., Hayashi, J.-I., Mihara, K., Oka, T.
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Journal Title
J.Cell Sci. 121
Pages: 2588-2600
Related Report
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