| Budget Amount *help |
¥29,900,000 (Direct Cost: ¥23,000,000、Indirect Cost: ¥6,900,000)
Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Research Abstract |
Biomembranes are various in form, and the diversity of the shapes of biomembranes are critical for cell viability. To understand the function of the shapes in intra-and inter-cellular activities, we attempted to reconstitute in vitro the cristae structure, an invaginated inner membrane of mitochondria, onto liposomes. Using a recombinant protein of LETM1, a mitochondrial protein required for maintenance of the cristae structure, multiple membrane invagination was successfully formed on liposomes.
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