The role of sphingolipids in hepatitis C virus replication and its alteration of spingolipids metabolism.
| Project/Area Number |
20200067
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Virology
Cell biology
|
|---|
| Research Institution | Tokyo Metropolitan Organization for Medical Research |
|---|
Principal Investigator |
HIRATA Yuichi Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 研究員 (50439452)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YASUI Fumihiko 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (40399473)
MUNAKATA Tsubasa 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (50420237)
SEKIGUCHI Satoshi 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (10462780)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KOHARA Michinori 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 参事研究員 (10250218)
TAGUCHI Ryo 東京大学, 医学(系)研究科(研究院), 客員教授 (20080210)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥31,070,000 (Direct Cost: ¥23,900,000、Indirect Cost: ¥7,170,000)
Fiscal Year 2010: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2009: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2008: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
|
|---|
| Keywords | 分子・生体膜 / スフィンゴ脂質 / C型肝炎ウイルス / スフィンゴミエリン分子種 / セラミド / スファンゴ脂質 |
|---|
| Research Abstract |
We demonstrated that HCV altered sphingolipids metabolism, performing the analysis, using MS spectrometer, of the sphingolipids content in uninfected humanized chimeric mice, HCV infected chimeric mice, and HCV infected chimeric mice treated with the inhibitor of sphingolipids biosynthesis. Furthermore, specific sphingomyelin molecular species contributed to HCV replication, and these sphigomyelin molecular species activated the polymerase of HCV.
|
Report
(4 results)
Research Products
(55 results)
-
-
-
-
[Journal Article] Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.2010
Author(s)
Takano T., Tsukiyama-Kohara K., Hayashi M., Hirata Y., Satoh M., Tateno C., Hayashi Y., Hishima T., Funata N., Sudo M., Kohara M.
-
Journal Title
Related Report
Peer Reviewed
-
[Journal Article] Pathogenesis of hepatitis C virus infection in Tupaia belangeri.2010
Author(s)
Amako Y., Tsukiyama-Kohara K., Katsume A., Hirata Y., Sekiguchi S., Tobita Y., Hayashi Y., Hishima T., Funata N., Yonekawa .H, Kohara M.
-
Journal Title
J Virol. 84(1)
Pages: 303-311
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Hepatitis C virus impairs p53 via persistent overexpression of 3beta-hydroxysterol Delta24-reductase.2009
Author(s)
Nishimura T., Kohara M., Izumi K., Kasama Y., Hirata Y., Huang Y., Shuda M., Mukaidani C., Takano T., Tokunaga Y., Nuriya H., Satoh M., Saito M., Kai C., Tsukiyama-Kohara K.
-
Journal Title
J Biol Chem 284(52)
Pages: 36442-36452
Related Report
-
[Journal Article] Disruption of IFN signaling and HCV synergistically enhance lymphoproliferation through type II CD95 and interleukins.2009
Author(s)
Machida K., Tsukiyama-Kohara K., Sekiguchi S., Seike E., Tone S., Hayashi Y., Kasama Y., Shimizu M., Takahashi H., Taya C., Yonekawa H., Tanaka N., Kohara M.
-
Journal Title
Gastroenterology 137(1)
Pages: 285-296
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
