| Project/Area Number |
20200067
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
Cell biology
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
HIRATA Yuichi Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 研究員 (50439452)
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| Co-Investigator(Kenkyū-buntansha) |
YASUI Fumihiko 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (40399473)
MUNAKATA Tsubasa 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (50420237)
SEKIGUCHI Satoshi 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (10462780)
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| Co-Investigator(Renkei-kenkyūsha) |
KOHARA Michinori 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 参事研究員 (10250218)
TAGUCHI Ryo 東京大学, 医学(系)研究科(研究院), 客員教授 (20080210)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥31,070,000 (Direct Cost: ¥23,900,000、Indirect Cost: ¥7,170,000)
Fiscal Year 2010: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2009: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2008: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | 分子・生体膜 / スフィンゴ脂質 / C型肝炎ウイルス / スフィンゴミエリン分子種 / セラミド / スファンゴ脂質 |
|---|
| Research Abstract |
We demonstrated that HCV altered sphingolipids metabolism, performing the analysis, using MS spectrometer, of the sphingolipids content in uninfected humanized chimeric mice, HCV infected chimeric mice, and HCV infected chimeric mice treated with the inhibitor of sphingolipids biosynthesis. Furthermore, specific sphingomyelin molecular species contributed to HCV replication, and these sphigomyelin molecular species activated the polymerase of HCV.
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