Autoimmune diseases and RNA modifications: Molecular mechanism of pathogenesis of systemic lupus erythematosus.
| Project/Area Number |
20200070
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
膠原病・アレルギー・感染症内科学
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| Research Institution | University of Miyazaki |
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Principal Investigator |
UECHI Tamayo 宮崎大学, フロンティア科学実験総合センター, 研究員 (10381104)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAYANAGI Atsushi 慶応義塾大学, 医学部, 講師 (80245464)
TAKAMI Yasunari 宮崎大学, 医学部, 准教授 (80236356)
HIGA Sayomi 琉球大学, 医学研究科, 助教 (20381105)
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| Co-Investigator(Renkei-kenkyūsha) |
KENMOCHI Naoya 宮崎大学, フロンティア科学実験総合センター, 教授 (00133124)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥32,630,000 (Direct Cost: ¥25,100,000、Indirect Cost: ¥7,530,000)
Fiscal Year 2010: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2009: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2008: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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| Keywords | RNA修飾 / 自己免疫疾患 / 人工抗体 / SLE / ゼブラフィッシュ / モルフォリノアンチセンスオリゴ / ノンコーディングRNA / ファージディスプレイ / 人工杭体 |
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| Research Abstract |
A majority of non-coding RNAs undergo posttranscriptional modifications. Lack of such modifications might lead to autoimmune response. To investigate the possible mechanism of pathogenesis, we isolated recombinant anti-RNA antibodies that can bind to the modification sites related to patient autoantibodies. We also developed a zebrafish model of defective rRNA modifications and demonstrated that loss of rRNA modification, even at a single site, have deleterious effects on early development in vertebrates.
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Report
(4 results)
Research Products
(35 results)
