Attempt to the establishment of new approach for mouse germ cell induction in vivo.
Project/Area Number |
20200071
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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Allocation Type | Single-year Grants |
Research Field |
Developmental biology
Obstetrics and gynecology
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Research Institution | Kumamoto University |
Principal Investigator |
TANAKA Satomi 熊本大学, 発生医学研究所, 助教 (10321944)
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Project Period (FY) |
2008 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥32,630,000 (Direct Cost: ¥25,100,000、Indirect Cost: ¥7,530,000)
Fiscal Year 2010: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2009: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2008: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
|
Keywords | 生殖細胞 / マウス / 応用動物科学 / 再生医療 / WNTシグナル / BMPシグナル / Dullard遺伝子 / 発生生物学 / Ifitm1遺伝子 / Ifitm3遺伝子 / 全胚培養系 / 生殖医学 / 微小環境 |
Research Abstract |
To establish the new approach for germ cell induction in vivo, I examined the essential signals for germ cell formation in the mouse embryo. I found that in addition to Bmp signal, Wnt signal is also essential for germ cell formation, which is strictly regulated by Dullard. Further, I also found that Six1 and Six4 transcription factors act downstream to Bmp signal in mouse germ cell formation.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme2010
Author(s)
Yukako Uchiyama, Masagi Sakaguchi, Takeshi Terabayashi, Toshiaki Inenaga, Shuji Inoue, Chiyoko Kobayashi, Naoko Oshima, Hiroshi Kiyonari, Naoko Nakagata, Yuka Sato, Kiyotoshi Sekiguchi, Hiroaki Miki, Eiichi Araki, Sayoko Fujimura, Satomi S. Tanaka, Ryuichi Nishinakamura
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Journal Title
Proc Natl Acad Sci U S A
Volume: 107
Pages: 9240-9245
Related Report
Peer Reviewed
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[Journal Article] Draxin, a Repulsive Guidance Protein for Spinal Cord and Forebrain Commissures2009
Author(s)
Shahidul M. Islam, Yohei Shinmyo, Tatsuya Okafuji, Yuhong Su, Iftekhar Bin Naser, Giasuddin Ahmed, Sanbing Zhang, Sandy Chen, Kunimasa Ohta, Hiroshi Kiyonari, Takaya Abe, Satomi Tanaka, Ryuichi Nishinakamura, Toshio Terashima, Toshio Kitamura, Hideaki Tanaka
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Journal Title
Science
Volume: 323
Pages: 388-393
Related Report
Peer Reviewed
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