Studies of the novel chemotherapeutic drugs for herpesvirus infections
| Project/Area Number |
20200073
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
Virology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
FUJIMURO Masahiro University of Yamanashi, 医学工学総合研究部, 准教授 (20360927)
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| Co-Investigator(Renkei-kenkyūsha) |
ICHIKAWA Satoshi 北海道大学, 大学院・薬学研究院, 准教授 (60333621)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥29,900,000 (Direct Cost: ¥23,000,000、Indirect Cost: ¥6,900,000)
Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Keywords | 核酸 / 薬学 / ウイルス / 感染症 / がん / リンパ腫 / 抗腫瘍剤 / 抗ウイルス剤 / 創薬 / ヘルペスウイルス / 核酸代謝拮抗薬 / KSHV |
|---|
| Research Abstract |
Primary effusion lymphoma (PEL) is classified as non-Hodgkin's B-cell lymphoma associated with immunocompromised patients such as AIDS patients. PEL cells are universally infected with Kaposi's sarcoma-associated herpesvirus (KSHV). Previously, we had developed anti-tumor compounds, CNDAG and its derivatives, which induce apoptosis in PEL cells. To establish the effective treatment for PEL and KSHV infection, we have demonstrated the mechanisms of action of CNDAG and novel functions, namely anti-herpesviral activities. We furthermore identified sangivamycin, fullerene analogues and sodium valproate as new anti-PEL compounds.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Silencing of autocrine motility factor induces mesenchymal to epithelial transition and suppression of osteosarcoma pulmonary metastasis.2010
Author(s)
Niinaka Y, Harada K, Fujimuro M, Oda M, Haga A, Hosoki M, Uzawa N, Arai N, Yamaguchi S, Yamashiro M, Raz A.
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Journal Title
Cancer Res. 70
Pages: 9483-9493
Related Report
Peer Reviewed
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[Journal Article] BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation.2010
Author(s)
Ikeda O, Miyasaka Y, Yoshida R, Mizushima A, Oritani K, Sekine Y, Kuroda M, Yasui T, Fujimuro M, Muromoto R, Nanbo A, Matsuda T.
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Journal Title
FEBS Lett. 584
Pages: 865-872
Related Report
Peer Reviewed
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[Journal Article] An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis2009
Author(s)
Wakasaya Y, Watanabe M, Tomiyama M, Suzuki C, Jackson M, Fujimuro M, Kimura T, Seino Y, Kawarabayashi T, Yamamoto-Watanabe Y, Matsubara E, Shirahama I, Takamura A, Nakahata N, Shoji M.
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Journal Title
Intern Med 48
Pages: 1311-1313
NAID
Related Report
Peer Reviewed
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[Journal Article] Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly.2008
Author(s)
Sawamura N, Ando T, Maruyama Y, Fujimuro M, Mochizuki H, Honjo K, Shimoda M, Toda H, Sawamura-Yamamoto T, Makuch LA, Hayashi A, Ishizuka K, Cascella NG, Kamiya A, Ishida N, Tomoda T, Hai T, Furukubo-Tokunaga K, Sawa A.
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Journal Title
Mol Psychiatry. 13
Pages: 1138-1148
Related Report
Peer Reviewed
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