Role of Inflammasomes as an initial sensor for cardiovascular stress
Project/Area Number |
20200077
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
Experimental pathology
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Research Institution | Shinshu University |
Principal Investigator |
TAKAHASHI Masafumi Shinshu University, 医学部, 教授 (40296108)
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Co-Investigator(Renkei-kenkyūsha) |
TANIGUCHI Shun'ichiro (60117166)
IKEDA Uichi (30221063)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2010: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2009: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2008: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
|
Keywords | インフラマソーム / 心血管 / シグナル伝達 / 炎症 / マクロファージ / 心臓 / 虚血再灌流 / 骨髄細胞 / 動脈硬化 / 虚血性心疾患 / 炎症反応 |
Research Abstract |
Inflammation plays a key role in the pathophysiology of cardiovascular diseases. In particular, recent studies suggest that a sterile inflammatory response is mediated through a multiple-protein complex called the inflammasomes. The purpose of this study is to investigate the role of inflammasomes in the pathogenesis of cardiovascular diseases and explore a therapeutic potential of regulating inflammasomes for cardiovascular diseases using a murine model of myocardial ischemia-reperfusion (I/R) injury. Our results demonstrate the importance of inflammasomes for the initial inflammatory response after myocardial I/R and suggest that the inflammasome is a potential novel therapeutic target for preventing myocardial I/R injury.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia reperfusion injury.2011
Author(s)
Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U.
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Journal Title
Circulation 123
Pages: 594-604
Related Report
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[Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischemia.2011
Author(s)
Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U.
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Journal Title
Cardiovasc Res 90
Pages: 364-372
Related Report
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[Journal Article] Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia reperfusion injury.2011
Author(s)
Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U.
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Journal Title
Circulation
Volume: 123
Pages: 594-604
Related Report
Peer Reviewed
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[Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischemia.2011
Author(s)
Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U.
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Journal Title
Cardiovasc Res
Volume: Jan11(in press)
Related Report
Peer Reviewed
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[Journal Article] Therapeutic neovascularization by the implantation of autologous mononuclear cells in patients with connective tissue diseases.2009
Author(s)
Takahashi M, Izawa A, Ishigatsubo Y, Fujimoto K, Miyamoto M, Horie T, Aizawa Y, Amano J, Minota S, Murohara T, Matsubara H, Ikeda U.
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Journal Title
Curr Pharm Design 15
Pages: 2778-2783
Related Report
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[Journal Article] Bone marrow CXCR4 induction by cultivation enhances therapeutic angiogenesis.2009
Author(s)
Shiba, Y., Takahashi, M., Hata, T., Mutrayama, H., Morimoro, H., Ise, H., Nagasawa, T., Ikeda, U.
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Journal Title
Cardiovasc Res 81(1)
Pages: 169-177
Related Report
Peer Reviewed
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[Journal Article] Therapeutic neovascularization by the implantation of autologous mononuclear cells in patients with connective tissue diseases.2009
Author(s)
Takahashi, M., Izawa, A., Ishigatsubo, Y., Fujimoto, K., Miyamoto, M., Horie, T., Aizawa, Y., Amano, J., Minota, S., Murohara, T., Matsubara, H., Ikeda, U.
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Journal Title
Current Pharmaceutical Design 15(24)
Pages: 2778-2783
Related Report
Peer Reviewed
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[Journal Article] Surface coating of bone marrow cells with N-acetylglucosamine for bone marrow implantation therapy.2009
Author(s)
Kobayashi, S., Ise, H., Takahashi, M., Goto, M., Akaike, T., Ikeda, U.
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Journal Title
Biomaterials 30(4)
Pages: 574-582
Related Report
Peer Reviewed
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[Journal Article] Effects of hormone-sensitive lipase disruption on cardiac energy metabolism in reponse to fasting and refeeding.2009
Author(s)
Suzuki,J., Ueno,M., Uno,M., Hirose,Y., Zenimaru,Y., Takahashi,S., Osuga,J., Ishibashi,S., Takahashi,M., Hirose,M., Yamada,M., Kraemer,F,B., Mitamori,I.
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Journal Title
Am J Physiol Endocrinol Metab 297
Related Report
Peer Reviewed
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[Journal Article] Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice.2008
Author(s)
Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, J Sagara, Nakayama J, Taniguchi S, Ikeda U.
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Journal Title
Circulation 117
Pages: 3079-3087
Related Report
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[Journal Article] Critical role of bone marrow-derived ASC, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice2008
Author(s)
Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, J Sagara, Nakayama J, Taniguchi S, Ikeda U.
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Journal Title
Circulation 117
Pages: 3079-3087
Related Report
Peer Reviewed
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[Journal Article] Alveolar bone regeneration of subcutaneously transplanted ratmolar2008
Author(s)
Hosoya A, Ninomiya T, Hiraga T, Zhao C, Yoshiba K, Yoshiba N, Takahashi M, Okabe T, Wakitani S, Yamada H, Kasahara E, Ozawa H, Nakamura H.
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Th17 cells, a new subset of CD4^+ T-cells, plays an important role in angiogenic response to hindlimb ischemia.2009
Author(s)
Takahashi M, Hata T, Kawaguchi M, Kashima Y, Hida S, Izawa A, Iwakura Y, Taki S, Ikeda U.
Organizer
第15回日本遺伝子治療学会
Place of Presentation
大阪
Related Report
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[Presentation] Contribution of Th17 cells, a new subset of CD4^+ T cells, to angiogenic response to hindlimb ischmia.2009
Author(s)
Hata T, Takahashi M, Kawaguchi M, Kashima Y, Izawa A, Hida S, Iwakuma Y, Taki S, Ikeda U.
Organizer
American Heart Association Scientific Sessions
Place of Presentation
Orlando, USA
Related Report
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[Presentation] Deficiency of ASC (apotosis-associatde speck-like protein containing a caspase recruitment domain) in bone marrow cells improved myocardial ischemia-reperfusion injury in mice.2009
Author(s)
Kawaguchi,M., Takahashi.M., Hata,T., Kashima,Y., Takahashi,Y., Sagara,J., Taniguchi,S., Ikeda,U.
Organizer
American Heart Association Scientific Sessions
Place of Presentation
Orlando, U.S.A.
Related Report
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[Presentation] Inflammasome activation in cardiac fibroblasts is essential for myocardial ischemia-reperfusion injury.2009
Author(s)
Kawaguchi,M., Takahashi,M., Hata,T., Kashima,Y., Takahasni,Y., Sagara,J., Taniguchi,S., Ikeda,U.
Organizer
American Heart Association Scientific Sessions
Place of Presentation
Orlando, U.S.A.
Related Report
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[Presentation] Role of an Inflammasome adaptor molecule ASC in myocardial ischemia-reperfusion injury.2008
Author(s)
Kawaguchi M, Takahashi M, Hata T, Takahashi Y, Morimoto H, Ise H, Sagara J, Hongo M, Taniguchi S, Ikeda U.
Organizer
American Heart Association Scientific Sessions
Place of Presentation
New Orleans, USA
Related Report
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[Presentation] Critical role of Th17-CD4^+ T cells in angiogenic response to hindlimb ischemia in mice.2008
Author(s)
Hata T, Takahashi M, Kawaguchi T, Kashima Y, Shiba Y, Ise H, Hida S, Iwakura Y, Taki S, Ikeda U.
Organizer
American Heart Association Scientific Sessions
Place of Presentation
New Orleans, USA
Related Report
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