| Project/Area Number |
20200080
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Gastroenterology
Immunology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
INOUE Nagamu Keio University, 医学部, 講師 (00232546)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Susumu 慶應義塾大学, 医学部, 講師 (70255446)
HISAMATSU Tadakazu 慶應義塾大学, 医学部, 講師 (60255437)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HIBI Toshifumi 慶應義塾大学, 医学部, 教授 (50129623)
WATANABE Mamoru 東京医科歯科大学, 大学院・医歯学総合研究科器官システム制御学系消化器病態学, 教授 (10175127)
MORIMOTO Chikao 東京大学, 医科学研究所先端医療研究センター免疫病態分野, 教授 (30119028)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥33,800,000 (Direct Cost: ¥26,000,000、Indirect Cost: ¥7,800,000)
Fiscal Year 2010: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2009: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2008: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
|
|---|
| Keywords | 炎症性腸疾患 / 粘膜免疫 / 腸内細菌 / マクロファージ / クローン病 / オートファジー / 自然免疫 / 細胞内寄生菌 |
|---|
| Research Abstract |
We tried to elucidate the roles of macrophages in intestinal inflammation by using an IL-10-deficient (IL-10-/-) mouse colitis model, and demonstrated that abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria. Moreover, we found that lamina propria macrophages (LPMs) could be separated into two subsets with distinct side-scattered properties. LPM2 subset migrated in response to MCP-1 and produced a larger amount of IL-10 in response to commensal bacteria.
|
