|Budget Amount *help
¥166,010,000 (Direct Cost: ¥127,700,000、Indirect Cost: ¥38,310,000)
Fiscal Year 2012: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2011: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2010: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2009: ¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2008: ¥41,210,000 (Direct Cost: ¥31,700,000、Indirect Cost: ¥9,510,000)
The present study was designed to develop two advanced methodological approaches to elucidation of structural bases for neural networks and to analyze the architecture and functions of the cortico-basal ganglia circuits in primates. First, we attempted target neuron-selective activity suppression using a novel lentiviral vector system and examined changes in behavioral pattern and neuronal activity in relation to motor tasks. Second, we established a novel system that achieved retrograde transneuronal tract-tracing with rabies virus and its recombinant vectors and investigated the organization of multisynaptic inputs to the prefrontal, premotor, and higher visual areas of the cortex.