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Establishment of an IL-1-related gene-manipulated mice library, aiming at uncovering pathophysiology of disease from a view point of systems biology

Research Project

Project/Area Number 20220009
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionThe University of Tokyo

Principal Investigator

IWAKURA Yoichiro  東京大学, 医科学研究所, 教授 (10089120)

Co-Investigator(Kenkyū-buntansha) SAIJO Shinobu  千葉大学, 真菌医学研究センター, 特任准教授 (60396877)
KAKUTA Shigeru  信州大学, 医学部, 助教 (80345032)
FUJIKADO Noriyuki  東京大学, 医科学研究所, 助教 (90447334)
KUSAKA Toshimasa  東京大学, 医科学研究所, 特任研究員 (60466836)
KAIFU TomonoriI  東京大学, 医科学研究所, 助教 (90343037)
CE Tang  東京大学, 医科学研究所, 助教 (00572166)
MA GUANGYU  東京大学, 医科学研究所, 助教 (60572162)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥101,530,000 (Direct Cost: ¥78,100,000、Indirect Cost: ¥23,430,000)
Fiscal Year 2011: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2010: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2009: ¥62,400,000 (Direct Cost: ¥48,000,000、Indirect Cost: ¥14,400,000)
Fiscal Year 2008: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Keywordsサイトカイン / 疾患モデル動物 / 自己免疫疾患 / Th17細胞 / 関節リウマチ / 間接リウマチ
Research Abstract

The project’s aim is to deeply understand the pathological and physiological roles of IL-1 and IL-1-relating genes in maintaining homeostasis and developing diseases in the immune, the nervous, and the endocrine system. In addition to evaluating the pathophysiological role of these genes, we intended to establish a system of bio-source to provide the gene-manipulated mice with all researchers. We newly generated five gene-targeting mice, which have been finished in backcrossing toward C57BL6/c background, and four additional gene-targeting mice (DCIR, IL-1R2, IL-1F6, and SCPL) were backcrossed to C57BL6/c background. We demonstrated that IL-1-related genes were involved in the regulation of bone metabolism and the development of autoimmune diseases, like arthritis. Moreover, IL-1 was a mediator in controlling activity of the nervous system and had a direct effect on lipid metabolism. On the basis of our analysis in gene-targeting mice, these mice are novel useful disease-models for analyzing the pathology of bony and autoimmune diseases. Finally, we set up the system that supplies gene-manipulated mice that we generated to all researchers, contributing to the progress of research horizons in laboratory animal.

Report

(5 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (311 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (209 results) (of which Peer Reviewed: 209 results) Presentation (78 results) Book (13 results) Remarks (4 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 4 results)

  • [Journal Article] Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice2012

    • Author(s)
      F.Usui
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 420 Issue: 1 Pages: 72-77

    • DOI

      10.1016/j.bbrc.2012.02.117

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule2012

    • Author(s)
      T.Yoshida
    • Journal Title

      J Neurosci

      Volume: 32 Issue: 8 Pages: 2588-2600

    • DOI

      10.1523/jneurosci.4637-11.2012

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors2012

    • Author(s)
      H.Shime
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Issue: 6 Pages: 2066-2071

    • DOI

      10.1073/pnas.1113099109

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier2012

    • Author(s)
      有馬康伸
    • Journal Title

      Cell

      Volume: 148(3) Issue: 3 Pages: 447-457

    • DOI

      10.1016/j.cell.2012.01.022

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Interleukin-1 in Lead Nitrate-Induced Hypercholesterolemia in Mice2012

    • Author(s)
      M.Kojima
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 35 Issue: 2 Pages: 246-250

    • DOI

      10.1248/bpb.35.246

    • NAID

      130001872300

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toxoplasma gondii Infection Inhibits Th17-Mediated Spontaneous Development of Arthritis in Interleukin-1 Receptor Antagonist-Deficient Mice2012

    • Author(s)
      T.Washino
    • Journal Title

      Infect Immun

      Volume: 80 Issue: 4 Pages: 1437-1444

    • DOI

      10.1128/iai.05680-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration2012

    • Author(s)
      Y.H.Liao
    • Journal Title

      J Am Coll Cardiol

      Volume: 59 Issue: 4 Pages: 420-429

    • DOI

      10.1016/j.jacc.2011.10.863

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice2012

    • Author(s)
      F.M.Botelho
    • Journal Title

      PLoS One

      Volume: 6 Issue: 12 Pages: e28457-e28457

    • DOI

      10.1371/journal.pone.0028457

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of interleukin-17 in an experimental Legionella pneumophila pneumonia model2012

    • Author(s)
      Y.Kimizuka
    • Journal Title

      Infect Immun

      Volume: 80 Issue: 3 Pages: 1121-1127

    • DOI

      10.1128/iai.05544-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17A deficiency accelerates unstable atherosclerotic plaque for mation in apolipoprotein E-deficient mice2012

    • Author(s)
      K.Danzaki
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 32 Issue: 2 Pages: 273-280

    • DOI

      10.1161/atvbaha.111.229997

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th172012

    • Author(s)
      H.Nishimori
    • Journal Title

      Blood

      Volume: 119 Issue: 1 Pages: 285-295

    • DOI

      10.1182/blood-2011-01-332478

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-4 (IL-4) and IL-13 suppress excessive neutrophil infiltration and hepatocyte damage during acute murine schistosomiasis japonica2012

    • Author(s)
      T.Seki
    • Journal Title

      Infect Immun

      Volume: 80 Issue: 1 Pages: 159-168

    • DOI

      10.1128/iai.05581-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of thymic stromal lymphopoietin production by xylene and exacerbation of picryl chloride-induced allergic inflammation in mice2012

    • Author(s)
      N.Satou
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 157 Issue: 2 Pages: 194-201

    • DOI

      10.1159/000327545

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of polymeric immunoglobulin receptor expression by the heat-inactivated potential probiotic Bifidobacterium bifidum OLB6378 in a mouse intestinal explant model2012

    • Author(s)
      Y.Nakamura
    • Journal Title

      Scand J Immunol

      Volume: 72 Issue: 2 Pages: 176-183

    • DOI

      10.1111/j.1365-3083.2011.02645.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-1 signaling is dispensable for protective immunity in Leishmania-resistant mice2011

    • Author(s)
      Kautz-Neu, K., Kostka, S. L., Dinges, S., Iwakura, Y., Udey, M. C., and Von Stebut, E.
    • Journal Title

      Exp. Dermatol.

      Volume: 20 Pages: 76-78

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Muramyldipeptide augments the actions of lipopolysacchairde in mice by stimulating macrophages to produe pro-IL-1B and by down-regulation of suppressor of cytokine signaling 1(SOCS1)2011

    • Author(s)
      Shikama, Y., Kuroishi, T., Nagai, Y., Iwakura, Y., Shimauchi, H., Takada, H., Sugawara, S., and Endo, Y.
    • Journal Title

      Innate Immun.

      Volume: 17 Pages: 54-59

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Local microbleeding facilitates IL-6-and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells2011

    • Author(s)
      Murakami, M., Okuyama, Y., Ogura, H., Asano, S., Arima, Y., Tsuruoka, M., Harada, M., Kanamoto, M., Sawa, Y., Iwakura, Y., Takatsu, K., Kamimura, D., and Hirano, T.
    • Journal Title

      J. Exp. Med.

      Volume: 208 Pages: 103-114

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] G. Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation2011

    • Author(s)
      Rivera, A., Hohl, T. M., Collins, N., Leiner, I., Gallegos, A., Saijo, S., Coward, J. W., Iwakura, Y., and Pamer, E.
    • Journal Title

      J. Exp. Med.

      Volume: 208 Pages: 369-381

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in melanocortin receptor 2. deficient mice2011

    • Author(s)
      Chida, D., Miyoshi, K., Sato, T., Yoda, T., Kikusui, T., and Iwakura, Y.
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 1652-1660

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional specialization of IL-17 family members2011

    • Author(s)
      Iwakura, Y., Ishigame, H., Saijo, S., and Nakae, S.
    • Journal Title

      Immunity

      Volume: 34 Pages: 149-162

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Memory/effector(CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology2011

    • Author(s)
      Kamanaka, M., Huber, S., Zenewicz, L. A., Gagliani, N., Rathinam, C., O' Connor, W. Jr., Wan, Y. Y., Nakae, S., Iwakura, Y., Hao, L., and Flavell, R. A.
    • Journal Title

      J. Exp. Med.

      Volume: 208 Pages: 1027-1040

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-1 and Dectin-2 in innate immunity against fungi2011

    • Author(s)
      Saijo, S., and Iwakura, Y.
    • Journal Title

      Int. Immunol.

      Volume: 23 Pages: 467-472

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Control of T(H) 17 cells occurs in the small intestine2011

    • Author(s)
      Esplugues, E., Huber, S., Gagliani, N., Hauser, A. E., Town, T., Wan, Y. Y., O' Connor, W., Rongvaux, A., Van Rooijen, N., Haberman, A. M., Iwakura, Y., Kuchroo, V. K., Kolls, J. K., Bluestone, J. A., Herold, K. C., and Flavell, R. A.
    • Journal Title

      Nature

      Volume: 475 Pages: 514-518

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Desmoglein 3-specific CD4+T cells induce pemphigus vulgaris and interface dermatitis in mice2011

    • Author(s)
      Takahashi, H., Kouno, M., Nagao, K., Wada, N., Hata, T., Nishimoto, S., Iwakura, Y., Yoshimura, A., Yamada, T., Kuwana, M., Fujii, H., Koyasu, S., and Amagai, M.
    • Journal Title

      J. Clin. Invest.

      Volume: 121 Pages: 3677-3688

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional recovery after peripheral nerve injury is dependent on the proinflammatory cytokines IL-1. and TNF : implicaitons for neuropathic pain2011

    • Author(s)
      Nadeau, S., Filali, M., Zhang, J., Kerr, B. J., Rivest, S., Soulet, D., Iwakura, Y., de Rivero Vaccari, J. P., Keane, R. W., and Lacroix, S.
    • Journal Title

      J. Neurosci.

      Volume: 31 Pages: 12533-12542

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase2011

    • Author(s)
      Yoshida, T., Yasumura, M., Uemura, T., Lee, S. J., Ra, M., Taguchi, R., Iwakura, Y., and Mishina, M.
    • Journal Title

      J. Neurosci.

      Volume: 31 Pages: 13485-13499

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling2011

    • Author(s)
      S.Nishimura
    • Journal Title

      Blood

      Volume: 119 Issue: 8 Pages: 128-131

    • DOI

      10.1182/blood-2011-09-381400

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kjellmaniella crassifolia Miyabe (Gagome) Extract Modulates Intestinal and Systemic Immune Responses2011

    • Author(s)
      H.Yan
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 75 Issue: 11 Pages: 2178-2183

    • DOI

      10.1271/bbb.110473

    • NAID

      10030396791

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-12011

    • Author(s)
      T.Ashino
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 36 Issue: 5 Pages: 635-643

    • DOI

      10.2131/jts.36.635

    • NAID

      10029481491

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-1 Controls the Constitutive Expression of the Cyp7a1 Gene by Regulating the Expression of Cyp7a1 Transcriptional Regulators in the Mouse Liver2011

    • Author(s)
      M.Kojima
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 34 Issue: 10 Pages: 1644-1647

    • DOI

      10.1248/bpb.34.1644

    • NAID

      130001086603

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17A is involved in enhancement of tumor progression in murine intestine2011

    • Author(s)
      K.Oshiro
    • Journal Title

      Immunobiology

      Volume: 217 Issue: 1 Pages: 54-60

    • DOI

      10.1016/j.imbio.2011.08.002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production2011

    • Author(s)
      M.Xu
    • Journal Title

      Eur J Immunol

      Volume: 41 Issue: 10 Pages: 2828-2839

    • DOI

      10.1002/eji.201141291

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NYAP : a phosphoprotein family that links PI3K to WAVE1 signalling in neurons2011

    • Author(s)
      K.Yokoyama
    • Journal Title

      EMBO J

      Volume: 30 Issue: 23 Pages: 4739-4754

    • DOI

      10.1038/emboj.2011.348

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ2011

    • Author(s)
      T.Yoshida
    • Journal Title

      J Neurosci

      Volume: 31 Issue: 38 Pages: 13485-13499

    • DOI

      10.1523/jneurosci.2136-11.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion2011

    • Author(s)
      S.Itoh
    • Journal Title

      Circulation

      Volume: 124 Issue: 11_suppl_1

    • DOI

      10.1161/circulationaha.110.014852

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1ss and TNF : implications for neuropathic pain2011

    • Author(s)
      S.Nadeau
    • Journal Title

      J Neurosci

      Volume: 31 Issue: 35 Pages: 12533-12542

    • DOI

      10.1523/jneurosci.2840-11.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective role of naturally occurring interleukin-17A-producing Yδ T cells in the lung at the early stage of systemic candidiasis in mice2011

    • Author(s)
      T.Dejima
    • Journal Title

      Infect Immun

      Volume: 79 Issue: 11 Pages: 4503-4510

    • DOI

      10.1128/iai.05799-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of autoimmune thyroiditis by depletion of CD4+CD25+ regulatory T cells in thyroiditis-resistant IL-17, but not interferon-gamma receptor, knockout nonobese diabetic-H2h4 mice2011

    • Author(s)
      I.Hoie
    • Journal Title

      Endocrinology

      Volume: 152 Issue: 11 Pages: 4448-4454

    • DOI

      10.1210/en.2011-1356

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice2011

    • Author(s)
      Takahashi H, Kouno M, Nagao K, Wada N, Hata T, Nishimoto S, 他
    • Journal Title

      J Clin Invest

      Volume: 121 Issue: 9 Pages: 3677-3688

    • DOI

      10.1172/jci57379

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early activation and interferon-Y production of tumor-infiltrating mature CD27 high natural killer cells2011

    • Author(s)
      Y.Hayakawa
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 11 Pages: 1967-1971

    • DOI

      10.1111/j.1349-7006.2011.02042.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A critical role for regulatory T cells in driving cytokine profiles of Th17 cells and their modulation of glioma microenvironment2011

    • Author(s)
      G.Cantini
    • Journal Title

      Cancer Immunol Immunother

      Volume: 60 Issue: 12 Pages: 1739-1750

    • DOI

      10.1007/s00262-011-1069-4

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of TH17 cells occurs in the small intestine2011

    • Author(s)
      E.Esplugues
    • Journal Title

      Nature

      Volume: 475 Issue: 7357 Pages: 514-518

    • DOI

      10.1038/nature10228

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17A promotes early but attenuates established disease in crescentic glomerulonephritis in mice2011

    • Author(s)
      D.Odobasic
    • Journal Title

      Am J Pathol

      Volume: 179 Issue: 3 Pages: 1188-1198

    • DOI

      10.1016/j.ajpath.2011.05.039

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-dependent regulation of depression-like behaviors through modulation of adrenergic receptor α1A subtype expression revealed by the analysis of interleukin-1 receptor antagonist knockout mice2011

    • Author(s)
      C.Wakabayashi
    • Journal Title

      Neuroscience

      Volume: 192 Pages: 475

    • DOI

      10.1016/j.neuroscience.2011.06.031

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-1 and Dectin-2 in innate immunity against fungi2011

    • Author(s)
      S.Saijo
    • Journal Title

      Int Immunol

      Volume: 23 Issue: 8 Pages: 467-472

    • DOI

      10.1093/intimm/dxr046

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fungal allergen ss-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells2011

    • Author(s)
      W.A.Neveu
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 45 Issue: 6 Pages: 1133-1141

    • DOI

      10.1165/rcmb.2011-0054oc

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch-Hes1 pathway is required for the development of IL-17-producing Yδ T cells2011

    • Author(s)
      K.Shibata
    • Journal Title

      Blood

      Volume: 118 Issue: 3 Pages: 586-593

    • DOI

      10.1182/blood-2011-02-334995

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived ss-glucans2011

    • Author(s)
      C.Qi
    • Journal Title

      Blood

      Volume: 117 Issue: 25 Pages: 6825-6836

    • DOI

      10.1182/blood-2011-02-339812

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for leukocyte-derived IL-1RA in DC homeostasis revealed by increased susceptibility of IL-1RA-deficient mice to cutaneous leishmaniasis2011

    • Author(s)
      K.Kautz-Neu
    • Journal Title

      J Invest Dermatol

      Volume: 131 Issue: 8 Pages: 1650-1659

    • DOI

      10.1038/jid.2011.99

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology2011

    • Author(s)
      M.Kamanaka
    • Journal Title

      J Exp Med

      Volume: 208 Issue: 5 Pages: 1027-1040

    • DOI

      10.1084/jem.20102149

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production2011

    • Author(s)
      C.F.Brereton
    • Journal Title

      J Immunol

      Volume: 186 Issue: 10 Pages: 5896-5906

    • DOI

      10.4049/jimmunol.1003789

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice2011

    • Author(s)
      M.S.Madhur
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 31 Issue: 7 Pages: 1565-1572

    • DOI

      10.1161/atvbaha.111.227629

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNF-{alpha} from inflammatory dendritic cells(DCs)regulates lung IL-17A/IL-5 Levels and neutrophilia versus eosinophilia during persistent fungal infection.2011

    • Author(s)
      Fei, M.
    • Journal Title

      Proc.Natl.Acad..SCI.USA.

      Volume: 108 Pages: 5360-5365

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional specialization of interleukin-17 family members.2011

    • Author(s)
      Iwakura, Y.
    • Journal Title

      Immunity

      Volume: 34 Pages: 149-162

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of Syk/CARD9 coupled C-type lectins in antifungal immunity.2011

    • Author(s)
      Drummond, R.A
    • Journal Title

      Eur.J.Immunol.

      Volume: 41 Pages: 276-281

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with apredominance of alternatively activated phenotype.2011

    • Author(s)
      Bhatia, S.
    • Journal Title

      PLoS One.

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-1 diversifies Aspergillus fumigates-specific T cell responses by inhibiting Thelper type 1 CD4 T cell differentiation.2011

    • Author(s)
      Rives, A
    • Journal Title

      J.Exp.Med.

      Volume: 208 Pages: 369-381

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local microbleeding facilitates 1L-6-and IL-17-dependent althritis in the absence of tissue antigen recognition by activated T cells.2011

    • Author(s)
      Murakami, M.
    • Journal Title

      J.Exp.Med.

      Volume: 208 Pages: 103-114

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice.2011

    • Author(s)
      Kautz-Neu, K
    • Journal Title

      Exp.Dermatol.

      Volume: 20 Pages: 76-78

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct role of T helper Type 17 immune response for Graves'hyperthyroidism in mice with different genetic backgrounds.2011

    • Author(s)
      Horie, I.
    • Journal Title

      Autoimmunity

      Volume: 44 Pages: 159-165

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective role of IL-1β against post-arthroplasty Staphylococcus aureus infection.2011

    • Author(s)
      Bernthal, N.M.
    • Journal Title

      J.Orthop.Res.

      Volume: (in press)(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor receptor-associated factor(Traf)2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease.2011

    • Author(s)
      Piao, J.H.
    • Journal Title

      J.Biol.Chem.

      Volume: (in press)(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natural Killer T Cell-Derived IL-17Mediates Lung Ischemia-Reperfusion Injury2011

    • Author(s)
      Sharma, A K
    • Journal Title

      Am.J.Respir.Crit.Care Med.

      Volume: (in press)(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin2011

    • Author(s)
      Andrews, D.M.
    • Journal Title

      Immunol.Cell Biol.

      Volume: (in press)(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IFN-regulates the requirement for IL-17 in proteoglycan-induced arthritis2010

    • Author(s)
      Doodes, P. D., Cao, Y., Hamel, K. M., Wang, Y., Rodeghero, R. I., Mikecz, K., Glant T. T., Iwakura, Y., and Finnegan, A.
    • Journal Title

      J. Immunol.

      Volume: 184 Pages: 1552-1559

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural tube defects and impaired neural progenitor cell proliferation in G. 1-deficient mice2010

    • Author(s)
      Okae, H., and Iwakura, Y.
    • Journal Title

      Developmental Dynamics

      Volume: 239 Pages: 1089-1101

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung2010

    • Author(s)
      Okamoto Yoshida, Y., Umemura, M., Yahagi, A., O' Brien, R. L., Ikuta, K., Kishihara, K., Hara, H., Nakae, S., Iwakura, Y., and Matsuzaki, G.
    • Journal Title

      J. Immunol.

      Volume: 184 Pages: 4414-4422

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-2 recognition ofα-mannans and induction of Th17 differentiation is essential for host defense against Candida albicans2010

    • Author(s)
      Saijo, S., Ikeda, S., Yamabe, K., Kakuta, S., Ishigame, H., Akitsu, A., Fujikado, N., Kusaka, T., Kubo, S., Chung, S., Komatsu, R., Miura, N., Adachi, Y., Ohno, N., Shibuya, K., Yamamoto, N., Kawakami, K., Yamasaki, S., Saito, T., Akira, S., and Iwakura,
    • Journal Title

      Immunity

      Volume: 32 Pages: 681-691

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection2010

    • Author(s)
      Miyazaki, Y., Hamano, S., Wang, S., Shimanoe, Y., Iwakura, Y., and Yoshida, H.
    • Journal Title

      J. Immunol.

      Volume: 185 Pages: 1150-1157

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] M. Type I interferon signaling constrains IL-17A/F secretion byγδT cells during bacterial infection2010

    • Author(s)
      Henry, T., Kirimanjeswara, G. S., Ruby, T., Jones, J. W., Peng, K., Perret, M., Ho, L., Sauer, J.-D., Iwakura, Y., Metzger, D. W., and Monack, D.
    • Journal Title

      J. Immunol.

      Volume: 184 Pages: 3755-3767

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Il1rn^<-/-> mice2010

    • Author(s)
      Nakajima, A., Matsuki, T., Komine, M., Asahina, A., Horai, R., Nakae, S., Ishigame, H., Kakuta, S., Saijo, S., and Iwakura, Y.
    • Journal Title

      J. Immunol.

      Volume: 185 Pages: 1887-1893

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-1 plays an important role in the bone metabolism under physiological conditions2010

    • Author(s)
      Lee, Y.-M., Fujikado, N., Manaka, H., Yasuda, H., and Iwakura, Y.
    • Journal Title

      Int. Immunol.

      Volume: 22 Pages: 805-816

    • NAID

      10027907526

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] D. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis2010

    • Author(s)
      Chou, R. C., Kim, N. D., Sadik, C. D., Seung, E., Lan, Y., Byrne, M. H., Haribabu, B., Iwakura, Y., and Luster, A.
    • Journal Title

      Immunity

      Volume: 33 Pages: 266-278

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] L. Lung CD4-CD8-double-negative T cells are prominent producers of IL-17A and IFN-during primary respiratory murine infection with Francisella tularensis live vaccine strain2010

    • Author(s)
      Cowley, S. C., Meierovics, A. I., Frelinger, J. A., Iwakura, Y., and Elkins, K.
    • Journal Title

      J. Immunol.

      Volume: 184 Pages: 5791-5801

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis2010

    • Author(s)
      Chung, S. H., Seki, K., Choi, B. I., Kimura, K. B., Ito, A., Fujikado, N., Saijo, S., and Iwakura, Y.
    • Journal Title

      Arthritis Res. Ther.

      Volume: 12 Pages: 188-188

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD30 ligand is a tazget for a novel biological therapy against colitis associated with Th 17 responses.2010

    • Author(s)
      Sun, X
    • Journal Title

      J.Immunol.

      Volume: 185 Pages: 7671-7680

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of endogenous glucocorticoids in lymphocyte development in melanowrtin receptor 2-deficient mice.2010

    • Author(s)
      Sato, Y.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 403 Pages: 253-257

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of experimental cerebral malaria is independent of IL-23 and IL-172010

    • Author(s)
      Lshida, H.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 402 Pages: 790-795

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis.2010

    • Author(s)
      Chung, S.H.
    • Journal Title

      Arthritis Res.Ther.

      Volume: 12

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity.2010

    • Author(s)
      Lee, H.H.
    • Journal Title

      J.Immunol.

      Volume: 185 Pages: 5225-5235

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional hypothalamic amenorrhea due to increased CRH tone in melanocortin receptor 2-deficient mice.2010

    • Author(s)
      Matsuwaki, T.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 5489-5496

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periprosthetic osteolysis : characterizing the innate immune response to titanium wear-particles.2010

    • Author(s)
      St Pierre, C.A
    • Journal Title

      J.Orthop.Res.

      Volume: 28 Pages: 1418-1424

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of regulatory Tcell in Th17-mediated minor antigen-disparate rejection2010

    • Author(s)
      Vokaer, B.
    • Journal Title

      J.Immunol.

      Volume: 185 Pages: 3417-3425

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a marine model of inflammatory arthritis.2010

    • Author(s)
      Chou, R C.
    • Journal Title

      Immunity

      Volume: 33 Pages: 266-278

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-1 plays an important role in the bone metabolism under physiological conditions.2010

    • Author(s)
      Lee, Y.M.
    • Journal Title

      Int.Immunol

      Volume: 22 Pages: 805-816

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of interleukin-17A in cell-mediated protection against Staphylococcus aureus infection in mice immunized with the fibrinogen-binding domain of clumping factor A2010

    • Author(s)
      Narita, K
    • Journal Title

      Infect.Immun.

      Volume: 78 Pages: 4234-4242

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1α, 25-Dihydroxyvitamin D3 and all-traps retinoic acid synergistically inhibit the differentiation and expansion of Th17 cells2010

    • Author(s)
      Ikeda, U.
    • Journal Title

      Immunol.Lett.

      Volume: 134 Pages: 7-16

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammasome activation by adenylate cyclase toxin directs Th 17 responses and protection against Bordetella pertussis.2010

    • Author(s)
      Dunne, A.
    • Journal Title

      J.Immunol.

      Volume: 185 Pages: 1711-1719

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNF but not IL-6 and IL17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Ill rn-/-mice.2010

    • Author(s)
      Nakajima, A.
    • Journal Title

      J.Immunol.

      Volume: 185 Pages: 1887-1893

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17A during local and systemic Staphylococcus aureus-induced arthritis in mice.2010

    • Author(s)
      Henningsson, L.
    • Journal Title

      Infect.Immun.

      Volume: 78 Pages: 3783-3790

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered effector CD4+ T cell function in IL-21R-/-CD4+ T cell-mediated graft-versus-host disease.2010

    • Author(s)
      Oh, I.
    • Journal Title

      J Immunol

      Volume: 185 Pages: 1920-1926

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection.2010

    • Author(s)
      Miyazaki, Y.
    • Journal Title

      J.Immunol.

      Volume: 185 Pages: 1150-1157

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The mechanism of lipopolysaccharide-induced human immunodefieiency virus type I activation in transgenic mouse macrophages.2010

    • Author(s)
      Kadoki, M.
    • Journal Title

      Int.Immunol.

      Volume: 22 Pages: 469-478

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice.2010

    • Author(s)
      Hadano, S.
    • Journal Title

      Neurosci.Res.

      Volume: 68 Pages: 131-136

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AT(h)17-polarized cell population that has infiltrated the lung requires cells that convert to IFN-{gamma}production in order to induce airway hyperresponsiveness.2010

    • Author(s)
      Ashino, S.
    • Journal Title

      Int.Immunol.

      Volume: 22 Pages: 503-513

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-2 recognition of alpha-mannans and induction of Th 17 cell differentiation is essential for host defense against Candida albicans.2010

    • Author(s)
      Saijo, S.
    • Journal Title

      Immunity

      Volume: 32 Pages: 681-691

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensisvia a Toll-like receptor 9-dependent pathway.2010

    • Author(s)
      Xiao, G
    • Journal Title

      Cell Immunol

      Volume: 263 Pages: 241-250

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma.2010

    • Author(s)
      Hill, G.R.
    • Journal Title

      Blood

      Volume: 116 Pages: 819-828

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-23 suppresses innate immune response independently of IL-17A duringcar cinogenesis and metastasis.2010

    • Author(s)
      Teng, M.W.
    • Journal Title

      Proc.Natl.Acad.Sci.U S A.

      Volume: 107 Pages: 8328-8333

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor-infiltrating IL-17-producing gammadelta T cells support the progression of tumor by promoting angiogenesis.2010

    • Author(s)
      Wakita, D.
    • Journal Title

      Eur.J.Immunol.

      Volume: 40 Pages: 1927-1937

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lung CD4-CD8-double-negative T cell are prominent producer of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain.2010

    • Author(s)
      Cowley, S.C.
    • Journal Title

      J.Immunol.

      Volume: 184 Pages: 5791-5891

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy.2010

    • Author(s)
      Baldeviano, G.C.
    • Journal Title

      Circ.Res.

      Volume: 106 Pages: 1636-1655

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis.2010

    • Author(s)
      Gan, P.Y.
    • Journal Title

      J.Am.Soc.Nephrol

      Volume: 21 Pages: 925-931

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the cellular sensor that stimulates the inflammatory response to sterilecell death.2010

    • Author(s)
      Kono, H.
    • Journal Title

      J Immunol

      Volume: 184 Pages: 4470-4478

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of Il-17A in the formation of a mycobacterial infection-induced granuloma in the lung.2010

    • Author(s)
      Okamoto, Yoshida, Y.
    • Journal Title

      J.Immunol.

      Volume: 184 Pages: 4414-4422

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural tube defects and impaired neural progenitor cell proliferation in Gbetal-deficient mice.2010

    • Author(s)
      Okae, H.
    • Journal Title

      Dev Dyn.

      Volume: 239 Pages: 1089-1010

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections.2010

    • Author(s)
      Henry, T.
    • Journal Title

      J.Immunol.

      Volume: 184 Pages: 3755-3767

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nucleoprotein diet ameliorates arthritis symptoms in mice transgenic for humanT-cell leukemia virus type I(HTLV-I).2010

    • Author(s)
      Ohtaki, H.
    • Journal Title

      J.Clin.Biochem.Nutr. 46

      Pages: 93-104

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IFN-γ is a master regulator of endotoxin shock syndrome in mice primed withheat-killed Propionibacterium acnes.2010

    • Author(s)
      Kawa, K.
    • Journal Title

      Int.Immunol. 22

      Pages: 157-166

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in BALB/c mice.2010

    • Author(s)
      Isoda, K.
    • Journal Title

      Arterioscler. Thromb.Vasc.Biol. 30

      Pages: 708-715

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17 contributes to the development of chronic rejection in a murine-heart transpant model.2010

    • Author(s)
      Itoh, S.
    • Journal Title

      J.Clin.Immunol. 30

      Pages: 235-240

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors.2010

    • Author(s)
      Adamopoulos, I.E.
    • Journal Title

      Arthritis Res.Ther 12

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periprosthetic Osteolysis : Characterizing the innate immune response to titanium wear particles.2010

    • Author(s)
      St.Pierre, C.A.
    • Journal Title

      J.Orthopedic Res. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The mechanism of lipopolysaccharide-induced human immunodeficiency virus type I activation in transgenic mouse macrophages.2010

    • Author(s)
      Kadoki, M.
    • Journal Title

      Int.Immunol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a variant virus from ascites of subacute granulomatous serositis in interferon-γ-deficient C57BL/6 mice persistently infected with murine coronavirus strain JHM.2010

    • Author(s)
      Taguchi, F.
    • Journal Title

      Viral Immunol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis.2010

    • Author(s)
      Teng, M.W.L
    • Journal Title

      Proc.Natl.Acad.Sci.USA (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy.2010

    • Author(s)
      Baldeviano, G.C.
    • Journal Title

      Circulation Res. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stem cell mobilization with G-CSF induces Type-17 differentiaion and promotes scleroderma.2010

    • Author(s)
      Hill, G.R.
    • Journal Title

      Blood (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dectin-2 recognition of α-mannans and induction of Th17 differentiation is essential for host defense against Candida albicans.2010

    • Author(s)
      Saijo, S.
    • Journal Title

      Immunity (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The roles of IL-17A and IL-17A in mucosal infection and allergy. In"Th17 cells in health and disease",(ed.S.Jiang).2010

    • Author(s)
      Ishigame, H.
    • Journal Title

      Springer Science+Buisiness Media, LLC, New York, NY (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Th17 nephritogenic immunity induces autoimmune anti-MPO glomerulonephritis.2010

    • Author(s)
      Gan, P.-Y.
    • Journal Title

      J.Am.Soc.Nephrol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type I interferon signaling constrains IL-17A/F secretion by γδ T cells duringbacterial infection.2010

    • Author(s)
      Henry, T.
    • Journal Title

      J.Immunol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death.2010

    • Author(s)
      Kono, H.
    • Journal Title

      J.Immunol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muramyldipeptide augments the actions of lipopolysacchairde in mice by stimulating macrophages to produe pro-IL-1B and by down-regulation of suppressor of cytokine signaling 1 (SOCS1).2010

    • Author(s)
      Shikama, Y.
    • Journal Title

      Innate Immun. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential roles of IL-17A and IL-17F in host defense against mucoepithelial bacterial infection and allergic responses2009

    • Author(s)
      Ishigame, H., Kakuta, S., Nagai, T., Nambu, A., Komiyama, Y., Kadoki, M., Tanahashi, Y., Akitsu, A., Kotaki, H., Sudo, K., Nakae, S., Sasakawa, C., and Iwakura, Y
    • Journal Title

      Immunity

      Volume: 30 Pages: 108-119

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice2009

    • Author(s)
      Lopez Kostka, S., Dinges, S., Griewank, K., Iwakura, Y., Udey, M. C., and Von Stebut, E.
    • Journal Title

      J. Immunol.

      Volume: 182 Pages: 3039-3046

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] M. Virus binding to a plasma membrane receptor triggers interleukin-1α-mediated proinflammatory macrophage response in vivo2009

    • Author(s)
      Di Paolo, N. C., Miao, E. A., Iwakura, Y., Kaja, M-K., Aderem, A., Flavell, R. A., Papayannopoulou, T., and Shayakhmetov, D.
    • Journal Title

      Immunity

      Volume: 31 Pages: 110-121

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of mice deficient in Melanocortin 2 receptor on a B6/Balbc mix background2009

    • Author(s)
      Chida, D., Sato, T., Sato, Y., Kubo, M., Yoda, T., Suzuki, H., and Iwakura, Y.
    • Journal Title

      Mol. Cell. Endocrinol.

      Volume: 300 Pages: 32-36

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation2009

    • Author(s)
      Inoue, A., Setoguchi, K., Matsubara, Y., Okada, K., Sato, N., Iwakura, Y., Higuchi, O., and Yamanashi, Y.
    • Journal Title

      Science Signaling

      Volume: 2 Pages: 7-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A. A protective function for interleukin 17A in T cell-mediated intestinal inflammation2009

    • Author(s)
      O' Connor, W. Jr., Kamanaka, M., Booth, C. J., Town, T., Nakae, S., Iwakura, Y., Kolls, J. K., and Flavell, R.
    • Journal Title

      Nat. Immunol.

      Volume: 10 Pages: 603-609

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] E. Pulmonary inflammation triggered by Ricin toxin requires macrophages and IL-1 signaling2009

    • Author(s)
      Lindauer, M. L., Wong, J., Iwakura, Y., and Magun, B.
    • Journal Title

      J. Immunol.

      Volume: 183 Pages: 1419-1426

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pivotal role of cerebral interleukin-17-producingγδT cells in the delayed phase of ischemic brain injury2009

    • Author(s)
      Shichita, T., Sugiyama, Y., Ooboshi, H., Sugimori, H., Nakagawa, R., Takada, I., Iwaki, T., Okada, Y., Iida, M., Cua, D. J., Iwakura, Y., and Yoshimura, A.
    • Journal Title

      Nat. Med.

      Volume: 15 Pages: 946-950

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin(IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-172009

    • Author(s)
      Munoz, M., Heimesaat, M. M., Danker, K., Struck, D., Lohmann, U., Plickert, R., Bereswill, S., Fischer, A., Dunay, I. R., Wolk, K., Loddenkemper, C., Krell, H.-W., Libert, C., Lund, L. R., Frey, O., Holscher, C., Iwakura, Y., Ghilardi, N., Ouyang, W., Kamradt, T., Sabat, R., and Liesenfeld, O.
    • Journal Title

      J. Exp. Med.

      Volume: 206 Pages: 3047-3059

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CXCL12 promotes CCR7-dependent naive T-cell trafficking to lymphnodes and Peyer's patches.2009

    • Author(s)
      Bai, Z.B.
    • Journal Title

      J.Immunol. 182

      Pages: 1287-1295

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential roles of IL-17A and IL-17F in host defense against mucoepithelial bacterial infection and allergic responses.2009

    • Author(s)
      Ishigame, H.
    • Journal Title

      Immunity 30

      Pages: 108-119

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice.2009

    • Author(s)
      Lopez Kostka, S.
    • Journal Title

      J.Immunol. 182

      Pages: 3039-3046

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MHC-matched corneal allograft rejection in an IFN-γ/IL-17-independent manner in C57BL/6 mice.2009

    • Author(s)
      Yamada, J.
    • Journal Title

      Invest.Ophthalmol. Vis.Sci. 50

      Pages: 2139-2146

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biotin status affects nickel allergy via regulation of IL-1β production in mice.2009

    • Author(s)
      Kuroishi, T.
    • Journal Title

      J.Nutrition. 139

      Pages: 1031-1036

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host-derived Interleukin 1α is important in determining the immunog enicity of3-Methylcholantrene-tumor cells.2009

    • Author(s)
      Elkabets, M.
    • Journal Title

      J.Immunol. 182

      Pages: 4874-4881

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Virus binding to a plasma membrane receptor triggers interleukin-1α-mediated proinflammatory macrophage response in vivo.2009

    • Author(s)
      Di Paolo, N.
    • Journal Title

      Immunity 31

      Pages: 110-121

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 9-dependent activation of myeloid dendritic cells bydeoxynucleic acids from Candida albicans.2009

    • Author(s)
      Miyazato, A.
    • Journal Title

      Infect.Immun. 77

      Pages: 3056-3064

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic platelet accumulation in Fas-mediated hepatitis in mice.2009

    • Author(s)
      Ohtaki, Y.
    • Journal Title

      Int.Immunopharmacol. 9

      Pages: 1071-1078

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A protective function for interleukin 17A in T cell-mediated intestinal inflammation.2009

    • Author(s)
      O'Connor, W.Jr.
    • Journal Title

      Nat.Immunol. 10

      Pages: 603-609

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17 is involved in bone resorption in mouse periapical lesions.2009

    • Author(s)
      Oseko, F.
    • Journal Title

      Microbiol.Immunol. 53

      Pages: 287-294

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The antihyperalgesic activity of selective P2X7 receptor antagonist, A-839977, is lost in IL-1α knockout mice.2009

    • Author(s)
      Honore, P.
    • Journal Title

      Behav.BrainRes. 204

      Pages: 77-81

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft versus host disease.2009

    • Author(s)
      Yi, T.
    • Journal Title

      Blood 114

      Pages: 3101-3112

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary inflammation triggered by Ricin toxin requires macrophages and IL-1 signaling.2009

    • Author(s)
      Lindauer, M.L.
    • Journal Title

      J.Immunol. 183

      Pages: 1419-1426

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pivotal role of cerebral interleukin-17-producing γδT cells in the delayed phase of ischemic brain injury.2009

    • Author(s)
      Shichita, T.
    • Journal Title

      Nat.Med. 15

      Pages: 946-950

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A.2009

    • Author(s)
      Okiyama, N.
    • Journal Title

      Arth.Rheum. 60

      Pages: 2505-2512

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-1 deficency in combination with macrophage depletion increases susceptibility to Pseudomonas aeruginosa bacteremia.2009

    • Author(s)
      Horino, T.
    • Journal Title

      Microbiol.Immunol. 53

      Pages: 502-511

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior.2009

    • Author(s)
      Taniguchi, S.
    • Journal Title

      EMBO J. 28

      Pages: 3717-3729

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice.2009

    • Author(s)
      Horie, I.
    • Journal Title

      Endocrinology 150

      Pages: 5135-5142

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Fracisella tularensis.2009

    • Author(s)
      Lin, Y.
    • Journal Title

      Immunity 31

      Pages: 799-810

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natural occurring IL-17 producing T cells regulagte the initial phase of neutrophil mediated airway responses.2009

    • Author(s)
      Tanaka, S.
    • Journal Title

      J.Immunol. 183

      Pages: 7523-7530

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of T cell TGFβ signaling and IL-17 in allograft acceptance and fibrosisassociated with chronic rejection.2009

    • Author(s)
      Faust, S.M.
    • Journal Title

      J.Immunol. 183

      Pages: 7297-7306

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responsesfor the development of experimental autoimmune encephalo myelitis.2009

    • Author(s)
      Oyamada, A.
    • Journal Title

      J.Immunol. 183

      Pages: 7539-7546

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin(IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17.2009

    • Author(s)
      Munoz, M.
    • Journal Title

      J.Exp.Med. 206

      Pages: 3047-3059

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IFN- regulates the requirement for IL-17 in proteoglycan-induced arthritis.2009

    • Author(s)
      Doodes, P.D.
    • Journal Title

      J.Immunol. 184

      Pages: 1552-1559

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction.2009

    • Author(s)
      Madhur, M.S.
    • Journal Title

      Hypertension 55

      Pages: 500-507

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IFN-γ expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T death.2009

    • Author(s)
      Atsumi, T.
    • Journal Title

      Int. Immjnol., 21

      Pages: 73-80

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] II-17 contributes to CD4-mediatd graft-versus-host disease.2009

    • Author(s)
      Kappel, L. W.
    • Journal Title

      Blood, 113

      Pages: 945-952

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of mice deficient in Melanocortin 2 receptor on a B6/Balbc mix background.2009

    • Author(s)
      Chida, D.
    • Journal Title

      mol. Cell. Endocrinol., 300

      Pages: 32-36

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-1 regulates the Cyp7al gene and serum total cholesterol level at steady state in mice.2009

    • Author(s)
      Kojima, M.
    • Journal Title

      Biochem. Biophys. Res. Commun., 279

      Pages: 239-242

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dfferential roles of IL-17A and IL-17F in defense against mucoepithelial bacterial infection and allergic responses.2009

    • Author(s)
      Ishigame, H.
    • Journal Title

      Immunity, 29

      Pages: 628-636

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis.2009

    • Author(s)
      Irie, N.
    • Journal Title

      J Biol Chem. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.2009

    • Author(s)
      Yoneda, M.
    • Journal Title

      Cancer Sci., (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of Natural Killer T cells and IL-172008

    • Author(s)
      Pichavant, M., Goya, S., Meyer, E. H., Johnston, R. A., Kim, H. Y., Matangkasombut, P., Zhu, M., Iwakura, Y., Savage, P. B., DeKruyff, R. H., Shore, S. A., and Umetsu, D. T.
    • Journal Title

      J. Exp. Med.

      Volume: 205 Pages: 385-393

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The roles of IL-17A in inflammatory immune responses and host defense against pathogens2008

    • Author(s)
      Iwakura, Y., Nakae, S., Saijo, S., and Ishigame, H.
    • Journal Title

      Immunological Rev.

      Volume: 226 Pages: 57-79

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] K. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia2008

    • Author(s)
      Aujla, S. J., Fei, M., Pociask, D. A., Reinhart, T. A., Edeal, J., Gaus, K., Kreindler, J. L., Dubin, P. J., Zheng, M., Pilewski, J. M., Myerburg, M. M., Mason, C. A., Iwakura, Y., and Kolls, J.
    • Journal Title

      Nature Med.

      Volume: 14 Pages: 275-281

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Either a Th17 or a Th1 effector response can drive autoimmunity : conditions of disease induction affect dominant effector category2008

    • Author(s)
      Luger, D., Silver, P. B., Tang, J., Cua, D., Chen, Z., Iwakura, Y., Bowman, E. P., Sgambellone, N. M., Chan, C.-C. and Caspi, R.
    • Journal Title

      J. Exp. Med.

      Volume: 205 Pages: 799-810

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis2008

    • Author(s)
      Izcue, A., Hue, S., Buonocore, S., Arancibia-Carcamo, C. V., Ahern, P. P., Iwakura, Y., Maloy, K. J., and Powrie, F
    • Journal Title

      Immunity

      Volume: 28 Pages: 559-570

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] L-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8^+T cells2008

    • Author(s)
      Tajima, M., Wakita, D., Noguchi, D., Chamoto, K., Yue, Z, Fugo, K., Ishigame, H., Iwakura, Y., Kitamura, H., and Nishimura, T
    • Journal Title

      J. Exp. Med.

      Volume: 205 Pages: 1019-1027

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased fat-to-carbohydrate oxidation ratio in Il1ra^<-/-> mice on a high fat diet is associated with increased sympathetic tone2008

    • Author(s)
      Chida, D., Hashimoto, O., Kuwahara, M., Sagara, H., Osaka, T., Tsubone, H., and Iwakura, Y.
    • Journal Title

      Diabetologia

      Volume: 51 Pages: 1698-1706

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction2008

    • Author(s)
      Ogura, H., Murakami, M., Okyuyama, Y., Tsuruoka, M., Kitabayashi, C., Kanamoto, M., Nishihara, M., Iwakura, Y., and Hirano, T.
    • Journal Title

      Immunity

      Volume: 29 Pages: 628-636

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of DCIR in the development of autoimmune diseases2008

    • Author(s)
      Fujikado, N., Saijo, S., Yonezawa, T., Shimamori, K., Ishii, A., Sugai, S., Kotaki, H., Sudo, K., Nose, M., and Iwakura, Y.
    • Journal Title

      Cytokine

      Volume: 43 Pages: 244-244

    • NAID

      40017145116

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The mechanisms of the stress-induced behavioral abnormality in the IL-1 receptor antagonist(IL-1Ra) KO mice2008

    • Author(s)
      Wakabayashi, C., and Iwakura, Y.
    • Journal Title

      Neuroscience Res.

      Volume: 61 Pages: 63-63

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of IL-1 to resistance to Streptococcus pneumoniae infection2008

    • Author(s)
      Kafka, D., Ling, E., Feldman, G., Benharroch, D., Voronov, E., Givon-Laci, N., Iwakura, Y., Dagan, R., Apte, R. N., and Mizrachi-Nebenzahi, Y.
    • Journal Title

      Int. Immunol.

      Volume: 9 Pages: 1139-1146

    • NAID

      10022599302

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interlerkin-1β and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression.2008

    • Author(s)
      Honda, A.
    • Journal Title

      J. Dermato. Sci., 49

      Pages: 63-72

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis.2008

    • Author(s)
      Okumura, A.
    • Journal Title

      Arthritis Rheum., 58

      Pages: 413-421

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differntial roles for IFN-γ and IL-17 in expecimental autoimmune uveoretinitis.2008

    • Author(s)
      Yoshimura, T.
    • Journal Title

      Int. Immunol., 20

      Pages: 209-214

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells.2008

    • Author(s)
      Fujikado, N.
    • Journal Title

      Nat. Med., 14

      Pages: 176-180

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages.2008

    • Author(s)
      Ashimo, T.
    • Journal Title

      Mol. Immunol., 45

      Pages: 2106-2115

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17.2008

    • Author(s)
      Pichavant, M.
    • Journal Title

      J.Exp. Med., 205

      Pages: 385-393

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deoxynucleic Acids from Cryptococcus neoformans Activate Myeloid Dendritic Cells via a TLR9-Dependent Pathway.2008

    • Author(s)
      Nakamura, K.
    • Journal Title

      J. Immjnol. 180

      Pages: 6067-4074

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kid-Mediated Chromoseme Compaction Ensures Proper Nuclear Envelope Formation.2008

    • Author(s)
      Ohsugi, M.
    • Journal Title

      Cell, 132

      Pages: 771-782

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-22 mediates mucosal host defense agalnst Gram-negative bacterial pneumonia.2008

    • Author(s)
      Aujla, S. J.
    • Journal Title

      Nat. Med., 14

      Pages: 275-281

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-23 restrains regulatory T cell activity to drive T ce11-dependent colitis.2008

    • Author(s)
      Izcue, A.
    • Journal Title

      Immunity. 28

      Pages: 559-570

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Either a Th17 or a Thl effector response can drive autoimmunity: conditions of disease induction affect dominant effector category.2008

    • Author(s)
      Luger, D.
    • Journal Title

      J. Exp. Med., 205

      Pages: 799-810

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8^+T cells.2008

    • Author(s)
      Tajima, M.
    • Journal Title

      J. Exp. Med., 205

      Pages: 1019-1027

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host T Cells Are the Main Producers of IL-17 within the Central Nervous System during Initiation of Experimental Autoimmune Encephalomyelitis Induced by Adoptive Transfer of Thl Cll Lines.2008

    • Author(s)
      Lees, J. R.
    • Journal Title

      180

      Pages: 8066-8072

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Proteoglycan-lnduced Arthritis Is hdependent of IL-17.2008

    • Author(s)
      Doodes, P. D.
    • Journal Title

      J. Immunol., 181

      Pages: 329-337

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCL2 recruitment of IL-6-producing CD11b^+ monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity.2008

    • Author(s)
      Bai, Y.
    • Journal Title

      Eur. J. Immunol., 38

      Pages: 1877-1888

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding.2008

    • Author(s)
      Kugota, N
    • Journal Title

      Cell Metab., 8

      Pages: 49-64

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous IL-17 Does Not Play a Significant Role in the Development of Experimental Murine Allergic Conjunctivitis.2008

    • Author(s)
      Fukushima, A.
    • Journal Title

      Int. Arch. Allergy Immjnol., 147

      Pages: 206-212

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD44 and Bak Expression in IL-6 or TNF-α Gene Knockout Mice After Whole Lung Irradiation.2008

    • Author(s)
      Sakai, M.
    • Journal Title

      J. Radiat. Res. (Tokyo), 49

      Pages: 409-416

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased fat:carbohydrate oxidation ratio in IIIra^+ mice on a high fat diet is associated with increased sympathetic tone.2008

    • Author(s)
      Chida, D.
    • Journal Title

      Diaberologia, 51

      Pages: 1698-1706

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17A is produced by Th17, γδT cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance.2008

    • Author(s)
      Schulz, S. M.
    • Journal Title

      Int. Immunol., 20

      Pages: 1129-1138

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of IL-1 to resistance to Stretococcus pneumoiae infection.2008

    • Author(s)
      Kafka, D.
    • Journal Title

      Int. Immunol., 20

      Pages: 1139-1146

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17A Produced by γδT Cells Plays a Critical Role in Immunity against Listeria monocytogenes Infection in the Liver.2008

    • Author(s)
      Hamada, S.
    • Journal Title

      J. Immunol., 181

      Pages: 3456-3463

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules.2008

    • Author(s)
      Teruya, H.
    • Journal Title

      Retrovirology, 5

      Pages: 86-86

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction.2008

    • Author(s)
      Ogura, H.
    • Journal Title

      Immunity. 29

      Pages: 629-636

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of Tumor Necrosis Factor-α and Interferon-γ in Bone Marrow Cells Synergistically Inhibits Neointimal Formation Following Vascular Injury.2008

    • Author(s)
      Muryama, H.
    • Journal Title

      Cardiovasc. Res., 80

      Pages: 175-180

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 2(TLR2) and dectin-l contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei.2008

    • Author(s)
      Nakamura, K.
    • Journal Title

      Microbes Infect., 10

      Pages: 1223-1227

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-23 and Th17 Cells Enhance Th2 Cell-mediated Eosinophilic Airway Inflammation in Mice. Am . J . Respir.2008

    • Author(s)
      Wakashim, H.
    • Journal Title

      Crit. Care Med., 178

      Pages: 1023-1032

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of IL-17 in the pathogenesis of DSS-induced colittis in mece.2008

    • Author(s)
      Ito, R.
    • Journal Title

      Biochem. Biophys. Res. Commun., 377

      Pages: 12-16

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective Immunity to Systemic Infection with Attenuated Samonella enterica serovar Enteritidis in the Absence of IL-12 Associated with IL-23-Dependent IL-22, but Not IL-17.2008

    • Author(s)
      Schuiz, S. M.
    • Journal Title

      181

      Pages: 7891-7901

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1α Released from Dying Cells.2008

    • Author(s)
      Eigenbrod, T.
    • Journal Title

      J. Immunol., 181

      Pages: 8197-8198

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17 is Involved in Hlicobacter pylori-Iduced Gastric Inflammatory Responses in a Mouse Model.2008

    • Author(s)
      Shiomi, S.
    • Journal Title

      Helicobacter, 13

      Pages: 518-524

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The roles of IL-17A in inflammatory immune responses and host defense against pathogens.2008

    • Author(s)
      iwakura, Y.
    • Journal Title

      Immunol. Rev., 226

      Pages: 57-79

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 遺伝子改変マウスを用いた創薬標的の探索2012

    • Author(s)
      岩倉洋一郎
    • Organizer
      第8回生命資源研究・支援センターシンポジウム
    • Place of Presentation
      熊本大学生命資源研究・支援センター(招待講演)
    • Year and Date
      2012-02-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腸管ポリープ形成におけるIL-17ファミリーの役割の解析2012

    • Author(s)
      角田茂
    • Organizer
      平成23年度「個体レベルでのがん研究支援活動」班 ワークショップ
    • Place of Presentation
      大津
    • Related Report
      2011 Annual Research Report
  • [Presentation] 遺伝子改変マウスを用いたIL-17A/Fの感染・炎症・発がんにおける役割の解析2011

    • Author(s)
      角田茂
    • Organizer
      第30回信州免疫アレルギー懇話会
    • Place of Presentation
      松本
    • Year and Date
      2011-12-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of Th17 cells in the absence of IL-6 in IL-1 receptor antagonist deficient mice2011

    • Author(s)
      岩倉洋一郎
    • Organizer
      日本分子生物学会ワークショップ
    • Place of Presentation
      パシフィコ横浜(招待講演)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] T細胞上に発現するケモカインレセプターCXCR4の自己免疫性関節炎の発症における役割2011

    • Author(s)
      鄭〓絢
    • Organizer
      IMSUT&RCAST GCOEセミナー「医科学研究所システム疾患モデル研究センター若手研究者セミナー」
    • Place of Presentation
      東京大学医科学研究所講堂
    • Year and Date
      2011-11-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 2種の関節炎自然発症モデルマウスより探索された感受性候補遺伝子とその生理機能解析2011

    • Author(s)
      日下智聖
    • Organizer
      IMSUT&RCAST GCOEセミナー「医科学研究所システム疾患モデル研究センター若手研究者セミナー」
    • Place of Presentation
      東京大学医科学研究所講堂
    • Year and Date
      2011-11-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 遺伝子改変マウスを取り巻く最近の動向と基礎医学研究への応用2011

    • Author(s)
      角田茂
    • Organizer
      信州実験動物研究会第76回勉強会
    • Place of Presentation
      松本
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウスモデルを用いた関節リウマチ発症機構の解析2011

    • Author(s)
      岩倉洋一郎
    • Place of Presentation
      北海道大学遺伝子病制御研究所(招待講演)
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 動物モデルを用いた関節リウマチ発症機構の解析2011

    • Author(s)
      岩倉洋一郎
    • Organizer
      第39回臨床免疫学会(免疫疾患学会連合2011)教育講演
    • Place of Presentation
      京王プラザホテル,東京(招待講演)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 先進的医学研究のための遺伝子改変動物コンソーシアムの設立2011

    • Author(s)
      岩倉洋一郎
    • Organizer
      医科学研究所主催シンポジウム「先進的医学研究のための遺伝子改変動物研究の推進」
    • Place of Presentation
      医科学研究所トミーホール(招待講演)
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウスモデルを用いた関節リウマチ発症機構の解析2011

    • Author(s)
      岩倉洋一郎
    • Organizer
      御茶ノ水膠原病・リウマチ内科研究会
    • Place of Presentation
      山野上ホテル,東京,(招待講演)
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 自己免疫性関節炎発症におけるサイトカインの役割2011

    • Author(s)
      岩倉洋一郎
    • Organizer
      東京理科大学生命科学研究科大学院特別講義「免疫記憶・炎症研究の新展開」
    • Place of Presentation
      東京理科大カナル会館(招待講演)
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-17の感染防御・免疫応答における役割2011

    • Author(s)
      岩倉洋一郎
    • Organizer
      京都大学ウイルス研究所セミナー「ウイルス研究の潮流シリーズ8」
    • Place of Presentation
      京都大学ウイルス研究所会議室(招待講演)
    • Year and Date
      2011-07-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Gene Manipulated Mice as a Tool for the Analysis of Pathogenesis and the Search for Therapeutic Targets2011

    • Author(s)
      岩倉洋一郎
    • Organizer
      東京大学医科学研究所大学院セミナー
    • Place of Presentation
      東京大学医科学研究所講堂(招待講演)
    • Year and Date
      2011-06-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 先進的医学研究のための遺伝子改変動物研究コンソーシアムの設立2011

    • Author(s)
      岩倉洋一郎
    • Organizer
      日本学術会議シンポジウム「生命科学の生来に向けたマスタープラン」
    • Place of Presentation
      日本学術会議講堂(招待講演)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional specialization of IL-17A and IL-17F2011

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Sylvester Comprehensive Cancer Center and School of Medicine
    • Place of Presentation
      University of Miami, Miami, U.S.A.(招待講演)
    • Year and Date
      2011-05-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Therapeutic targets for rheumatoid arthritis : lessons from animal models2011

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Bio-Rheumatology International Congress(BRIC) Tokyo、The 8th GARN Meeting
    • Place of Presentation
      Hilton Tokyo Bay Hotel
    • Related Report
      2011 Final Research Report
  • [Presentation] Gene manipulated mice as a tool for the analysis of pathogenesis and development of new therapeutics2011

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Animal Research Center
    • Place of Presentation
      Jirin University, Changchun
    • Related Report
      2011 Final Research Report
  • [Presentation] Involvement of interleukin (IL)-17A and IL-17F in development of intestinal polyps in Apc^<Min> mice2011

    • Author(s)
      Shigeru Kakuta
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-17F, rather than IL-17A promotes CD4^+ T cell activation and Th-1-type immunity2011

    • Author(s)
      Ce Tang
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-17産生性YδT細胞はリウマチ様関節炎発症に重要である2011

    • Author(s)
      秋津葵
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] DCIR欠損マウスは強直性脊椎炎様の病態を示す2011

    • Author(s)
      Maruhashi Takumi
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] DCIR, a C-type lectin receptor, is a new negative regulator in osteoclas togenesis2011

    • Author(s)
      Tomonori Kaifu
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dectin-1 signaling promotes DSS-induced colitis in a microflora dependent manner2011

    • Author(s)
      Tomonori Kamiya
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-6-independent arthritis and Th17 differentiation in IL-1Ra IL-6 double deficient mice2011

    • Author(s)
      Satoshi Ikeda
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腸管細菌感染防御におけるssグルカン/Dectin-1シグナルの役割2011

    • Author(s)
      角木基彦
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] 関節炎自然発症モデルマウスを用いて探索された関節炎感受性候補遺伝子の生理機能解析2011

    • Author(s)
      日下智聖
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] No significant abnormality of HIDE1 deficient mice in collagen-induced arthritis and experimental autoimmune encephalomyelitis2011

    • Author(s)
      清水謙次
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] Experimental autoimmune encephalomyelitis is aggravated in DCIR knockout mice2011

    • Author(s)
      妹尾彬正
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] DCIR : A new therapeutic target for autoimmune disorders2011

    • Author(s)
      Rikio Yabe
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of rheumatoid arthritis-related gene by comparative analysis of two rheumatoid arthritis model mice2011

    • Author(s)
      Masanori A.Murayama
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ,千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] Therapeutic targets for rheumatoid arthritis : lessons from animal models2011

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      1st Bio-Rheumatology International Congress Tokyo 8th GARN Meeting
    • Place of Presentation
      Hilton Tokyo Bay Hotel, Tokyo(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-17-producing-gamma-delta T cells are important for the development of arthritis in a rheumatoid arthritis model2011

    • Author(s)
      Aoi Akitsu
    • Organizer
      1st Bio-Rheumatology International Congress Tokyo 8th GARN Meeting
    • Place of Presentation
      Hilton Tokyo Bay Hotel, Tokyo
    • Related Report
      2011 Annual Research Report
  • [Presentation] The roles of Dectin-1/2 in the host defens against fungal infection2011

    • Author(s)
      Shinobu Saijo
    • Organizer
      9^<th> Joint Meeting of the ICS and ISICR
    • Place of Presentation
      Florence, Italy
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-17F, rather than IL-17A promotes CD4^+ T cell activation and Th-1-type immunity2011

    • Author(s)
      Ce Tang
    • Organizer
      9^<th> Joint Meeting of the ICS and ISICR
    • Place of Presentation
      Florence, Italy
    • Related Report
      2011 Annual Research Report
  • [Presentation] DCIR, a C-type lectin receptor, is a new negative regulator in osteoclas togenesis2011

    • Author(s)
      Tomonori Kaifu
    • Organizer
      9^<th> Joint Meeting of the ICS and ISICR
    • Place of Presentation
      Florence, Italy
    • Related Report
      2011 Annual Research Report
  • [Presentation] DCIR deficient mice develop ankylosing spondylitis-like pathology in humans2011

    • Author(s)
      Takumi Maruhashi
    • Organizer
      9^<th> Joint Meeting of the ICS and ISICR
    • Place of Presentation
      Florence, Italy
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-17-producing-gamma-delta T cells are important for the development of arthritis in a rheumatoid arthritis model2011

    • Author(s)
      Aoi Akitsu
    • Organizer
      9^<th> Joint Meeting of the ICS and ISICR
    • Place of Presentation
      Florence, Italy
    • Related Report
      2011 Annual Research Report
  • [Presentation] DCIRリガンドの探索2011

    • Author(s)
      矢部力朗
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 疾患モデルマウスを用いた腸管ポリープ形成におけるIL-17AおよびIL-17Fの役割の解析2011

    • Author(s)
      角田茂
    • Organizer
      第58回日本実験動物学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-17-producing-gamma-delta T cells are important for the development of arthritis in a rheumatoid arthritis model2011

    • Author(s)
      Aoi Akitsu
    • Organizer
      JSICR-MMCB2011
    • Place of Presentation
      ANA Gate Tower Hotel Osaka, Osaka
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of IL-17A and IL-17F in inflammation, infection, and tumorigenesis2011

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      JSICR-MMCB2011
    • Place of Presentation
      ANA Gate Tower Hotel Osaka, Osaka(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] インターロイキン-17の腸管ポリープ形成における役割の解析2010

    • Author(s)
      角田茂
    • Organizer
      第5回核酸・核タンパク機能性研究会学術集会
    • Place of Presentation
      北海道恵庭リサーチビジネスパーク
    • Year and Date
      2010-08-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発生工学的アプローチによるIL-17ファミリーを中心としたサイトカインの機能解析2010

    • Author(s)
      角田茂
    • Organizer
      東海医学会講演会・例会
    • Place of Presentation
      伊勢原東海大学
    • Year and Date
      2010-07-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-17A and IL-17F are important for the development of intestinal polyps in APC^<MIN> mice by accelerating blood vessel formation.2010

    • Author(s)
      Shigeru Kakuta
    • Organizer
      8th Joint Conference of the ICS and ISICR, Cytokines 2010
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-17F promotes type 1 immunity by directly enhancing CD4+ T cell activation.2010

    • Author(s)
      Ce Tang
    • Organizer
      8th Joint Conference of the ICS and ISICR, Cytokines 2010
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] The roles of C-type lectins in the host defense against fungal infection.2010

    • Author(s)
      Shinobu Saijo
    • Organizer
      8th Joint Conference of the ICS and ISICR, Cytokines 2010
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel arthritis-regulatory gene identified by using two mouse rheumatoid arthritis models.2010

    • Author(s)
      Masanori A.Murayama
    • Organizer
      8th Joint Conference of the ICS and ISICR, Cytokines 2010
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-17-producing γδ T cells are important for the development of arthritis in arheumatoid arthritis model.2010

    • Author(s)
      Aoi Akitsu
    • Organizer
      8th Joint Conference of the ICS and ISICR, Cytokines 2010
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis.2010

    • Author(s)
      Soo-hyuq Chung
    • Organizer
      8th Joint Conference of the ICS and ISICR, Cytokines 2010
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] DCIR : A new therapeutic target for autoimmune disorders.2010

    • Author(s)
      Guangyu Ma
    • Organizer
      8th Joint Conference of the ICS and ISICR, Cytokines 2010
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Develqpment of TH 17-dependent athritis in IL-6-deficient IL-1 receptor antagonist-deficient mice.2010

    • Author(s)
      Satoshi Ikeda
    • Organizer
      8th Joint Conference of the ICS and ISICR, Cytokines 2010
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Oral administration of β-glucan stimulates mucosal immune system and improves immunological homeostasis oral tolerance.2010

    • Author(s)
      Huimin Yan
    • Organizer
      14^<th> interntional congress of immunology
    • Place of Presentation
      Kobe神戸ポートピアホテル神戸国際展示場
    • Related Report
      2010 Annual Research Report
  • [Presentation] CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis.2010

    • Author(s)
      Soo-hyun Chung
    • Organizer
      14^<th> interntional congress of immunology
    • Place of Presentation
      Kobe神戸ポートピアホテル神戸国際展示場
    • Related Report
      2010 Annual Research Report
  • [Presentation] Generation and analysis of oligoadenylate synthetase family genes-deficient mice.2010

    • Author(s)
      Shigeru Kakuta
    • Organizer
      14^<th> interntional congress of immunology
    • Place of Presentation
      Kobe神戸ポートピアホテル神戸国際展示場
    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-17-producing gamma-delta T cells is important for the development of arthritis in arheumatoid arthribs model.2010

    • Author(s)
      Aoi Akitsu
    • Organizer
      14^<th> interntional congress of immunology
    • Place of Presentation
      Kobe神戸ポートピアホテル神戸国際展示場
    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-17F promotes Th 1-type immunity by inducing IL-2 production.2010

    • Author(s)
      Ce Tang
    • Organizer
      14^<th> interntional congress of immunology
    • Place of Presentation
      Kobe神戸ポートピアホテル神戸国際展示場
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of Tb17-dependent arthritis in IL-6-deficient IL-1 receptor antagonist-deficient mice.2010

    • Author(s)
      Satoshi Ikeda
    • Organizer
      14^<th> interntional congress of immunology
    • Place of Presentation
      Kobe神戸ポートピアホテル神戸国際展示場
    • Related Report
      2010 Annual Research Report
  • [Presentation] The roles of C-type lectins in the host defense against fungal infecrion.2010

    • Author(s)
      Shinobu Saijo
    • Organizer
      14^<th> interntional congress of immunology
    • Place of Presentation
      Kobe神戸ポートピアホテル神戸国際展示場
    • Related Report
      2010 Annual Research Report
  • [Presentation] The roles of Dcir in bone metabolic diseases2010

    • Author(s)
      Guangyu Ma
    • Organizer
      14^<th> interntional congress of immunology
    • Place of Presentation
      Kobe神戸ポートピアホテル神戸国際展示場
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of IL-1 and 17 family genes in development of intestinal polyps.2010

    • Author(s)
      Shigeru Kakuta
    • Organizer
      第33回日本分子生物学会年会 第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] 病原微生物による潜伏HIV-1再活性化の分子機構2010

    • Author(s)
      角木基彦
    • Organizer
      第33回日本分子生物学会年会 第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腸管ポリープ形成におけるIL-17の役割の検討2010

    • Author(s)
      角田茂
    • Organizer
      第75回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      小倉北北九州国際会議場
    • Related Report
      2010 Annual Research Report
  • [Presentation] C型レクチンによるサイトカイン産生と生体防御機構2010

    • Author(s)
      西城忍
    • Organizer
      第75回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      小倉北北九州国際会議場
    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-17産生性γδT細胞は自己免疫性関節炎モデルマウスにおける関節炎発症に重要である.2010

    • Author(s)
      秋津葵
    • Organizer
      第75回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      小倉北北九州国際会議場
    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-17産生性γδT細胞は自己免疫性関節炎モデルマウスにおける関節炎発症に重要である2010

    • Author(s)
      秋津葵
    • Organizer
      第57回日本実験動物学会
    • Place of Presentation
      京都テレサ
    • Related Report
      2010 Annual Research Report
  • [Presentation] 東京大学医科学研究所システム疾患モデル研究センターにおける遺伝子改変マウスの供給について2010

    • Author(s)
      角田茂
    • Organizer
      第57回日本実験動物学会
    • Place of Presentation
      京都号テレサ
    • Related Report
      2010 Annual Research Report
  • [Presentation] HIV感受性マウス作製に向けたヒトLEDGFトランスジェニックマウス(Tg)の作製2010

    • Author(s)
      多田卓哉
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島県郷土文化会館
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adoptive and innate immunity related gene-deficient mice generated by IMSUT.2009

    • Author(s)
      Kakuta S
    • Organizer
      Manitoba Centre for Disease Modeling Symposium
    • Place of Presentation
      Winnipeg, Canada
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] The roles of IL-17A and IL-17F in the immune system2009

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      Th17 Cells in Health and Disease, Keystone Symposium
    • Place of Presentation
      British Columbia, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] Generation and analysis of oligoadenylate synthetase family genes-deficient mice.2009

    • Author(s)
      Kakuta S
    • Organizer
      4th Asia Mutant Mouse Resource Association(AMMRA)meeting
    • Place of Presentation
      Kumamoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] The roles of C-type lectins in the host defense against fungal infection.2009

    • Author(s)
      Saijo S
    • Organizer
      International Society for Interferon and Cytokine
    • Place of Presentation
      Lisbon, Portugal
    • Related Report
      2009 Annual Research Report
  • [Presentation] The roles of C-type lectins in the host defense against fungal infection.2009

    • Author(s)
      Saijo S
    • Organizer
      The 9^<th> AWAJI International Forum on Infection and Immunity
    • Place of Presentation
      Awaji
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of Dcir in the inflammatory diseases.2009

    • Author(s)
      Fujikado N、
    • Organizer
      World Congress of Immunology
    • Place of Presentation
      Tokyo
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of DCIR in the development of autoimmune diseases.2008

    • Author(s)
      Noriyuki Fujikado
    • Organizer
      Cytokines 2008
    • Place of Presentation
      Montreal
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] A C-type lectin that involved in the host defense against fungi plays an important role in the development of soutoimmune arthritis2008

    • Author(s)
      Shinobu Saijo
    • Organizer
      13th congress of the sdia pacigic league of associations for rheumatology
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Differential roles of IL-17A and IL-17F in allergic responses and host defense against mucoepithelial bacterial infection.2008

    • Author(s)
      Harumichi Ishigame
    • Organizer
      The 8th Awaji Internatonal Forum on Infection and Immunity
    • Place of Presentation
      Hyogo
    • Year and Date
      2008-09-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] The role of DCIR in the development of autoimmune arthritis2008

    • Author(s)
      Yoichiro Iwakura
    • Organizer
      The Australian Health and Medical Research Congress, Brisbane Convention Center
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2011 Final Research Report
  • [Book] 遺伝子改変動物.新しい薬学事典2012

    • Author(s)
      角田茂、岩倉洋一郎
    • Publisher
      朝倉書店(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] 真菌免疫応答におけるC型レクチン受容体の役割2012

    • Author(s)
      角田茂、西城忍
    • Publisher
      化学療法の領域
    • Related Report
      2011 Annual Research Report
  • [Book] 免疫疾患.疾患モデルの作製と利用.シリーズ「モデル動物利用マニュアル」2011

    • Author(s)
      岩倉洋一郎
    • Total Pages
      580
    • Publisher
      エル・アイ・シー
    • Related Report
      2011 Final Research Report
  • [Book] リウマチ.論文ができてしまう!疾患モデルマウス表現型解析指南2011

    • Author(s)
      角田茂
    • Publisher
      中山書店
    • Related Report
      2011 Annual Research Report
  • [Book] IL-1. seriesモデル動物利用マニュアル 免疫疾患-疾患モデルの作製と利用2011

    • Author(s)
      角田茂、岩倉洋一郎
    • Publisher
      エル・アイ・シー
    • Related Report
      2011 Annual Research Report
  • [Book] 遺伝子改変マウス."哺乳動物の分子生物学"を切り拓いた技術バイオテクノロジーの温故知新2011

    • Author(s)
      岩倉洋一郎
    • Publisher
      羊土社
    • Related Report
      2011 Annual Research Report
  • [Book] 発刊にあたって.免疫疾患-疾患モデルの作製と利用.シリーズモデル動物利用マニュアル2011

    • Author(s)
      岩倉洋一郎
    • Total Pages
      580
    • Publisher
      エル・アイ・シー
    • Related Report
      2011 Annual Research Report
  • [Book] IL-17.免疫疾患-疾患モデルの作製と利用.シリーズ モデル動物利用マニュアル2011

    • Author(s)
      石亀晴道
    • Publisher
      エル・アイ・シー
    • Related Report
      2011 Annual Research Report
  • [Book] アグリゲーション法によるキメラマウスの作製.改訂第5版新遺伝子工学ハンドブック2010

    • Author(s)
      角田茂、佐藤希、久保幸子、岩倉洋一郎
    • Publisher
      羊土社
    • Related Report
      2011 Final Research Report
  • [Book] アグリゲーション法によるキメラマウスの作製改訂第5版新2010

    • Author(s)
      角田茂
    • Publisher
      遺伝子工学ハンドブック
    • Related Report
      2010 Annual Research Report
  • [Book] コンディショナルターゲティング法改訂第5版新2010

    • Author(s)
      角田茂
    • Publisher
      遺伝子工学ハンドブック
    • Related Report
      2010 Annual Research Report
  • [Book] Dcirと自己免疫疾患最新医学2009

    • Author(s)
      藤門範行、岩倉洋一郎
    • Related Report
      2011 Final Research Report
  • [Book] サイトカインシグナルと代謝疾患2008

    • Author(s)
      千田大、岩倉洋一郎
    • Publisher
      ニュー・サイエンス社
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.rs.tus.ac.jp/iwakuralab/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/cem_dcb/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.ip/cem_dcb/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/cem_dcb/indes.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 樹状細胞免疫受容体刺激剤2011

    • Inventor(s)
      岩倉洋一郎、藤門範行、馬光宇
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2011-02-23
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 腸疾患の治療方法および治療用医薬組成物2011

    • Inventor(s)
      岩倉洋一郎、角田茂、鈴木俊佐
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2011-02-02
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 骨免疫疾患の予防・治療剤2010

    • Inventor(s)
      岩倉洋一郎、藤門範行、馬光宇
    • Industrial Property Rights Holder
      国立大学法人,東京大学, 他3名
    • Filing Date
      2010-02-23
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] IL-17A/IL-17Fを介した大腸がん発症抑制2010

    • Inventor(s)
      岩倉洋一郎、角田茂、鈴木俊佐
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2010-02-03
    • Related Report
      2009 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 骨免疫疾患の予防・治療剤2010

    • Inventor(s)
      岩倉洋一郎、藤門範行、馬光宇
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2010-02-23
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] IL-1タイプIIレセプター遺伝子の欠損変異体マウス2009

    • Inventor(s)
      岩倉洋一郎、角田茂, 他4名
    • Industrial Property Rights Holder
      国立大学法人,東京大学, 他10名
    • Acquisition Date
      2009-08-20
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] IL-17A/IL-17F制御による感染症治療・予防薬、Differentail Roles of Interleukin-17A and Interleukin-17F in Host defense against Mucoepithelial Bacterial Infection and Allegic Responses2009

    • Inventor(s)
      岩倉洋一郎、角田茂、石亀晴道
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2009-12-28
    • Related Report
      2009 Annual Research Report
    • Overseas

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Published: 2008-04-01   Modified: 2016-04-21  

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