Establishment of an IL-1-related gene-manipulated mice library, aiming at uncovering pathophysiology of disease from a view point of systems biology

• Project/Area Number: 20220009
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Laboratory animal science
• Research Institution: The University of Tokyo
• Principal Investigator: IWAKURA Yoichiro 東京大学, 医科学研究所, 教授 (10089120)
• Co-Investigator(Kenkyū-buntansha): SAIJO Shinobu 千葉大学, 真菌医学研究センター, 特任准教授 (60396877) ; KAKUTA Shigeru 信州大学, 医学部, 助教 (80345032) ; FUJIKADO Noriyuki 東京大学, 医科学研究所, 助教 (90447334) ; KUSAKA Toshimasa 東京大学, 医科学研究所, 特任研究員 (60466836) ; KAIFU TomonoriI 東京大学, 医科学研究所, 助教 (90343037) ; CE Tang 東京大学, 医科学研究所, 助教 (00572166) ; MA GUANGYU 東京大学, 医科学研究所, 助教 (60572162)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥101,530,000 (Direct Cost: ¥78,100,000、Indirect Cost: ¥23,430,000); Fiscal Year 2011: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000); Fiscal Year 2010: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000); Fiscal Year 2009: ¥62,400,000 (Direct Cost: ¥48,000,000、Indirect Cost: ¥14,400,000); Fiscal Year 2008: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
• Keywords: サイトカイン / 疾患モデル動物 / 自己免疫疾患 / Th17細胞 / 関節リウマチ / 間接リウマチ

Research Abstract

The project’s aim is to deeply understand the pathological and physiological roles of IL-1 and IL-1-relating genes in maintaining homeostasis and developing diseases in the immune, the nervous, and the endocrine system. In addition to evaluating the pathophysiological role of these genes, we intended to establish a system of bio-source to provide the gene-manipulated mice with all researchers. We newly generated five gene-targeting mice, which have been finished in backcrossing toward C57BL6/c background, and four additional gene-targeting mice (DCIR, IL-1R2, IL-1F6, and SCPL) were backcrossed to C57BL6/c background. We demonstrated that IL-1-related genes were involved in the regulation of bone metabolism and the development of autoimmune diseases, like arthritis. Moreover, IL-1 was a mediator in controlling activity of the nervous system and had a direct effect on lipid metabolism. On the basis of our analysis in gene-targeting mice, these mice are novel useful disease-models for analyzing the pathology of bony and autoimmune diseases. Finally, we set up the system that supplies gene-manipulated mice that we generated to all researchers, contributing to the progress of research horizons in laboratory animal.

Research Products

• [Journal Article] Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice (2012)
  • Author(s): F.Usui
  • Journal Title: Biochem Biophys Res Commun Volume: 420 Pages: 72-7
  • DOI: 10.1016/j.bbrc.2012.02.117
  • Peer Reviewed
• [Journal Article] Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule (2012)
  • Author(s): T.Yoshida
  • Journal Title: Journal of Neuroscience Volume: 32 Pages: 2588-2600
  • DOI: 10.1523/jneurosci.4637-11.2012
  • Peer Reviewed
• [Journal Article] Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors (2012)
  • Author(s): H.Shime
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 109 Pages: 2066-2071
  • DOI: 10.1073/pnas.1113099109
  • Peer Reviewed
• [Journal Article] Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier (2012)
  • Author(s): 有馬康伸
  • Journal Title: Cell Volume: 148(3) Pages: 447-457
  • DOI: 10.1016/j.cell.2012.01.022
  • Peer Reviewed
• [Journal Article] Involvement of Interleukin-1 in Lead Nitrate-Induced Hypercholesterolemia in Mice (2012)
  • Author(s): M.Kojima
  • Journal Title: Biol. Pharm. Bull. Volume: 35 Issue: 2 Pages: 246-250
  • DOI: 10.1248/bpb.35.246
  • NAID: 130001872300
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Toxoplasma gondii Infection Inhibits Th17-Mediated Spontaneous Development of Arthritis in Interleukin-1 Receptor Antagonist-Deficient Mice (2012)
  • Author(s): T.Washino
  • Journal Title: Infect. Immun. Volume: 80 Pages: 1437-1444
  • DOI: 10.1128/iai.05680-11
  • Peer Reviewed
• [Journal Article] Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration (2012)
  • Author(s): Y.H.Liao
  • Journal Title: J Am Coll Cardiol Volume: 59 Pages: 420-429
  • DOI: 10.1016/j.jacc.2011.10.863
  • Peer Reviewed
• [Journal Article] IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice (2012)
  • Author(s): F.M.Botelho
  • Journal Title: PLoS One Volume: 6
  • DOI: 10.1371/journal.pone.0028457
  • Peer Reviewed
• [Journal Article] Roles of interleukin-17 in an experimental Legionella pneumophila pneumonia model (2012)
  • Author(s): Y.Kimizuka
  • Journal Title: Infect Immun Volume: 80 Pages: 1121-1127
  • DOI: 10.1128/iai.05544-11
  • Peer Reviewed
• [Journal Article] Interleukin-17A deficiency accelerates unstable atherosclerotic plaque for mation in apolipoprotein E-deficient mice (2012)
  • Author(s): K.Danzaki
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 32 Pages: 273-280
  • DOI: 10.1161/atvbaha.111.229997
  • Peer Reviewed
• [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling (2012)
  • Author(s): S.Nishimura
  • Journal Title: Blood. Volume: 119 Pages: 128-131
  • DOI: 10.1182/blood-2011-09-381400
  • Peer Reviewed
• [Journal Article] Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17 (2012)
  • Author(s): H.Nishimori
  • Journal Title: Blood Volume: 119 Pages: 285-295
  • DOI: 10.1182/blood-2011-01-332478
  • NAID: 120006344939
  • Peer Reviewed
• [Journal Article] Interleukin-4 (IL-4) and IL-13 suppress excessive neutrophil infiltration and hepatocyte damage during acute murine schistosomiasis japonica (2012)
  • Author(s): T.Seki
  • Journal Title: Infection and Immunity Volume: 80 Pages: 159-168
  • DOI: 10.1128/iai.05581-11
  • Peer Reviewed
• [Journal Article] Induction of thymic stromal lymphopoietin production by xylene and exacerbation of picryl chloride-induced allergic inflammation in mice (2012)
  • Author(s): N.Satou
  • Journal Title: Int Arch Allergy Immunol. Volume: 157 Pages: 194-201
  • DOI: 10.1159/000327545
  • Peer Reviewed
• [Journal Article] Up-regulation of polymeric immunoglobulin receptor expression by the heat-inactivated potential probiotic Bifidobacterium bifidum OLB6378 in a mouse intestinal explant model (2012)
  • Author(s): Y.Nakamura
  • Journal Title: Scandinavian Journal of Immunology Volume: 72 Pages: 176-183
  • DOI: 10.1111/j.1365-3083.2011.02645.x
  • Peer Reviewed
• [Journal Article] Interleukin-17A is involved in enhancement of tumor progression in murine intestine (2012)
  • Author(s): K.Oshiro
  • Journal Title: Immunobiology Volume: 217 Pages: 54-60
  • DOI: 10.1016/j.imbio.2011.08.002
  • Peer Reviewed
• [Journal Article] IL-1 signaling is dispensable for protective immunity in Leishmania-resistant mice (2011)
  • Author(s): Kautz-Neu, K., Kostka, S. L., Dinges, S., Iwakura, Y., Udey, M. C., and Von Stebut, E.
  • Journal Title: Exp. Dermatol. Volume: 20 Pages: 76-78
  • Peer Reviewed
• [Journal Article] Muramyldipeptide augments the actions of lipopolysacchairde in mice by stimulating macrophages to produe pro-IL-1B and by down-regulation of suppressor of cytokine signaling 1(SOCS1) (2011)
  • Author(s): Shikama, Y., Kuroishi, T., Nagai, Y., Iwakura, Y., Shimauchi, H., Takada, H., Sugawara, S., and Endo, Y.
  • Journal Title: Innate Immun. Volume: 17 Pages: 54-59
  • Peer Reviewed
• [Journal Article] Local microbleeding facilitates IL-6-and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells (2011)
  • Author(s): Murakami, M., Okuyama, Y., Ogura, H., Asano, S., Arima, Y., Tsuruoka, M., Harada, M., Kanamoto, M., Sawa, Y., Iwakura, Y., Takatsu, K., Kamimura, D., and Hirano, T.
  • Journal Title: J. Exp. Med. Volume: 208 Pages: 103-114
  • Peer Reviewed
• [Journal Article] G. Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation (2011)
  • Author(s): Rivera, A., Hohl, T. M., Collins, N., Leiner, I., Gallegos, A., Saijo, S., Coward, J. W., Iwakura, Y., and Pamer, E.
  • Journal Title: J. Exp. Med. Volume: 208 Pages: 369-381
  • Peer Reviewed
• [Journal Article] The role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in melanocortin receptor 2. deficient mice (2011)
  • Author(s): Chida, D., Miyoshi, K., Sato, T., Yoda, T., Kikusui, T., and Iwakura, Y.
  • Journal Title: Endocrinology Volume: 152 Pages: 1652-1660
  • Peer Reviewed
• [Journal Article] Functional specialization of IL-17 family members (2011)
  • Author(s): Iwakura, Y., Ishigame, H., Saijo, S., and Nakae, S.
  • Journal Title: Immunity Volume: 34 Pages: 149-162
  • Peer Reviewed
• [Journal Article] Memory/effector(CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology (2011)
  • Author(s): Kamanaka, M., Huber, S., Zenewicz, L. A., Gagliani, N., Rathinam, C., O' Connor, W. Jr., Wan, Y. Y., Nakae, S., Iwakura, Y., Hao, L., and Flavell, R. A.
  • Journal Title: J. Exp. Med. Volume: 208 Pages: 1027-1040
  • Peer Reviewed
• [Journal Article] Dectin-1 and Dectin-2 in innate immunity against fungi (2011)
  • Author(s): Saijo, S., and Iwakura, Y.
  • Journal Title: Int. Immunol. Volume: 23 Pages: 467-472
  • Peer Reviewed
• [Journal Article] Control of T(H) 17 cells occurs in the small intestine (2011)
  • Author(s): Esplugues, E., Huber, S., Gagliani, N., Hauser, A. E., Town, T., Wan, Y. Y., O' Connor, W., Rongvaux, A., Van Rooijen, N., Haberman, A. M., Iwakura, Y., Kuchroo, V. K., Kolls, J. K., Bluestone, J. A., Herold, K. C., and Flavell, R. A.
  • Journal Title: Nature Volume: 475 Pages: 514-518
  • Peer Reviewed
• [Journal Article] Desmoglein 3-specific CD4+T cells induce pemphigus vulgaris and interface dermatitis in mice (2011)
  • Author(s): Takahashi, H., Kouno, M., Nagao, K., Wada, N., Hata, T., Nishimoto, S., Iwakura, Y., Yoshimura, A., Yamada, T., Kuwana, M., Fujii, H., Koyasu, S., and Amagai, M.
  • Journal Title: J. Clin. Invest. Volume: 121 Pages: 3677-3688
  • Peer Reviewed
• [Journal Article] Functional recovery after peripheral nerve injury is dependent on the proinflammatory cytokines IL-1. and TNF : implicaitons for neuropathic pain (2011)
  • Author(s): Nadeau, S., Filali, M., Zhang, J., Kerr, B. J., Rivest, S., Soulet, D., Iwakura, Y., de Rivero Vaccari, J. P., Keane, R. W., and Lacroix, S.
  • Journal Title: J. Neurosci. Volume: 31 Pages: 12533-12542
  • Peer Reviewed
• [Journal Article] IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase (2011)
  • Author(s): Yoshida, T., Yasumura, M., Uemura, T., Lee, S. J., Ra, M., Taguchi, R., Iwakura, Y., and Mishina, M.
  • Journal Title: J. Neurosci. Volume: 31 Pages: 13485-13499
  • Peer Reviewed
• [Journal Article] Kjellmaniella crassifolia Miyabe (Gagome) Extract Modulates Intestinal and Systemic Immune Responses (2011)
  • Author(s): H.Yan
  • Journal Title: Biosci. Biotechnol. Biochem. Volume: 75 Issue: 11 Pages: 2178-2183
  • DOI: 10.1271/bbb.110473
  • NAID: 10030396791
  • ISSN: 0916-8451, 1347-6947
  • Peer Reviewed
• [Journal Article] Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1 (2011)
  • Author(s): T.Ashino
  • Journal Title: J. Toxicol. Sci. Volume: 36 Issue: 5 Pages: 635-643
  • DOI: 10.2131/jts.36.635
  • NAID: 10029481491
  • ISSN: 0388-1350, 1880-3989
  • Peer Reviewed
• [Journal Article] Interleukin-1 Controls the Constitutive Expression of the Cyp7a1 Gene by Regulating the Expression of Cyp7a1 Transcriptional Regulators in the Mouse Liver (2011)
  • Author(s): M.Kojima
  • Journal Title: Biol. Pharm. Bull. Volume: 34 Issue: 10 Pages: 1644-1647
  • DOI: 10.1248/bpb.34.1644
  • NAID: 130001086603
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production (2011)
  • Author(s): M.Xu
  • Journal Title: Eur J Immunol. Volume: 41 Pages: 2828-2839
  • DOI: 10.1002/eji.201141291
  • Peer Reviewed
• [Journal Article] NYAP : a phosphoprotein family that links PI3K to WAVE1 signalling in neurons (2011)
  • Author(s): K.Yokoyama
  • Journal Title: EMBO Journal Volume: 30 Pages: 4739-4754
  • DOI: 10.1038/emboj.2011.348
  • Peer Reviewed
• [Journal Article] IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ (2011)
  • Author(s): T.Yoshida
  • Journal Title: The Journal of Neuroscience Volume: 31 Pages: 13485-13499
  • DOI: 10.1523/jneurosci.2136-11.2011
  • Peer Reviewed
• [Journal Article] Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion (2011)
  • Author(s): S.Itoh
  • Journal Title: circulation Volume: 124
  • DOI: 10.1161/circulationaha.110.014852
  • Peer Reviewed
• [Journal Article] Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1ss and TNF : implications for neuropathic pain (2011)
  • Author(s): S.Nadeau
  • Journal Title: J Neurosci Volume: 31 Pages: 12533-12542
  • DOI: 10.1523/jneurosci.2840-11.2011
  • Peer Reviewed
• [Journal Article] Protective role of naturally occurring interleukin-17A-producing Yδ T cells in the lung at the early stage of systemic candidiasis in mice (2011)
  • Author(s): T.Dejima
  • Journal Title: Infection and immunity Volume: 79 Pages: 4503-4510
  • DOI: 10.1128/iai.05799-11
  • Peer Reviewed
• [Journal Article] Induction of autoimmune thyroiditis by depletion of CD4+CD25+ regulatory T cells in thyroiditis-resistant IL-17, but not interferon-gamma receptor, knockout nonobese diabetic-H2h4 mice (2011)
  • Author(s): I.Hoie
  • Journal Title: Endocrinology Volume: 152 Pages: 4448-4454
  • DOI: 10.1210/en.2011-1356
  • Peer Reviewed
• [Journal Article] Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice (2011)
  • Author(s): Takahashi H, Kouno M, Nagao K, Wada N, Hata T, Nishimoto S, 他
  • Journal Title: Journal of Clinical Investigation Volume: 121 Pages: 3677-3688
  • DOI: 10.1172/jci57379
  • Peer Reviewed
• [Journal Article] Early activation and interferon-Y production of tumor-infiltrating mature CD27 high natural killer cells (2011)
  • Author(s): Y.Hayakawa
  • Journal Title: Cancer Sci. Volume: 102 Pages: 1967-1971
  • DOI: 10.1111/j.1349-7006.2011.02042.x
  • Peer Reviewed
• [Journal Article] A critical role for regulatory T cells in driving cytokine profiles of Th17 cells and their modulation of glioma microenvironment (2011)
  • Author(s): G.Cantini
  • Journal Title: Cancer Immunol Immunother Volume: 60 Pages: 1739-1750
  • DOI: 10.1007/s00262-011-1069-4
  • Peer Reviewed
• [Journal Article] Control of TH17 cells occurs in the small intestine (2011)
  • Author(s): E.Esplugues
  • Journal Title: Nature Volume: 475 Pages: 514-518
  • DOI: 10.1038/nature10228
  • Peer Reviewed
• [Journal Article] Interleukin-17A promotes early but attenuates established disease in crescentic glomerulonephritis in mice (2011)
  • Author(s): D.Odobasic
  • Journal Title: Am J Pathol Volume: 179 Pages: 1188-1198
  • DOI: 10.1016/j.ajpath.2011.05.039
  • Peer Reviewed
• [Journal Article] Age-dependent regulation of depression-like behaviors through modulation of adrenergic receptor α_1A subtype expression revealed by the analysis of interleukin-1 receptor antagonist knockout mice (2011)
  • Author(s): C.Wakabayashi
  • Journal Title: Neuroscience Volume: 192 Pages: 475-484
  • DOI: 10.1016/j.neuroscience.2011.06.031
  • Peer Reviewed
• [Journal Article] Dectin-1 and Dectin-2 in innate immunity against fungi (2011)
  • Author(s): S.Saijo
  • Journal Title: International immunology Volume: 23 Pages: 467-472
  • DOI: 10.1093/intimm/dxr046
  • Peer Reviewed
• [Journal Article] Fungal allergen ss-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells (2011)
  • Author(s): W.A.Neveu
  • Journal Title: Am J Respir Cell Mol Biol Volume: 45 Pages: 1133-1141
  • DOI: 10.1165/rcmb.2011-0054oc
  • Peer Reviewed
• [Journal Article] Notch-Hes1 pathway is required for the development of IL-17-producing Yδ T cells (2011)
  • Author(s): K.Shibata
  • Journal Title: Blood Volume: 118 Pages: 586-593
  • DOI: 10.1182/blood-2011-02-334995
  • Peer Reviewed
• [Journal Article] Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived ss-glucans (2011)
  • Author(s): C.Qi
  • Journal Title: Blood Volume: 117 Pages: 6825-36
  • DOI: 10.1182/blood-2011-02-339812
  • Peer Reviewed
• [Journal Article] A role for leukocyte-derived IL-1RA in DC homeostasis revealed by increased susceptibility of IL-1RA-deficient mice to cutaneous leishmaniasis (2011)
  • Author(s): K.Kautz-Neu
  • Journal Title: J Invest Dermatol Volume: 131 Pages: 1650-1659
  • DOI: 10.1038/jid.2011.99
  • Peer Reviewed
• [Journal Article] Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology (2011)
  • Author(s): M.Kamanaka
  • Journal Title: J Exp Med Volume: 208 Pages: 1027-1040
  • DOI: 10.1084/jem.20102149
  • Peer Reviewed
• [Journal Article] Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production (2011)
  • Author(s): C.F.Brereton
  • Journal Title: J Immunol Volume: 186 Pages: 5896-5906
  • DOI: 10.4049/jimmunol.1003789
  • Peer Reviewed
• [Journal Article] Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice (2011)
  • Author(s): M.S.Madhur
  • Journal Title: Arterioscler Thromb Vase Biol Volume: 31 Pages: 1565-1572
  • DOI: 10.1161/atvbaha.111.227629
  • Peer Reviewed
• [Journal Article] TNF-{alpha} from inflammatory dendritic cells(DCs)regulates lung IL-17A/IL-5 Levels and neutrophilia versus eosinophilia during persistent fungal infection. (2011)
  • Author(s): Fei, M.
  • Journal Title: Proc.Natl.Acad..SCI.USA. Volume: 108 Pages: 5360-5365
  • Peer Reviewed
• [Journal Article] Functional specialization of interleukin-17 family members. (2011)
  • Author(s): Iwakura, Y.
  • Journal Title: Immunity Volume: 34 Pages: 149-162
  • Peer Reviewed
• [Journal Article] The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. (2011)
  • Author(s): Drummond, R.A
  • Journal Title: Eur.J.Immunol. Volume: 41 Pages: 276-281
  • Peer Reviewed
• [Journal Article] Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with apredominance of alternatively activated phenotype. (2011)
  • Author(s): Bhatia, S.
  • Journal Title: PLoS One. Volume: 6
  • Peer Reviewed
• [Journal Article] Dectin-1 diversifies Aspergillus fumigates-specific T cell responses by inhibiting Thelper type 1 CD4 T cell differentiation. (2011)
  • Author(s): Rives, A
  • Journal Title: J.Exp.Med. Volume: 208 Pages: 369-381
  • Peer Reviewed
• [Journal Article] Local microbleeding facilitates 1L-6-and IL-17-dependent althritis in the absence of tissue antigen recognition by activated T cells. (2011)
  • Author(s): Murakami, M.
  • Journal Title: J.Exp.Med. Volume: 208 Pages: 103-114
  • Peer Reviewed
• [Journal Article] IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice. (2011)
  • Author(s): Kautz-Neu, K
  • Journal Title: Exp.Dermatol. Volume: 20 Pages: 76-78
  • Peer Reviewed
• [Journal Article] Distinct role of T helper Type 17 immune response for Graves'hyperthyroidism in mice with different genetic backgrounds. (2011)
  • Author(s): Horie, I.
  • Journal Title: Autoimmunity Volume: 44 Pages: 159-165
  • Peer Reviewed
• [Journal Article] Protective role of IL-1β against post-arthroplasty Staphylococcus aureus infection. (2011)
  • Author(s): Bernthal, N.M.
  • Journal Title: J.Orthop.Res. Volume: (in press)(掲載確定)
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor receptor-associated factor(Traf)2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease. (2011)
  • Author(s): Piao, J.H.
  • Journal Title: J.Biol.Chem. Volume: (in press)(掲載確定)
  • Peer Reviewed
• [Journal Article] Natural Killer T Cell-Derived IL-17Mediates Lung Ischemia-Reperfusion Injury (2011)
  • Author(s): Sharma, A K
  • Journal Title: Am.J.Respir.Crit.Care Med. Volume: (in press)(掲載確定)
  • Peer Reviewed
• [Journal Article] Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin (2011)
  • Author(s): Andrews, D.M.
  • Journal Title: Immunol.Cell Biol. Volume: (in press)(掲載確定)
  • Peer Reviewed
• [Journal Article] IFN-regulates the requirement for IL-17 in proteoglycan-induced arthritis (2010)
  • Author(s): Doodes, P. D., Cao, Y., Hamel, K. M., Wang, Y., Rodeghero, R. I., Mikecz, K., Glant T. T., Iwakura, Y., and Finnegan, A.
  • Journal Title: J. Immunol. Volume: 184 Pages: 1552-1559
  • Peer Reviewed
• [Journal Article] Neural tube defects and impaired neural progenitor cell proliferation in G. 1-deficient mice (2010)
  • Author(s): Okae, H., and Iwakura, Y.
  • Journal Title: Developmental Dynamics Volume: 239 Pages: 1089-1101
  • Peer Reviewed
• [Journal Article] Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung (2010)
  • Author(s): Okamoto Yoshida, Y., Umemura, M., Yahagi, A., O' Brien, R. L., Ikuta, K., Kishihara, K., Hara, H., Nakae, S., Iwakura, Y., and Matsuzaki, G.
  • Journal Title: J. Immunol. Volume: 184 Pages: 4414-4422
  • Peer Reviewed
• [Journal Article] Dectin-2 recognition ofα-mannans and induction of Th17 differentiation is essential for host defense against Candida albicans (2010)
  • Author(s): Saijo, S., Ikeda, S., Yamabe, K., Kakuta, S., Ishigame, H., Akitsu, A., Fujikado, N., Kusaka, T., Kubo, S., Chung, S., Komatsu, R., Miura, N., Adachi, Y., Ohno, N., Shibuya, K., Yamamoto, N., Kawakami, K., Yamasaki, S., Saito, T., Akira, S., and Iwakura,
  • Journal Title: Immunity Volume: 32 Pages: 681-691
  • Peer Reviewed
• [Journal Article] IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection (2010)
  • Author(s): Miyazaki, Y., Hamano, S., Wang, S., Shimanoe, Y., Iwakura, Y., and Yoshida, H.
  • Journal Title: J. Immunol. Volume: 185 Pages: 1150-1157
  • Peer Reviewed
• [Journal Article] M. Type I interferon signaling constrains IL-17A/F secretion byγδT cells during bacterial infection (2010)
  • Author(s): Henry, T., Kirimanjeswara, G. S., Ruby, T., Jones, J. W., Peng, K., Perret, M., Ho, L., Sauer, J.-D., Iwakura, Y., Metzger, D. W., and Monack, D.
  • Journal Title: J. Immunol. Volume: 184 Pages: 3755-3767
  • Peer Reviewed
• [Journal Article] TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Il1rn^<-/-> mice (2010)
  • Author(s): Nakajima, A., Matsuki, T., Komine, M., Asahina, A., Horai, R., Nakae, S., Ishigame, H., Kakuta, S., Saijo, S., and Iwakura, Y.
  • Journal Title: J. Immunol. Volume: 185 Pages: 1887-1893
  • Peer Reviewed
• [Journal Article] IL-1 plays an important role in the bone metabolism under physiological conditions (2010)
  • Author(s): Lee, Y.-M., Fujikado, N., Manaka, H., Yasuda, H., and Iwakura, Y.
  • Journal Title: Int. Immunol. Volume: 22 Pages: 805-816
  • NAID: 10027907526
  • Peer Reviewed
• [Journal Article] D. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis (2010)
  • Author(s): Chou, R. C., Kim, N. D., Sadik, C. D., Seung, E., Lan, Y., Byrne, M. H., Haribabu, B., Iwakura, Y., and Luster, A.
  • Journal Title: Immunity Volume: 33 Pages: 266-278
  • Peer Reviewed
• [Journal Article] L. Lung CD4-CD8-double-negative T cells are prominent producers of IL-17A and IFN-during primary respiratory murine infection with Francisella tularensis live vaccine strain (2010)
  • Author(s): Cowley, S. C., Meierovics, A. I., Frelinger, J. A., Iwakura, Y., and Elkins, K.
  • Journal Title: J. Immunol. Volume: 184 Pages: 5791-5801
  • Peer Reviewed
• [Journal Article] CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis (2010)
  • Author(s): Chung, S. H., Seki, K., Choi, B. I., Kimura, K. B., Ito, A., Fujikado, N., Saijo, S., and Iwakura, Y.
  • Journal Title: Arthritis Res. Ther. Volume: 12 Pages: 188-188
  • Peer Reviewed
• [Journal Article] CD30 ligand is a tazget for a novel biological therapy against colitis associated with Th 17 responses. (2010)
  • Author(s): Sun, X
  • Journal Title: J.Immunol. Volume: 185 Pages: 7671-7680
  • Peer Reviewed
• [Journal Article] The role of endogenous glucocorticoids in lymphocyte development in melanowrtin receptor 2-deficient mice. (2010)
  • Author(s): Sato, Y.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 403 Pages: 253-257
  • Peer Reviewed
• [Journal Article] Development of experimental cerebral malaria is independent of IL-23 and IL-17 (2010)
  • Author(s): Lshida, H.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 402 Pages: 790-795
  • Peer Reviewed
• [Journal Article] CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis. (2010)
  • Author(s): Chung, S.H.
  • Journal Title: Arthritis Res.Ther. Volume: 12
  • Peer Reviewed
• [Journal Article] Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity. (2010)
  • Author(s): Lee, H.H.
  • Journal Title: J.Immunol. Volume: 185 Pages: 5225-5235
  • Peer Reviewed
• [Journal Article] Functional hypothalamic amenorrhea due to increased CRH tone in melanocortin receptor 2-deficient mice. (2010)
  • Author(s): Matsuwaki, T.
  • Journal Title: Endocrinology Volume: 151 Pages: 5489-5496
  • Peer Reviewed
• [Journal Article] Periprosthetic osteolysis : characterizing the innate immune response to titanium wear-particles. (2010)
  • Author(s): St Pierre, C.A
  • Journal Title: J.Orthop.Res. Volume: 28 Pages: 1418-1424
  • Peer Reviewed
• [Journal Article] Critical role of regulatory Tcell in Th17-mediated minor antigen-disparate rejection (2010)
  • Author(s): Vokaer, B.
  • Journal Title: J.Immunol. Volume: 185 Pages: 3417-3425
  • Peer Reviewed
• [Journal Article] Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a marine model of inflammatory arthritis. (2010)
  • Author(s): Chou, R C.
  • Journal Title: Immunity Volume: 33 Pages: 266-278
  • Peer Reviewed
• [Journal Article] IL-1 plays an important role in the bone metabolism under physiological conditions. (2010)
  • Author(s): Lee, Y.M.
  • Journal Title: Int.Immunol Volume: 22 Pages: 805-816
  • Peer Reviewed
• [Journal Article] Role of interleukin-17A in cell-mediated protection against Staphylococcus aureus infection in mice immunized with the fibrinogen-binding domain of clumping factor A (2010)
  • Author(s): Narita, K
  • Journal Title: Infect.Immun. Volume: 78 Pages: 4234-4242
  • Peer Reviewed
• [Journal Article] 1α, 25-Dihydroxyvitamin D3 and all-traps retinoic acid synergistically inhibit the differentiation and expansion of Th17 cells (2010)
  • Author(s): Ikeda, U.
  • Journal Title: Immunol.Lett. Volume: 134 Pages: 7-16
  • Peer Reviewed
• [Journal Article] Inflammasome activation by adenylate cyclase toxin directs Th 17 responses and protection against Bordetella pertussis. (2010)
  • Author(s): Dunne, A.
  • Journal Title: J.Immunol. Volume: 185 Pages: 1711-1719
  • Peer Reviewed
• [Journal Article] TNF but not IL-6 and IL17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Ill rn-/-mice. (2010)
  • Author(s): Nakajima, A.
  • Journal Title: J.Immunol. Volume: 185 Pages: 1887-1893
  • Peer Reviewed
• [Journal Article] Interleukin-17A during local and systemic Staphylococcus aureus-induced arthritis in mice. (2010)
  • Author(s): Henningsson, L.
  • Journal Title: Infect.Immun. Volume: 78 Pages: 3783-3790
  • Peer Reviewed
• [Journal Article] Altered effector CD4+ T cell function in IL-21R-/-CD4+ T cell-mediated graft-versus-host disease. (2010)
  • Author(s): Oh, I.
  • Journal Title: J Immunol Volume: 185 Pages: 1920-1926
  • Peer Reviewed
• [Journal Article] IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection. (2010)
  • Author(s): Miyazaki, Y.
  • Journal Title: J.Immunol. Volume: 185 Pages: 1150-1157
  • Peer Reviewed
• [Journal Article] The mechanism of lipopolysaccharide-induced human immunodefieiency virus type I activation in transgenic mouse macrophages. (2010)
  • Author(s): Kadoki, M.
  • Journal Title: Int.Immunol. Volume: 22 Pages: 469-478
  • Peer Reviewed
• [Journal Article] Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice. (2010)
  • Author(s): Hadano, S.
  • Journal Title: Neurosci.Res. Volume: 68 Pages: 131-136
  • Peer Reviewed
• [Journal Article] AT(h)17-polarized cell population that has infiltrated the lung requires cells that convert to IFN-{gamma}production in order to induce airway hyperresponsiveness. (2010)
  • Author(s): Ashino, S.
  • Journal Title: Int.Immunol. Volume: 22 Pages: 503-513
  • Peer Reviewed
• [Journal Article] Dectin-2 recognition of alpha-mannans and induction of Th 17 cell differentiation is essential for host defense against Candida albicans. (2010)
  • Author(s): Saijo, S.
  • Journal Title: Immunity Volume: 32 Pages: 681-691
  • Peer Reviewed
• [Journal Article] Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensisvia a Toll-like receptor 9-dependent pathway. (2010)
  • Author(s): Xiao, G
  • Journal Title: Cell Immunol Volume: 263 Pages: 241-250
  • Peer Reviewed
• [Journal Article] Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma. (2010)
  • Author(s): Hill, G.R.
  • Journal Title: Blood Volume: 116 Pages: 819-828
  • Peer Reviewed
• [Journal Article] IL-23 suppresses innate immune response independently of IL-17A duringcar cinogenesis and metastasis. (2010)
  • Author(s): Teng, M.W.
  • Journal Title: Proc.Natl.Acad.Sci.U S A. Volume: 107 Pages: 8328-8333
  • Peer Reviewed
• [Journal Article] Tumor-infiltrating IL-17-producing gammadelta T cells support the progression of tumor by promoting angiogenesis. (2010)
  • Author(s): Wakita, D.
  • Journal Title: Eur.J.Immunol. Volume: 40 Pages: 1927-1937
  • Peer Reviewed
• [Journal Article] Lung CD4-CD8-double-negative T cell are prominent producer of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain. (2010)
  • Author(s): Cowley, S.C.
  • Journal Title: J.Immunol. Volume: 184 Pages: 5791-5891
  • Peer Reviewed
• [Journal Article] Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. (2010)
  • Author(s): Baldeviano, G.C.
  • Journal Title: Circ.Res. Volume: 106 Pages: 1636-1655
  • Peer Reviewed
• [Journal Article] Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis. (2010)
  • Author(s): Gan, P.Y.
  • Journal Title: J.Am.Soc.Nephrol Volume: 21 Pages: 925-931
  • Peer Reviewed
• [Journal Article] Identification of the cellular sensor that stimulates the inflammatory response to sterilecell death. (2010)
  • Author(s): Kono, H.
  • Journal Title: J Immunol Volume: 184 Pages: 4470-4478
  • Peer Reviewed
• [Journal Article] Essential role of Il-17A in the formation of a mycobacterial infection-induced granuloma in the lung. (2010)
  • Author(s): Okamoto, Yoshida, Y.
  • Journal Title: J.Immunol. Volume: 184 Pages: 4414-4422
  • Peer Reviewed
• [Journal Article] Neural tube defects and impaired neural progenitor cell proliferation in Gbetal-deficient mice. (2010)
  • Author(s): Okae, H.
  • Journal Title: Dev Dyn. Volume: 239 Pages: 1089-1010
  • Peer Reviewed
• [Journal Article] Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections. (2010)
  • Author(s): Henry, T.
  • Journal Title: J.Immunol. Volume: 184 Pages: 3755-3767
  • Peer Reviewed
• [Journal Article] Nucleoprotein diet ameliorates arthritis symptoms in mice transgenic for humanT-cell leukemia virus type I(HTLV-I). (2010)
  • Author(s): Ohtaki, H.
  • Journal Title: J.Clin.Biochem.Nutr. 46 Pages: 93-104
  • Peer Reviewed
• [Journal Article] IFN-γ is a master regulator of endotoxin shock syndrome in mice primed withheat-killed Propionibacterium acnes. (2010)
  • Author(s): Kawa, K.
  • Journal Title: Int.Immunol. 22 Pages: 157-166
  • Peer Reviewed
• [Journal Article] Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in BALB/c mice. (2010)
  • Author(s): Isoda, K.
  • Journal Title: Arterioscler. Thromb.Vasc.Biol. 30 Pages: 708-715
  • Peer Reviewed
• [Journal Article] IL-17 contributes to the development of chronic rejection in a murine-heart transpant model. (2010)
  • Author(s): Itoh, S.
  • Journal Title: J.Clin.Immunol. 30 Pages: 235-240
  • Peer Reviewed
• [Journal Article] Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors. (2010)
  • Author(s): Adamopoulos, I.E.
  • Journal Title: Arthritis Res.Ther 12
  • Peer Reviewed
• [Journal Article] Periprosthetic Osteolysis : Characterizing the innate immune response to titanium wear particles. (2010)
  • Author(s): St.Pierre, C.A.
  • Journal Title: J.Orthopedic Res. (in press)
  • Peer Reviewed
• [Journal Article] The mechanism of lipopolysaccharide-induced human immunodeficiency virus type I activation in transgenic mouse macrophages. (2010)
  • Author(s): Kadoki, M.
  • Journal Title: Int.Immunol. (in press)
  • Peer Reviewed
• [Journal Article] Characterization of a variant virus from ascites of subacute granulomatous serositis in interferon-γ-deficient C57BL/6 mice persistently infected with murine coronavirus strain JHM. (2010)
  • Author(s): Taguchi, F.
  • Journal Title: Viral Immunol. (in press)
  • Peer Reviewed
• [Journal Article] IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis. (2010)
  • Author(s): Teng, M.W.L
  • Journal Title: Proc.Natl.Acad.Sci.USA (in press)
  • Peer Reviewed
• [Journal Article] IL-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. (2010)
  • Author(s): Baldeviano, G.C.
  • Journal Title: Circulation Res. (in press)
  • Peer Reviewed
• [Journal Article] Stem cell mobilization with G-CSF induces Type-17 differentiaion and promotes scleroderma. (2010)
  • Author(s): Hill, G.R.
  • Journal Title: Blood (in press)
  • Peer Reviewed
• [Journal Article] Dectin-2 recognition of α-mannans and induction of Th17 differentiation is essential for host defense against Candida albicans. (2010)
  • Author(s): Saijo, S.
  • Journal Title: Immunity (in press)
  • Peer Reviewed
• [Journal Article] The roles of IL-17A and IL-17A in mucosal infection and allergy. In"Th17 cells in health and disease",(ed.S.Jiang). (2010)
  • Author(s): Ishigame, H.
  • Journal Title: Springer Science+Buisiness Media, LLC, New York, NY (in press)
  • Peer Reviewed
• [Journal Article] Th17 nephritogenic immunity induces autoimmune anti-MPO glomerulonephritis. (2010)
  • Author(s): Gan, P.-Y.
  • Journal Title: J.Am.Soc.Nephrol. (in press)
  • Peer Reviewed
• [Journal Article] Type I interferon signaling constrains IL-17A/F secretion by γδ T cells duringbacterial infection. (2010)
  • Author(s): Henry, T.
  • Journal Title: J.Immunol. (in press)
  • Peer Reviewed
• [Journal Article] Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death. (2010)
  • Author(s): Kono, H.
  • Journal Title: J.Immunol. (in press)
  • Peer Reviewed
• [Journal Article] Muramyldipeptide augments the actions of lipopolysacchairde in mice by stimulating macrophages to produe pro-IL-1B and by down-regulation of suppressor of cytokine signaling 1 (SOCS1). (2010)
  • Author(s): Shikama, Y.
  • Journal Title: Innate Immun. (in press)
  • Peer Reviewed
• [Journal Article] Differential roles of IL-17A and IL-17F in host defense against mucoepithelial bacterial infection and allergic responses (2009)
  • Author(s): Ishigame, H., Kakuta, S., Nagai, T., Nambu, A., Komiyama, Y., Kadoki, M., Tanahashi, Y., Akitsu, A., Kotaki, H., Sudo, K., Nakae, S., Sasakawa, C., and Iwakura, Y
  • Journal Title: Immunity Volume: 30 Pages: 108-119
  • Peer Reviewed
• [Journal Article] IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice (2009)
  • Author(s): Lopez Kostka, S., Dinges, S., Griewank, K., Iwakura, Y., Udey, M. C., and Von Stebut, E.
  • Journal Title: J. Immunol. Volume: 182 Pages: 3039-3046
  • Peer Reviewed
• [Journal Article] M. Virus binding to a plasma membrane receptor triggers interleukin-1α-mediated proinflammatory macrophage response in vivo (2009)
  • Author(s): Di Paolo, N. C., Miao, E. A., Iwakura, Y., Kaja, M-K., Aderem, A., Flavell, R. A., Papayannopoulou, T., and Shayakhmetov, D.
  • Journal Title: Immunity Volume: 31 Pages: 110-121
  • Peer Reviewed
• [Journal Article] Characterization of mice deficient in Melanocortin 2 receptor on a B6/Balbc mix background (2009)
  • Author(s): Chida, D., Sato, T., Sato, Y., Kubo, M., Yoda, T., Suzuki, H., and Iwakura, Y.
  • Journal Title: Mol. Cell. Endocrinol. Volume: 300 Pages: 32-36
  • Peer Reviewed
• [Journal Article] Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation (2009)
  • Author(s): Inoue, A., Setoguchi, K., Matsubara, Y., Okada, K., Sato, N., Iwakura, Y., Higuchi, O., and Yamanashi, Y.
  • Journal Title: Science Signaling Volume: 2 Pages: 7-7
  • Peer Reviewed
• [Journal Article] A. A protective function for interleukin 17A in T cell-mediated intestinal inflammation (2009)
  • Author(s): O' Connor, W. Jr., Kamanaka, M., Booth, C. J., Town, T., Nakae, S., Iwakura, Y., Kolls, J. K., and Flavell, R.
  • Journal Title: Nat. Immunol. Volume: 10 Pages: 603-609
  • Peer Reviewed
• [Journal Article] E. Pulmonary inflammation triggered by Ricin toxin requires macrophages and IL-1 signaling (2009)
  • Author(s): Lindauer, M. L., Wong, J., Iwakura, Y., and Magun, B.
  • Journal Title: J. Immunol. Volume: 183 Pages: 1419-1426
  • Peer Reviewed
• [Journal Article] Pivotal role of cerebral interleukin-17-producingγδT cells in the delayed phase of ischemic brain injury (2009)
  • Author(s): Shichita, T., Sugiyama, Y., Ooboshi, H., Sugimori, H., Nakagawa, R., Takada, I., Iwaki, T., Okada, Y., Iida, M., Cua, D. J., Iwakura, Y., and Yoshimura, A.
  • Journal Title: Nat. Med. Volume: 15 Pages: 946-950
  • Peer Reviewed
• [Journal Article] Interleukin(IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17 (2009)
  • Author(s): Munoz, M., Heimesaat, M. M., Danker, K., Struck, D., Lohmann, U., Plickert, R., Bereswill, S., Fischer, A., Dunay, I. R., Wolk, K., Loddenkemper, C., Krell, H.-W., Libert, C., Lund, L. R., Frey, O., Holscher, C., Iwakura, Y., Ghilardi, N., Ouyang, W., Kamradt, T., Sabat, R., and Liesenfeld, O.
  • Journal Title: J. Exp. Med. Volume: 206 Pages: 3047-3059
  • Peer Reviewed
• [Journal Article] CXCL12 promotes CCR7-dependent naive T-cell trafficking to lymphnodes and Peyer's patches. (2009)
  • Author(s): Bai, Z.B.
  • Journal Title: J.Immunol. 182 Pages: 1287-1295
  • Peer Reviewed
• [Journal Article] Differential roles of IL-17A and IL-17F in host defense against mucoepithelial bacterial infection and allergic responses. (2009)
  • Author(s): Ishigame, H.
  • Journal Title: Immunity 30 Pages: 108-119
  • Peer Reviewed
• [Journal Article] IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice. (2009)
  • Author(s): Lopez Kostka, S.
  • Journal Title: J.Immunol. 182 Pages: 3039-3046
  • Peer Reviewed
• [Journal Article] MHC-matched corneal allograft rejection in an IFN-γ/IL-17-independent manner in C57BL/6 mice. (2009)
  • Author(s): Yamada, J.
  • Journal Title: Invest.Ophthalmol. Vis.Sci. 50 Pages: 2139-2146
  • Peer Reviewed
• [Journal Article] Biotin status affects nickel allergy via regulation of IL-1β production in mice. (2009)
  • Author(s): Kuroishi, T.
  • Journal Title: J.Nutrition. 139 Pages: 1031-1036
  • Peer Reviewed
• [Journal Article] Host-derived Interleukin 1α is important in determining the immunog enicity of3-Methylcholantrene-tumor cells. (2009)
  • Author(s): Elkabets, M.
  • Journal Title: J.Immunol. 182 Pages: 4874-4881
  • Peer Reviewed
• [Journal Article] Virus binding to a plasma membrane receptor triggers interleukin-1α-mediated proinflammatory macrophage response in vivo. (2009)
  • Author(s): Di Paolo, N.
  • Journal Title: Immunity 31 Pages: 110-121
  • Peer Reviewed
• [Journal Article] Toll-like receptor 9-dependent activation of myeloid dendritic cells bydeoxynucleic acids from Candida albicans. (2009)
  • Author(s): Miyazato, A.
  • Journal Title: Infect.Immun. 77 Pages: 3056-3064
  • Peer Reviewed
• [Journal Article] Hepatic platelet accumulation in Fas-mediated hepatitis in mice. (2009)
  • Author(s): Ohtaki, Y.
  • Journal Title: Int.Immunopharmacol. 9 Pages: 1071-1078
  • Peer Reviewed
• [Journal Article] A protective function for interleukin 17A in T cell-mediated intestinal inflammation. (2009)
  • Author(s): O'Connor, W.Jr.
  • Journal Title: Nat.Immunol. 10 Pages: 603-609
  • Peer Reviewed
• [Journal Article] IL-17 is involved in bone resorption in mouse periapical lesions. (2009)
  • Author(s): Oseko, F.
  • Journal Title: Microbiol.Immunol. 53 Pages: 287-294
  • Peer Reviewed
• [Journal Article] The antihyperalgesic activity of selective P2X7 receptor antagonist, A-839977, is lost in IL-1α knockout mice. (2009)
  • Author(s): Honore, P.
  • Journal Title: Behav.BrainRes. 204 Pages: 77-81
  • Peer Reviewed
• [Journal Article] Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft versus host disease. (2009)
  • Author(s): Yi, T.
  • Journal Title: Blood 114 Pages: 3101-3112
  • Peer Reviewed
• [Journal Article] Pulmonary inflammation triggered by Ricin toxin requires macrophages and IL-1 signaling. (2009)
  • Author(s): Lindauer, M.L.
  • Journal Title: J.Immunol. 183 Pages: 1419-1426
  • Peer Reviewed
• [Journal Article] Pivotal role of cerebral interleukin-17-producing γδT cells in the delayed phase of ischemic brain injury. (2009)
  • Author(s): Shichita, T.
  • Journal Title: Nat.Med. 15 Pages: 946-950
  • Peer Reviewed
• [Journal Article] Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A. (2009)
  • Author(s): Okiyama, N.
  • Journal Title: Arth.Rheum. 60 Pages: 2505-2512
  • Peer Reviewed
• [Journal Article] Interleukin-1 deficency in combination with macrophage depletion increases susceptibility to Pseudomonas aeruginosa bacteremia. (2009)
  • Author(s): Horino, T.
  • Journal Title: Microbiol.Immunol. 53 Pages: 502-511
  • Peer Reviewed
• [Journal Article] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior. (2009)
  • Author(s): Taniguchi, S.
  • Journal Title: EMBO J. 28 Pages: 3717-3729
  • Peer Reviewed
• [Journal Article] T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice. (2009)
  • Author(s): Horie, I.
  • Journal Title: Endocrinology 150 Pages: 5135-5142
  • Peer Reviewed
• [Journal Article] Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Fracisella tularensis. (2009)
  • Author(s): Lin, Y.
  • Journal Title: Immunity 31 Pages: 799-810
  • Peer Reviewed
• [Journal Article] Natural occurring IL-17 producing T cells regulagte the initial phase of neutrophil mediated airway responses. (2009)
  • Author(s): Tanaka, S.
  • Journal Title: J.Immunol. 183 Pages: 7523-7530
  • Peer Reviewed
• [Journal Article] Role of T cell TGFβ signaling and IL-17 in allograft acceptance and fibrosisassociated with chronic rejection. (2009)
  • Author(s): Faust, S.M.
  • Journal Title: J.Immunol. 183 Pages: 7297-7306
  • Peer Reviewed
• [Journal Article] Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responsesfor the development of experimental autoimmune encephalo myelitis. (2009)
  • Author(s): Oyamada, A.
  • Journal Title: J.Immunol. 183 Pages: 7539-7546
  • Peer Reviewed
• [Journal Article] Interleukin(IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. (2009)
  • Author(s): Munoz, M.
  • Journal Title: J.Exp.Med. 206 Pages: 3047-3059
  • Peer Reviewed
• [Journal Article] IFN- regulates the requirement for IL-17 in proteoglycan-induced arthritis. (2009)
  • Author(s): Doodes, P.D.
  • Journal Title: J.Immunol. 184 Pages: 1552-1559
  • Peer Reviewed
• [Journal Article] Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. (2009)
  • Author(s): Madhur, M.S.
  • Journal Title: Hypertension 55 Pages: 500-507
  • Peer Reviewed
• [Journal Article] IFN-γ expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T death. (2009)
  • Author(s): Atsumi, T.
  • Journal Title: Int. Immjnol., 21 Pages: 73-80
  • Peer Reviewed
• [Journal Article] II-17 contributes to CD4-mediatd graft-versus-host disease. (2009)
  • Author(s): Kappel, L. W.
  • Journal Title: Blood, 113 Pages: 945-952
  • Peer Reviewed
• [Journal Article] Characterization of mice deficient in Melanocortin 2 receptor on a B6/Balbc mix background. (2009)
  • Author(s): Chida, D.
  • Journal Title: mol. Cell. Endocrinol., 300 Pages: 32-36
  • Peer Reviewed
• [Journal Article] IL-1 regulates the Cyp7al gene and serum total cholesterol level at steady state in mice. (2009)
  • Author(s): Kojima, M.
  • Journal Title: Biochem. Biophys. Res. Commun., 279 Pages: 239-242
  • Peer Reviewed
• [Journal Article] Dfferential roles of IL-17A and IL-17F in defense against mucoepithelial bacterial infection and allergic responses. (2009)
  • Author(s): Ishigame, H.
  • Journal Title: Immunity, 29 Pages: 628-636
  • Peer Reviewed
• [Journal Article] Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. (2009)
  • Author(s): Irie, N.
  • Journal Title: J Biol Chem. (in press)
  • Peer Reviewed
• [Journal Article] Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. (2009)
  • Author(s): Yoneda, M.
  • Journal Title: Cancer Sci., (in press)
  • Peer Reviewed
• [Journal Article] Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of Natural Killer T cells and IL-17 (2008)
  • Author(s): Pichavant, M., Goya, S., Meyer, E. H., Johnston, R. A., Kim, H. Y., Matangkasombut, P., Zhu, M., Iwakura, Y., Savage, P. B., DeKruyff, R. H., Shore, S. A., and Umetsu, D. T.
  • Journal Title: J. Exp. Med. Volume: 205 Pages: 385-393
  • Peer Reviewed
• [Journal Article] The roles of IL-17A in inflammatory immune responses and host defense against pathogens (2008)
  • Author(s): Iwakura, Y., Nakae, S., Saijo, S., and Ishigame, H.
  • Journal Title: Immunological Rev. Volume: 226 Pages: 57-79
  • Peer Reviewed
• [Journal Article] K. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia (2008)
  • Author(s): Aujla, S. J., Fei, M., Pociask, D. A., Reinhart, T. A., Edeal, J., Gaus, K., Kreindler, J. L., Dubin, P. J., Zheng, M., Pilewski, J. M., Myerburg, M. M., Mason, C. A., Iwakura, Y., and Kolls, J.
  • Journal Title: Nature Med. Volume: 14 Pages: 275-281
  • Peer Reviewed
• [Journal Article] Either a Th17 or a Th1 effector response can drive autoimmunity : conditions of disease induction affect dominant effector category (2008)
  • Author(s): Luger, D., Silver, P. B., Tang, J., Cua, D., Chen, Z., Iwakura, Y., Bowman, E. P., Sgambellone, N. M., Chan, C.-C. and Caspi, R.
  • Journal Title: J. Exp. Med. Volume: 205 Pages: 799-810
  • Peer Reviewed
• [Journal Article] Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis (2008)
  • Author(s): Izcue, A., Hue, S., Buonocore, S., Arancibia-Carcamo, C. V., Ahern, P. P., Iwakura, Y., Maloy, K. J., and Powrie, F
  • Journal Title: Immunity Volume: 28 Pages: 559-570
  • Peer Reviewed
• [Journal Article] L-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8^+T cells (2008)
  • Author(s): Tajima, M., Wakita, D., Noguchi, D., Chamoto, K., Yue, Z, Fugo, K., Ishigame, H., Iwakura, Y., Kitamura, H., and Nishimura, T
  • Journal Title: J. Exp. Med. Volume: 205 Pages: 1019-1027
  • Peer Reviewed
• [Journal Article] Increased fat-to-carbohydrate oxidation ratio in Il1ra^<-/-> mice on a high fat diet is associated with increased sympathetic tone (2008)
  • Author(s): Chida, D., Hashimoto, O., Kuwahara, M., Sagara, H., Osaka, T., Tsubone, H., and Iwakura, Y.
  • Journal Title: Diabetologia Volume: 51 Pages: 1698-1706
  • Peer Reviewed
• [Journal Article] Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction (2008)
  • Author(s): Ogura, H., Murakami, M., Okyuyama, Y., Tsuruoka, M., Kitabayashi, C., Kanamoto, M., Nishihara, M., Iwakura, Y., and Hirano, T.
  • Journal Title: Immunity Volume: 29 Pages: 628-636
  • Peer Reviewed
• [Journal Article] The role of DCIR in the development of autoimmune diseases (2008)
  • Author(s): Fujikado, N., Saijo, S., Yonezawa, T., Shimamori, K., Ishii, A., Sugai, S., Kotaki, H., Sudo, K., Nose, M., and Iwakura, Y.
  • Journal Title: Cytokine Volume: 43 Pages: 244-244
  • NAID: 40017145116
  • Peer Reviewed
• [Journal Article] The mechanisms of the stress-induced behavioral abnormality in the IL-1 receptor antagonist(IL-1Ra) KO mice (2008)
  • Author(s): Wakabayashi, C., and Iwakura, Y.
  • Journal Title: Neuroscience Res. Volume: 61 Pages: 63-63
  • Peer Reviewed
• [Journal Article] Contribution of IL-1 to resistance to Streptococcus pneumoniae infection (2008)
  • Author(s): Kafka, D., Ling, E., Feldman, G., Benharroch, D., Voronov, E., Givon-Laci, N., Iwakura, Y., Dagan, R., Apte, R. N., and Mizrachi-Nebenzahi, Y.
  • Journal Title: Int. Immunol. Volume: 9 Pages: 1139-1146
  • NAID: 10022599302
  • Peer Reviewed
• [Journal Article] Interlerkin-1β and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression. (2008)
  • Author(s): Honda, A.
  • Journal Title: J. Dermato. Sci., 49 Pages: 63-72
  • Peer Reviewed
• [Journal Article] Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis. (2008)
  • Author(s): Okumura, A.
  • Journal Title: Arthritis Rheum., 58 Pages: 413-421
  • Peer Reviewed
• [Journal Article] Differntial roles for IFN-γ and IL-17 in expecimental autoimmune uveoretinitis. (2008)
  • Author(s): Yoshimura, T.
  • Journal Title: Int. Immunol., 20 Pages: 209-214
  • Peer Reviewed
• [Journal Article] Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells. (2008)
  • Author(s): Fujikado, N.
  • Journal Title: Nat. Med., 14 Pages: 176-180
  • Peer Reviewed
• [Journal Article] Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages. (2008)
  • Author(s): Ashimo, T.
  • Journal Title: Mol. Immunol., 45 Pages: 2106-2115
  • Peer Reviewed
• [Journal Article] Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. (2008)
  • Author(s): Pichavant, M.
  • Journal Title: J.Exp. Med., 205 Pages: 385-393
  • Peer Reviewed
• [Journal Article] Deoxynucleic Acids from Cryptococcus neoformans Activate Myeloid Dendritic Cells via a TLR9-Dependent Pathway. (2008)
  • Author(s): Nakamura, K.
  • Journal Title: J. Immjnol. 180 Pages: 6067-4074
  • Peer Reviewed
• [Journal Article] Kid-Mediated Chromoseme Compaction Ensures Proper Nuclear Envelope Formation. (2008)
  • Author(s): Ohsugi, M.
  • Journal Title: Cell, 132 Pages: 771-782
  • Peer Reviewed
• [Journal Article] IL-22 mediates mucosal host defense agalnst Gram-negative bacterial pneumonia. (2008)
  • Author(s): Aujla, S. J.
  • Journal Title: Nat. Med., 14 Pages: 275-281
  • Peer Reviewed
• [Journal Article] Interleukin-23 restrains regulatory T cell activity to drive T ce11-dependent colitis. (2008)
  • Author(s): Izcue, A.
  • Journal Title: Immunity. 28 Pages: 559-570
  • Peer Reviewed
• [Journal Article] Either a Th17 or a Thl effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. (2008)
  • Author(s): Luger, D.
  • Journal Title: J. Exp. Med., 205 Pages: 799-810
  • Peer Reviewed
• [Journal Article] IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8^+T cells. (2008)
  • Author(s): Tajima, M.
  • Journal Title: J. Exp. Med., 205 Pages: 1019-1027
  • Peer Reviewed
• [Journal Article] Host T Cells Are the Main Producers of IL-17 within the Central Nervous System during Initiation of Experimental Autoimmune Encephalomyelitis Induced by Adoptive Transfer of Thl Cll Lines. (2008)
  • Author(s): Lees, J. R.
  • Journal Title: 180 Pages: 8066-8072
  • Peer Reviewed
• [Journal Article] Development of Proteoglycan-lnduced Arthritis Is hdependent of IL-17. (2008)
  • Author(s): Doodes, P. D.
  • Journal Title: J. Immunol., 181 Pages: 329-337
  • Peer Reviewed
• [Journal Article] CCL2 recruitment of IL-6-producing CD11b^+ monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity. (2008)
  • Author(s): Bai, Y.
  • Journal Title: Eur. J. Immunol., 38 Pages: 1877-1888
  • Peer Reviewed
• [Journal Article] Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding. (2008)
  • Author(s): Kugota, N
  • Journal Title: Cell Metab., 8 Pages: 49-64
  • Peer Reviewed
• [Journal Article] Endogenous IL-17 Does Not Play a Significant Role in the Development of Experimental Murine Allergic Conjunctivitis. (2008)
  • Author(s): Fukushima, A.
  • Journal Title: Int. Arch. Allergy Immjnol., 147 Pages: 206-212
  • Peer Reviewed
• [Journal Article] CD44 and Bak Expression in IL-6 or TNF-α Gene Knockout Mice After Whole Lung Irradiation. (2008)
  • Author(s): Sakai, M.
  • Journal Title: J. Radiat. Res. (Tokyo), 49 Pages: 409-416
  • Peer Reviewed
• [Journal Article] Increased fat:carbohydrate oxidation ratio in IIIra^+ mice on a high fat diet is associated with increased sympathetic tone. (2008)
  • Author(s): Chida, D.
  • Journal Title: Diaberologia, 51 Pages: 1698-1706
  • Peer Reviewed
• [Journal Article] IL-17A is produced by Th17, γδT cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance. (2008)
  • Author(s): Schulz, S. M.
  • Journal Title: Int. Immunol., 20 Pages: 1129-1138
  • Peer Reviewed
• [Journal Article] Contribution of IL-1 to resistance to Stretococcus pneumoiae infection. (2008)
  • Author(s): Kafka, D.
  • Journal Title: Int. Immunol., 20 Pages: 1139-1146
  • Peer Reviewed
• [Journal Article] IL-17A Produced by γδT Cells Plays a Critical Role in Immunity against Listeria monocytogenes Infection in the Liver. (2008)
  • Author(s): Hamada, S.
  • Journal Title: J. Immunol., 181 Pages: 3456-3463
  • Peer Reviewed
• [Journal Article] Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules. (2008)
  • Author(s): Teruya, H.
  • Journal Title: Retrovirology, 5 Pages: 86-86
  • Peer Reviewed
• [Journal Article] Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction. (2008)
  • Author(s): Ogura, H.
  • Journal Title: Immunity. 29 Pages: 629-636
  • Peer Reviewed
• [Journal Article] Deficiency of Tumor Necrosis Factor-α and Interferon-γ in Bone Marrow Cells Synergistically Inhibits Neointimal Formation Following Vascular Injury. (2008)
  • Author(s): Muryama, H.
  • Journal Title: Cardiovasc. Res., 80 Pages: 175-180
  • Peer Reviewed
• [Journal Article] Toll-like receptor 2(TLR2) and dectin-l contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei. (2008)
  • Author(s): Nakamura, K.
  • Journal Title: Microbes Infect., 10 Pages: 1223-1227
  • Peer Reviewed
• [Journal Article] IL-23 and Th17 Cells Enhance Th2 Cell-mediated Eosinophilic Airway Inflammation in Mice. Am . J . Respir. (2008)
  • Author(s): Wakashim, H.
  • Journal Title: Crit. Care Med., 178 Pages: 1023-1032
  • Peer Reviewed
• [Journal Article] Involvement of IL-17 in the pathogenesis of DSS-induced colittis in mece. (2008)
  • Author(s): Ito, R.
  • Journal Title: Biochem. Biophys. Res. Commun., 377 Pages: 12-16
  • Peer Reviewed
• [Journal Article] Protective Immunity to Systemic Infection with Attenuated Samonella enterica serovar Enteritidis in the Absence of IL-12 Associated with IL-23-Dependent IL-22, but Not IL-17. (2008)
  • Author(s): Schuiz, S. M.
  • Journal Title: 181 Pages: 7891-7901
  • Peer Reviewed
• [Journal Article] Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1α Released from Dying Cells. (2008)
  • Author(s): Eigenbrod, T.
  • Journal Title: J. Immunol., 181 Pages: 8197-8198
  • Peer Reviewed
• [Journal Article] IL-17 is Involved in Hlicobacter pylori-Iduced Gastric Inflammatory Responses in a Mouse Model. (2008)
  • Author(s): Shiomi, S.
  • Journal Title: Helicobacter, 13 Pages: 518-524
  • Peer Reviewed
• [Journal Article] The roles of IL-17A in inflammatory immune responses and host defense against pathogens. (2008)
  • Author(s): iwakura, Y.
  • Journal Title: Immunol. Rev., 226 Pages: 57-79
  • Peer Reviewed
• [Presentation] 遺伝子改変マウスを用いた創薬標的の探索 (2012)
  • Author(s): 岩倉洋一郎
  • Organizer: 第8回生命資源研究・支援センターシンポジウム
  • Place of Presentation: 熊本大学生命資源研究・支援センター(招待講演)
  • Year and Date: 2012-02-24
• [Presentation] 腸管ポリープ形成におけるIL-17ファミリーの役割の解析 (2012)
  • Author(s): 角田茂
  • Organizer: 平成23年度「個体レベルでのがん研究支援活動」班 ワークショップ
  • Place of Presentation: 大津
• [Presentation] 遺伝子改変マウスを用いたIL-17A/Fの感染・炎症・発がんにおける役割の解析 (2011)
  • Author(s): 角田茂
  • Organizer: 第30回信州免疫アレルギー懇話会
  • Place of Presentation: 松本
  • Year and Date: 2011-12-21
• [Presentation] Development of Th17 cells in the absence of IL-6 in IL-1 receptor antagonist deficient mice (2011)
  • Author(s): 岩倉洋一郎
  • Organizer: 日本分子生物学会ワークショップ
  • Place of Presentation: パシフィコ横浜(招待講演)
  • Year and Date: 2011-12-14
• [Presentation] T細胞上に発現するケモカインレセプターCXCR4の自己免疫性関節炎の発症における役割 (2011)
  • Author(s): 鄭〓絢
  • Organizer: IMSUT&RCAST GCOEセミナー「医科学研究所システム疾患モデル研究センター若手研究者セミナー」
  • Place of Presentation: 東京大学医科学研究所講堂
  • Year and Date: 2011-11-02
• [Presentation] 2種の関節炎自然発症モデルマウスより探索された感受性候補遺伝子とその生理機能解析 (2011)
  • Author(s): 日下智聖
  • Organizer: IMSUT&RCAST GCOEセミナー「医科学研究所システム疾患モデル研究センター若手研究者セミナー」
  • Place of Presentation: 東京大学医科学研究所講堂
  • Year and Date: 2011-11-02
• [Presentation] 遺伝子改変マウスを取り巻く最近の動向と基礎医学研究への応用 (2011)
  • Author(s): 角田茂
  • Organizer: 信州実験動物研究会第76回勉強会
  • Place of Presentation: 松本
  • Year and Date: 2011-10-21
• [Presentation] マウスモデルを用いた関節リウマチ発症機構の解析 (2011)
  • Author(s): 岩倉洋一郎
  • Place of Presentation: 北海道大学遺伝子病制御研究所(招待講演)
  • Year and Date: 2011-10-21
• [Presentation] 動物モデルを用いた関節リウマチ発症機構の解析 (2011)
  • Author(s): 岩倉洋一郎
  • Organizer: 第39回臨床免疫学会(免疫疾患学会連合2011)教育講演
  • Place of Presentation: 京王プラザホテル,東京(招待講演)
  • Year and Date: 2011-09-15
• [Presentation] 先進的医学研究のための遺伝子改変動物コンソーシアムの設立 (2011)
  • Author(s): 岩倉洋一郎
  • Organizer: 医科学研究所主催シンポジウム「先進的医学研究のための遺伝子改変動物研究の推進」
  • Place of Presentation: 医科学研究所トミーホール(招待講演)
  • Year and Date: 2011-09-13
• [Presentation] マウスモデルを用いた関節リウマチ発症機構の解析 (2011)
  • Author(s): 岩倉洋一郎
  • Organizer: 御茶ノ水膠原病・リウマチ内科研究会
  • Place of Presentation: 山野上ホテル,東京,(招待講演)
  • Year and Date: 2011-09-09
• [Presentation] 自己免疫性関節炎発症におけるサイトカインの役割 (2011)
  • Author(s): 岩倉洋一郎
  • Organizer: 東京理科大学生命科学研究科大学院特別講義「免疫記憶・炎症研究の新展開」
  • Place of Presentation: 東京理科大カナル会館(招待講演)
  • Year and Date: 2011-09-03
• [Presentation] IL-17の感染防御・免疫応答における役割 (2011)
  • Author(s): 岩倉洋一郎
  • Organizer: 京都大学ウイルス研究所セミナー「ウイルス研究の潮流シリーズ8」
  • Place of Presentation: 京都大学ウイルス研究所会議室(招待講演)
  • Year and Date: 2011-07-27
• [Presentation] Gene Manipulated Mice as a Tool for the Analysis of Pathogenesis and the Search for Therapeutic Targets (2011)
  • Author(s): 岩倉洋一郎
  • Organizer: 東京大学医科学研究所大学院セミナー
  • Place of Presentation: 東京大学医科学研究所講堂(招待講演)
  • Year and Date: 2011-06-06
• [Presentation] 先進的医学研究のための遺伝子改変動物研究コンソーシアムの設立 (2011)
  • Author(s): 岩倉洋一郎
  • Organizer: 日本学術会議シンポジウム「生命科学の生来に向けたマスタープラン」
  • Place of Presentation: 日本学術会議講堂(招待講演)
  • Year and Date: 2011-05-19
• [Presentation] Functional specialization of IL-17A and IL-17F (2011)
  • Author(s): Yoichiro Iwakura
  • Organizer: Sylvester Comprehensive Cancer Center and School of Medicine
  • Place of Presentation: University of Miami, Miami, U.S.A.(招待講演)
  • Year and Date: 2011-05-12
• [Presentation] Therapeutic targets for rheumatoid arthritis : lessons from animal models (2011)
  • Author(s): Yoichiro Iwakura
  • Organizer: Bio-Rheumatology International Congress(BRIC) Tokyo、The 8th GARN Meeting
  • Place of Presentation: Hilton Tokyo Bay Hotel
• [Presentation] Gene manipulated mice as a tool for the analysis of pathogenesis and development of new therapeutics (2011)
  • Author(s): Yoichiro Iwakura
  • Organizer: Animal Research Center
  • Place of Presentation: Jirin University, Changchun
• [Presentation] Involvement of interleukin (IL)-17A and IL-17F in development of intestinal polyps in Apc^<Min> mice (2011)
  • Author(s): Shigeru Kakuta
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ,千葉
• [Presentation] IL-17F, rather than IL-17A promotes CD4^+ T cell activation and Th-1-type immunity (2011)
  • Author(s): Ce Tang
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ,千葉
• [Presentation] IL-17産生性YδT細胞はリウマチ様関節炎発症に重要である (2011)
  • Author(s): 秋津葵
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ,千葉
• [Presentation] DCIR欠損マウスは強直性脊椎炎様の病態を示す (2011)
  • Author(s): Maruhashi Takumi
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ,千葉
• [Presentation] DCIR, a C-type lectin receptor, is a new negative regulator in osteoclas togenesis (2011)
  • Author(s): Tomonori Kaifu
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ,千葉
• [Presentation] Dectin-1 signaling promotes DSS-induced colitis in a microflora dependent manner (2011)
  • Author(s): Tomonori Kamiya
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ,千葉
• [Presentation] IL-6-independent arthritis and Th17 differentiation in IL-1Ra IL-6 double deficient mice (2011)
  • Author(s): Satoshi Ikeda
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ,千葉
• [Presentation] 腸管細菌感染防御におけるssグルカン/Dectin-1シグナルの役割 (2011)
  • Author(s): 角木基彦
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ,千葉
• [Presentation] 関節炎自然発症モデルマウスを用いて探索された関節炎感受性候補遺伝子の生理機能解析 (2011)
  • Author(s): 日下智聖
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ,千葉
• [Presentation] No significant abnormality of HIDE1 deficient mice in collagen-induced arthritis and experimental autoimmune encephalomyelitis (2011)
  • Author(s): 清水謙次
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ,千葉
• [Presentation] Experimental autoimmune encephalomyelitis is aggravated in DCIR knockout mice (2011)
  • Author(s): 妹尾彬正
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ,千葉
• [Presentation] DCIR : A new therapeutic target for autoimmune disorders (2011)
  • Author(s): Rikio Yabe
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ,千葉
• [Presentation] Identification of rheumatoid arthritis-related gene by comparative analysis of two rheumatoid arthritis model mice (2011)
  • Author(s): Masanori A.Murayama
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ,千葉
• [Presentation] Therapeutic targets for rheumatoid arthritis : lessons from animal models (2011)
  • Author(s): Yoichiro Iwakura
  • Organizer: 1st Bio-Rheumatology International Congress Tokyo 8th GARN Meeting
  • Place of Presentation: Hilton Tokyo Bay Hotel, Tokyo(招待講演)
• [Presentation] IL-17-producing-gamma-delta T cells are important for the development of arthritis in a rheumatoid arthritis model (2011)
  • Author(s): Aoi Akitsu
  • Organizer: 1st Bio-Rheumatology International Congress Tokyo 8th GARN Meeting
  • Place of Presentation: Hilton Tokyo Bay Hotel, Tokyo
• [Presentation] The roles of Dectin-1/2 in the host defens against fungal infection (2011)
  • Author(s): Shinobu Saijo
  • Organizer: 9^<th> Joint Meeting of the ICS and ISICR
  • Place of Presentation: Florence, Italy
• [Presentation] IL-17F, rather than IL-17A promotes CD4^+ T cell activation and Th-1-type immunity (2011)
  • Author(s): Ce Tang
  • Organizer: 9^<th> Joint Meeting of the ICS and ISICR
  • Place of Presentation: Florence, Italy
• [Presentation] DCIR, a C-type lectin receptor, is a new negative regulator in osteoclas togenesis (2011)
  • Author(s): Tomonori Kaifu
  • Organizer: 9^<th> Joint Meeting of the ICS and ISICR
  • Place of Presentation: Florence, Italy
• [Presentation] DCIR deficient mice develop ankylosing spondylitis-like pathology in humans (2011)
  • Author(s): Takumi Maruhashi
  • Organizer: 9^<th> Joint Meeting of the ICS and ISICR
  • Place of Presentation: Florence, Italy
• [Presentation] IL-17-producing-gamma-delta T cells are important for the development of arthritis in a rheumatoid arthritis model (2011)
  • Author(s): Aoi Akitsu
  • Organizer: 9^<th> Joint Meeting of the ICS and ISICR
  • Place of Presentation: Florence, Italy
• [Presentation] DCIRリガンドの探索 (2011)
  • Author(s): 矢部力朗
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
• [Presentation] 疾患モデルマウスを用いた腸管ポリープ形成におけるIL-17AおよびIL-17Fの役割の解析 (2011)
  • Author(s): 角田茂
  • Organizer: 第58回日本実験動物学会総会
  • Place of Presentation: 東京
• [Presentation] IL-17-producing-gamma-delta T cells are important for the development of arthritis in a rheumatoid arthritis model (2011)
  • Author(s): Aoi Akitsu
  • Organizer: JSICR-MMCB2011
  • Place of Presentation: ANA Gate Tower Hotel Osaka, Osaka
• [Presentation] Roles of IL-17A and IL-17F in inflammation, infection, and tumorigenesis (2011)
  • Author(s): Yoichiro Iwakura
  • Organizer: JSICR-MMCB2011
  • Place of Presentation: ANA Gate Tower Hotel Osaka, Osaka(招待講演)
• [Presentation] インターロイキン-17の腸管ポリープ形成における役割の解析 (2010)
  • Author(s): 角田茂
  • Organizer: 第5回核酸・核タンパク機能性研究会学術集会
  • Place of Presentation: 北海道恵庭リサーチビジネスパーク
  • Year and Date: 2010-08-06
• [Presentation] 発生工学的アプローチによるIL-17ファミリーを中心としたサイトカインの機能解析 (2010)
  • Author(s): 角田茂
  • Organizer: 東海医学会講演会・例会
  • Place of Presentation: 伊勢原東海大学
  • Year and Date: 2010-07-13
• [Presentation] IL-17A and IL-17F are important for the development of intestinal polyps in APC^<MIN> mice by accelerating blood vessel formation. (2010)
  • Author(s): Shigeru Kakuta
  • Organizer: 8th Joint Conference of the ICS and ISICR, Cytokines 2010
  • Place of Presentation: Chicago, USA
• [Presentation] IL-17F promotes type 1 immunity by directly enhancing CD4+ T cell activation. (2010)
  • Author(s): Ce Tang
  • Organizer: 8th Joint Conference of the ICS and ISICR, Cytokines 2010
  • Place of Presentation: Chicago, USA
• [Presentation] The roles of C-type lectins in the host defense against fungal infection. (2010)
  • Author(s): Shinobu Saijo
  • Organizer: 8th Joint Conference of the ICS and ISICR, Cytokines 2010
  • Place of Presentation: Chicago, USA
• [Presentation] A novel arthritis-regulatory gene identified by using two mouse rheumatoid arthritis models. (2010)
  • Author(s): Masanori A.Murayama
  • Organizer: 8th Joint Conference of the ICS and ISICR, Cytokines 2010
  • Place of Presentation: Chicago, USA
• [Presentation] IL-17-producing γδ T cells are important for the development of arthritis in arheumatoid arthritis model. (2010)
  • Author(s): Aoi Akitsu
  • Organizer: 8th Joint Conference of the ICS and ISICR, Cytokines 2010
  • Place of Presentation: Chicago, USA
• [Presentation] CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis. (2010)
  • Author(s): Soo-hyuq Chung
  • Organizer: 8th Joint Conference of the ICS and ISICR, Cytokines 2010
  • Place of Presentation: Chicago, USA
• [Presentation] DCIR : A new therapeutic target for autoimmune disorders. (2010)
  • Author(s): Guangyu Ma
  • Organizer: 8th Joint Conference of the ICS and ISICR, Cytokines 2010
  • Place of Presentation: Chicago, USA
• [Presentation] Develqpment of TH 17-dependent athritis in IL-6-deficient IL-1 receptor antagonist-deficient mice. (2010)
  • Author(s): Satoshi Ikeda
  • Organizer: 8th Joint Conference of the ICS and ISICR, Cytokines 2010
  • Place of Presentation: Chicago, USA
• [Presentation] Oral administration of β-glucan stimulates mucosal immune system and improves immunological homeostasis oral tolerance. (2010)
  • Author(s): Huimin Yan
  • Organizer: 14^<th> interntional congress of immunology
  • Place of Presentation: Kobe神戸ポートピアホテル神戸国際展示場
• [Presentation] CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis. (2010)
  • Author(s): Soo-hyun Chung
  • Organizer: 14^<th> interntional congress of immunology
  • Place of Presentation: Kobe神戸ポートピアホテル神戸国際展示場
• [Presentation] Generation and analysis of oligoadenylate synthetase family genes-deficient mice. (2010)
  • Author(s): Shigeru Kakuta
  • Organizer: 14^<th> interntional congress of immunology
  • Place of Presentation: Kobe神戸ポートピアホテル神戸国際展示場
• [Presentation] IL-17-producing gamma-delta T cells is important for the development of arthritis in arheumatoid arthribs model. (2010)
  • Author(s): Aoi Akitsu
  • Organizer: 14^<th> interntional congress of immunology
  • Place of Presentation: Kobe神戸ポートピアホテル神戸国際展示場
• [Presentation] IL-17F promotes Th 1-type immunity by inducing IL-2 production. (2010)
  • Author(s): Ce Tang
  • Organizer: 14^<th> interntional congress of immunology
  • Place of Presentation: Kobe神戸ポートピアホテル神戸国際展示場
• [Presentation] Development of Tb17-dependent arthritis in IL-6-deficient IL-1 receptor antagonist-deficient mice. (2010)
  • Author(s): Satoshi Ikeda
  • Organizer: 14^<th> interntional congress of immunology
  • Place of Presentation: Kobe神戸ポートピアホテル神戸国際展示場
• [Presentation] The roles of C-type lectins in the host defense against fungal infecrion. (2010)
  • Author(s): Shinobu Saijo
  • Organizer: 14^<th> interntional congress of immunology
  • Place of Presentation: Kobe神戸ポートピアホテル神戸国際展示場
• [Presentation] The roles of Dcir in bone metabolic diseases (2010)
  • Author(s): Guangyu Ma
  • Organizer: 14^<th> interntional congress of immunology
  • Place of Presentation: Kobe神戸ポートピアホテル神戸国際展示場
• [Presentation] The role of IL-1 and 17 family genes in development of intestinal polyps. (2010)
  • Author(s): Shigeru Kakuta
  • Organizer: 第33回日本分子生物学会年会 第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 病原微生物による潜伏HIV-1再活性化の分子機構 (2010)
  • Author(s): 角木基彦
  • Organizer: 第33回日本分子生物学会年会 第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 腸管ポリープ形成におけるIL-17の役割の検討 (2010)
  • Author(s): 角田茂
  • Organizer: 第75回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 小倉北北九州国際会議場
• [Presentation] C型レクチンによるサイトカイン産生と生体防御機構 (2010)
  • Author(s): 西城忍
  • Organizer: 第75回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 小倉北北九州国際会議場
• [Presentation] IL-17産生性γδT細胞は自己免疫性関節炎モデルマウスにおける関節炎発症に重要である. (2010)
  • Author(s): 秋津葵
  • Organizer: 第75回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 小倉北北九州国際会議場
• [Presentation] IL-17産生性γδT細胞は自己免疫性関節炎モデルマウスにおける関節炎発症に重要である (2010)
  • Author(s): 秋津葵
  • Organizer: 第57回日本実験動物学会
  • Place of Presentation: 京都テレサ
• [Presentation] 東京大学医科学研究所システム疾患モデル研究センターにおける遺伝子改変マウスの供給について (2010)
  • Author(s): 角田茂
  • Organizer: 第57回日本実験動物学会
  • Place of Presentation: 京都号テレサ
• [Presentation] HIV感受性マウス作製に向けたヒトLEDGFトランスジェニックマウス(Tg)の作製 (2010)
  • Author(s): 多田卓哉
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島県郷土文化会館
• [Presentation] Adoptive and innate immunity related gene-deficient mice generated by IMSUT. (2009)
  • Author(s): Kakuta S
  • Organizer: Manitoba Centre for Disease Modeling Symposium
  • Place of Presentation: Winnipeg, Canada
  • Year and Date: 2009-10-19
• [Presentation] The roles of IL-17A and IL-17F in the immune system (2009)
  • Author(s): Yoichiro Iwakura
  • Organizer: Th17 Cells in Health and Disease, Keystone Symposium
  • Place of Presentation: British Columbia, Canada
• [Presentation] Generation and analysis of oligoadenylate synthetase family genes-deficient mice. (2009)
  • Author(s): Kakuta S
  • Organizer: 4th Asia Mutant Mouse Resource Association(AMMRA)meeting
  • Place of Presentation: Kumamoto
• [Presentation] The roles of C-type lectins in the host defense against fungal infection. (2009)
  • Author(s): Saijo S
  • Organizer: International Society for Interferon and Cytokine
  • Place of Presentation: Lisbon, Portugal
• [Presentation] The roles of C-type lectins in the host defense against fungal infection. (2009)
  • Author(s): Saijo S
  • Organizer: The 9^<th> AWAJI International Forum on Infection and Immunity
  • Place of Presentation: Awaji
• [Presentation] The role of Dcir in the inflammatory diseases. (2009)
  • Author(s): Fujikado N、
  • Organizer: World Congress of Immunology
  • Place of Presentation: Tokyo
• [Presentation] The role of DCIR in the development of autoimmune diseases. (2008)
  • Author(s): Noriyuki Fujikado
  • Organizer: Cytokines 2008
  • Place of Presentation: Montreal
  • Year and Date: 2008-10-12
• [Presentation] A C-type lectin that involved in the host defense against fungi plays an important role in the development of soutoimmune arthritis (2008)
  • Author(s): Shinobu Saijo
  • Organizer: 13th congress of the sdia pacigic league of associations for rheumatology
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-23
• [Presentation] Differential roles of IL-17A and IL-17F in allergic responses and host defense against mucoepithelial bacterial infection. (2008)
  • Author(s): Harumichi Ishigame
  • Organizer: The 8th Awaji Internatonal Forum on Infection and Immunity
  • Place of Presentation: Hyogo
  • Year and Date: 2008-09-07
• [Presentation] The role of DCIR in the development of autoimmune arthritis (2008)
  • Author(s): Yoichiro Iwakura
  • Organizer: The Australian Health and Medical Research Congress, Brisbane Convention Center
  • Place of Presentation: Brisbane, Australia
• [Book] 遺伝子改変動物.新しい薬学事典 (2012)
  • Author(s): 角田茂、岩倉洋一郎
  • Publisher: 朝倉書店(印刷中)
• [Book] 真菌免疫応答におけるC型レクチン受容体の役割 (2012)
  • Author(s): 角田茂、西城忍
  • Publisher: 化学療法の領域
• [Book] 免疫疾患.疾患モデルの作製と利用.シリーズ「モデル動物利用マニュアル」 (2011)
  • Author(s): 岩倉洋一郎
  • Total Pages: 580
  • Publisher: エル・アイ・シー
• [Book] リウマチ.論文ができてしまう!疾患モデルマウス表現型解析指南 (2011)
  • Author(s): 角田茂
  • Publisher: 中山書店
• [Book] IL-1. seriesモデル動物利用マニュアル 免疫疾患-疾患モデルの作製と利用 (2011)
  • Author(s): 角田茂、岩倉洋一郎
  • Publisher: エル・アイ・シー
• [Book] 遺伝子改変マウス."哺乳動物の分子生物学"を切り拓いた技術バイオテクノロジーの温故知新 (2011)
  • Author(s): 岩倉洋一郎
  • Publisher: 羊土社
• [Book] 発刊にあたって.免疫疾患-疾患モデルの作製と利用.シリーズモデル動物利用マニュアル (2011)
  • Author(s): 岩倉洋一郎
  • Total Pages: 580
  • Publisher: エル・アイ・シー
• [Book] IL-17.免疫疾患-疾患モデルの作製と利用.シリーズ モデル動物利用マニュアル (2011)
  • Author(s): 石亀晴道
  • Publisher: エル・アイ・シー
• [Book] アグリゲーション法によるキメラマウスの作製.改訂第5版新遺伝子工学ハンドブック (2010)
  • Author(s): 角田茂、佐藤希、久保幸子、岩倉洋一郎
  • Publisher: 羊土社
• [Book] アグリゲーション法によるキメラマウスの作製改訂第5版新 (2010)
  • Author(s): 角田茂
  • Publisher: 遺伝子工学ハンドブック
• [Book] コンディショナルターゲティング法改訂第5版新 (2010)
  • Author(s): 角田茂
  • Publisher: 遺伝子工学ハンドブック
• [Book] Dcirと自己免疫疾患最新医学 (2009)
  • Author(s): 藤門範行、岩倉洋一郎
• [Book] サイトカインシグナルと代謝疾患 (2008)
  • Author(s): 千田大、岩倉洋一郎
  • Publisher: ニュー・サイエンス社
• [Remarks]
  • URL: http://www.rs.tus.ac.jp/iwakuralab/
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/cem_dcb/index.html
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.ip/cem_dcb/index.html
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/cem_dcb/indes.html
• [Patent(Industrial Property Rights)] 樹状細胞免疫受容体刺激剤 (2011)
  • Inventor(s): 岩倉洋一郎、藤門範行、馬光宇
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2011-02-23
  • Overseas
• [Patent(Industrial Property Rights)] 腸疾患の治療方法および治療用医薬組成物 (2011)
  • Inventor(s): 岩倉洋一郎、角田茂、鈴木俊佐
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2011-02-02
  • Overseas
• [Patent(Industrial Property Rights)] 骨免疫疾患の予防・治療剤 (2010)
  • Inventor(s): 岩倉洋一郎、藤門範行、馬光宇
  • Industrial Property Rights Holder: 国立大学法人,東京大学, 他3名
  • Filing Date: 2010-02-23
• [Patent(Industrial Property Rights)] IL-17A/IL-17Fを介した大腸がん発症抑制 (2010)
  • Inventor(s): 岩倉洋一郎、角田茂、鈴木俊佐
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2010-02-03
  • Overseas
• [Patent(Industrial Property Rights)] 骨免疫疾患の予防・治療剤 (2010)
  • Inventor(s): 岩倉洋一郎、藤門範行、馬光宇
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2010-02-23
• [Patent(Industrial Property Rights)] IL-1タイプIIレセプター遺伝子の欠損変異体マウス (2009)
  • Inventor(s): 岩倉洋一郎、角田茂, 他4名
  • Industrial Property Rights Holder: 国立大学法人,東京大学, 他10名
  • Acquisition Date: 2009-08-20
• [Patent(Industrial Property Rights)] IL-17A/IL-17F制御による感染症治療・予防薬、Differentail Roles of Interleukin-17A and Interleukin-17F in Host defense against Mucoepithelial Bacterial Infection and Allegic Responses (2009)
  • Inventor(s): 岩倉洋一郎、角田茂、石亀晴道
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2009-12-28
  • Overseas