| Project/Area Number |
20225002
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic chemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
SOAI Kenso 東京理科大学, 理学部, 教授 (90147504)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Tsuneomi 福井大学, 工学(系)研究科(研究院), 准教授 (40385513)
SHIBATA Takanori 早稲田大学, 理工学術院, 教授 (80265735)
SHINDO Hitoshi 中央大学, 理工学部, 教授 (90245986)
MATSUMOTO Arimasa 東京理科大学, 理学部, 助教 (20633407)
|
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| Co-Investigator(Renkei-kenkyūsha) |
TSUKIYAMA Koichi 東京理科大学, 理学部, 教授 (20188519)
MIYAMURA Kazuo 東京理科大学, 理学部, 教授 (40157673)
SAITO Yukio 慶応大学, 理工学部, 教授 (20162240)
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| Project Period (FY) |
2008 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥206,960,000 (Direct Cost: ¥159,200,000、Indirect Cost: ¥47,760,000)
Fiscal Year 2012: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2011: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2010: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2009: ¥52,000,000 (Direct Cost: ¥40,000,000、Indirect Cost: ¥12,000,000)
Fiscal Year 2008: ¥66,560,000 (Direct Cost: ¥51,200,000、Indirect Cost: ¥15,360,000)
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| Keywords | 反応有機化学 / 不斉自己触媒 / 不斉の起源 / 不斉認識 / ホモキラリティー / 不斉触媒 / キラル結晶 / キラリティー / アデニン / 不斉自己触媒反応 / 不斉増幅 |
|---|
| Research Abstract |
Biologically related compounds such as L-amino acids are composed of one of the enantiomers. The phenomenon is called biological homochirality, and the origin of homochirality has attracted broad interest. Asymmetric autocatalysis, i.e., Soai reaction, is a reaction in which chiral product acts as a chiral catalyst for its own production. It was found that chiral isotopomers of carbon, hydrogen and oxygen, spontaneous absolute asymmetric synthesis, chiral crystals formed from achiral organic compounds such as nucleic acid base act as chiral initiators of asymmetric autocatalysis. Highly enantioenriched chiral compounds withthe corresponding absolute configurations with those of chiral initiators are obtained.
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| Assessment Rating |
Verification Result (Rating)
A
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