|Budget Amount *help
¥207,740,000 (Direct Cost: ¥159,800,000、Indirect Cost: ¥47,940,000)
Fiscal Year 2012: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2011: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2010: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2009: ¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2008: ¥69,420,000 (Direct Cost: ¥53,400,000、Indirect Cost: ¥16,020,000)
We have investigated the molecular mechanisms that underlie the diversity of cell responses and physiological functions, using the photoreceptive system of animals as a model system. Differences in molecular properties between rhodopsin and cone visual pigments are the molecular basis of the differences in photoresponse between rods and cones. We characterized differences in molecular properties by using genetically modified mice and extensive in vitro experiments. Additionally, we demonstrated unique properties of visual and non-visual opsins that have independently diversified, and identified the amino acid residues responsible for these properties.