| Budget Amount *help |
¥207,870,000 (Direct Cost: ¥159,900,000、Indirect Cost: ¥47,970,000)
Fiscal Year 2012: ¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2011: ¥53,040,000 (Direct Cost: ¥40,800,000、Indirect Cost: ¥12,240,000)
Fiscal Year 2010: ¥38,350,000 (Direct Cost: ¥29,500,000、Indirect Cost: ¥8,850,000)
Fiscal Year 2009: ¥36,140,000 (Direct Cost: ¥27,800,000、Indirect Cost: ¥8,340,000)
Fiscal Year 2008: ¥52,910,000 (Direct Cost: ¥40,700,000、Indirect Cost: ¥12,210,000)
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| Research Abstract |
Membrane transporters maintain the intracellular circumstances by strictly regulating the import and export of metal ions, sugars, metabolites and drugs etc. To elucidate (A) how the transporters drive their transport, (B) how the transporters exclusively select their specific substrates and (C) how the transporters regulate their transporting activities at at an atomic resolution, we performed (1) structure determination by X-ray crystallography, (2) dynamic property analysis by MD simulation and (3) in vivo and in vitro complementary experiments, focusing on ion transporters of magnesium, iron and heavy metals, light-gated cation channels, protein transporters, peptide transporter and multidrug transporters. Especially, we uncovered the essential molecular mechanism of membrane transport by comparing and integrating the functional mechanisms of transporters specific for various kinds of target solutes.
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