| Budget Amount *help |
¥152,490,000 (Direct Cost: ¥117,300,000、Indirect Cost: ¥35,190,000)
Fiscal Year 2012: ¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000)
Fiscal Year 2011: ¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000)
Fiscal Year 2010: ¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000)
Fiscal Year 2009: ¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000)
Fiscal Year 2008: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
|
|---|
| Research Abstract |
Gut is the largest and longest organ in the body. The average of the length of human gut is about 10 meter and the inner surface area of which is expanded to the order of 400 square-meters. It is constantly interfacing with many external factors including would-be pathogens, and creates artful barrier systems. On the other hand, liver is positioned downstream of the gut, and thus the liver adaptively responds to extra-intestinal and intestinal inflammation, which is termed as "Gut-Liver Axis". In this study, we focused on inflammatory reactions of mesenchymal cellsdistributed in Gut-Liver Axis. Findings obtained in this study are as follows; inflammatory actions of lipid mediators, interaction between autonomic nervous system and inflammation, changes in contractile systems in inflammation, circulatory dysfunction in liver disease, role of professional immune cells in gut inflammation, formation of gut-like structure from ES cells and role of PARs in gut inflammation.
|
