| Co-Investigator(Kenkyū-buntansha) |
UCHIDA Chiyoko 福島大学, 人間発達文化学類, 教授 (80312776)
YAMASHITA Mari 東北大学, 大学院農学研究科, 教授 (50192430)
HIROSE Keiko 独立行政法人産業技術総合研究所, セルエンジニアリング研究部門, 主任研究員 (90357872)
OKUDA Toru 玉川大学, 学術研究所, 教授 (40328026)
日高 將文 (日高 将文) 東北大学, (連合)農学研究科(研究院), 助教 (00584848)
二井 勇人 東北大学, (連合)農学研究科(研究院), 准教授 (90447459)
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| Budget Amount *help |
¥105,040,000 (Direct Cost: ¥80,800,000、Indirect Cost: ¥24,240,000)
Fiscal Year 2012: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2011: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2010: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2009: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2008: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
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| Research Abstract |
Based on the hypothesis that Alzheimer disease is caused by the defect of microtubule polymerization, we have studied the functions of the newly identified the microtubule- regulatory molecules, Pin1 and Gas7b (the proteins consisting of the similar sequence to the WW domain of Pin1). We suggested that Pin1 and Gas7b are useful to the diagnosis and treatment of the age-related diseases. We succeeded in establishing the high throughput screening technology for the low molecular inhibitors of Pin1 and identifying DTM, TME-1 and seaweed polyphenol (974B). We showed that Gas7b accelerates microtubule polymerization by binding phosphorylated tau, regulates neuronal cell morphology by regulating the bundling of microtubules and cross linking of microtubule and actin filament, and exists less level in the brains of patients with Alzheimer disease. (original papers; 41)
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