Mechanisms to form neural circuits of the spinal cord and cerebellum

• Project/Area Number: 20240029
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Chiba University
• Principal Investigator: SAITO Tetsuichiro 千葉大学, 大学院・医学研究院, 教授 (00202078)
• Co-Investigator(Kenkyū-buntansha): MUROYAMA Yuko 千葉大学, 大学院・医学研究院, 特任講師 (20422248) ; KAWAUCHI Daisuke 千葉大学, 大学院・医学研究院, 助教 (10400996)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000); Fiscal Year 2011: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000); Fiscal Year 2010: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000); Fiscal Year 2009: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
• Keywords: 分子 / 細胞神経科学 / 遺伝子 / 細胞・組織 / 神経科学 / 脳・神経 / 発生・分化 / 脊髄 / 小脳 / ホメオボックス

Research Abstract

The spinal cord and cerebellum are morphologically and functionally different. Our previous results, however, have suggested that commissural neurons in the spinal cord and granule cells in the cerebellum are generated by the same genes. This research project has revealed novel relationship between the genes in neuronal differentiation and neural circuit formation in the spinal cord and cerebellum.

Research Products

• [Journal Article] Nepro : A novel Notch effector for the maintenance of neural progenitor cells in the neocortex (2011)
  • Author(s): Tetsuichiro Saito
  • Journal Title: Adv. Exp. Med. Biol Volume: 727 Pages: 61-70
  • DOI: 10.1007/978-1-4614-0899-4_5
  • ISBN: 9781461408987, 9781461408994
• [Journal Article] Nepro : A novel notch effector for maintenance of neural progenitor cells in the neocortex (2011)
  • Author(s): Tetsuichiro Saito
  • Journal Title: Advances in Experimental Medicine and Biology Volume: 727 Pages: 61-69
• [Journal Article] Expression of major guidance receptors is differentially regulated in spin al commissural neurons transfated by mammalian Barh genes (2010)
  • Author(s): Daisuke Kawauchi, Yuko Muroyama, Tatsuya Sato and Tetsuichiro Saito
  • Journal Title: Dev. Biol Volume: 344 Issue: 2 Pages: 1026-1034
  • DOI: 10.1016/j.ydbio.2010.06.025
  • Peer Reviewed
• [Journal Article] Embryonic in vivo electroporation in the mouse. in "Guide to Techniques in Mouse Development, Part B" edited by Paul M (2010)
  • Author(s): Tetsuichiro Saito
  • Journal Title: Wasserman and Philip M. Soriano. Methods in Enzymology Volume: 477 Pages: 37-50
  • DOI: 10.1016/s0076-6879(10)77003-8
• [Journal Article] Expression of major guidance receptors is differentially regulated in spinal commissural neurons transfated by mammalian Barh genes (2010)
  • Author(s): Daisuke Kawauchi, Yoko Muroyama Tatsuya Sato, Tetsuichiro Saito
  • Journal Title: Dev.Biol. 344 Pages: 1026-1034
  • Peer Reviewed
• [Journal Article] Embryonic in vivo electroporation in the mouse. in "Guide to Techniques in Mouse Development, Part B" (2010)
  • Author(s): Tetsuichiro Saito
  • Journal Title: Methods in Enzymology(edited by Paul M.Wasserman and Philip M.Soriano.Academic Press.) 477 Pages: 37-50
• [Journal Article] Expression of major guidance receptors is differentially regulated in spinal commissural neurons transfated by mammalian Barh genes (2010)
  • Author(s): Daisuke Kawauchi
  • Journal Title: Developmental Biology Volume: 344 Pages: 1026-1034
  • Peer Reviewed
• [Journal Article] Embryonic in vivo electroporation in the mouse (2010)
  • Author(s): Tetsuichiro Saito
  • Journal Title: Methods in Enzymology Volume: 477 Pages: 37-50
• [Journal Article] Identification of Nepro, a gene required for the maintenance of neocortex neural progenitor cells downstream of Notch (2009)
  • Author(s): Yuko Muroyama Tetsuichiro Saito
  • Journal Title: Development Volume: 136 Issue: 23 Pages: 3889-3893
  • DOI: 10.1242/dev.039180
  • Peer Reviewed
• [Journal Article] Identification of Nepro, a gene required for the maintenance of neocortex neural progenitor cells downstream of Notch (2009)
  • Author(s): Yuko Muroyama, Tetsuichiro Saito
  • Journal Title: Development 136 Pages: 3889-3893
  • Peer Reviewed
• [Journal Article] Identification of Nepro, a gene required for the maintenance of neocortex neural progenitor cells downstream of Notch (2009)
  • Author(s): Yuko Muroyama
  • Journal Title: Development 136 Pages: 3889-3893
  • Peer Reviewed
• [Journal Article] Transcriptional cascade fromMath1 toMbh1and Mbh2is required for cerebellar granule cell differentiation (2008)
  • Author(s): Daisuke Kawauchi Tetsuichiro Saito
  • Journal Title: Dev. Biol Volume: 322 Issue: 2 Pages: 345-354
  • DOI: 10.1016/j.ydbio.2008.08.005
  • Peer Reviewed
• [Journal Article] Consequence of the loss of Sox2 in the developing brain of the mouse (2008)
  • Author(s): Satoru Miyagi, Shinji Masui, Hitoshi Niwa, Tetsuichiro Saito, Takuya Shimazaki, Hideyuki Okano, Masazumi Nishimoto, Masami Muramatsu, Atsushi Iwama Akihiko Okuda
  • Journal Title: FEBS Lett Volume: 582 Issue: 18 Pages: 2811-2815
  • DOI: 10.1016/j.febslet.2008.07.011
  • Peer Reviewed
• [Journal Article] Transcriptional cascade from Math1 to Mbhl and Mbh2 is required for cerebellar granule cell differentiation (2008)
  • Author(s): Daisuke Kawauchi, Tetsuichiro Saito
  • Journal Title: Dev.Biol. 322 Pages: 345-354
  • Peer Reviewed
• [Journal Article] Consequence of the loss of Sox2 in the developing brain of the mouse. (2008)
  • Author(s): Satoru Miyagi, Shinji Masui, Hitoshi Niwa, Tetsuichiro Saito, Takuya Shimazaki, Hideyuki Okano, Masazumi Nishimoto, Masami Muramatsu, Atsushi Iwama, Akihiko Okuda
  • Journal Title: FEBS Lett 582 Pages: 2811-2815
  • Peer Reviewed
• [Journal Article] Transcriptional cascade from Math1 to Mbh1 and Mbh2 is required for cerebellar granule cell differentiation. (2008)
  • Author(s): Daisuke Kawauchi
  • Journal Title: Developmental Biology 322 Pages: 345-354
  • Peer Reviewed
• [Journal Article] Consequence of the loss of Sox2 in the developing brain of the mouse. (2008)
  • Author(s): Satoru Miyagi
  • Journal Title: FEBS Letters 582 Pages: 2811-2815
  • Peer Reviewed
• [Presentation] Nepro is required for the maintenance of neural progenitor cells in the early neocortex (2012)
  • Author(s): Tetsuichiro Saito
  • Organizer: 1st International Symposium Neocortex Organization
  • Place of Presentation: 岡崎
  • Year and Date: 2012-03-12
• [Presentation] Nepro is required for the maintenance of neural stem cells in the early neocortex (2012)
  • Author(s): Tetsuichiro Saito
  • Organizer: 1st International Symposium "Neocortical Organization"
  • Place of Presentation: 愛知県岡崎カンファレンスセンター
  • Year and Date: 2012-03-12
• [Presentation] 大脳皮質神経前駆細胞の維持に必要な遺伝子Neproの機能解析 (2011)
  • Author(s): 佐藤達也, 室山優子, 斎藤哲一郎
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] 大脳皮質神経前駆細胞の維持に必要な遺伝子Neproの機能解析 (2011)
  • Author(s): Tatsuya Sato
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 神奈川県パシフィコ横浜
  • Year and Date: 2011-09-16
• [Presentation] Major guidance receptor genes are differentially regulated downstream of Barh genes in commissural neurons (2010)
  • Author(s): Tetsuichiro Saito
  • Organizer: Society for neuroscience 40th annual meeting
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2010-11-03
• [Presentation] Major guidance receptor genes are differentially regulated downstream of Barh genes (2010)
  • Author(s): Tetsuichiro Saito
  • Organizer: in commissural neurons
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2010-11-03
• [Presentation] Major guidance receptor genes are differentially regulated downstream of Barh genes in commissural neurons (2010)
  • Author(s): Tetsuichiro Saito
  • Organizer: Society for neuroscience 40th annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-03
• [Presentation] 神経回路の構築を制御する遺伝子カスケード (2010)
  • Author(s): 斎藤哲一郎
  • Organizer: 第1回発生システムシンポジウム「細胞と個体をつなぐメカニズム」
  • Place of Presentation: 千葉
  • Year and Date: 2010-02-15
• [Presentation] 神経ネットワークを構築する機構 (2010)
  • Author(s): 斎藤哲一郎
  • Organizer: 第3回ちばBasic & Clinical Research Conference
  • Place of Presentation: 千葉
  • Year and Date: 2010-02-06
• [Presentation] 大脳皮質神経前駆細胞の維持におけるNotch下流因子Neproの機能 (2009)
  • Author(s): 室山優子, 斎藤哲一郎
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] マウス脊髄における部域特異的な細胞分化制御 (2009)
  • Author(s): 室山優子
  • Organizer: 第5回Chiba Neuroresearch Meeting
  • Place of Presentation: 千葉
  • Year and Date: 2009-05-30
• [Presentation] 小脳ニューロンの個性決定に関わる転写因子間の相互抑制 (2008)
  • Author(s): 川内大輔, 斎藤哲一郎
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] 小脳ニューロンの個性決定に関わる転写因子間の相互抑制 (2008)
  • Author(s): 川内大輔
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Book] Notch signaling in embryology and cancer(Nepro : A novel Notch effector for maintenanance of neural progenitor cells in the neocortex)(edited by jorg Reichrath and Sandra Reichrath) (2010)
  • Author(s): Tetsuichiro Saito
  • Publisher: Landes Bioscience.
• [Book] Notch signaling in embryology and cancer (2010)
  • Author(s): Tetsuichiro Saito
  • Total Pages: 10
  • Publisher: Landes Bioscience
• [Book] Encyclopedia of Neuroscience edited by Marc D. Binder, Nobutaka Hirokawa and Uwe Windhorst (2009)
  • Author(s): Tetsuichiro Saito
  • Publisher: Transcriptional factor
• [Book] Encyclopedia of Neuroscience(Transcriptional factor)(edited by Marc D.Binder, Nobutaka Hirokawa and Uwe Windhorst) (2009)
  • Author(s): Tetsuichiro Saito
  • Publisher: Springer
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