| Co-Investigator(Renkei-kenkyūsha) |
WATAKABE Akiya 基礎生物学研究所, 脳生物学研究部門, 准教授 (40290910)
KOMINE Yuriko 基礎生物学研究所, 脳生物学研究部門, 助教 (90280586)
SADAKANE Osamu 基礎生物学研究所, 脳生物学研究部門, 助教 (90446261)
KOMATSU Yusuke 生理学研究所, 多次元共同脳科学推進センター・脳科学新領域開拓研究室, 特任助教 (80450203)
HIROKAWA Junya 基礎生物学研究所, 脳生物学研究部門, 特別協力研究員 (40546470)
|
|---|
| Budget Amount *help |
¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000)
Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2009: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2008: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
|
|---|
| Research Abstract |
First, we aimed to analyze the function of the genes selectively expressed in the primate neocortical areas in comparison with that in rodents. We examined the expression of c-Fos when rats were subjected to an audio-visual multisensory task. We found that specific enhancement of c-Fos expression in V2L (the lateral secondary visual area) upon being exposed to the task. Using previously developed cortical box method, we analyzed three layer specific genes (RORb, ER81, Nurr1) in the rat neocortex. Each of three genes showed a mutually exclusive and complimentary expression pattern, which demonstrated that the areas in rodents were able to be automatically or objectively described although the area selective expression was not as prominent as that in primates. We reported SLIT1 as a gene that was selectively expressed in the association areas of the macaque neocortex. Finally, we have established the gene manipulation system in the primate neocortex
|
