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Elucidation of the genetic factors in rat epileptic seizures

Research Project

Project/Area Number 20240042
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionKyoto University

Principal Investigator

SERIKAWA Tadao  京都大学, 医学研究科, 教授 (30025655)

Co-Investigator(Kenkyū-buntansha) KURAMOTO Takashi  京都大学, 医学研究科, 准教授 (20311409)
MASHIMO Tomoji  京都大学, 医学研究科, 特定准教授 (80397554)
OHNO Yukihiro  大阪薬科大学, 薬学部, 教授 (00432534)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥36,010,000 (Direct Cost: ¥27,700,000、Indirect Cost: ¥8,310,000)
Fiscal Year 2011: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2010: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2009: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Keywordsてんかん / ラット / 疾患モデル / 原因遺伝子 / NER / コンジェニック系統 / 遺伝解析 / BACクローン
Research Abstract

Using an epilepsy rat model NER and a non-epileptic rat strain F344, we generated several congenic lines for two seizure-related QTLs. Comprehensive gene expression analyses in the brains of NER and a seizure-resistant NER. F344 double congenic strain revealed that one unknown gene and other six known genes were differentially expressed. Thus, we succeeded to disclose possible candidates for genetic factors contributing to seizure susceptibility.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (91 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (34 results) (of which Peer Reviewed: 30 results) Presentation (45 results) Book (8 results) Remarks (4 results)

  • [Journal Article] Kindling-associated SV2A expression in hilar GABAergic interneurons of the mouse dentate gyrus2012

    • Author(s)
      Y.Ohno, et al
    • Journal Title

      Neurosci.Lett

      Volume: 510 Issue: 2 Pages: 93-98

    • DOI

      10.1016/j.neulet.2012.01.009

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The rapy for hyper ther mia-induced seizures in Scn1a mutant rats2011

    • Author(s)
      Hayashi K, Ueshima S, Ouchida M, Mashimo T, Nishiki T, Sendo T, Serikawa T, Matsui H, Ohmori I
    • Journal Title

      Epilepsia

      Volume: 52(5) Issue: 5 Pages: 1010-1017

    • DOI

      10.1111/j.1528-1167.2011.03046.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kcnal-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures2011

    • Author(s)
      Ishida S, et al
    • Journal Title

      Brain Research

      Volume: 1435 Pages: 154-166

    • DOI

      10.1016/j.brainres.2011.11.023

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective effect of levetiracetam on hippocampal sclerosis-like change in spontaneously epileptic rats2011

    • Author(s)
      Sugata S, et al
    • Journal Title

      Brain Research Bull

      Volume: 86(1-2) Issue: 1-2 Pages: 36-41

    • DOI

      10.1016/j.brainresbull.2011.05.017

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scnla missense mutation causes limbic hyperexcitability and vulnerability to experimental febrile seizures2011

    • Author(s)
      Y.Ohno, et al
    • Journal Title

      Neurobiol.Dis

      Volume: 41 Issue: 2 Pages: 261-269

    • DOI

      10.1016/j.nbd.2010.09.013

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scn1a missense mutation causes limbic hype rexcitability and vulne rability to expe rimental febrile seizures2010

    • Author(s)
      Ohno Y, Ishihara S, Mashimo T, Sofue N, Shimizu S, Imaoku T, Tsurumi T, Sasa M, Serikawa T
    • Journal Title

      Neurobiol Dis

      Volume: 41(2) Pages: 261-269

    • URL

      http://dx.doi.org/10.1016/j.nbd.2010.09.013

    • Related Report
      2011 Final Research Report
  • [Journal Article] Scn1a missense mutation impairs GABAA receptor-mediated synaptic transmission in the rat hippocampus2010

    • Author(s)
      Ohno Y, Sofue N, Ishihara S, Mashimo T, Sasa M, Serikawa T
    • Journal Title

      Biophys Res Commun

      Volume: 400(1) Pages: 117-122

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2010.08.021

    • Related Report
      2011 Final Research Report
  • [Journal Article] A missense mutation of the gene encoding voltage-dependent sodium channel(Nav1. 1) confers susce ptibility to febrile seizures in rats2010

    • Author(s)
      Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, Serikawa T
    • Journal Title

      J Neurosci

      Volume: 30(16) Issue: 16 Pages: 5744-5753

    • DOI

      10.1523/jneurosci.3360-09.2010

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of levetiracetam on hippocampal kindling in Noda epileptic rats2010

    • Author(s)
      Ishimaru Y, Chiba S, Serikawa T, Sasa M, Inaba H, Tamura Y, Ishimoto T, Takasaki H, Sakamoto K, Yamaguchi K
    • Journal Title

      Brain Res

      Volume: 1309 Pages: 104-109

    • URL

      http://dx.doi.org/10.1016/j.brainres.2009.10.056

    • Related Report
      2011 Final Research Report
  • [Journal Article] A missense mutation of the geneencoding voltage-dependent sodiumchannel (Nav1.1) confers susceptibility tofebrile seizures in rats.2010

    • Author(s)
      Mashimo T, Ohmori I, Ouchida M,Ohno Y, Tsurumi T, Miki T, Wakamori M,Ishihara S, Yoshida T, Takizawa A, Kato M,Hirabayashi M, Sasa M, Mori Y, SerikawaT.
    • Journal Title

      J Neurosci 30

      Pages: 5744-5753

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Antiepileptogenic andanticonvulsive actions of levetiracetam in apentylenetetrazole kindling model.2010

    • Author(s)
      Ohno Y, Ishihara S, Terada R, SerikawaT, Sasa M.
    • Journal Title

      Epilepsy Res 89

      Pages: 360-364

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Effects of levetiracetam on hippocampalkindling in Noda epileptic rats.2010

    • Author(s)
      Ishimaru Y, Chiba S, Serikawa T, SasaM, Inaba H, Tamura Y, Ishimoto T,Takasaki H, Sakamoto K, Yamaguchi K.
    • Journal Title

      Brain Res 1309

      Pages: 104-109

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Effects of levetiracetam on hippocampal kindling in Noda epileptic rats2010

    • Author(s)
      Ishimaru Y, et al.
    • Journal Title

      Brain Research

      Volume: 1309 Pages: 104-109

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiepileptogenic and anticonvulsive actions of levetiracetam in a pentylenetetrazole kindling model.2010

    • Author(s)
      Ohno Y, et al.
    • Journal Title

      Epilepsy Research

      Volume: 89 Pages: 360-364

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hippocampal cell loss and propagation of abnormal discharges accompanied with the expression of tonic convulsion in the spontaneously epileptic rat.2010

    • Author(s)
      Hanaya R, et al.
    • Journal Title

      Brain Research

      Volume: 1328 Pages: 171-180

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scnla missense mutation impairs GABA_A receptor-mediated synaptic transmission in the rat hippocampus2010

    • Author(s)
      Ohno Y, et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 400 Pages: 117-122

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scnla missense mutation causes limbic hyperexcitability and vulnerability to experimental febrile seizures.2010

    • Author(s)
      Ohno Y, et al.
    • Journal Title

      Neurobiol Dis

      Volume: 41 Pages: 261-269

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of levetiracetam on absence seizures in a novel absence-like epilepsy animal model, Groggy rat.2010

    • Author(s)
      Tokuda S, et al.
    • Journal Title

      Brain Research

      Volume: 1359 Pages: 298-303

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serotonergic Modulation of Absence-Like Seizures in Groggy Rats : a Novel Rat Model of Absence Epilepsy.2010

    • Author(s)
      Ohno Y, et al.
    • Journal Title

      J Pharmacol Sci

      Volume: 114 Pages: 99-105

    • NAID

      10029889960

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Re gional expression of Fos-like immuno reactivity following seizures in Noda epileptic rat(NER)2009

    • Author(s)
      Ohno Y, Shimizu S, Harada Y, Morishita M, Ishihara S, Kumafuji K, Sasa M, Serikawa T
    • Journal Title

      Epilepsy Res

      Volume: 87(1) Pages: 70-76

    • URL

      http://dx.doi.org/10.1016/j.eplepsyres.2009.07.012

    • Related Report
      2011 Final Research Report
  • [Journal Article] Preferential increase in the hippocampalsynaptic vesicle protein 2A (SV2A) bypentylenetetrazole kindling.2009

    • Author(s)
      Ohno Y, Ishihara S, Terada R, KikutaM, Sofue N, Kawai Y, Serikawa T, Sasa M.
    • Journal Title

      BiochemBiophys Res Commun 390

      Pages: 415-420

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Regional expression ofFos-like immunoreactivity followingseizures in Noda epileptic rat (NER).2009

    • Author(s)
      Ohno Y, Shimizu S, Harada Y,Morishita M, Ishihara S, Kumafuji K, SasaM, Serikawa T.
    • Journal Title

      Epilepsy Res. 87

      Pages: 70-76

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Regional expression of Fos-like immunoreactivity following seizures in Noda epileptic rat (NER)2009

    • Author(s)
      Y.Ohno, et al.
    • Journal Title

      Epilepsy Research 87

      Pages: 70-76

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An informative set of SSLP Markers and genomic profiles in the rat MHC, the RT1 complex.2009

    • Author(s)
      Takagi Y, et al.
    • Journal Title

      Immunogenetics. 2009 61(3)

      Pages: 189-197

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rat resources in biomedical research.2009

    • Author(s)
      Mashimo T, Serikawa T.
    • Journal Title

      Curr Pharm Biotechnol. 10(2)

      Pages: 214-220

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myelin Lipid Abnormalities in the Aspartoacylase-Deficient Tremor Rat.2009

    • Author(s)
      Wang J, et al.
    • Journal Title

      Neurochem Res. 34(1)

      Pages: 138-148

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the Kyoto circling (KCI) rat carrying a spontaneous nonsense mutation in the protocadherin 15 (Pcdh15)gene.2009

    • Author(s)
      Naoi K, et al.
    • Journal Title

      Exp. Anim. 58(1)

      Pages: 1-10

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of LEXF/FXLE rat recombinant inbred strains for the genetic dissection of complex traits.2008

    • Author(s)
      Voigt B, et al.
    • Journal Title

      Physiol Genomics 32(3)

      Pages: 335-342

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional polymorphisms in inbred rat strains and their allele frequencies in commercially available outbred stocks.2008

    • Author(s)
      Kuramoto T, et al.
    • Journal Title

      Physiol Genomics 33

      Pages: 205-211

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pancreatic metaplasia in the gastro-achlorhydria in WTC-dfk rat, a potassium channel Kcnql mutant.2008

    • Author(s)
      Kuwamura M, et al.
    • Journal Title

      Vet Pathol. 45(4)

      Pages: 586-591

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-Acetyl-1 aspartate activates hippocampal CA3 neurons in rodent slice preparations.2008

    • Author(s)
      Hanaya R, et al.
    • Journal Title

      Brain Res Bull. 75(5)

      Pages: 663-667

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SNP and haplotype mapping for genetic analysis in the rat.2008

    • Author(s)
      The STAR Consortium
    • Journal Title

      Nat Genet. 40(5)

      Pages: 560-566

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Progress and prospects in rat genetics : a community view.2008

    • Author(s)
      Aitman TJ, et al.
    • Journal Title

      Nat Genet. 40 (5)

      Pages: 516-522

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An ENU-induced mutant archive for gene targeting in rats.2008

    • Author(s)
      Mashimo T, et al.
    • Journal Title

      Nat Genet. 40(5)

      Pages: 514-515

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Pathophysiological alterations of synaptic vesicle protein 2A (SV2A)in Groggy rat, a rat model of absence seizure2012

    • Author(s)
      Takahiro Okumura, ら
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 欠神発作モデルGroggyラットにおけるSV2AおよびSNARE関連タンパクの発現解析2011

    • Author(s)
      奥村貴裕, ら
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2011
    • Place of Presentation
      北里大学薬学部(東京)
    • Year and Date
      2011-08-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] 全般性強直-間代発作モデルNoda epileptic ratにおけるアストロサイトKir4. 1チャンネルの病態解析2011

    • Author(s)
      長尾侑紀、原田悠耶、奥田葵、藤本恵、芹川忠夫、笹征史、大野行弘
    • Organizer
      第7回日本てんかん学会近畿地方会
    • Place of Presentation
      京都
    • Year and Date
      2011-07-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 全般性強直-間代発作モデルNoda epileptic ratにおけるアストロサイトKir4.1チャンネルの病態解析2011

    • Author(s)
      長尾侑紀, ら
    • Organizer
      第7回日本てんかん学会近畿地方会
    • Place of Presentation
      京都大学芝蘭会館(京都)
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lgi1変異ラットの開発:常染色体優性外側側頭葉てんかん(ADLTE)のモデル動物として2011

    • Author(s)
      石田紗恵子, ら
    • Organizer
      第7回日本てんかん学会近畿地方会
    • Place of Presentation
      京都大学芝蘭会館(京都)
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] てんかんモデルNoda epileptic rat(NER)におけるアストロサイト内向き整流性カリウムチャネルKir4. 1の発現解析2011

    • Author(s)
      長尾侑紀、原田悠耶、奥田葵、藤本恵、芹川忠夫、笹征史、大野行弘
    • Organizer
      第119回日本薬理学会近畿部会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-07-08
    • Related Report
      2011 Final Research Report
  • [Presentation] てんかんモデルNoda epileptic rat (NER)におけるアストロサイト内向き整流性カリウムKir4.1の発現解析2011

    • Author(s)
      長尾侑紀, ら
    • Organizer
      第119回日本薬理学会近畿部会
    • Place of Presentation
      ういんく愛知(名古屋)
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 強直-間代性発作モデルNoda epileptic rat(NER)におけるSV2AおよびSNARE関連タンパクの発現解析2011

    • Author(s)
      奥村貴裕、寺田亮、石原靜、北宅良祐、冨田知里、徳留健太郎、田中智也、笹征史、芹川忠夫、大野行弘
    • Organizer
      第21回臨床精神薬理学会・第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Noda epileptic rat(NER)における扁桃核アストロサイトKir4. 1チャネルの発現低下2011

    • Author(s)
      長尾侑紀、原田悠耶、奥田葵、藤本恵、向井崇浩、小野朝香、阪上嘉久、芹川忠夫、笹征史、大野行弘
    • Organizer
      第21回臨床精神薬理学会・第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 強直-間代性発作モデルNoda epileptic rat (NER)におけるSV2AおよびSNARE関連タンパクの発現解析2011

    • Author(s)
      奥村貴裕, ら
    • Organizer
      第21回臨床精神薬理学会・第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Noda epileptic rat (NER)における扁桃核アストロサイトKir4.1チャネルの発現低下2011

    • Author(s)
      長尾侑紀, ら
    • Organizer
      第21回臨床精神薬理学会・第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mutant rat resources at National BioResource Project-Rat in Japan2010

    • Author(s)
      Serikawa T
    • Organizer
      The 4^<th> AFLAS congress meeting
    • Place of Presentation
      Taipei
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immunohisto chemical studies in Noda epileptic rat(NER): Exploring the seizure foci by brain mapping of c-Fos protein expression2010

    • Author(s)
      Harada Y, Shimizu S, Ishihara S, Kumafuji K, Serikawa T, Sasa M, Ohno Y
    • Organizer
      The XVIIIth International Workshop on Genetic Systems in the Rat
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] Pharma cological analysis of the hyper the rmia-induced seizure-susceptible(Hiss) rats, a novel rat model of febrile seizure2010

    • Author(s)
      Ohno Y, Ishihara S, Sofue N, Mashimo T, Sasa M, Serikawa T
    • Organizer
      The XVIIIth International Workshop on Genetic Systems in the Rat
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] 自発性てんかんモデルNER(Noda epileptic rat)における脳内Fos発現解析2010

    • Author(s)
      原田悠耶、清水佐紀、石原靜、芹川忠夫、熊藤健太、笹征史、大野行弘
    • Organizer
      第57回日本実験動物学会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 自発性てんかんモデルNER (Noda epileptic rat)における脳内Fos 発現解析2010

    • Author(s)
      原田悠耶、清水佐紀、石原靜、芹川忠夫、熊藤健太、笹 征史、大野行弘
    • Organizer
      第57回日本実験動物学会
    • Place of Presentation
      京都市
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Na_<v1.1>チャネルにミスセンス変異を有するHissラットにおける海馬GABAニューロンの機能異常2010

    • Author(s)
      大野行弘, ら
    • Organizer
      第20回日本臨床精神神経薬理学会第40回日本神経精神薬理学会 合同年会
    • Place of Presentation
      仙台
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immunohistochemical studies in Noda epileptic rat (NER) : Exploring the seizure foci by brain mapping of c-Fos protein expression2010

    • Author(s)
      Harada Y, et al
    • Organizer
      The XVIIIth International Workshop on Genetic System in the Rat
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pharmacological analysis of the hyperthermia-induced-seizure-susceptible (Hiss) rats, a novel rat model of febrile seizure.2010

    • Author(s)
      Ohno Y, et al
    • Organizer
      The XVIIIth International Workshop on Genetic System in the Rat
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Annual Research Report
  • [Presentation] 熱刺激誘発けいれん感受性ラットの開発:新たな熱性けいれんモデルとして2009

    • Author(s)
      真下知士、大守伊織、大内田守、大野行弘、鶴見東志子、三木崇史、若森実、森泰生、芹川忠夫
    • Organizer
      Neuro2009(第32回日本神経科学大会)
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 熱刺激誘発けいれん感受性ラットの開発:新たな熱性けいれんモデルとして2009

    • Author(s)
      真下知士、大守伊織、大内田守、大野行弘、鶴見東志子、三木崇史、若森実、森泰生、芹川忠夫
    • Organizer
      Neuro2009(第32 回日本神経科学大会)
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] チャネル病のモデル動物:電位依存性Na+チャネルNav1. 1変異ラット2009

    • Author(s)
      真下知士、芹川忠夫
    • Organizer
      第295回CBI学会研究講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 新たな熱性けいれんモデルScnla変異ラットの行動解析2009

    • Author(s)
      石原静, ら
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pharmacological evaluation of hyperthemia-induced seizure in Senla mutant rats.2009

    • Author(s)
      石原静, ら
    • Organizer
      第82回日本薬理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Noda Epileptic Rat(NER)における発作時脳内Fos発現の解析2009

    • Author(s)
      原田悠耶、清水佐紀、森下真帆、石原靜、熊藤健太、芹川忠夫、笹征史、大野行弘
    • Organizer
      第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会・第1回アジアCINP会議合同年会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] てんかん感受性遺伝子を同定するためのNERコンジェニック系の作製2009

    • Author(s)
      中西聡、熊藤健太、山崎賢一、Birger Voigt、庫本高志、芹川忠夫
    • Organizer
      第56回日本実験動物学会
    • Place of Presentation
      さいたま
    • Related Report
      2011 Final Research Report
  • [Presentation] てんかん感受性遺伝子を同定するためのNER コンジェニック系の作製2009

    • Author(s)
      中西 聡、熊藤健太、山崎賢一、BirgerVoigt、庫本高志、芹川忠夫
    • Organizer
      第56回日本実験動物学会
    • Place of Presentation
      さいたま市
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Seizure-evoked brain Fos expression in Noda epileptic rat (NER)2009

    • Author(s)
      原田悠耶, ら
    • Organizer
      第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会・第1回アジア神経精神薬理学会 合同学会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rat models for human epilepsy at NBRP-Rat2009

    • Author(s)
      T.Serikawa, et al.
    • Organizer
      Rat Genomics & Models
    • Place of Presentation
      CSHL, New York, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新たな疾患モデルScnla変異ラットの熱性けいれん感受性の評価2008

    • Author(s)
      石原静, ら
    • Organizer
      第4回日本てんかん学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] ENUミュータジェネシスを利用した標的遺伝子変異ラットの作製2008

    • Author(s)
      真下知士, ら
    • Organizer
      第44回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      島根
    • Year and Date
      2008-11-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 電位依存性Na+チャネルScnla変異ラットのけいれん感受性評価2008

    • Author(s)
      石原静, ら
    • Organizer
      第114回日本薬理学会近畿部会
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] KURMA : an ENU-induced mutant archive for gene-targeting in rats.2008

    • Author(s)
      真下知士, ら
    • Organizer
      The 22nd International Mammalian Genome Conference.
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2008-11-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 電位依存性Na+チャネルScnla変異ラットのけいれん発現感受性評価 : (1)行動薬理学的および脳波学的検討2008

    • Author(s)
      大野行弘, ら
    • Organizer
      第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 電位依存性Na+チャネルScnla変異ラットのけいれん感受既評価 : (2)Fos発現を指標とした神経化学的検討2008

    • Author(s)
      石原静, ら
    • Organizer
      第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gene-targeted rat models of human diseases developed by ENU mutagenesis.2008

    • Author(s)
      真下知士, ら
    • Organizer
      The 3rd AFLAS Congress & the 8th CALAS Annual Meeting.
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-09-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Latest activities of the National Bio Resource Project for the Rat in Japan.2008

    • Author(s)
      芹川忠夫
    • Organizer
      The 3rd AFLAS Congress & the 8th CALAS Annual Meeting.
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-09-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] ナショナルバイオリソースプロジェクト「ラツト」(NBRP-Rat)の紹介2008

    • Author(s)
      芹川忠夫
    • Organizer
      日本動物学会第79回大会
    • Place of Presentation
      福岡
    • Year and Date
      2008-09-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] ユビキチンE3リガーゼのミスセンス変異により小脳性運動失調をおこすマウス2008

    • Author(s)
      真下知士, ら
    • Organizer
      Neuro2008 (第31回神経科学大会)
    • Place of Presentation
      東京
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetic dissection of the LEXF/FXLE recombinant inbred strains.2008

    • Author(s)
      庫本 高志 ら
    • Organizer
      13th International SHR symposium.
    • Place of Presentation
      Prague, Czech Republic.
    • Year and Date
      2008-06-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット機能多型のジェノタイピング2008

    • Author(s)
      中西聡, ら
    • Organizer
      第55回日本実験動物学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 日本産野生由来DOBラットの遺伝的特徴2008

    • Author(s)
      岡島涼子, ら
    • Organizer
      第55回日本実験動物学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラットLEXF/FXLEリコンビナント近交系を用いたQTL解析2008

    • Author(s)
      庫本高志, ら
    • Organizer
      第55回日本実験動物学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] TBLマウスの小脳性運動失調はユビキチンE3リガーゼのミスセンス変異に起因する2008

    • Author(s)
      真下知士, ら
    • Organizer
      第55回日本実験動物学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 日本における疾患モデルラット研究の流れ2008

    • Author(s)
      芹川忠夫
    • Organizer
      第55回日本実験動物学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Book] てんかんラット研究の推進p439-p4402012

    • Author(s)
      芹川忠夫
    • Total Pages
      600
    • Publisher
      てんかん研究第29巻第3号(巻頭言)
    • Related Report
      2011 Annual Research Report
  • [Book] 生物機能モデルと新しいリソース・リサーチツール、〈seriesモデル動物利用マニュアル〉2011

    • Author(s)
      小畑裕一、城石俊彦、芹川忠小畑裕一、城石俊彦、芹川忠夫、田中啓二、米川博通(編集)
    • Publisher
      (株)エル・アイ・シー
    • Related Report
      2011 Final Research Report
  • [Book] 疾患モデルの作製と利用-脳・神経疾患〈seriesモデル動物利用マニュアル〉2011

    • Author(s)
      小畑裕一、城石俊彦、芹川忠夫、田中啓二、米川博通(編集)
    • Publisher
      株式会社エル・アイ・シー
    • Related Report
      2011 Final Research Report
  • [Book] 論文ができてしまう!疾患モデルマウス表現型解析指南,脳・神経系(中枢系)てんかん2011

    • Author(s)
      芹川忠夫
    • Publisher
      株式会社中山書店
    • Related Report
      2011 Final Research Report
  • [Book] 疾患モデルの作製と利用-脳・神経疾患<seriesモデル動物利用マニュアル>2011

    • Author(s)
      芹川忠夫
    • Total Pages
      307
    • Publisher
      株式会社エル・アイ・シー
    • Related Report
      2011 Annual Research Report
  • [Book] 論文ができてしまう!疾患モデルマウス表現型解析指南脳・神経系(中枢系)てんかん2011

    • Author(s)
      芹川忠夫
    • Total Pages
      477
    • Publisher
      株式会社中山書店
    • Related Report
      2011 Annual Research Report
  • [Book] 生物機能モデルと新しいリソース・リサーチツール2011

    • Author(s)
      小畑裕一、城石俊彦、芹川忠夫、田中啓二、米川博通(編集)
    • Publisher
      (株)エル・アイ・シー
    • Related Report
      2010 Self-evaluation Report
  • [Book] 生物機能モデルと新しいリソース・リサーチツール2011

    • Author(s)
      編集委員:小幡裕一、城石俊彦、芹川忠夫、田中啓二、米川博通
    • Total Pages
      671
    • Publisher
      株式会社 エル・アイ・シー
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.anim.med.kyoto-u.ac.jp/serikawas%20Lab/03_Publications.htm

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.anim.med.kyoto-u.ac.jp/serikawas%20Lab/03_Publications.htm

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.anim.med.kyoto-u.ac.jp/serikawas%20Lab/03_Publications.htm

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.anim.med.kyoto-u.ac.ip/research.htm

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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