• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of high performance artificial bone

Research Project

Project/Area Number 20240043
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionThe University of Tokyo

Principal Investigator

TEI Yuichi  東京大学, 大学院・工学系研究科, 教授 (30345053)

Co-Investigator(Kenkyū-buntansha) SAKAI Takamasa  東京大学, 大学院・工学系研究科, 教授 (70456151)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2011: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2010: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2009: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2008: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Keywords人工臓器学 / 再生医工学 / 生体材料 / トランスレーショナル・リサーチ / 再生医学 / 生理活性
Research Abstract

Artificial bones are inferior to autograft and allograft bone in performance, leaving clinicians dissatisfied. We integrated the method to control 3D shape of artificial bones made of calcium phosphate powder materials, which have high biocompatibility, biosafety and biodegradability, and the method to endow biomaterials with bioactivity, which controls the function of surrounding cells, and created two types of novel artificial bones : custom-made artificial bone and tetrapod-shaped artificial bones.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (123 results)

All 2011 2010 2009 2008 Other

All Journal Article (80 results) (of which Peer Reviewed: 80 results) Presentation (22 results) Book (5 results) Remarks (6 results) Patent(Industrial Property Rights) (10 results) (of which Overseas: 4 results)

  • [Journal Article] Effect of trehalose coating on basic fibroblast growth factor release from tailor-made artificial bone implant2011

    • Author(s)
      Choi S, Lee J, Igawa K, Suzuki S, Mochizuki M, Nishimura R, Chung U, Sasaki N.
    • Journal Title

      J Vet Med Sci

      Volume: 73 Pages: 1547-1552

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Examination of the theories of rubber elasticity using an ideal polymer network2011

    • Author(s)
      Akagi Y, Katashima T, Katsumoto Y, Fujii K, Matsunaga T, Chung U, Shibayama M, Sakai T.
    • Journal Title

      Macromolecules

      Volume: 44 Pages: 5817-5821

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Harmine promotes osteoblast differentiation through bone morphogenetic protein signaling2011

    • Author(s)
      Yonezawa T, Lee J, Hibino A, Asai M, Hojo H, Ha B, Teruya T, Nagai K, ChungU, Yagasaki K, Woo J.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 409 Pages: 260-265

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Precise control and prediction of hydrogel degradation behavior2011

    • Author(s)
      Li X, Tsutsui Y, Matsunaga T, Shibayama M, Chung U, Sakai T.
    • Journal Title

      Macromolecules

      Volume: 44 Pages: 3567-3571

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] SANS Studies on Tetra-PEG Gel under Uniaxial Deformation2011

    • Author(s)
      Matsunaga T, Asai H, Akagi Y, Sakai T, Chung U, Shibayama M.
    • Journal Title

      Macromolecules

      Volume: 44 Pages: 1203-1210

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel method for designing and fabricating custom-made artificial bones2011

    • Author(s)
      Saijo H, Kanno Y, Mori Y, Suzuki S, Ohkubo K, Chikazu D, Yonehara Y, ChungU, Takato T.
    • Journal Title

      Int J OralMaxillofac Surg

      Volume: 40 Pages: 955-960

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gα<sub>q</sub> signal in osteoblasts is inhibitory to the osteoanabolic action of parathyroid hormone2011

    • Author(s)
      Ogata N, 他
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 15 Pages: 13733

    • DOI

      10.1074/jbc.m110.200196

    • URL

      https://pure.teikyo.jp/en/publications/71658699-dc30-4687-8ee7-90283156397f

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trehalose May Prevent Postsurgical Adhesions in a Rabbit Model of Hysterotomy2011

    • Author(s)
      Fujino H, 他
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 73 Issue: 7 Pages: 931-935

    • DOI

      10.1292/jvms.10-0342

    • NAID

      130000445084

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel method for designing and fabricating custom-made artificial bones2011

    • Author(s)
      Saijo H, 他
    • Journal Title

      Int J Oral Maxillofac Surg

      Volume: 40 Issue: 9 Pages: 955-960

    • DOI

      10.1016/j.ijom.2011.03.018

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and dymanics of tetra-PEG gel by Brownian dynamics2010

    • Author(s)
      Hashimoto Y, Takasu M, Kawamoto S, Oda T, Nagao H, Sakai T, Chung U.
    • Journal Title

      Trans Mater Res Soc Japan

      Volume: 35 Pages: 547-553

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Highly elastic and deformable hydrogel formed from tetra-arm polymers2010

    • Author(s)
      Sakai T, Matsunaga T, Akagi Y, Kurakazu M, Chung U, Shibayama M.
    • Journal Title

      Macromolecular Rapid Commun

      Volume: 31 Pages: 1954-1959

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development2010

    • Author(s)
      Hojo H, Ohba S, Yano F, Chung U.
    • Journal Title

      J Bone Miner Metab

      Volume: 28 Pages: 489-502

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of endochondral ossification by HIF2A during skeletal growth and osteoarthritis development2010

    • Author(s)
      Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, and Kawaguchi H.
    • Journal Title

      Nature Med

      Volume: 16 Pages: 678-683

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and mechanical properties of a nanocomposite gel consisting of a tetra-PEG/clay network2010

    • Author(s)
      Fukasawa M, Sakai T, Chung U, Haraguchi K.
    • Journal Title

      Macromolecules

      Volume: 43 Pages: 4370-4378

    • NAID

      40018879965

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trehalose inhibits oral xerosis by protecting cell membrane2010

    • Author(s)
      Mori Y, Yano F, Shimohata S, Suzuki S, Chung U, Takato T.
    • Journal Title

      Int J Oral Maxillofac Surg

      Volume: 36 Pages: 916-921

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of bone formation ex vivo and in vivo by a helioxanthin-derivative2010

    • Author(s)
      Nakajima K, Komiyama Y, Hojo H, Ohba S, Yano F, Nishikawa N, Aburatani H, Takato T, Chung U.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 395 Pages: 502-508

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeted deletion of the Nesp55 DMR provides evidence for another principal imprinting control region within Gnas and a mouse model of autosomal dominant pseudohypoparathyroidism type Ib2010

    • Author(s)
      Frohlich LF, Mrakovcic M, Steinborn S, Chung U, Bastepe M, Juppner H.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107 Pages: 9275-9280

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxytetracycline induces chondrogenic differentiation without promoting terminal differentiation2010

    • Author(s)
      Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Ikeda T, Yonezawa T, Woo J, TakatoT, Nakamura K, Kawaguchi H, Chung U.
    • Journal Title

      J Bone Miner Metab

      Volume: 28 Pages: 489-502

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of gelation kinetics of Tetra-PEG gel2010

    • Author(s)
      Kurakazu M, Katashima T, Chijiishi M, Nishi K, Akagi Y, Matsunaga T, Shibayama M, Chung U, Sakai T.
    • Journal Title

      Macromolecules

      Volume: 43 Pages: 3935-3940

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Runx1 and Runx2 cooperate during sternum morphogenesis2010

    • Author(s)
      Kimura A, Inose H, Yano F, Fujita F, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, Takeuchi Y, Itoh H, Imamura T, Kawaguchi H, Chung U, Martin JF, Iseki S, Shinomiya K, Takeda S.
    • Journal Title

      Development

      Volume: 137 Pages: 1159-1167

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of topological defects in Tetra-PEG gels2010

    • Author(s)
      Akagi Y, Matsunaga T, Shibayama M, Chung U, Sakai T.
    • Journal Title

      Macromolecules

      Volume: 43 Pages: 488-493

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Akt1 in chondrocytes controls cartilage calcification during endochondral ossification under physiological and pathological conditions2010

    • Author(s)
      Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa H, Yano F, Ogata N, Nakamura K, Chung U, Kawaguchi H.
    • Journal Title

      Arthritis Rheum

      Volume: 62 Pages: 826-836

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms underlying catabolic and anabolic functions of parathyroid hormone on bone by combination of culture systems of mouse cells2010

    • Author(s)
      Shinoda Y, Kawaguchi H, Higashikawa A, Nakamura K, Chung U, and Ogata N.
    • Journal Title

      J Cell Biochem

      Volume: 109 Pages: 755-763

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Icariin : A potential osteoconductive compound for bone tissue engineering2010

    • Author(s)
      Zhao J, Ohba S, Komiyama Y, Shinkai M, Chung U, Nagamune T.
    • Journal Title

      Tissue Eng Part A

      Volume: 16 Pages: 233-243

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of endochondral ossification by HIF2A during skeletal growth and osteoarthritis development.2010

    • Author(s)
      Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H.
    • Journal Title

      Nature Med 16

      Pages: 678-683

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Highly elastic and deformable hydrogel formed from tetra-arm polymers.2010

    • Author(s)
      Sakai T, 他
    • Journal Title

      Macromolecular Rapid Commun

      Volume: 1954-1959 Pages: 1954-1959

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of endochondral ossification by HIF2A duringskeletal growth and osteoarthritis development.2010

    • Author(s)
      Saito T, 他
    • Journal Title

      Nature Med

      Volume: 16 Pages: 678-683

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of bone formation ex vivo and in vivo by a helioxanthin-derivative.2010

    • Author(s)
      Nakajima K, 他
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 395 Pages: 502-508

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of trehalose and sodium carboxymethyl cellulose on prevention of organ adhesion after laparotomy : apreclinical study2009

    • Author(s)
      Lee S, Miwa Y, Nishimura R, Chung U, Suzuki S, Sasaki N.
    • Journal Title

      Jpn J Vet Aneth Surg

      Volume: 40 Pages: 19-26

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone regeneration within a tailor-made tricalcium phosphate bone implant with both horizontal and vertical cylindrical holes transplanted into the skull of dogs2009

    • Author(s)
      Choi SJ, Lee JI, Igawa K, Sugimori O, Suzuki S, Mochizuki M, Nishimura R, Chung UI, Sasaki N.
    • Journal Title

      J Artif Organs

      Volume: 12 Pages: 274-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] SANS and SLS Studies on Tetra-Arm PEG Gels in As-prepared and Swollen States2009

    • Author(s)
      Matsunaga T, Sakai T, Akagi Y, Chung U, Shibayama M.
    • Journal Title

      Macromolecules

      Volume: 42 Pages: 6245-6252

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology2009

    • Author(s)
      Saijo H, Kanno Y, Igawa K, Mori Y, Kondo K, Shimizu K, Suzuki S, Chikazu D, Iino M, Sasaki N, Anzai M, Chung U, Takato T.
    • Journal Title

      J Artif Organs

      Volume: 12 Pages: 200-205

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure characterization of Tetra-PEG Gel by Small-angle Neutron Scattering2009

    • Author(s)
      Matsunaga T, Sakai T, Akagi Y, Chung U, Shibayama M.
    • Journal Title

      Macromolecules

      Volume: 42 Pages: 1344-51

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Haematopoietic stem cells depend on Gαs-mediated signalling to engraft bone marrow2009

    • Author(s)
      Adams GB, Alley IR, Chung U, Chabner KT, Marsters ES, Chen M, Weinstein LS, Kronenberg HM, Scadden DT.
    • Journal Title

      Nature

      Volume: 459 Pages: 103-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Screening of Chondrogenic Factors by a Real-Time Fluorescence Monitoring Cell Line ATDC5-C2ER : Identification of Sorting Nexin 19 as a Novel Factor2009

    • Author(s)
      Kan A, Ikeda T, Saito T, Yano F, Ogata N, Nakamura K, Chung U, Kawaguchi H.
    • Journal Title

      Arthritis Rheum

      Volume: 60 Pages: 3314-3323

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional induction of SOX9 by NF-κB family member RelA in chondrogenic cells2009

    • Author(s)
      Ushita M, Saito T, Ikeda T, Yano F, Higashikawa A, Ogata N, Chung UI, Nakamura K, Kawaguchi H.
    • Journal Title

      Osteoarthritis Cartilage

      Volume: 17 Pages: 1065-1075

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells2009

    • Author(s)
      Wang W, Itaka K, Ohba S, Nishiyama N, Chung U, Yamasaki Y, Kataoka K.
    • Journal Title

      Biomaterials

      Volume: 30 Pages: 2705-15

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Temporal and spatial changes in element distribution in bone and cartilage2009

    • Author(s)
      Yamamoto K, Igawa K, Ueno H, Yano F, Chung U, Koshima I.
    • Journal Title

      J Orthop Sci

      Volume: 14 Pages: 190-203

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone Regeneration Using Collagen Type I Vitrigel with Bone Morphogenetic Protein-22009

    • Author(s)
      Zhao J, Shinkai M, Takezawa T, Ohba S, Chung U, Nagamune T. Zhao J, Shinkai M, Takezawa T, Ohba S, Chung U, Nagamune T.
    • Journal Title

      J Biosci Bioeng

      Volume: 107 Pages: 318-323

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the core element responsive to Runx2 in the promoter of human type X collagengene2009

    • Author(s)
      Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Nakamura K, ChungU, Kawag uchi H.
    • Journal Title

      Arthritis Rheum

      Volume: 60 Pages: 166-178

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] C/EBPβpromotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57Kip22009

    • Author(s)
      Hirata M, Kugimiya F, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Fukai A, Ikeda T, Nakamura K, Chung UI, Kawaguchi H.
    • Journal Title

      PLoS ONE

      Volume: 4 Pages: 4543-4543

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology.2009

    • Author(s)
      Sai jo H, Kanno Y, Igawa K, Mori Y, Kondo K, Shimizu K, Suzuki S, Chikazu D, Iino M, Sasaki N, Anzai M, Chung U, Takato T.
    • Journal Title

      J Artif Organs 12

      Pages: 200-205

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Bone regeneration within a tailor-made tricalcium phosphate bone implant with both horizontal and vertical cylindrical holes transplanted into the skull of dogs.2009

    • Author(s)
      Choi SJ, Lee JI, Igawa K, Sugimori O, Suzuki S, Mochizuki M, Nishimura R, Chung UI, Sasaki N.
    • Journal Title

      J Artif Organs. 12

      Pages: 274-277

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology2009

    • Author(s)
      Saijo H, Kanno Y, Igawa K, Mori Y, Kondo K, Shimizu K, Suzuki S, Chikazu D, Iino M, Sasaki N, Anzai M, Chung U, Takato T.
    • Journal Title

      J Artif Organs 12

      Pages: 200-205

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone Regeneration Using Collagen Type I Vitrigel with Bone Morphogenetic Protein-2009

    • Author(s)
      Zhao J, Shinkai M, Takezawa T, Ohba S, Chung U, Nagamune T.
    • Journal Title

      J Biosci Bioeng 107

      Pages: 318-323

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Haematopoietic stem cells depend on Gas-mediated signalling to engraft bone marrov2009

    • Author(s)
      Adams GB, Alley IR, Chung U, Chabner KT, Marsters ES, Chen M, Weinstein LS, Kronenberg HM, Scadden DT.
    • Journal Title

      Nature 459

      Pages: 103-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone regeneration within a tailor-made tricalcium phosphate bone implant with both horizontal and vertical cylindrical holes transplanted into the skull of dogs.2009

    • Author(s)
      Choi SJ, Lee JI, Igawa K, Sugimori O, Suzuki S, Mochizuki M, Nishimura R, Chung UI, Sasaki N.
    • Journal Title

      J Artif Organs 12

      Pages: 274-277

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue engineering of bone and cartilage.2009

    • Author(s)
      Ohba S, Yano F, Chung U.
    • Journal Title

      IBMS Bone KEy 6

      Pages: 405-419

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Manufacturing of artificial bones using 3D inkjet printing technology.2009

    • Author(s)
      Chung U.
    • Journal Title

      Int J Automation Technology 3

      Pages: 509-513

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selection of highly osteogenic and chondrogenic cells form bone marrow stromal cells in biocompatible polymer-coated plates.2009

    • Author(s)
      Liu G, Ogasawara T, Watanabe J, Ishihara K, Asawa K, Chung U, Moro T, Takatori T, Takato T, Nakamura K, Kawaguchi H, Hoshi K.
    • Journal Title

      J Biomed Mater Res A 92A

      Pages: 1273-1282

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells.2009

    • Author(s)
      Wang W, Itaka K, Ohba S, Nishiyama N, Chung U, Yamasaki Y, Kataoka K.
    • Journal Title

      Biomaterials 30

      Pages: 2705-2715

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal and spatial changes in element distribution in bone and cartilage.2009

    • Author(s)
      Yamamoto K, Igawa K, Ueno H, Yano F, Chung U, Koshima I.
    • Journal Title

      J Orthop Sci 14

      Pages: 190-203

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the core element responsive to Runx2 in the promoter of human type X collagen gene.2009

    • Author(s)
      Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Nakamura K, Chung U, Kawaguchi H.
    • Journal Title

      Arthritis Rheum 60

      Pages: 166-178

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C/EBPss promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57Kip2.2009

    • Author(s)
      Hirata M, Kugimiya F, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Fukai A, Ikeda T, Nakamura K, Chung UI, Kawaguchi H.
    • Journal Title

      PLoS ONE 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and fabrication of a high-strength hydrogel with ideally homogeneous network structure from tetrahedron-like macromonomers2008

    • Author(s)
      Sakai T, Matsunaga T, Yamamoto Y, Ito C, Yoshida R, Sasaki N, Suzuki S, Shibayama M, Chung U.
    • Journal Title

      Macromolecules

      Volume: 41 Pages: 5379-84

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of high-throughput screening system for osteogenic drugs using a cell-based sensor2008

    • Author(s)
      Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama Y, Ikeda T, Lichtler AC, Woo J-T, Yonezawa T, Takato T, Chung U.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 376 Pages: 375-379

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis2008

    • Author(s)
      Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung U, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S.
    • Journal Title

      J Biol Chem

      Volume: 283 Pages: 26499-508

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 92008

    • Author(s)
      Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, and Kawaguchi H
    • Journal Title

      J Biol Chem

      Volume: 283 Pages: 24682-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of GSK-3βby cyclic GMP-dependent protein kinase II promotes chondrocyte hypertrophy and skeletalgrowth2008

    • Author(s)
      Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung U, Kawaguchi H.
    • Journal Title

      J Clin Invest

      Volume: 118 Pages: 2506-2515

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of Angiogenesis Through Stabilization of Hypoxia-inducible Factor-1 by Silencing Prolyl Hydroxylase Domain-2 Gene2008

    • Author(s)
      Wu S, Nishiyama N, Kano MR, Morishita Y, Miyazono K, Itaka K, Chung UI, Kataoka K.
    • Journal Title

      Mol Ther

      Volume: 16 Pages: 1227-34

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity2008

    • Author(s)
      Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung U.
    • Journal Title

      Dev Cell

      Volume: 14 Pages: 689-699

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders2008

    • Author(s)
      Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, Kudo I, Uematsu S, Akira S, Chung U, Nakamura K, Kawaguchi H.
    • Journal Title

      Arthritis Rheum

      Volume: 58 Pages: 172-183

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Icariin induce osteoblastic differentiation in vitro by a BMP and runx2 pathway2008

    • Author(s)
      Zhao J, Shinkai M, Ohba S, Chung U, Nagamune T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 369 Pages: 444-448

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of an osteoblast cell-based 3D continuous perfusion microfluidic system for drug screening2008

    • Author(s)
      Jang K, Sato K, Igawa K, Chung U, Kitamori T.
    • Journal Title

      Analytical Bioanalytical Chemistry

      Volume: 390 Pages: 825-832

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design and fabrication of a high-strength hydrogel with ideally homogeneous network structure from tetrahedron-like macromonomers.2008

    • Author(s)
      Sakai T, Matsunaga T, Yamamoto Y, Ito C, Yoshida R, Sasaki N, Suzuki S, Shibayama M, Chung U.
    • Journal Title

      Macromolecules 41

      Pages: 5379-5384

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Patchedl haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity.2008

    • Author(s)
      Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung U.
    • Journal Title

      Dev Cell 14

      Pages: 689-699

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Design and fabrication of a high-strength hydrogel with ideally homogeneous network struc2008

    • Author(s)
      Sakai T, Matsunaga T, Yamamoto Y, Ito C, Yoshida R, Sasaki N, Suzuki S, Shibavama M, Chung U
    • Journal Title

      Macromolecules 41

      Pages: 5379-5384

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical application of artificial bone in the maxillofacial region.2008

    • Author(s)
      Saijo H, Chung U, Igawa K, Mori Y, Chikazu D, Iino M, Takato T
    • Journal Title

      J Artif Organs 11

      Pages: 171-176

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of high-throughput screening system for osteogenic drugs using a cell-based2008

    • Author(s)
      Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama Y, Ikeda T, Lichtler AC, Woo J-T, Yonezawa T
    • Journal Title

      Biochem Biophys Res Commun 376

      Pages: 375-379

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experimental Parathyroid Hormone Gene Therapy using 0C31 Integrase.2008

    • Author(s)
      Lee S, Hong SW, Choi HS, Lee LY, Nam C, Rhee Y, Chung UI, Lim SK
    • Journal Title

      Endocr J 55

      Pages: 1033-1041

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.2008

    • Author(s)
      Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakevama H. Kawamura N, Ikeda T
    • Journal Title

      J Biol Chem 283

      Pages: 26499-26508

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metallci2008

    • Author(s)
      Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiva F, Ikeda T. Kawamura N.
    • Journal Title

      J Biol Chem 283

      Pages: 24682-24689

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of GSK-3 β by cyclic GMP-dependent protein kinase II promotes chondrc2008

    • Author(s)
      Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A.
    • Journal Title

      J Clin Invest 118

      Pages: 2506-2515

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of Angiogenesis Through Stabilization of Hypoxia-inducible Factor-1 by Silen2008

    • Author(s)
      Wu S, Nishiyama N, Kano MR, Monshita Y, Miyazono K, Itaka K, Chung UI. Kataoka K
    • Journal Title

      Mol Ther 16

      Pages: 1227-1234

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Patchedl haploinsufficiency increases adult bone mass and modulates Gli3 repressor activi2008

    • Author(s)
      Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Mivajima T.
    • Journal Title

      Dev Cell 14

      Pages: 689-699

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF22008

    • Author(s)
      Tamiya H, Ikeda T, Jung JH, Saito T, Jung YK, Kawaguchi H, Ohba S, Chung UT. and Choi JY
    • Journal Title

      Gene 416

      Pages: 53-60

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of microsomal prostaglandin E synthase I deficiency with impaired fracture hear2008

    • Author(s)
      Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M. Kudo I. Uematsu S.
    • Journal Title

      Arthritis Rheum 58

      Pages: 172-183

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Icariin induce osteoblastic differentiation in vitro by a BMP and runx2 pathway2008

    • Author(s)
      Zhao J, Shinkai M, Ohba S, Chung U, Nagamune T
    • Journal Title

      Biochem Biophys Res Commun 369

      Pages: 444-448

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scaffolds for skeletal regeneration.2008

    • Author(s)
      Chung U
    • Journal Title

      NanoBiotechnology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an osteoblast cell-based 3D continuous perfusion microfluidic system for d2008

    • Author(s)
      Jang K, Sato K, Igawa K, Chung U, Kitamori T
    • Journal Title

      Analytical Bioanalytical Chemistry 390

      Pages: 825-832

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] C/EBP-βand RUNX2 Cooperatively Control Cartilage Degradation with MMP-13 as the Target and HIF-2α as the Inducer in Chondrocytes2011

    • Author(s)
      Hirata M
    • Organizer
      33th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      米国サンディエゴ
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional Redundancy of GSK-3α and GSK-3β To Control Chondrocyte Differentiation through Phosphorylation of RelA/NF-κB p652011

    • Author(s)
      Ito S
    • Organizer
      33th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      米国サンディエゴ
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Notch/Rbpj/Hes1 signal in chondrocytes modulates terminal stage of end ochondral ossification during skeletal growth and osteoarthritis development2011

    • Author(s)
      Hosaka Y
    • Organizer
      33th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      米国サンディエゴ
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] GSK-3α and GSK-3βmodulate early stages of chondrocytes differentiation through phosphorylation of RelA/NF-κB p652011

    • Author(s)
      Ito S
    • Organizer
      2011 World Cogress on Osteoarthritis (OARSI)
    • Place of Presentation
      米国サンディエゴ
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Notch/Rbpj/Hes1 signal in chondrocytes modulates terminal stage of end ochondral ossification during skeletal growth and osteoarthritis development2011

    • Author(s)
      Hosaka Y
    • Organizer
      2011 World Cogress on Osteoarthritis (OARSI)
    • Place of Presentation
      米国サンディエゴ
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Tetra-PEGゲルにおける高分子網目の膨潤・乾燥と弾性の関係2011

    • Author(s)
      倉員麻奈美
    • Organizer
      第22回高分子ゲル研究討論会
    • Place of Presentation
      東京大学山上会館
    • Year and Date
      2011-01-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Notch/Rbpj/Hes1 signal in chondrocytes modulates terminal stage of endochondral ossification during skeletal growth and osteoarthritis development2011

    • Author(s)
      Hosaka Y, Saito T, Sugita S, Fukai A, Hikata T, Akiyama H, Nakamura T, NakamuraK, Chung UI, Kawaguchi H.
    • Organizer
      33th annual meeting of the American Society for Bone and Mineral Research(ASBMR)
    • Place of Presentation
      San diego, America
    • Related Report
      2011 Final Research Report
  • [Presentation] GSK-3・and GSK-3・modulate early stages of chondrocytes differentiation through phosphorylation of RelA/NF-κB p652011

    • Author(s)
      Ito S, Saito T, Hirata M, Ushita m, IkedaT, Nakamura K, Chung UI, Kawaguchi H.
    • Organizer
      2011 World Cogress on Osteoarthritis(OARSI)
    • Place of Presentation
      San diego, America
    • Related Report
      2011 Final Research Report
  • [Presentation] Akt in chondrocytes controls cartilage calcification during skeletal growth and asteophyte formation in osteoarthritis2010

    • Author(s)
      Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Yano F, Ogata N, Nakamura K, ChungUI, Kawaguchi H
    • Organizer
      56 th Annual Meeting of the Orthopaedic Research Society(ORS)
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular network on the C/EBP-bete axis including Runx2, MMP13, and HIF2A controls osteoarthritis development2010

    • Author(s)
      Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H.
    • Organizer
      2010 World Cogress on Osteoarthritis(OARSI)
    • Place of Presentation
      Brussels, Belgium
    • Related Report
      2011 Final Research Report
  • [Presentation] 三次元造形技術を用いた人工骨の開発2009

    • Author(s)
      鄭雄一
    • Organizer
      第18回日本コンピューター外科学会
    • Place of Presentation
      東京大学鉄門記念講堂(東京都)
    • Year and Date
      2009-11-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Signaling factors coordinating chondrogenesis and osteogenesis in endochondral bone development.2009

    • Author(s)
      Chung U.
    • Organizer
      The 26th Naito Conference on Osteobiology
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Year and Date
      2009-11-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 均一構造を有するtetra-PEGゲルの構造解析2009

    • Author(s)
      酒井崇匡、松永拓郎、柴山充弘、鄭雄一
    • Organizer
      第20回高分子ゲル研究討論会
    • Place of Presentation
      東京
    • Year and Date
      2009-01-15
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] Signaling factors coordinating chondrogenesis and osteogenesis in endochondral bone development2009

    • Author(s)
      Chung U.
    • Organizer
      The 26th Naito Conferenceon Osteobiology
    • Place of Presentation
      Hyogo
    • Related Report
      2011 Final Research Report
  • [Presentation] Signaling factors coordinating chondrogenesis and osteogenesis in endochondral bone development.2009

    • Author(s)
      Chung U.
    • Organizer
      The 26th Naito Conference on Osteobiology.
    • Place of Presentation
      Hyogo
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 新規低分子化合物チエノインダゾール誘導俸はRunx1とSox trioを介して永久軟骨再生を誘導する2008

    • Author(s)
      矢野文子、池田敏之、斎藤琢、緒方直史、木村文子、竹田秀、中村耕三、高戸毅、川口浩、鄭雄一
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪、日本
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel small thienoindazole-derivative compound promotes chondrogenic differentiation without inducing hypertrophy through production of Runxl2008

    • Author(s)
      F. Yano, T. Ikeda, T. Saito, N. Ogata, K. Nakamura, T. Takato, H. Kawaguchi. U. Chune
    • Organizer
      The Osteoarthritis Research Society International World Congress on Osteoarthritis
    • Place of Presentation
      ローマ、イタリア
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 均一構造を有するtetra-PEGゲルの構造解析2008

    • Author(s)
      酒井崇匡、松永拓郎、吉田亮、柴山充弘、鄭雄一
    • Organizer
      第19回高分子ゲル研究討論会
    • Place of Presentation
      東京、日本
    • Year and Date
      2008-01-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規低分子化合物チエノインダゾール誘導体はRunx1とSox trioを介して永久軟骨再生を誘導する2008

    • Author(s)
      矢野文子、池田敏之、斎藤琢、緒方直史、木村文子、竹田秀、中村耕三、高戸毅、川口浩、鄭雄一
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] A novel small thienoindazole-derivative compound promotes chondrogenic differentiation without inducing hypertrophy through production of Runx12008

    • Author(s)
      F. Yano, T. Ikeda, T. Saito, N. Ogata, K. Nakamura, T. Takato, H. Kawaguchi, U. Chung.
    • Organizer
      A novel small thienoindazole-derivative compound promotes chondrogenic differentiation without inducing hypertrophy through production of Runx1
    • Place of Presentation
      Roma, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] A novel small thienoindazole-derivative compound promotes chondrogenic differentiation without inducing hypertrophy through production of Runxl.2008

    • Author(s)
      F.Yano, T.Ikeda, T.Saito, N.Ogata, K.Nakamura, T.Takato, H.Kawaguchi, U.Chung
    • Organizer
      2008 OARSI (The Osteoarthritis Research Society International) World Congress on Osteoarthritis
    • Place of Presentation
      Roma, Italy(口頭発表、Young Investigator Award)
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 新規低分子化合物チエノインダゾール誘導体はRunxlとSox trioを介して永久軟骨再生を誘導する2008

    • Author(s)
      矢野文子、池田敏之、斎藤琢、緒方直史、木村文子、竹田秀、中村耕三、高戸毅、川口浩、鄭雄一
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場、大阪(口頭発表、優秀演題賞(基礎系)、IBMS-ANZBMS Meeting Travel Award 2009)
    • Related Report
      2010 Self-evaluation Report
  • [Book] 図解骨博士が教える「老いない体」のつくり方実践編2011

    • Author(s)
      鄭雄一
    • Total Pages
      111
    • Publisher
      ワック株式会社
    • Related Report
      2011 Final Research Report
  • [Book] 図解 骨博士が教える「老いない体」のつくり方 実践編2011

    • Author(s)
      鄭雄一
    • Total Pages
      111
    • Publisher
      ワック株式会社
    • Related Report
      2011 Annual Research Report
  • [Book] 骨博士が教える「老いない体」のつくり方2010

    • Author(s)
      鄭雄一
    • Total Pages
      180
    • Publisher
      ワック株式会社
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Book] 骨博士が教える「老いない体」のつくり方.2010

    • Author(s)
      鄭雄一
    • Total Pages
      180
    • Publisher
      ワック株式会社
    • Related Report
      2010 Annual Research Report
  • [Book] 生体材料:セラミック三次元材料2008

    • Author(s)
      井川和代、鄭雄一
    • Publisher
      日刊工業新聞社
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.tetrapod.t.u-tokyo.ac.jp

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • Related Report
      2011 Annual Research Report
  • [Remarks] 研究室ホムーページ

    • URL

      http://www.tetraDod.t.u-tokvo.ac.jp/

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.tetrapod.tu.tokyo.ac.jp

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 3次元形成可能な格子構造体2011

    • Inventor(s)
      鄭雄一, 他
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2011-09-12
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] トレハロースを含有する炎症性呼吸器疾患の治療剤2011

    • Inventor(s)
      鄭雄一, 他
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2011-096657
    • Filing Date
      2011-04-24
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] ケロイド又は肥厚性瘢痕の治療剤又は予防剤2011

    • Inventor(s)
      鄭雄一, 他
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2011-12-05
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 人工骨構成ユニット及び人工骨構成システム2010

    • Inventor(s)
      鄭雄一, 他
    • Industrial Property Rights Holder
      東京大学, 他
    • Filing Date
      2010-07-22
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 組織癒着防止液及び組織癒着防止方法2010

    • Inventor(s)
      鄭雄一, 他
    • Industrial Property Rights Holder
      東京大学, 他
    • Filing Date
      2010-07-27
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 人工骨構成ユニット及び人工骨構成システム2010

    • Inventor(s)
      鄭雄一, 他
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2010-07-22
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] カルシウムイオン溶出を制御した人工骨材料2010

    • Inventor(s)
      鄭雄一, 他
    • Industrial Property Rights Holder
      東京大学
    • Acquisition Date
      2010-02-19
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 人工骨構成ユニット及び人工骨構成システム2010

    • Inventor(s)
      鄭雄一, 他
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 人工骨構成ユニット及び人工骨構成システム2009

    • Inventor(s)
      鄭雄一, 他
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2009-07-22
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] カルシウムイオン溶出を制御した人工骨材料2008

    • Inventor(s)
      鄭雄一、上野洋史、井川禾日代、山本健一
    • Industrial Property Rights Holder
      鄭雄一、上野洋史、井川禾日代、山本健一
    • Industrial Property Number
      2008-174025
    • Filing Date
      2008-07-02
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi