| Project/Area Number |
20240045
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Hokkaido University |
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Principal Investigator |
YASUDA Kazunori Hokkaido University, 大学院・医学研究科, 教授 (20166507)
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| Co-Investigator(Kenkyū-buntansha) |
OHMIYA Yoshihiro 産業技術総合研究所, 副研究部門長 (20223951)
KITAMURA Nobuto 北海道大学, 大学院・医学研究科, 講師 (80447044)
ONODERA Shin 北海道大学, 大学院・医学研究科, 客員准教授 (00359481)
KWON Hyuck Joon 北海道大学, 大学院・医学研究科, 特任助教 (20455629)
KUROKAWA Takayuki 北海道大学, 大学院・先端生命科学研究院, 特任助教 (40451439)
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| Co-Investigator(Renkei-kenkyūsha) |
OSADA Yoshihito 理化学研究所, 基幹研究所, 副所長 (60007804)
GONG Jian Ping 北海道大学, 大学院・先端生命科学研究院, 教授 (20250417)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥50,570,000 (Direct Cost: ¥38,900,000、Indirect Cost: ¥11,670,000)
Fiscal Year 2010: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2009: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
Fiscal Year 2008: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
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| Keywords | 関節軟骨 / 自然再生 / 再生誘導材料 / ダブルネットワークゲル / 分子機序 / 関節軟骨欠損 / 硝子軟骨 / 高機能生体材料 / 再生誘導 |
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| Research Abstract |
(1) We clarified genetic characteristics of the articular cartilage spontaneously regenerated by double-network (DN) gel, using microarray. (2) We found that PAMPS, a component of the DN gel, has an ability that can induces the spontaneous articular cartilage regeneration. (3) We observed marker genes in a chondrogenic differentiation process, using multi-colored bioluminescence probes. We discovered a synchronized oscillation phenomenon of cell metabolism in prechondrogenic condensation. (4) We developed the transgenic bioluminescence mouse to be used for in vivo imaging. (5) These results provided important information to clarify a comprehensive mechanism of the spontaneous cartilage regeneration phenomenon.
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