Nucleic acid-based nanomachine systems for tumor treatment
Project/Area Number |
20240049
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | Kyushu University |
Principal Investigator |
MARUYAMA Atsushi Kyushu University, 先導物質化学研究所, 教授 (40190566)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥48,880,000 (Direct Cost: ¥37,600,000、Indirect Cost: ¥11,280,000)
Fiscal Year 2010: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2009: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2008: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
|
Keywords | 機能性核酸 / 核酸シャペロン / 医薬送達システム / 高分子電解質複合体 / グラフトコポリマー / 構造転移 / ナノマシン / ポリカチオン / くし型共重合体 / DNA / 高次構造転移 / 核酸4重鎖 |
Research Abstract |
In this research project, we studied polymer materials to construct therapeutic nanomachine systems for tumor treatment. Polymer materials that accumulates in tumor tissues and exhibits nucleic acid chaperoning activity were designed and evaluated. Cationic comb-type copolymers having hydrophilic graft chains were found to accumulate effectively in tumor tissue subcutaneously implanted in mice. The copolymer was also found to facilitate structural transition between stem-loop structure and duplex and assembly of quadruplex DNA. These results suggested that activity of functional nucleic acids could be regulated with the cationic copolymers at tumor sites.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Interaction of Self-assembled Cationic Nanogels with Oligo-DNA and Function as Artificial Nucleic Acid Chaperone2009
Author(s)
Morimoto, N., Tamada, J., Sawada, S., Shimada, N., Kano, A., Maruyama, A., Akiyoshi, K.
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Journal Title
Chemistry Letters 38
Pages: 496-497
NAID
Related Report
Peer Reviewed
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[Journal Article] A highly efficient siRNA carrier of PBLG modified hyperbranched PEI2009
Author(s)
Chen, J., Tian, H., Guo, Z., Xia, J., Kano, A., Maruyama, A., Jing, X., Chen, X.
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Journal Title
Macromol Biosci 9
Pages: 1247-1253
Related Report
Peer Reviewed
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